begin name
yamada1
end name

begin reactions
v1 {1.0}JAK + {1.0}R = {1.0}RJ
v10 {1.0}IFNRJ2starSHP2 = {1.0}SHP2 + {1.0}IFNRJ2
v11 {1.0}STAT1cstar + {1.0}PPX = {1.0}STAT1cstarPPX
v12 {1.0}STAT1cstarPPX = {1.0}STAT1c + {1.0}PPX
v13 {1.0}STAT1cstarSTAT1cstar + {1.0}PPX = {1.0}STAT1cstarSTAT1cstarPPX
v14 {1.0}STAT1cstarSTAT1cstarPPX = {1.0}STAT1cSTAT1cstar + {1.0}PPX
v15 {1.0}STAT1cstar + {1.0}STAT1c = {1.0}STAT1cSTAT1cstar
v16 {1.0}STAT1cstarSTAT1cstar = {1.0}STAT1nstarSTAT1nstar
v17 {2.0}STAT1nstar = {1.0}STAT1nstarSTAT1nstar
v18 {1.0}STAT1nstar + {1.0}PPN = {1.0}STAT1nstarPPN
v19 {1.0}STAT1nstarPPN = {1.0}STAT1n + {1.0}PPN
v2 {1.0}RJ + {1.0}$IFN = {1.0}IFNRJ
v20 {1.0}STAT1nstarSTAT1nstar + {1.0}PPN = {1.0}STAT1nstarSTAT1nstarPPN
v21 {1.0}STAT1nstarSTAT1nstarPPN = {1.0}STAT1nSTAT1nstar + {1.0}PPN
v22 {1.0}STAT1nstar + {1.0}STAT1n = {1.0}STAT1nSTAT1nstar
v23 {1.0}STAT1n = {1.0}STAT1c
v24 {1.0}$EXTERNAL = {1.0}mRNAn
v25 {1.0}mRNAn = {1.0}mRNAc
v26 {1.0}$EXTERNAL = {1.0}SOCS1
v27 {1.0}mRNAc = {1.0}$EXTERNAL
v28 {1.0}SOCS1 = {1.0}$EXTERNAL
v29 {1.0}IFNRJ2star + {1.0}SOCS1 = {1.0}IFNRJ2starSOCS1
v3 {2.0}IFNRJ = {1.0}IFNRJ2
v30 {1.0}IFNRJ2starSOCS1 + {1.0}STAT1c = {1.0}IFNRJ2starSOCS1STAT1c
v31 {1.0}IFNRJ2starSOCS1STAT1c + {1.0}SHP2 = {1.0}IFNRJ2starSHP2SOCS1STAT1c
v32 {1.0}IFNRJ2starSHP2SOCS1STAT1c = {1.0}IFNRJ2 + {1.0}SOCS1 + {1.0}STAT1c + {1.0}SHP2
v33 {1.0}IFNRJ2starSHP2SOCS1STAT1c = {1.0}IFNRJ2starSHP2STAT1c
v34 {1.0}IFNRJ2starSOCS1 + {1.0}SHP2 = {1.0}IFNRJ2starSHP2SOCS1
v35 {1.0}IFNRJ2starSHP2SOCS1 + {1.0}STAT1c = {1.0}IFNRJ2starSHP2SOCS1STAT1c
v36 {1.0}IFNRJ2starSTAT1c + {1.0}SHP2 = {1.0}IFNRJ2starSHP2STAT1c
v37 {1.0}IFNRJ2starSHP2STAT1c = {1.0}STAT1c + {1.0}SHP2 + {1.0}IFNRJ2
v38 {1.0}IFNRJ2starSOCS1STAT1c = {1.0}IFNRJ2starSTAT1c
v39 {1.0}IFNRJ2starSHP2SOCS1 = {1.0}IFNRJ2starSHP2
v4 {1.0}IFNRJ2 = {1.0}IFNRJ2star
v40 {1.0}IFNRJ2starSHP2SOCS1 = {1.0}SHP2 + {1.0}IFNRJ2 + {1.0}SOCS1
v41 {1.0}IFNRJ2starSOCS1 = {1.0}IFNRJ2star
v42 {1.0}IFNRJ2starSTAT1c + {1.0}SOCS1 = {1.0}IFNRJ2starSOCS1STAT1c
v43 {1.0}IFNRJ2starSHP2 + {1.0}SOCS1 = {1.0}IFNRJ2starSHP2SOCS1
v44 {1.0}IFNRJ2starSHP2STAT1c + {1.0}SOCS1 = {1.0}IFNRJ2starSHP2SOCS1STAT1c
v45 {1.0}R + {1.0}$IFN = {1.0}IFNR
v46 {1.0}JAK + {1.0}IFNR = {1.0}IFNRJ
v5 {1.0}IFNRJ2star + {1.0}STAT1c = {1.0}IFNRJ2starSTAT1c
v6 {1.0}IFNRJ2starSTAT1c = {1.0}STAT1cstar + {1.0}IFNRJ2star
v7 {1.0}STAT1cstar + {1.0}IFNRJ2star = {1.0}IFNRJ2starSTAT1cstar
v8 {2.0}STAT1cstar = {1.0}STAT1cstarSTAT1cstar
v9 {1.0}SHP2 + {1.0}IFNRJ2star = {1.0}IFNRJ2starSHP2
end reactions

begin rate equations
v1 = cytoplasm*(v1kf*JAK[t]*R[t] - v1kb*RJ[t])
v10 = cytoplasm*v10kf*IFNRJ2starSHP2[t]
v11 = cytoplasm*(v11kf*PPX[t]*STAT1cstar[t] - v11kb*STAT1cstarPPX[t])
v12 = cytoplasm*v12kf*STAT1cstarPPX[t]
v13 = cytoplasm*(v13kf*PPX[t]*STAT1cstarSTAT1cstar[t] - v13kb*STAT1cstarSTAT1cstarPPX[t])
v14 = cytoplasm*v14kf*STAT1cstarSTAT1cstarPPX[t]
v15 = cytoplasm*(v15kf*STAT1c[t]*STAT1cstar[t] - v15kb*STAT1cSTAT1cstar[t])
v16 = cytoplasm*v16kf*STAT1cstarSTAT1cstar[t]
v17 = nucleus*(v17kf*STAT1nstar[t]^2 - v17kb*STAT1nstarSTAT1nstar[t])
v18 = nucleus*(v18kf*PPN[t]*STAT1nstar[t] - v18kb*STAT1nstarPPN[t])
v19 = nucleus*v19kf*STAT1nstarPPN[t]
v2 = cytoplasm*(-(v2kb*IFNRJ[t]) + IFN*v2kf*RJ[t])
v20 = nucleus*(v20kf*PPN[t]*STAT1nstarSTAT1nstar[t] - v20kb*STAT1nstarSTAT1nstarPPN[t])
v21 = nucleus*v21kf*STAT1nstarSTAT1nstarPPN[t]
v22 = nucleus*(v22kf*STAT1n[t]*STAT1nstar[t] - v22kb*STAT1nSTAT1nstar[t])
v23 = nucleus*v23kf*STAT1n[t]
v24 = (nucleus*v24ka*STAT1nstarSTAT1nstar[t])/(v24kb + STAT1nstarSTAT1nstar[t])
v25 = nucleus*v25kf*mRNAn[t]
v26 = cytoplasm*v26kf*mRNAc[t]
v27 = cytoplasm*v27kf*mRNAc[t]
v28 = cytoplasm*v28kf*SOCS1[t]
v29 = cytoplasm*(-(v29kb*IFNRJ2starSOCS1[t]) + v29kf*IFNRJ2star[t]*SOCS1[t])
v3 = cytoplasm*(v3kf*IFNRJ[t]^2 - v3kb*IFNRJ2[t])
v30 = cytoplasm*(-(v30kb*IFNRJ2starSOCS1STAT1c[t]) + v30kf*IFNRJ2starSOCS1[t]*STAT1c[t])
v31 = cytoplasm*(-(v31kb*IFNRJ2starSHP2SOCS1STAT1c[t]) + v31kf*IFNRJ2starSOCS1STAT1c[t]*SHP2[t])
v32 = cytoplasm*v32kf*IFNRJ2starSHP2SOCS1STAT1c[t]
v33 = cytoplasm*v33kf*IFNRJ2starSHP2SOCS1STAT1c[t]
v34 = cytoplasm*(-(v34kb*IFNRJ2starSHP2SOCS1[t]) + v34kf*IFNRJ2starSOCS1[t]*SHP2[t])
v35 = cytoplasm*(-(v35kb*IFNRJ2starSHP2SOCS1STAT1c[t]) + v35kf*IFNRJ2starSHP2SOCS1[t]*STAT1c[t])
v36 = cytoplasm*(-(v36kb*IFNRJ2starSHP2STAT1c[t]) + v36kf*IFNRJ2starSTAT1c[t]*SHP2[t])
v37 = cytoplasm*v37kf*IFNRJ2starSHP2STAT1c[t]
v38 = cytoplasm*v38kf*IFNRJ2starSOCS1STAT1c[t]
v39 = cytoplasm*v39kf*IFNRJ2starSHP2SOCS1[t]
v4 = cytoplasm*v4kf*IFNRJ2[t]
v40 = cytoplasm*v40kf*IFNRJ2starSHP2SOCS1[t]
v41 = cytoplasm*v41kf*IFNRJ2starSOCS1[t]
v42 = cytoplasm*(-(v42kb*IFNRJ2starSOCS1STAT1c[t]) + v42kf*IFNRJ2starSTAT1c[t]*SOCS1[t])
v43 = cytoplasm*(-(v43kb*IFNRJ2starSHP2SOCS1[t]) + v43kf*IFNRJ2starSHP2[t]*SOCS1[t])
v44 = cytoplasm*(-(v44kb*IFNRJ2starSHP2SOCS1STAT1c[t]) + v44kf*IFNRJ2starSHP2STAT1c[t]*SOCS1[t])
v45 = cytoplasm*(-(v45kb*IFNR[t]) + IFN*v45kf*R[t])
v46 = cytoplasm*(-(v46kb*IFNRJ[t]) + v46kf*IFNR[t]*JAK[t])
v5 = cytoplasm*(-(v5kb*IFNRJ2starSTAT1c[t]) + v5kf*IFNRJ2star[t]*STAT1c[t])
v6 = cytoplasm*v6kf*IFNRJ2starSTAT1c[t]
v7 = cytoplasm*(-(v7kb*IFNRJ2starSTAT1cstar[t]) + v7kf*IFNRJ2star[t]*STAT1cstar[t])
v8 = cytoplasm*(v8kf*STAT1cstar[t]^2 - v8kb*STAT1cstarSTAT1cstar[t])
v9 = cytoplasm*(-(v9kb*IFNRJ2starSHP2[t]) + v9kf*IFNRJ2star[t]*SHP2[t])
end rate equations

begin parameters
IFN = 10.0
v1kf = 0.1
v1kb = 0.05
v2kf = 0.02
v2kb = 0.02
v3kf = 0.04
v3kb = 0.2
v4kf = 0.005
v5kf = 0.008
v5kb = 0.8
v6kf = 0.4
v7kf = 0.005
v7kb = 0.5
v8kf = 0.02
v8kb = 0.1
v9kf = 0.001
v9kb = 0.2
v10kf = 0.003
v11kf = 0.001
v11kb = 0.2
v12kf = 0.003
v13kf = 0.001
v13kb = 0.2
v14kf = 0.003
v15kf = "2e-07"
v15kb = 0.2
v16kf = 0.005
v17kf = 0.02
v17kb = 0.1
v18kf = 0.001
v18kb = 0.2
v19kf = 0.005
v20kf = 0.001
v20kb = 0.2
v21kf = 0.005
v22kf = "2e-07"
v22kb = 0.2
v23kf = 0.05
v24ka = 0.01
v24kb = 400.0
v25kf = 0.001
v26kf = 0.01
v27kf = 0.0005
v28kf = 0.0005
v29kf = 0.02
v29kb = 0.1
v30kf = 0.008
v30kb = 0.8
v31kf = 0.001
v31kb = 0.2
v32kf = 0.003
v33kf = 0.0005
v34kf = 0.001
v34kb = 0.2
v35kf = 0.008
v35kb = 0.8
v36kf = 0.001
v36kb = 0.2
v37kf = 0.003
v38kf = 0.0005
v39kf = 0.0005
v40kf = 0.003
v41kf = 0.0005
v42kf = 0.02
v42kb = 0.1
v43kf = 0.02
v43kb = 0.1
v44kf = 0.02
v44kb = 0.1
v45kf = 0.02
v45kb = 0.02
v46kf = 0.1
v46kb = 0.05
cytoplasm = 1.0
nucleus = 1.0
end parameters

begin initial conditions
IFNR[0] = IFNRi
IFNRJ[0] = IFNRJi
IFNRJ2[0] = IFNRJ2i
IFNRJ2star[0] = IFNRJ2stari
IFNRJ2starSHP2[0] = IFNRJ2starSHP2i
IFNRJ2starSHP2SOCS1[0] = IFNRJ2starSHP2SOCS1i
IFNRJ2starSHP2SOCS1STAT1c[0] = IFNRJ2starSHP2SOCS1STAT1ci
IFNRJ2starSHP2STAT1c[0] = IFNRJ2starSHP2STAT1ci
IFNRJ2starSOCS1[0] = IFNRJ2starSOCS1i
IFNRJ2starSOCS1STAT1c[0] = IFNRJ2starSOCS1STAT1ci
IFNRJ2starSTAT1c[0] = IFNRJ2starSTAT1ci
IFNRJ2starSTAT1cstar[0] = IFNRJ2starSTAT1cstari
JAK[0] = JAKi
PPN[0] = PPNi
PPX[0] = PPXi
R[0] = Ri
RJ[0] = RJi
SHP2[0] = SHP2i
SOCS1[0] = SOCS1i
STAT1c[0] = STAT1ci
STAT1cSTAT1cstar[0] = STAT1cSTAT1cstari
STAT1cstar[0] = STAT1cstari
STAT1cstarPPX[0] = STAT1cstarPPXi
STAT1cstarSTAT1cstar[0] = STAT1cstarSTAT1cstari
STAT1cstarSTAT1cstarPPX[0] = STAT1cstarSTAT1cstarPPXi
STAT1n[0] = STAT1ni
STAT1nSTAT1nstar[0] = STAT1nSTAT1nstari
STAT1nstar[0] = STAT1nstari
STAT1nstarPPN[0] = STAT1nstarPPNi
STAT1nstarSTAT1nstar[0] = STAT1nstarSTAT1nstari
STAT1nstarSTAT1nstarPPN[0] = STAT1nstarSTAT1nstarPPNi
mRNAc[0] = mRNAci
mRNAn[0] = mRNAni
end initial conditions

begin initial values
IFNRi = 0.0
IFNRJi = 0.0
IFNRJ2i = 0.0
IFNRJ2stari = 0.0
IFNRJ2starSHP2i = 0.0
IFNRJ2starSHP2SOCS1i = 0.0
IFNRJ2starSHP2SOCS1STAT1ci = 0.0
IFNRJ2starSHP2STAT1ci = 0.0
IFNRJ2starSOCS1i = 0.0
IFNRJ2starSOCS1STAT1ci = 0.0
IFNRJ2starSTAT1ci = 0.0
IFNRJ2starSTAT1cstari = 0.0
JAKi = 10.0
PPNi = 60.0
PPXi = 50.0
Ri = 10.0
RJi = 0.0
SHP2i = 100.0
SOCS1i = 0.0
STAT1ci = 1000.0
STAT1cSTAT1cstari = 0.0
STAT1cstari = 0.0
STAT1cstarPPXi = 0.0
STAT1cstarSTAT1cstari = 0.0
STAT1cstarSTAT1cstarPPXi = 0.0
STAT1ni = 0.0
STAT1nSTAT1nstari = 0.0
STAT1nstari = 0.0
STAT1nstarPPNi = 0.0
STAT1nstarSTAT1nstari = 0.0
STAT1nstarSTAT1nstarPPNi = 0.0
mRNAci = 0.0
mRNAni = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
v1 http://identifiers.org/obo.go/GO:0005133
v1 http://identifiers.org/obo.go/GO:0005515
v10 http://identifiers.org/ec-code/3.1.3.48
v10 http://identifiers.org/kegg.reaction/R02585
v10 http://identifiers.org/obo.go/GO:0005001
v11 http://identifiers.org/obo.go/GO:0019902
v11 http://identifiers.org/obo.go/GO:0005515
v12 http://identifiers.org/obo.go/GO:0042512
v13 http://identifiers.org/obo.go/GO:0019902
v14 http://identifiers.org/obo.go/GO:0042512
v15 http://identifiers.org/obo.go/GO:0005515
v16 http://identifiers.org/obo.go/GO:0007262
v17 http://identifiers.org/obo.go/GO:0007261
v18 http://identifiers.org/obo.go/GO:0019902
v19 http://identifiers.org/obo.go/GO:0042512
v2 http://identifiers.org/obo.go/GO:0004906
v2 http://identifiers.org/obo.go/GO:0019964
v20 http://identifiers.org/obo.go/GO:0019902
v21 http://identifiers.org/obo.go/GO:0042512
v22 http://identifiers.org/obo.go/GO:0007261
v23 http://identifiers.org/obo.go/GO:0065002
v24 http://identifiers.org/obo.go/GO:0006351
v25 http://identifiers.org/obo.go/GO:0006406
v26 http://identifiers.org/obo.go/GO:0006412
v27 http://identifiers.org/obo.go/GO:0006402
v28 http://identifiers.org/obo.go/GO:0044257
v29 http://identifiers.org/obo.go/GO:0005515
v3 http://identifiers.org/obo.go/GO:0007171
v30 http://identifiers.org/obo.go/GO:0005515
v31 http://identifiers.org/obo.go/GO:0005515
v31 http://identifiers.org/obo.go/GO:0019902
v32 http://identifiers.org/obo.go/GO:0005001
v34 http://identifiers.org/obo.go/GO:0019902
v35 http://identifiers.org/obo.go/GO:0005515
v36 http://identifiers.org/obo.go/GO:0019902
v37 http://identifiers.org/obo.go/GO:0043624
v4 http://identifiers.org/ec-code/2.7.10.2
v4 http://identifiers.org/kegg.reaction/R02584
v4 http://identifiers.org/obo.go/GO:0004713
v40 http://identifiers.org/obo.go/GO:0005001
v40 http://identifiers.org/obo.go/GO:0043624
v42 http://identifiers.org/obo.go/GO:0005515
v43 http://identifiers.org/obo.go/GO:0005515
v44 http://identifiers.org/obo.go/GO:0005515
v45 http://identifiers.org/obo.go/GO:0019964
v45 http://identifiers.org/obo.go/GO:0004906
v46 http://identifiers.org/obo.go/GO:0005515
v46 http://identifiers.org/obo.go/GO:0005133
v5 http://identifiers.org/obo.go/GO:0005515
v6 http://identifiers.org/ec-code/2.7.10.2
v6 http://identifiers.org/obo.go/GO:0007260
v7 http://identifiers.org/obo.go/GO:0005515
v8 http://identifiers.org/obo.go/GO:0007261
v9 http://identifiers.org/obo.go/GO:0019902
v9 http://identifiers.org/obo.go/GO:0005515
end process annotations

begin species annotations
IFN http://identifiers.org/uniprot/P01572
IFNR http://identifiers.org/uniprot/O88507
IFNR http://identifiers.org/uniprot/P01572
JAK http://identifiers.org/uniprot/P52332
JAK http://identifiers.org/interpro/IPR009127
R http://identifiers.org/uniprot/O88507
SHP2 http://identifiers.org/uniprot/P35235
SHP2 http://identifiers.org/interpro/IPR000980
SOCS1 http://identifiers.org/uniprot/O35716
SOCS1 http://identifiers.org/interpro/IPR001496
STAT1c http://identifiers.org/uniprot/P42225
STAT1c http://identifiers.org/interpro/IPR001217
STAT1c_STAT1c_star http://identifiers.org/uniprot/P42225
STAT1c_star http://identifiers.org/uniprot/P42225
STAT1c_star_STAT1c_star http://identifiers.org/uniprot/P42225
STAT1n http://identifiers.org/uniprot/P42225
STAT1n_STAT1n_star http://identifiers.org/uniprot/P42225
STAT1n_star http://identifiers.org/uniprot/P42225
STAT1n_star_STAT1n_star http://identifiers.org/uniprot/P42225
mRNAc http://identifiers.org/obo.chebi/CHEBI:33699
mRNAc http://identifiers.org/kegg.compound/C00046
mRNAn http://identifiers.org/obo.chebi/CHEBI:33699
mRNAn http://identifiers.org/kegg.compound/C00046
end species annotations

begin units
end units