begin name
yildirim1
end name

begin reactions
ra1 {1.0}A = {1.0}$EXTERNAL
ra2 {1.0}A = {1.0}$EXTERNAL
ra3l1 {1.0}L = {1.0}A
rb1 {1.0}B = {1.0}$EXTERNAL
rb2i2 {1.0}I2 = {1.0}B
ri1 {1.0}$EXTERNAL = {1.0}I1
ri2 {1.0}$EXTERNAL = {1.0}I2
ri3 {1.0}$EXTERNAL = {1.0}I3
rl2 {1.0}L = {1.0}$EXTERNAL
rl3 {1.0}L = {1.0}$EXTERNAL
rl4 {1.0}$EXTERNAL = {1.0}L
rm1 {1.0}$EXTERNAL = {1.0}M
rm2 {1.0}M = {1.0}$EXTERNAL
rm3i1 {1.0}I1 = {1.0}M
rp1 {1.0}P = {1.0}$EXTERNAL
rp2i3 {1.0}I3 = {1.0}P
end reactions

begin rate equations
ra1 = cell*(gammaA + mu)*A[t]
ra2 = (betaA*cell*A[t]*B[t])/(KA + A[t])
ra3l1 = (alphaA*cell*B[t]*L[t])/(KL + L[t])
rb1 = cell*(gammaB + mu)*B[t]
rb2i2 = (cell*I2[t])/tauB
ri1 = (alphaM*cell*(1 + (K1*A[t]^2)/E^(2*mu*tauM)))/(K + (K1*A[t]^2)/E^(2*mu*tauM))
ri2 = (alphaB*cell*M[t])/E^(mu*tauB)
ri3 = (alphaP*cell*M[t])/E^(mu*(tauB + tauP))
rl2 = cell*(gammaL + mu)*L[t]
rl3 = (betaL1*cell*L[t]*P[t])/(KL1 + L[t])
rl4 = (alphaL*cell*Le*P[t])/(KLe + Le)
rm1 = cell*gamma0
rm2 = cell*(gammaM + mu)*M[t]
rm3i1 = (cell*I1[t])/tauM
rp1 = cell*(gammaP + mu)*P[t]
rp2i3 = (cell*I3[t])/(tauB + tauP)
end rate equations

begin parameters
K = 7200.0
K1 = 25200.0
KA = 1.95
KL = 0.97
KL1 = 1.81
KLe = 0.26
alphaA = 17600.0
alphaB = 0.0166
alphaL = 2880.0
alphaM = 0.000997
alphaP = 10.0
betaA = 21500.0
betaL1 = 2650.0
gamma0 = "7.25e-07"
gammaA = 0.52
gammaB = 0.000833
gammaL = 0.0
gammaM = 0.411
gammaP = 0.65
mu = 0.0226
tauB = 2.0
tauM = 0.1
tauP = 0.83
Le = 0.08
cell = 1.0
end parameters

begin initial conditions
A[0] = Ai
B[0] = Bi
I1[0] = I1i
I2[0] = I2i
I3[0] = I3i
L[0] = Li
M[0] = Mi
P[0] = Pi
end initial conditions

begin initial values
Ai = 0.038
Bi = 0.0
I1i = 0.0
I2i = 0.0
I3i = 0.0
Li = 0.372
Mi = 0.000626
Pi = 0.0149
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
r_a3_l1 http://identifiers.org/ec-code/3.2.1.108
r_a3_l1 http://identifiers.org/go/GO:0004565
r_l2 http://identifiers.org/go/GO:0005990
r_l3 http://identifiers.org/go/GO:0015155
r_l4 http://identifiers.org/go/GO:0015155
r_m2 http://identifiers.org/go/GO:0006402
end process annotations

begin species annotations
B http://identifiers.org/uniprot/P00722
L http://identifiers.org/chebi/CHEBI:17716
L http://identifiers.org/kegg.compound/C00243
L_e http://identifiers.org/chebi/CHEBI:17716
L_e http://identifiers.org/kegg.compound/C00243
M http://identifiers.org/chebi/CHEBI:33699
P http://identifiers.org/uniprot/P02920
end species annotations

begin units
end units