begin name schaber end name begin reactions v1 {1.0}Ste5 + {1.0}Ste11 = {1.0}Ste5Ste11 v10 {1.0}Ste5Ste11GbgKss1 = {1.0}Ste5Ste11GbgKss1P v11 {1.0}Ste5Ste11GbgKss1P = {1.0}Ste5Ste11GbgP + {1.0}Kss1PP v12 {1.0}Ste5Ste11GbgP + {1.0}Kss1 = {1.0}Ste5Ste11GbgKss1P v13 {1.0}Ste11 = {1.0}Ste11P v14 {1.0}Ste11P = {1.0}Ste11 v15 {1.0}Kss1 = {1.0}Kss1PP v16 {1.0}Kss1PP = {1.0}Kss1 v17 {1.0}Ste12Kss1 = {2.0}Kss1 + {1.0}Ste12 v18 {2.0}Kss1 + {1.0}Ste12 = {1.0}Ste12Kss1 v19 {1.0}Ste12 = {1.0}Ste12P v2 {1.0}Ste5Ste11 + {1.0}Gbg = {1.0}Ste5Ste11Gbg v20 {1.0}$s = {1.0}PREP v21 {1.0}Ste12TeSte5Kss1 = {1.0}Kss1 + {1.0}Ste12TeSte5 v22 {1.0}Kss1 + {1.0}Ste12TeSte5 = {1.0}Ste12TeSte5Kss1 v23 {1.0}Ste12TeSte5 = {1.0}Ste12TeSte5P v24 {1.0}Ste12TeSte5 = {1.0}$p v25 {1.0}$s = {1.0}FREP v26 {1.0}Fus3PP = {1.0}Fus3 v27 {1.0}Ste5Ste11 = {1.0}Ste5 + {1.0}Ste11 v28 {1.0}Ste12P = {1.0}Ste12 v29 {1.0}PREP = {1.0}$p v3 {1.0}Ste5Ste11Gbg + {1.0}Fus3 = {1.0}Ste5Ste11GbgFus3 v30 {1.0}Ste12TeSte5P = {1.0}Ste12TeSte5 v31 {1.0}FREP = {1.0}$p v4 {1.0}Ste5Ste11GbgFus3 = {1.0}Ste5Ste11GbgFus3P v5 {1.0}Ste5Ste11GbgFus3P = {1.0}Fus3PP + {1.0}Ste5Ste11GbgP v6 {1.0}Fus3 + {1.0}Ste5Ste11GbgP = {1.0}Ste5Ste11GbgFus3P v7 {1.0}Ste5Ste11GbgP = {1.0}Gbg + {1.0}Ste11Ubi + {1.0}Ste5 v8 {1.0}Ste11Ubi = {1.0}$p v9 {1.0}Ste5Ste11Gbg + {1.0}Kss1 = {1.0}Ste5Ste11GbgKss1 end reactions begin rate equations v1 = k1*Ste11[t]*Ste5[t] v10 = k10*Ste5Ste11GbgKss1[t] v11 = k11*Ste5Ste11GbgKss1P[t] v12 = k12*Kss1[t]*Ste5Ste11GbgP[t] v13 = beta*k13*Ste11[t] v14 = k14*Ste11P[t] v15 = k15*Kss1[t]*Ste11P[t] + k30*Kss1[t]*Ste11Ubi[t] v16 = k16*Kss1PP[t] + k28*Fus3PP[t]*Kss1PP[t] v17 = k17*Ste12Kss1[t] v18 = k18*Kss1[t]*Ste12[t] v19 = k19*Fus3PP[t]*Ste12[t] + k29*Kss1PP[t]*Ste12[t] v2 = alpha*k2*Gbg[t]*Ste5Ste11[t] v20 = k20*Ste12P[t] v21 = k21*Ste12TeSte5Kss1[t] v22 = k22*Kss1[t]*Ste12TeSte5[t] v23 = k23*Kss1PP[t]*Ste12TeSte5[t] v24 = k24*Fus3PP[t]*Ste12TeSte5[t] v25 = k25*Ste12TeSte5P[t] v26 = k26*Fus3PP[t] v27 = k27*Ste5Ste11[t] v28 = k31*Ste12P[t] v29 = k32*PREP[t] v3 = k3*Fus3[t]*Ste5Ste11Gbg[t] v30 = k33*Ste12TeSte5P[t] v31 = k34*FREP[t] v4 = k4*Ste5Ste11GbgFus3[t] v5 = k5*Ste5Ste11GbgFus3P[t] v6 = k6*Fus3[t]*Ste5Ste11GbgP[t] v7 = k7*Ste5Ste11GbgP[t] v8 = k8*Ste11Ubi[t] v9 = k9*Kss1[t]*Ste5Ste11Gbg[t] end rate equations begin parameters alphaA = 1.0 alphae = 10.0 alphas = 2.0 alphastim = 1.0 alphat = 0.0 betaA = 1.0 betae = 360.0 betas = 20.0 betastim = 1.0 betat = 0.0 k1 = 0.01 k10 = 1.0 k11 = 1.0 k12 = 1.0 k13 = 1.0 k14 = 0.1 k15 = 0.1 k16 = 0.1 k17 = 1.0 k18 = 10.0 k19 = 1.0 k2 = 0.01 k20 = 1.0 k21 = 1.0 k22 = 1.0 k23 = 1.0 k24 = 0.01 k25 = 1.0 k26 = 0.1 k27 = 1.0 k28 = 0.01 k29 = 0.01 k3 = 1.0 k30 = 0.1 k31 = 1.0 k32 = 1.0 k33 = 1.0 k34 = 1.0 k4 = 1.0 k5 = 1.0 k6 = 1.0 k7 = 10.0 k8 = 0.1 k9 = 1.0 p = 0.0 s = 0.0 defaultcompartment = 1.0 end parameters begin initial conditions FREP[0] = FREPi Fus3[0] = Fus3i Fus3PP[0] = Fus3PPi Gbg[0] = Gbgi Kss1[0] = Kss1i Kss1PP[0] = Kss1PPi PREP[0] = PREPi Ste11[0] = Ste11i Ste11P[0] = Ste11Pi Ste11Ubi[0] = Ste11Ubii Ste12[0] = Ste12i Ste12Kss1[0] = Ste12Kss1i Ste12P[0] = Ste12Pi Ste12TeSte5[0] = Ste12TeSte5i Ste12TeSte5Kss1[0] = Ste12TeSte5Kss1i Ste12TeSte5P[0] = Ste12TeSte5Pi Ste5[0] = Ste5i Ste5Ste11[0] = Ste5Ste11i Ste5Ste11Gbg[0] = Ste5Ste11Gbgi Ste5Ste11GbgFus3[0] = Ste5Ste11GbgFus3i Ste5Ste11GbgFus3P[0] = Ste5Ste11GbgFus3Pi Ste5Ste11GbgKss1[0] = Ste5Ste11GbgKss1i Ste5Ste11GbgKss1P[0] = Ste5Ste11GbgKss1Pi Ste5Ste11GbgP[0] = Ste5Ste11GbgPi end initial conditions begin initial values FREPi = 0.0 Fus3i = 217.0 Fus3PPi = 0.0 Gbgi = 53.0 Kss1i = 54.4 Kss1PPi = 0.0 PREPi = 0.0 Ste11i = 13.3 Ste11Pi = 0.0 Ste11Ubii = 0.0 Ste12i = 0.07 Ste12Kss1i = 35.9 Ste12Pi = 0.0 Ste12TeSte5i = 0.25 Ste12TeSte5Kss1i = 13.7 Ste12TeSte5Pi = 0.0 Ste5i = 42.3 Ste5Ste11i = 5.6 Ste5Ste11Gbgi = 0.0 Ste5Ste11GbgFus3i = 0.0 Ste5Ste11GbgFus3Pi = 0.0 Ste5Ste11GbgKss1i = 0.0 Ste5Ste11GbgKss1Pi = 0.0 Ste5Ste11GbgPi = 0.0 end initial values begin assignment rules beta := betastim*((betaA*Piecewise[{{1, -betae + t >= 0}}, 0])/E^((-betae + t)/betas) + betaA*(1 - E^(-((-betat + t)/betas)))*Piecewise[{{1, (betae - t)*(-betat + t) >= 0}}, 0]) alpha := alphastim*((alphaA*Piecewise[{{1, -alphae + t >= 0}}, 0])/E^((-alphae + t)/alphas) + alphaA*(1 - E^(-((-alphat + t)/alphas)))*Piecewise[{{1, (alphae - t)*(-alphat + t) >= 0}}, 0]) end assignment rules begin function definitions end function definitions begin events end events begin process annotations end process annotations begin species annotations end species annotations begin units end units