begin name
yao1
end name

begin reactions
r1 {1.0}$EXTERNAL = {1.0}MC
r10 {1.0}RP = {1.0}RB
r11 {1.0}MC = {1.0}$EXTERNAL
r12 {1.0}EF = {1.0}$EXTERNAL
r13 {1.0}CE = {1.0}$EXTERNAL
r14 {1.0}CD = {1.0}$EXTERNAL
r15 {1.0}RB = {1.0}$EXTERNAL
r16 {1.0}RP = {1.0}$EXTERNAL
r17 {1.0}RE = {1.0}$EXTERNAL
r2 {1.0}$EXTERNAL = {1.0}CD
r3 {1.0}$EXTERNAL = {1.0}EF
r4 {1.0}$EXTERNAL = {1.0}CE
r5 {1.0}$EXTERNAL = {1.0}CD
r6 {1.0}$EXTERNAL = {1.0}RB
r7 {1.0}RE = {1.0}EF + {1.0}RP
r8 {1.0}EF + {1.0}RB = {1.0}RE
r9 {1.0}RB = {1.0}RP
end reactions

begin rate equations
r1 = (cell*r1kM*S)/(r1KS + S)
r10 = (cell*r10kkRBUP*RP[t])/(r10Kp + RP[t])
r11 = cell*r11dMC*MC[t]
r12 = cell*r12dEF*EF[t]
r13 = cell*r13dCE*CE[t]
r14 = cell*r14dCD*CD[t]
r15 = cell*r15dRB*RB[t]
r16 = cell*r16dRP*RP[t]
r17 = cell*r17dRE*RE[t]
r2 = (cell*r2kkCDS*S)/(r2KS + S)
r3 = cell*((r3kkb*MC[t])/(r3KMC + MC[t]) + (r3kkEF*EF[t]*MC[t])/((r3KEF + EF[t])*(r3KMC + MC[t])))
r4 = (cell*r4kkCE*EF[t])/(r4KEF + EF[t])
r5 = (cell*r5kkCD*MC[t])/(r5KMC + MC[t])
r6 = cell*r6kkRB
r7 = cell*((r7kkRBPP*CD[t]*RE[t])/(r7KD + RE[t]) + (r7kkRBPP*CE[t]*RE[t])/(r7KE + RE[t]))
r8 = cell*r8kkRE*EF[t]*RB[t]
r9 = cell*((r9kkRBP*CD[t]*RB[t])/(r9KD + RB[t]) + (r9kkRBP2*CE[t]*RB[t])/(r9KE + RB[t]))
end rate equations

begin parameters
S = 1.0
r1KS = 0.5
r1kM = 1.0
r2KS = 0.5
r2kkCDS = 0.45
r3KEF = 0.15
r3KMC = 0.15
r3kkEF = 0.4
r3kkb = 0.003
r4KEF = 0.15
r4kkCE = 0.35
r5KMC = 0.15
r5kkCD = 0.03
r6kkRB = 0.18
r7KD = 0.92
r7KE = 0.92
r7kkRBPP = 18.0
r8kkRE = 180.0
r9KD = 0.92
r9KE = 0.92
r9kkRBP = 18.0
r9kkRBP2 = 18.0
r10Kp = 0.01
r10kkRBUP = 3.6
r11dMC = 0.7
r12dEF = 0.25
r13dCE = 1.5
r14dCD = 1.5
r15dRB = 0.06
r16dRP = 0.06
r17dRE = 0.03
cell = 1.0
end parameters

begin initial conditions
CD[0] = CDi
CE[0] = CEi
EF[0] = EFi
MC[0] = MCi
RB[0] = RBi
RE[0] = REi
RP[0] = RPi
end initial conditions

begin initial values
CDi = 0.0
CEi = 0.0
EFi = 0.0
MCi = 0.0
RBi = 0.0
REi = 0.55
RPi = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
e1 = (t > 0, {S -> 20}, 0)
e2 = (t > 5, {S -> 1}, 0)
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units