R1
vin
∅ > X
R2
Calcium export from cell
X > ∅
R3
CICR
Y > X
R4
serca
X > Y
R5
Leak flux
Y > X
R6
PLC
∅ > Z
R7
IP3 degradation
Z > ∅
Note that constraints are not enforced in simulations. It remains the responsibility of the user to verify that simulation results satisfy these constraints.
A mathematical model of spontaneous calcium(II) oscillations in astrocytes.
J. Theor. Biol. 2008;
251
(4):
553-560
- PubMed: 18275973
- DOI: 10.1016/j.jtbi.2007.12.011
- ISSN: 1095-8541
- URL: https://ncbi.nlm.nih.gov/pubmed/18275973
Abstract
Astrocytes exhibit oscillations and waves of Ca2+ ions within their cytosol and it appears that this behavior helps facilitate the astrocyte's interaction with its environment, including its neighboring neurons. Often changes in the oscillatory behavior are initiated by an external stimulus such as glutamate, recently however, it has been observed that oscillations are also initiated spontaneously. We propose here a mathematical model of how spontaneous Ca2+ oscillations arise in astrocytes. This model uses the calcium-induced calcium release and inositol cross-coupling mechanisms coupled with a receptor-independent method for producing inositol (1,4,5)-trisphosphate as the heart of the model. By computationally mimicking experimental constraints we have found that this model provides results that are qualitatively similar to experiment.
The SBML for this model was obtained from the BioModels database (BioModels ID: BIOMD0000000184)
Biomodels notes: The plot corresponds to Fig 3 of the paper. Result obtained using MathSBML.
JWS Online curation: This model was curated by reproducing the figures as described in the BioModels Notes. No additional changes were made.