#yao1



#reactions
r1:
 $pool = {1.0}MC
  cell * (kM * S / (KS + S))
r10:
 {1.0}RP = {1.0}RB
  cell * (kkRBUP * RP / (Kp + RP))
r11:
 {1.0}MC = $pool
  cell * dMC * MC
r12:
 {1.0}EF = $pool
  cell * dEF * EF
r13:
 {1.0}CE = $pool
  cell * dCE * CE
r14:
 {1.0}CD = $pool
  cell * dCD * CD
r15:
 {1.0}RB = $pool
  cell * dRB * RB
r16:
 {1.0}RP = $pool
  cell * dRP * RP
r17:
 {1.0}RE = $pool
  cell * dRE * RE
r2:
 $pool = {1.0}CD
  cell * (kkCDS * S / (KS + S))
r3:
 $pool = {1.0}EF
  cell * (kkEF * MC * EF / ((KMC + MC) * (KEF + EF)) + kkb * MC / (KMC + MC))
r4:
 $pool = {1.0}CE
  cell * (kkCE * EF / (KEF + EF))
r5:
 $pool = {1.0}CD
  cell * (kkCD * MC / (KMC + MC))
r6:
 $pool = {1.0}RB
  cell * kkRB
r7:
 {1.0}RE = {1.0}EF + {1.0}RP
  cell * (kkRBPP * CD * RE / (KD + RE) + kkRBPP * CE * RE / (KE + RE))
r8:
 {1.0}EF + {1.0}RB = {1.0}RE
  cell * kkRE * RB * EF
r9:
 {1.0}RB = {1.0}RP
  cell * (kkRBP * CD * RB / (KD + RB) + kkRBP2 * CE * RB / (KE + RB))


#parameters
S = 1.0
r1_KS = 0.5
r1_kM = 1.0
r2_KS = 0.5
r2_kkCDS = 0.45
r3_KEF = 0.15
r3_KMC = 0.15
r3_kkEF = 0.4
r3_kkb = 0.003
r4_KEF = 0.15
r4_kkCE = 0.35
r5_KMC = 0.15
r5_kkCD = 0.03
r6_kkRB = 0.18
r7_KD = 0.92
r7_KE = 0.92
r7_kkRBPP = 18.0
r8_kkRE = 180.0
r9_KD = 0.92
r9_KE = 0.92
r9_kkRBP = 18.0
r9_kkRBP2 = 18.0
r10_Kp = 0.01
r10_kkRBUP = 3.6
r11_dMC = 0.7
r12_dEF = 0.25
r13_dCE = 1.5
r14_dCD = 1.5
r15_dRB = 0.06
r16_dRP = 0.06
r17_dRE = 0.03
cell = 1.0


#initial values
CD = 0.0
CE = 0.0
EF = 0.0
MC = 0.0
RB = 0.0
RE = 0.55
RP = 0.0


#assignment rules