(* Generated by JWS Online *) (* This is an experimental feature of JWS Online. Please report any mistakes.*) (* Note that the following notable SBML entities or features are not supported in notebook outputyet: *) (* Events *) (* Constraints *) (* Units and UnitDefinitions *) (* AlgebraicRules *) (* conversionFactors *) variables = { A20[t], A20\[LetterSpace]mRNA[t], BAR[t], BAR\[LetterSpace]Casp8[t], Casp3[t], Casp6[t], Casp8[t], FADD[t], FLIP[t], FLIP\[LetterSpace]mRNA[t], IKK[t], IKKa[t], IkBa[t], IkBa\[LetterSpace]N[t], IkBa\[LetterSpace]NFkB[t], IkBa\[LetterSpace]NFkB\[LetterSpace]N[t], IkBa\[LetterSpace]mRNA[t], NFkB[t], NFkB\[LetterSpace]N[t], PARP[t], PIkBa[t], RIP[t], TNFR[t], TNFRC1[t], TNFRC2[t], TNFRC2\[LetterSpace]FLIP[t], TNFRC2\[LetterSpace]FLIP\[LetterSpace]FLIP[t], TNFRC2\[LetterSpace]FLIP\[LetterSpace]pCasp8[t], TNFRC2\[LetterSpace]FLIP\[LetterSpace]pCasp8\[LetterSpace]RIP\[LetterSpace]TRAF2[t], TNFRC2\[LetterSpace]pCasp8[t], TNFRC2\[LetterSpace]pCasp8\[LetterSpace]pCasp8[t], TNFRCint1[t], TNFRCint2[t], TNFRCint3[t], TNFR\[LetterSpace]E[t], TNF\[LetterSpace]E[t], TNF\[LetterSpace]TNFR\[LetterSpace]E[t], TNF\[LetterSpace]TNFR\[LetterSpace]TRADD[t], TRADD[t], TRAF2[t], XIAP[t], XIAP\[LetterSpace]Casp3[t], XIAP\[LetterSpace]mRNA[t], cPARP[t], pCasp3[t], pCasp6[t], pCasp8[t] }; initialValues = { A20[0] == 0.104434, A20\[LetterSpace]mRNA[0] == 5.56657*^-05, BAR[0] == 0.28789, BAR\[LetterSpace]Casp8[0] == 0.0, Casp3[0] == 0.0, Casp6[0] == 0.0, Casp8[0] == 0.0, FADD[0] == 0.30944, FLIP[0] == 0.0320472, FLIP\[LetterSpace]mRNA[0] == 0.000139056, IKK[0] == 0.64, IKKa[0] == 0.0, IkBa[0] == 0.00101518, IkBa\[LetterSpace]N[0] == 0.0013839, IkBa\[LetterSpace]NFkB[0] == 0.0151032, IkBa\[LetterSpace]NFkB\[LetterSpace]N[0] == 9.00189*^-05, IkBa\[LetterSpace]mRNA[0] == 5.31517*^-05, NFkB[0] == 0.000115365, NFkB\[LetterSpace]N[0] == 0.000691431, PARP[0] == 1.66667, PIkBa[0] == 0.0, RIP[0] == 0.20256, TNFR[0] == 0.00028, TNFRC1[0] == 0.0, TNFRC2[0] == 0.0, TNFRC2\[LetterSpace]FLIP[0] == 0.0, TNFRC2\[LetterSpace]FLIP\[LetterSpace]FLIP[0] == 0.0, TNFRC2\[LetterSpace]FLIP\[LetterSpace]pCasp8[0] == 0.0, TNFRC2\[LetterSpace]FLIP\[LetterSpace]pCasp8\[LetterSpace]RIP\[LetterSpace]TRAF2[0] == 0.0, TNFRC2\[LetterSpace]pCasp8[0] == 0.0, TNFRC2\[LetterSpace]pCasp8\[LetterSpace]pCasp8[0] == 0.0, TNFRCint1[0] == 0.0, TNFRCint2[0] == 0.0, TNFRCint3[0] == 0.0, TNFR\[LetterSpace]E[0] == 0.005, TNF\[LetterSpace]E[0] == 0.2688, TNF\[LetterSpace]TNFR\[LetterSpace]E[0] == 0.0, TNF\[LetterSpace]TNFR\[LetterSpace]TRADD[0] == 0.0, TRADD[0] == 0.29344, TRAF2[0] == 0.33056, XIAP[0] == 7.83371, XIAP\[LetterSpace]Casp3[0] == 0.0, XIAP\[LetterSpace]mRNA[0] == 0.000219646, cPARP[0] == 0.0, pCasp3[0] == 0.8, pCasp6[0] == 0.064, pCasp8[0] == 3.2 }; rates = { J1, J10, J11, J12, J13, J14, J15, J16, J17, J18, J19, J2, J20, J21, J22, J23, J24, J25, J26, J27, J28, J29, J3, J30, J31, J32, J33, J34, J35, J36, J37, J38, J39, J4, J40, J41, J42, J43, J44, J45, J46, J47, J48, J49, J5, J50, J51, J52, J53, J54, J55, J56, J57, J58, J59, J6, J60, J61, J62, J63, J64, J65, J66, J67, J68, J69, J7, J70, J71, J72, J73, J74, J75, J76, J77, J78, J79, J8, J80, J81, J82, J83, J84, J85, J86, J87, J88, J9 }; rateEquations = { J1 -> J1\[LetterSpace]ka\[LetterSpace]1*TNFR[t], J10 -> J10\[LetterSpace]ka\[LetterSpace]10*TNFRC1[t], J11 -> J11\[LetterSpace]ka\[LetterSpace]11*TNFRC2[t], J12 -> J12\[LetterSpace]ka\[LetterSpace]12*TNFRC2\[LetterSpace]FLIP[t], J13 -> J13\[LetterSpace]ka\[LetterSpace]13*TNFRC2\[LetterSpace]FLIP\[LetterSpace]FLIP[t], J14 -> J14\[LetterSpace]ka\[LetterSpace]14*TNFRC2\[LetterSpace]pCasp8[t], J15 -> J15\[LetterSpace]ka\[LetterSpace]15*TNFRC2\[LetterSpace]pCasp8\[LetterSpace]pCasp8[t], J16 -> J16\[LetterSpace]ka\[LetterSpace]16*TNFRC2\[LetterSpace]FLIP\[LetterSpace]pCasp8[t], J17 -> J17\[LetterSpace]ka\[LetterSpace]17*TNFRC2\[LetterSpace]FLIP\[LetterSpace]pCasp8\[LetterSpace]RIP\[LetterSpace]TRAF2[t], J18 -> J18\[LetterSpace]ka\[LetterSpace]18*TNFR\[LetterSpace]E[t]*TNF\[LetterSpace]E[t] - J18\[LetterSpace]kd\[LetterSpace]18*TNF\[LetterSpace]TNFR\[LetterSpace]E[t], J19 -> J19\[LetterSpace]ka\[LetterSpace]19*TNF\[LetterSpace]TNFR\[LetterSpace]E[t]*TRADD[t], J2 -> J2\[LetterSpace]ka\[LetterSpace]2, J20 -> J20\[LetterSpace]ka\[LetterSpace]20*RIP[t]*TNF\[LetterSpace]TNFR\[LetterSpace]TRADD[t]*TRAF2[t], J21 -> J21\[LetterSpace]ka\[LetterSpace]21*TNFRC1[t], J22 -> J22\[LetterSpace]ka\[LetterSpace]22*TNFRCint1[t], J23 -> J23\[LetterSpace]ka\[LetterSpace]23*FADD[t]^2*TNFRCint2[t], J24 -> J24\[LetterSpace]ka\[LetterSpace]24*TNFRCint3[t], J25 -> J25\[LetterSpace]ka\[LetterSpace]25*FLIP[t]*TNFRC2[t], J26 -> J26\[LetterSpace]ka\[LetterSpace]26*FLIP[t]*TNFRC2\[LetterSpace]FLIP[t], J27 -> J27\[LetterSpace]ka\[LetterSpace]27*pCasp8[t]*TNFRC2[t], J28 -> J28\[LetterSpace]ka\[LetterSpace]28*pCasp8[t]*TNFRC2\[LetterSpace]pCasp8[t], J29 -> J29\[LetterSpace]ka\[LetterSpace]29*TNFRC2\[LetterSpace]pCasp8\[LetterSpace]pCasp8[t], J3 -> J3\[LetterSpace]ka\[LetterSpace]3*TNFR\[LetterSpace]E[t], J30 -> J30\[LetterSpace]ka\[LetterSpace]30*FLIP[t]*TNFRC2\[LetterSpace]pCasp8[t], J31 -> J31\[LetterSpace]ka\[LetterSpace]31*pCasp8[t]*TNFRC2\[LetterSpace]FLIP[t], J32 -> J32\[LetterSpace]ka\[LetterSpace]32*TNFRC2\[LetterSpace]FLIP\[LetterSpace]pCasp8[t], J33 -> J33\[LetterSpace]ka\[LetterSpace]33*RIP[t]*TNFRC2\[LetterSpace]FLIP\[LetterSpace]pCasp8[t]*TRAF2[t], J34 -> J34\[LetterSpace]ka\[LetterSpace]34*IKK[t]*TNFRC2\[LetterSpace]FLIP\[LetterSpace]pCasp8\[LetterSpace]RIP\[LetterSpace]TRAF2[t], J35 -> J35\[LetterSpace]ka\[LetterSpace]35 - J35\[LetterSpace]kd\[LetterSpace]35*IKK[t], J36 -> J36\[LetterSpace]ka\[LetterSpace]36 - J36\[LetterSpace]kd\[LetterSpace]36*NFkB[t], J37 -> J37\[LetterSpace]ka\[LetterSpace]37 - J37\[LetterSpace]kd\[LetterSpace]37*FLIP[t], J38 -> J38\[LetterSpace]ka\[LetterSpace]38 - J38\[LetterSpace]kd\[LetterSpace]38*XIAP[t], J39 -> J39\[LetterSpace]ka\[LetterSpace]39 - J39\[LetterSpace]kd\[LetterSpace]39*A20[t], J4 -> J4\[LetterSpace]ka\[LetterSpace]4 - J4\[LetterSpace]kd\[LetterSpace]4*RIP[t], J40 -> J40\[LetterSpace]ka\[LetterSpace]40*IKKa[t], J41 -> J41\[LetterSpace]ka\[LetterSpace]41*IkBa\[LetterSpace]NFkB[t], J42 -> J42\[LetterSpace]ka\[LetterSpace]42*NFkB\[LetterSpace]N[t], J43 -> J43\[LetterSpace]ka\[LetterSpace]43*IkBa\[LetterSpace]mRNA[t], J44 -> J44\[LetterSpace]ka\[LetterSpace]44*IkBa[t], J45 -> J45\[LetterSpace]ka\[LetterSpace]45*IkBa\[LetterSpace]N[t], J46 -> J46\[LetterSpace]ka\[LetterSpace]46*IkBa\[LetterSpace]NFkB\[LetterSpace]N[t], J47 -> J47\[LetterSpace]ka\[LetterSpace]47*PIkBa[t], J48 -> J48\[LetterSpace]ka\[LetterSpace]48*A20\[LetterSpace]mRNA[t], J49 -> J49\[LetterSpace]ka\[LetterSpace]49*XIAP\[LetterSpace]mRNA[t], J5 -> J5\[LetterSpace]ka\[LetterSpace]5 - J5\[LetterSpace]kd\[LetterSpace]5*TRADD[t], J50 -> J50\[LetterSpace]ka\[LetterSpace]50*FLIP\[LetterSpace]mRNA[t], J51 -> J51\[LetterSpace]ka\[LetterSpace]51*IKK[t]*TNFRC1[t], J52 -> J52\[LetterSpace]ka\[LetterSpace]52*IKKa[t], J53 -> J53\[LetterSpace]ka\[LetterSpace]53*A20[t]*TNFRC1[t], J54 -> J54\[LetterSpace]ka\[LetterSpace]54*IkBa[t]*NFkB[t], J55 -> J55\[LetterSpace]ka\[LetterSpace]55*IkBa\[LetterSpace]NFkB[t]*IKKa[t], J56 -> J56\[LetterSpace]ka\[LetterSpace]56*NFkB[t], J57 -> J57\[LetterSpace]ka\[LetterSpace]57*NFkB\[LetterSpace]N[t], J58 -> J58\[LetterSpace]ka\[LetterSpace]58*IkBa\[LetterSpace]mRNA[t], J59 -> J59\[LetterSpace]ka\[LetterSpace]59*IkBa[t] - J59\[LetterSpace]kd\[LetterSpace]59*IkBa\[LetterSpace]N[t], J6 -> J6\[LetterSpace]ka\[LetterSpace]6 - J6\[LetterSpace]kd\[LetterSpace]6*TRAF2[t], J60 -> J60\[LetterSpace]ka\[LetterSpace]60*IkBa\[LetterSpace]N[t]*NFkB\[LetterSpace]N[t], J61 -> J61\[LetterSpace]ka\[LetterSpace]61*IkBa\[LetterSpace]NFkB\[LetterSpace]N[t], J62 -> J62\[LetterSpace]ka\[LetterSpace]62*NFkB\[LetterSpace]N[t], J63 -> J63\[LetterSpace]ka\[LetterSpace]63*A20\[LetterSpace]mRNA[t], J64 -> J64\[LetterSpace]ka\[LetterSpace]64*NFkB\[LetterSpace]N[t], J65 -> J65\[LetterSpace]ka\[LetterSpace]65*XIAP\[LetterSpace]mRNA[t], J66 -> J66\[LetterSpace]ka\[LetterSpace]66*NFkB\[LetterSpace]N[t], J67 -> J67\[LetterSpace]ka\[LetterSpace]67*FLIP\[LetterSpace]mRNA[t], J68 -> J68\[LetterSpace]ka\[LetterSpace]68 - J68\[LetterSpace]kd\[LetterSpace]68*pCasp8[t], J69 -> J69\[LetterSpace]ka\[LetterSpace]69 - J69\[LetterSpace]kd\[LetterSpace]69*pCasp3[t], J7 -> J7\[LetterSpace]ka\[LetterSpace]7 - J7\[LetterSpace]kd\[LetterSpace]7*FADD[t], J70 -> J70\[LetterSpace]ka\[LetterSpace]70 - J70\[LetterSpace]kd\[LetterSpace]70*pCasp6[t], J71 -> J71\[LetterSpace]ka\[LetterSpace]71*Casp8[t], J72 -> J72\[LetterSpace]ka\[LetterSpace]72*Casp3[t], J73 -> J73\[LetterSpace]ka\[LetterSpace]73*Casp6[t], J74 -> J74\[LetterSpace]ka\[LetterSpace]74*XIAP\[LetterSpace]Casp3[t], J75 -> J75\[LetterSpace]ka\[LetterSpace]75 - J75\[LetterSpace]kd\[LetterSpace]75*BAR[t], J76 -> J76\[LetterSpace]ka\[LetterSpace]76*BAR\[LetterSpace]Casp8[t], J77 -> -J77\[LetterSpace]kd\[LetterSpace]77 + J77\[LetterSpace]ka\[LetterSpace]77*PARP[t], J78 -> J78\[LetterSpace]ka\[LetterSpace]78*cPARP[t], J79 -> J79\[LetterSpace]ka\[LetterSpace]79*Casp8[t]*pCasp3[t], J8 -> J8\[LetterSpace]ka\[LetterSpace]8*TNF\[LetterSpace]TNFR\[LetterSpace]E[t], J80 -> J80\[LetterSpace]ka\[LetterSpace]80*Casp3[t]*pCasp6[t], J81 -> J81\[LetterSpace]ka\[LetterSpace]81*Casp6[t]*pCasp8[t], J82 -> J82\[LetterSpace]ka\[LetterSpace]82*Casp3[t]*XIAP[t] - J82\[LetterSpace]kd\[LetterSpace]82*XIAP\[LetterSpace]Casp3[t], J83 -> J83\[LetterSpace]ka\[LetterSpace]83*Casp3[t]*XIAP[t], J84 -> J84\[LetterSpace]ka\[LetterSpace]84*XIAP\[LetterSpace]Casp3[t], J85 -> J85\[LetterSpace]ka\[LetterSpace]85*Casp3[t]*RIP[t], J86 -> J86\[LetterSpace]ka\[LetterSpace]86*Casp3[t]*FLIP[t], J87 -> J87\[LetterSpace]ka\[LetterSpace]87*Casp3[t]*PARP[t], J88 -> -(J88\[LetterSpace]kd\[LetterSpace]88*BAR\[LetterSpace]Casp8[t]) + J88\[LetterSpace]ka\[LetterSpace]88*BAR[t]*Casp8[t], J9 -> J9\[LetterSpace]ka\[LetterSpace]9*TNF\[LetterSpace]TNFR\[LetterSpace]TRADD[t] }; parameters = { J1\[LetterSpace]ka\[LetterSpace]1 -> 0.001, J2\[LetterSpace]ka\[LetterSpace]2 -> 2.8*^-07, J3\[LetterSpace]ka\[LetterSpace]3 -> 5.6*^-05, J4\[LetterSpace]ka\[LetterSpace]4 -> 2.0256*^-05, J4\[LetterSpace]kd\[LetterSpace]4 -> 0.0001, J5\[LetterSpace]ka\[LetterSpace]5 -> 2.9344*^-05, J5\[LetterSpace]kd\[LetterSpace]5 -> 0.0001, J6\[LetterSpace]ka\[LetterSpace]6 -> 3.3056*^-05, J6\[LetterSpace]kd\[LetterSpace]6 -> 0.0001, J7\[LetterSpace]ka\[LetterSpace]7 -> 3.0944*^-05, J7\[LetterSpace]kd\[LetterSpace]7 -> 0.0001, J8\[LetterSpace]ka\[LetterSpace]8 -> 5.6*^-05, J9\[LetterSpace]ka\[LetterSpace]9 -> 0.02352, J10\[LetterSpace]ka\[LetterSpace]10 -> 5.6*^-05, J11\[LetterSpace]ka\[LetterSpace]11 -> 5.6*^-05, J12\[LetterSpace]ka\[LetterSpace]12 -> 5.6*^-05, J13\[LetterSpace]ka\[LetterSpace]13 -> 5.6*^-05, J14\[LetterSpace]ka\[LetterSpace]14 -> 5.6*^-05, J15\[LetterSpace]ka\[LetterSpace]15 -> 5.6*^-05, J16\[LetterSpace]ka\[LetterSpace]16 -> 5.6*^-05, J17\[LetterSpace]ka\[LetterSpace]17 -> 5.6*^-05, J18\[LetterSpace]ka\[LetterSpace]18 -> 0.00953471, J18\[LetterSpace]kd\[LetterSpace]18 -> 6.60377*^-05, J19\[LetterSpace]ka\[LetterSpace]19 -> 0.00427827, J20\[LetterSpace]ka\[LetterSpace]20 -> 0.0976562, J21\[LetterSpace]ka\[LetterSpace]21 -> 0.001135, J22\[LetterSpace]ka\[LetterSpace]22 -> 0.001135, J23\[LetterSpace]ka\[LetterSpace]23 -> 0.0118534, J24\[LetterSpace]ka\[LetterSpace]24 -> 0.1135, J25\[LetterSpace]ka\[LetterSpace]25 -> 0.3125, J26\[LetterSpace]ka\[LetterSpace]26 -> 0.3125, J27\[LetterSpace]ka\[LetterSpace]27 -> 0.03125, J28\[LetterSpace]ka\[LetterSpace]28 -> 0.03125, J29\[LetterSpace]ka\[LetterSpace]29 -> 0.45, J30\[LetterSpace]ka\[LetterSpace]30 -> 0.3125, J31\[LetterSpace]ka\[LetterSpace]31 -> 0.3125, J32\[LetterSpace]ka\[LetterSpace]32 -> 0.3, J33\[LetterSpace]ka\[LetterSpace]33 -> 0.00976562, J34\[LetterSpace]ka\[LetterSpace]34 -> 0.03125, J35\[LetterSpace]ka\[LetterSpace]35 -> 6.4*^-05, J35\[LetterSpace]kd\[LetterSpace]35 -> 0.0001, J36\[LetterSpace]ka\[LetterSpace]36 -> 1.6*^-06, J36\[LetterSpace]kd\[LetterSpace]36 -> 0.0001, J37\[LetterSpace]ka\[LetterSpace]37 -> 2.24902*^-06, J37\[LetterSpace]kd\[LetterSpace]37 -> 0.0001, J38\[LetterSpace]ka\[LetterSpace]38 -> 0.000772256, J38\[LetterSpace]kd\[LetterSpace]38 -> 0.0001, J39\[LetterSpace]ka\[LetterSpace]39 -> 9.6*^-06, J39\[LetterSpace]kd\[LetterSpace]39 -> 0.0001, J40\[LetterSpace]ka\[LetterSpace]40 -> 0.0001, J41\[LetterSpace]ka\[LetterSpace]41 -> 0.0001, J42\[LetterSpace]ka\[LetterSpace]42 -> 0.0001, J43\[LetterSpace]ka\[LetterSpace]43 -> 0.000394201, J44\[LetterSpace]ka\[LetterSpace]44 -> 0.00154022, J45\[LetterSpace]ka\[LetterSpace]45 -> 0.0001, J46\[LetterSpace]ka\[LetterSpace]46 -> 0.0001, J47\[LetterSpace]ka\[LetterSpace]47 -> 0.0115517, J48\[LetterSpace]ka\[LetterSpace]48 -> 0.000470498, J49\[LetterSpace]ka\[LetterSpace]49 -> 0.000104931, J50\[LetterSpace]ka\[LetterSpace]50 -> 0.000165744, J51\[LetterSpace]ka\[LetterSpace]51 -> 93.75, J52\[LetterSpace]ka\[LetterSpace]52 -> 0.1, J53\[LetterSpace]ka\[LetterSpace]53 -> 0.00625, J54\[LetterSpace]ka\[LetterSpace]54 -> 1.25, J55\[LetterSpace]ka\[LetterSpace]55 -> 0.104167, J56\[LetterSpace]ka\[LetterSpace]56 -> 0.0125, J57\[LetterSpace]ka\[LetterSpace]57 -> 3.0303*^-05, J58\[LetterSpace]ka\[LetterSpace]58 -> 0.0606061, J59\[LetterSpace]ka\[LetterSpace]59 -> 0.005, J59\[LetterSpace]kd\[LetterSpace]59 -> 0.00257576, J60\[LetterSpace]ka\[LetterSpace]60 -> 1.4348, J61\[LetterSpace]ka\[LetterSpace]61 -> 0.0151515, J62\[LetterSpace]ka\[LetterSpace]62 -> 3.78788*^-05, J63\[LetterSpace]ka\[LetterSpace]63 -> 0.0151515, J64\[LetterSpace]ka\[LetterSpace]64 -> 3.33333*^-05, J65\[LetterSpace]ka\[LetterSpace]65 -> 0.0506061, J66\[LetterSpace]ka\[LetterSpace]66 -> 3.33333*^-05, J67\[LetterSpace]ka\[LetterSpace]67 -> 0.00687273, J68\[LetterSpace]ka\[LetterSpace]68 -> 0.000197531, J68\[LetterSpace]kd\[LetterSpace]68 -> 6.17284*^-05, J69\[LetterSpace]ka\[LetterSpace]69 -> 4.93827*^-05, J69\[LetterSpace]kd\[LetterSpace]69 -> 6.17284*^-05, J70\[LetterSpace]ka\[LetterSpace]70 -> 3.95062*^-06, J70\[LetterSpace]kd\[LetterSpace]70 -> 6.17284*^-05, J71\[LetterSpace]ka\[LetterSpace]71 -> 5.78704*^-05, J72\[LetterSpace]ka\[LetterSpace]72 -> 5.78704*^-05, J73\[LetterSpace]ka\[LetterSpace]73 -> 5.78704*^-05, J74\[LetterSpace]ka\[LetterSpace]74 -> 5.78704*^-05, J75\[LetterSpace]ka\[LetterSpace]75 -> 1.66603*^-06, J75\[LetterSpace]kd\[LetterSpace]75 -> 5.78704*^-06, J76\[LetterSpace]ka\[LetterSpace]76 -> 5.78704*^-05, J77\[LetterSpace]ka\[LetterSpace]77 -> 5.78704*^-06, J77\[LetterSpace]kd\[LetterSpace]77 -> 9.64506*^-06, J78\[LetterSpace]ka\[LetterSpace]78 -> 5.78704*^-06, J79\[LetterSpace]ka\[LetterSpace]79 -> 0.015625, J80\[LetterSpace]ka\[LetterSpace]80 -> 0.009375, J81\[LetterSpace]ka\[LetterSpace]81 -> 0.0015625, J82\[LetterSpace]ka\[LetterSpace]82 -> 0.625, J82\[LetterSpace]kd\[LetterSpace]82 -> 0.001, J83\[LetterSpace]ka\[LetterSpace]83 -> 1.875, J84\[LetterSpace]ka\[LetterSpace]84 -> 5*^-05, J85\[LetterSpace]ka\[LetterSpace]85 -> 0.15625, J86\[LetterSpace]ka\[LetterSpace]86 -> 0.15625, J87\[LetterSpace]ka\[LetterSpace]87 -> 0.1875, J88\[LetterSpace]ka\[LetterSpace]88 -> 0.520833, J88\[LetterSpace]kd\[LetterSpace]88 -> 0.001, cytoplasm -> 3.2, extracellular -> 1344.0, nucleus -> 1.056 }; assignments = { }; events = { }; speciesAnnotations = { }; reactionAnnotations = { }; units = { {"time" -> "", "metabolite" -> "a_mole", "extent" -> "a_mole"} }; (* Time evolution *) odes = { A20'[t] == 1.0*J39 +1.0*J63 , A20\[LetterSpace]mRNA'[t] == 1.0*J62 -1.0*J48, BAR'[t] == 1.0*J75 -1.0*J88, BAR\[LetterSpace]Casp8'[t] == 1.0*J88 -1.0*J76, Casp3'[t] == 1.0*J79 -1.0*J72 -1.0*J82, Casp6'[t] == 1.0*J80 -1.0*J73, Casp8'[t] == 1.0*J29 +1.0*J32 +1.0*J81 -1.0*J71 -1.0*J88, FADD'[t] == 1.0*J7 -2.0*J23, FLIP'[t] == 1.0*J37 +1.0*J67 -1.0*J25 -1.0*J26 -1.0*J30 -1.0*J86, FLIP\[LetterSpace]mRNA'[t] == 1.0*J66 -1.0*J50, IKK'[t] == 1.0*J35 +1.0*J52 -1.0*J34 -1.0*J51, IKKa'[t] == 1.0*J34 +1.0*J51 -1.0*J40 -1.0*J52, IkBa'[t] == 1.0*J58 -1.0*J44 -1.0*J54 -1.0*J59, IkBa\[LetterSpace]N'[t] == 1.0*J59 -1.0*J45 -1.0*J60, IkBa\[LetterSpace]NFkB'[t] == 1.0*J54 +1.0*J61 -1.0*J41 -1.0*J55, IkBa\[LetterSpace]NFkB\[LetterSpace]N'[t] == 1.0*J60 -1.0*J46 -1.0*J61, IkBa\[LetterSpace]mRNA'[t] == 1.0*J57 -1.0*J43, NFkB'[t] == 1.0*J36 +1.0*J55 -1.0*J54 -1.0*J56, NFkB\[LetterSpace]N'[t] == 1.0*J56 -1.0*J42 -1.0*J60, PARP'[t] == -1.0*J77 -1.0*J87, PIkBa'[t] == 1.0*J55 -1.0*J47, RIP'[t] == 1.0*J4 +1.0*J22 -1.0*J20 -1.0*J33 -1.0*J85, TNFR'[t] == 1.0*J2 -1.0*J1, TNFRC1'[t] == 1.0*J20 -1.0*J10 -1.0*J21 -1.0*J53, TNFRC2'[t] == 1.0*J24 +1.0*J29 +1.0*J32 -1.0*J11 -1.0*J25 -1.0*J27, TNFRC2\[LetterSpace]FLIP'[t] == 1.0*J25 -1.0*J12 -1.0*J26 -1.0*J31, TNFRC2\[LetterSpace]FLIP\[LetterSpace]FLIP'[t] == 1.0*J26 -1.0*J13, TNFRC2\[LetterSpace]FLIP\[LetterSpace]pCasp8'[t] == 1.0*J30 +1.0*J31 -1.0*J16 -1.0*J32 -1.0*J33, TNFRC2\[LetterSpace]FLIP\[LetterSpace]pCasp8\[LetterSpace]RIP\[LetterSpace]TRAF2'[t] == 1.0*J33 -1.0*J17, TNFRC2\[LetterSpace]pCasp8'[t] == 1.0*J27 -1.0*J14 -1.0*J28 -1.0*J30, TNFRC2\[LetterSpace]pCasp8\[LetterSpace]pCasp8'[t] == 1.0*J28 -1.0*J15 -1.0*J29, TNFRCint1'[t] == 1.0*J21 -1.0*J22, TNFRCint2'[t] == 1.0*J22 -1.0*J23, TNFRCint3'[t] == 1.0*J23 -1.0*J24, TNFR\[LetterSpace]E'[t] == 1.0*J1 -1.0*J3 -1.0*J18, TNF\[LetterSpace]E'[t] == -1.0*J18, TNF\[LetterSpace]TNFR\[LetterSpace]E'[t] == 1.0*J18 -1.0*J8 -1.0*J19, TNF\[LetterSpace]TNFR\[LetterSpace]TRADD'[t] == 1.0*J19 +1.0*J53 -1.0*J9 -1.0*J20, TRADD'[t] == 1.0*J5 -1.0*J19, TRAF2'[t] == 1.0*J6 +1.0*J22 +1.0*J53 -1.0*J20 -1.0*J33, XIAP'[t] == 1.0*J38 +1.0*J65 +1.0*J84 -1.0*J82 -1.0*J83, XIAP\[LetterSpace]Casp3'[t] == 1.0*J82 -1.0*J74 -1.0*J84, XIAP\[LetterSpace]mRNA'[t] == 1.0*J64 -1.0*J49, cPARP'[t] == 1.0*J87 -1.0*J78, pCasp3'[t] == 1.0*J69 -1.0*J79, pCasp6'[t] == 1.0*J70 -1.0*J80, pCasp8'[t] == 1.0*J68 -1.0*J27 -1.0*J28 -1.0*J31 -1.0*J81 }; timeCourse = NDSolve[Join[odes, initialValues]//.rateEquations//.assignments//.parameters, variables, {t, 0, 100}]; (* Steady-state solution initialized with result of time evolution *) findRootEquations = odes /.D[_[t],t]->0; findRootVariables = Partition[Flatten[{#, #/.timeCourse/.t->100} &/@variables],2]; steadyStateVariables = FindRoot[findRootEquations//.rateEquations//.assignments//.parameters, findRootVariables, MaxIterations->100] fluxes = #//.assignments//.parameters/.steadyStateVariables&/@rateEquations (* Plot the time evolution of the variables *) plotTable=Table[Plot[variables[[i]]/.parameters/.timeCourse,{t,0,100},PlotLegends->variables[[i]],PlotRange->Full],{i,Length[variables]}]