begin name tyson8 end name begin reactions r0 {1.0}$EXTERNAL = {1.0}R r1 {1.0}$EXTERNAL = {1.0}R r2 {1.0}R = {1.0}$EXTERNAL r2prime {1.0}R = {1.0}$EXTERNAL r3 {1.0}$EXTERNAL = {1.0}$EXTERNAL r4 {1.0}$EXTERNAL = {1.0}$EXTERNAL r5 {1.0}$EXTERNAL = {1.0}X r6 {1.0}X = {1.0}$EXTERNAL end reactions begin rate equations r0 = env*Ep*k0 r1 = env*k1*S r2 = env*k2*R[t] r2prime = env*k2prime*R[t]*X[t] r3 = (E*env*k3*R[t])/(E + Km3) r4 = (env*Ep*k4)/(Ep + Km4) r5 = env*k5*R[t] r6 = env*k6*X[t] end rate equations begin parameters Et = 1.0 J3 = 0.3 J4 = 0.3 k0 = 4.0 k1 = 1.0 k2 = 1.0 k2prime = 1.0 k3 = 1.0 k4 = 1.0 k5 = 0.1 k6 = 0.075 S = 0.0 env = 1.0 end parameters begin initial conditions R[0] = Ri X[0] = Xi end initial conditions begin initial values Ri = 0.0 Xi = 0.0 end initial values begin assignment rules Km3 := Et*J3 Ep := Et*goldbeterkoshland[k3*R[t], k4, J3, J4] E := -Ep + Et Km4 := Et*J4 end assignment rules begin function definitions goldbeterkoshland[v1_,v2_,J1_,J2_] := (2*J2*v1)/(-v1 + J2*v1 + v2 + J1*v2 + Sqrt[-4*J2*v1*(-v1 + v2) + (-v1 + J2*v1 + v2 + J1*v2)^2]) end function definitions begin events end events begin process annotations end process annotations begin species annotations end species annotations begin units end units