begin name
zhu1
end name

begin reactions
CalciumInflux {1.0}$EXTERNAL = {1.0}Z
CalciumInfluxstimulation {1.0}$EXTERNAL = {1.0}Z
Calciumintocytoplasm {1.0}Y = {1.0}Z
Calciumintostore {1.0}Z = {1.0}Y
Leakage {1.0}Y = {1.0}Z
Leakagefromcytoplasm {1.0}Z = {1.0}$EXTERNAL
TFdegradation {1.0}X = {1.0}$EXTERNAL
TFsynthesis {1.0}$EXTERNAL = {1.0}X
TFsynthesisbasal {1.0}$EXTERNAL = {1.0}X
end reactions

begin rate equations
CalciumInflux = CalciumInfluxv0
CalciumInfluxstimulation = CalciumInfluxstimulationbeta*CalciumInfluxstimulationv1
Calciumintocytoplasm = (CalciumintocytoplasmVm3*Y[t]^Calciumintocytoplasmm*Z[t]^Calciumintocytoplasmp)/((CalciumintocytoplasmKr^Calciumintocytoplasmm + Y[t]^Calciumintocytoplasmm)*(CalciumintocytoplasmKA^Calciumintocytoplasmp + Z[t]^Calciumintocytoplasmp))
Calciumintostore = (CalciumintostoreVm2*Z[t]^Calciumintostoren)/(CalciumintostoreK2^Calciumintostoren + Z[t]^Calciumintostoren)
Leakage = Leakagek1*Y[t]
Leakagefromcytoplasm = Leakagefromcytoplasmk*Z[t]
TFdegradation = TFdegradationkd*X[t]
TFsynthesis = (kf*X[t]^2)/(Kd + X[t]^2)
TFsynthesisbasal = TFsynthesisbasalRbas
end rate equations

begin parameters
Ka = 0.5
Kb = 0.5
Kd0 = 10.0
gamma = 9.0
kf0 = 6.0
TFdegradationkd = 1.0
TFsynthesisbasalRbas = 0.1
CalciumInfluxv0 = 1.0
CalciumInfluxstimulationv1 = 5.7
CalciumInfluxstimulationbeta = 0.3
CalciumintostoreVm2 = 30.0
CalciumintostoreK2 = 0.5
Calciumintostoren = 2.0
CalciumintocytoplasmVm3 = 325.0
CalciumintocytoplasmKr = 1.7
CalciumintocytoplasmKA = 0.46
Calciumintocytoplasmm = 2.0
Calciumintocytoplasmp = 4.0
Leakagek1 = 0.7
Leakagefromcytoplasmk = 10.0
cytoplasm = 1.0
store = 1.0
end parameters

begin initial conditions
X[0] = Xi
Y[0] = Yi
Z[0] = Zi
end initial conditions

begin initial values
Xi = 15.0
Yi = 0.0
Zi = 0.25
end initial values

begin assignment rules
Kd := Kd0/(1 + Z[t]^4/Kb^4)
kf := kf0*(1 + (gamma*Z[t]^4)/(Ka^4 + Z[t]^4))
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
Y http://identifiers.org/chebi/CHEBI:22984
Y http://identifiers.org/kegg.compound/C00076
Z http://identifiers.org/chebi/CHEBI:22984
Z http://identifiers.org/kegg.compound/C00076
end species annotations

begin units
end units