begin name lavrentovich1 end name begin reactions R1 {1.0}$EXTERNAL = {1.0}X R2 {1.0}X = {1.0}$EXTERNAL R3 {1.0}Y = {1.0}X R4 {1.0}X = {1.0}Y R5 {1.0}Y = {1.0}X R6 {1.0}$EXTERNAL = {1.0}Z R7 {1.0}Z = {1.0}$EXTERNAL end reactions begin rate equations R1 = compartment*vin R2 = compartment*kout*X[t] R3 = (4*ER*kCaA^n*vM3*X[t]^n*(-X[t] + Y[t])*Z[t]^m)/((kCaA^n + X[t]^n)*(kCaI^n + X[t]^n)*(kip3^m + Z[t]^m)) R4 = (compartment*vM2*X[t]^2)/(k2^2 + X[t]^2) R5 = ER*kf*(-X[t] + Y[t]) R6 = (compartment*vp*X[t]^2)/(kp^2 + X[t]^2) R7 = compartment*kdeg*Z[t] end rate equations begin parameters k2 = 0.1 kCaA = 0.15 kCaI = 0.15 kdeg = 0.08 kf = 0.5 kip3 = 0.1 kout = 0.5 kp = 0.3 m = 2.2 n = 2.02 vM2 = 15.0 vM3 = 40.0 vin = 0.05 vp = 0.05 ER = 1.0 compartment = 1.0 end parameters begin initial conditions X[0] = Xi Y[0] = Yi Z[0] = Zi end initial conditions begin initial values Xi = 0.1 Yi = 1.5 Zi = 0.1 end initial values begin assignment rules end assignment rules begin function definitions end function definitions begin events end events begin process annotations end process annotations begin species annotations X http://identifiers.org/obo.chebi/CHEBI:29108 X http://identifiers.org/kegg.compound/C00076 Y http://identifiers.org/obo.chebi/CHEBI:29108 Y http://identifiers.org/kegg.compound/C00076 Z http://identifiers.org/obo.chebi/CHEBI:16595 Z http://identifiers.org/kegg.compound/C01245 end species annotations begin units end units