#yugi2

FIX: s1 s24 s28 s30 s32 s34

#reactions
re30:
 $pool = {1.0}s4
  s9 / (K_PFKL_f26bp + s9) * (K_PFKL_akg / (K_PFKL_akg + s7)) * (K_PFKL_pep / (K_PFKL_pep + s5)) * (K_PFKL_cit / (K_PFKL_cit + s10)) * (K_PFKL_icit / (K_PFKL_icit + s6)) * (K_PFKL_mal / (K_PFKL_mal + s8)) * (s13 / (K_PFKL_PHOS_S775 + s13)) * (Vf_PFKL * s22 / (K_PFKL_f6p + s22))
re31:
 {1.0}s4 = $pool
  K_FBPase_f26bp / (K_FBPase_f26bp + s9) * (s10 / (K_FBPase_cit + s10)) * (Vf_FBPase * s4 / (K_FBPase_f16bp + s4))
re32:
 {1.0}s4 = {1.0}s11
  k_ALDO * s4
re33:
 {1.0}s8 = {1.0}s14
  -k_mal
re34:
 {1.0}s7 = {1.0}s15
  -k_akg
re35:
 {1.0}s5 = {1.0}s16
  -k_pep
re36:
 {1.0}s6 = {1.0}s17
  -k_icit
re37:
 {1.0}s9 = {1.0}s18
  -k_f26bp
re38:
 {1.0}s10 = {1.0}s19
  -k_cit
re39:
 {1.0}s3 = {1.0}s21
  -k_f6p
re40:
 {1.0}s24 = {1.0}s23
  k1 * (s24 - s23)
re41:
 {1.0}s23 = {1.0}s25
  k1 * insulin * s23 - k2 * s25
re42:
 {1.0}s23 = {1.0}s26
  k1 * s23 * s31
re43:
 {1.0}s26 = {1.0}s27
  k1 * insulin * s26 - k2 * s27
re44:
 {1.0}s25 = {1.0}s27
  k1 * s25 * s31
re45:
 {1.0}s27 = {1.0}s25
  k1 * s27
re46:
 {1.0}s26 = {1.0}s23
  k1 * s26
re47:
 {1.0}s27 = {1.0}s36
  k1 * s27
re48:
 {1.0}s28 = {1.0}s29
  k1 * (s28 - s29) * s25
re49:
 {1.0}s29 = {1.0}s28
  k1 * s29
re50:
 {1.0}s26 = {1.0}s37
  k1 * s26
re51:
 {1.0}s25 = {1.0}s38
  k1 * s25
re52:
 {1.0}s30 = {1.0}s31
  k1 * (s30 - s31) * s29
re53:
 {1.0}s31 = {1.0}s30
  k1 * s31
re54:
 {1.0}s32 = {1.0}s33
  k1 * (s32 - s33) * s31
re55:
 {1.0}s33 = {1.0}s32
  k1 * s33 * s35
re56:
 {1.0}s34 = {1.0}s35
  k1 * (s34 - s35) * s31
re57:
 {1.0}s35 = {1.0}s34
  k1 * s35
re58:
 {1.0}s1 = {1.0}s13
  k1 * (s1 - s13) * s33
re59:
 {1.0}s13 = {1.0}s1
  k1 * s13


#parameters
K_FBPase_cit = 0.0211646
K_FBPase_f16bp = 0.104089638
K_FBPase_f26bp = 17.51744342
K_PFKL_PHOS_S775 = 6.283705757
K_PFKL_akg = 24661.01154
K_PFKL_cit = 41.30426029
K_PFKL_f26bp = 1.282443082
K_PFKL_f6p = 0.014114844
K_PFKL_icit = 1784.508205
K_PFKL_mal = 9.544729149
K_PFKL_pep = 0.633518366
Vf_FBPase = 9.932861302
Vf_PFKL = 695063.7194
insulin = 1.0
k_ALDO = 0.008187906
k_akg = -3.544494721
k_cit = -0.351935646
k_f26bp = -0.083430336
k_f6p = -0.930115636
k_icit = -0.038210156
k_mal = 1.005530417
k_pep = 43.99195576
s1 = 1.235570941
s24 = 46.2222520609226
s28 = 4.33812187331668
s30 = 0.0959163701057347
s32 = 2.7769943784158
s34 = 14.9913345914433
re40_k1 = 0.0477985900779305
re41_k1 = 7.78160761103111
re41_k2 = 1.61147523779118
re42_k1 = 9.93311225447353
re43_k1 = 0.363030286526969
re43_k2 = 0.408127912886804
re44_k1 = 3.88248960751442e-05
re45_k1 = 0.28442597446931
re46_k1 = 1.00000000282413e-05
re47_k1 = 0.0948960328385619
re48_k1 = 0.00919578911309774
re49_k1 = 7.70618517548016
re50_k1 = 1.00277786609339e-05
re51_k1 = 0.00792717614041237
re52_k1 = 0.419682384304397
re53_k1 = 0.124330492920416
re54_k1 = 0.00752464611370891
re55_k1 = 1.95497593092361
re56_k1 = 0.00105342379833469
re57_k1 = 0.00145811601430322
re58_k1 = 26.8316707654711
re59_k1 = 0.0166525139097609
default = 1.0


#initial values
s10 = 17.7476118652
s11 = 0.0
s12 = 1.0
s13 = 0.759332005
s14 = 0.0
s15 = 0.0
s16 = 0.0
s17 = 0.0
s18 = 0.0
s19 = 0.0
s2 = 1.0
s21 = 0.0
s23 = 37.81914621
s25 = 2.507671281
s26 = 852.608418
s27 = 3.930695895
s29 = 0.012942682
s3 = 14.0774258421
s31 = 0.004015031
s33 = 0.000988831
s35 = 0.043352951
s36 = 0.0
s37 = 0.0
s38 = 0.0
s4 = 104.07239819
s5 = 108.094519859
s6 = 1.79487179487
s7 = 25.1885369533
s8 = 68.8788335846
s9 = 1.0


#assignment rules
!F s22 = s3