begin name
sarma8
end name

begin reactions
reaction0 {1.0}species0 = {1.0}species1
reaction1 {1.0}species2 = {1.0}species3
reaction10 {1.0}species7 = {1.0}species11
reaction11 {1.0}$EXTERNAL = {1.0}species12
reaction12 {1.0}species12 = {1.0}species13
reaction13 {1.0}species13 = {1.0}$EXTERNAL
reaction14 {1.0}$EXTERNAL = {1.0}species14
reaction15 {1.0}species14 = {1.0}$EXTERNAL
reaction16 {1.0}species5 = {1.0}species16
reaction17 {1.0}species6 = {1.0}species17
reaction18 {1.0}species14 = {1.0}species18
reaction19 {1.0}species11 = {1.0}species17
reaction2 {1.0}species3 = {1.0}species4
reaction20 {1.0}species17 = {1.0}species16
reaction21 {1.0}species18 = {1.0}$EXTERNAL
reaction3 {1.0}species5 = {1.0}species6
reaction4 {1.0}species6 = {1.0}species7
reaction5 {1.0}species1 = {1.0}species0
reaction6 {1.0}species4 = {1.0}species3
reaction7 {1.0}species3 = {1.0}species2
reaction8 {1.0}species7 = {1.0}species6
reaction9 {1.0}species6 = {1.0}species5
end reactions

begin rate equations
reaction0 = compartment0*function411[reaction0K1, reaction0KI, reaction0V1, species0[t], species7[t]]
reaction1 = compartment0*function431[reaction1A, reaction1K3, reaction1Ka, reaction1k3, species1[t], species2[t], species3[t], species7[t]]
reaction10 = compartment0*function1[reaction10k11f, species7[t], reaction10k11b, species11[t]]
reaction11 = compartment0*function2[reaction11V12, reaction11n12, reaction11K12, species11[t]]
reaction12 = compartment0*reaction12k1*species12[t]
reaction13 = compartment0*reaction13k1*species13[t]
reaction14 = compartment0*function3[reaction14k15, species13[t]]
reaction15 = compartment0*reaction15k1*species14[t]
reaction16 = compartment0*(-(reaction16k2*species16[t]) + reaction16k1*species5[t])
reaction17 = compartment0*(-(reaction17k2*species17[t]) + reaction17k1*species6[t])
reaction18 = compartment0*(reaction18k1*species14[t] - reaction18k2*species18[t])
reaction19 = compartment0*function4[species11[t], species17[t], species18[t], reaction19k21, reaction19K21, reaction19K21i]
reaction2 = compartment0*function441[reaction2A, reaction2K4, reaction2Ka, reaction2k4, species1[t], species2[t], species3[t], species7[t]]
reaction20 = compartment0*function5[species18[t], species17[t], species11[t], reaction20k22, reaction20K22, reaction20K22i]
reaction21 = compartment0*reaction21k1*species18[t]
reaction3 = compartment0*function471[reaction3K7, reaction3k7, species4[t], species5[t], species6[t]]
reaction4 = compartment0*function481[reaction4K8, reaction4k8, species4[t], species5[t], species6[t]]
reaction5 = compartment0*function421[reaction5K2, reaction5k2, species1[t], species8[t]]
reaction6 = compartment0*function451[reaction6K5, reaction6k5, species3[t], species4[t], species9[t]]
reaction7 = compartment0*function461[reaction7K6, reaction7k6, species3[t], species4[t], species9[t]]
reaction8 = compartment0*function491[reaction8K9, reaction8k9, species10[t], species6[t], species7[t]]
reaction9 = compartment0*function4101[reaction9K10, reaction9k10, species10[t], species6[t], species7[t]]
end rate equations

begin parameters
reaction0K1 = 20.0
reaction0KI = 9.0
reaction0V1 = 2.5
reaction1A = 10.0
reaction1K3 = 20.0
reaction1Ka = 500.0
reaction1k3 = 0.1
reaction2A = 10.0
reaction2K4 = 20.0
reaction2Ka = 500.0
reaction2k4 = 0.1
reaction3K7 = 20.0
reaction3k7 = 0.1
reaction4K8 = 20.0
reaction4k8 = 0.1
reaction5K2 = 200.0
reaction5k2 = 0.025
reaction6K5 = 200.0
reaction6k5 = 0.1
reaction7K6 = 200.0
reaction7k6 = 0.1
reaction8K9 = 200.0
reaction8k9 = 0.1
reaction9K10 = 200.0
reaction9k10 = 0.1
reaction10k11f = 10.34
reaction10k11b = 2.86
reaction11V12 = 29.24
reaction11n12 = 3.97
reaction11K12 = 169.0
reaction12k1 = 0.022
reaction13k1 = 0.0078
reaction14k15 = 0.0012
reaction15k1 = 0.00025
reaction16k1 = 10.34
reaction16k2 = 2.86
reaction17k1 = 10.34
reaction17k2 = 2.86
reaction18k1 = 22.56
reaction18k2 = 15.4
reaction19k21 = 0.68
reaction19K21 = 10300.0
reaction19K21i = 87.0
reaction20k22 = 0.31
reaction20K22 = 87.0
reaction20K22i = 10300.0
reaction21k1 = 0.00025
compartment0 = 1.0
end parameters

begin initial conditions
species0[0] = species0i
species1[0] = species1i
species10[0] = species10i
species11[0] = species11i
species12[0] = species12i
species13[0] = species13i
species14[0] = species14i
species15[0] = species15i
species16[0] = species16i
species17[0] = species17i
species18[0] = species18i
species2[0] = species2i
species3[0] = species3i
species4[0] = species4i
species5[0] = species5i
species6[0] = species6i
species7[0] = species7i
species8[0] = species8i
species9[0] = species9i
end initial conditions

begin initial values
species0i = 999.999903688753
species1i = 0.0
species10i = 499.999975922188
species11i = 0.0
species12i = 0.0
species13i = 0.0
species14i = 0.0
species15i = 0.0
species16i = 0.0
species17i = 0.0
species18i = 0.0
species2i = 3999.99961475501
species3i = 0.0
species4i = 0.0
species5i = 999.999903688753
species6i = 0.0
species7i = 0.0
species8i = 99.9999903688752
species9i = 499.999951844377
end initial values

begin assignment rules
end assignment rules

begin function definitions
function451[K5_,k5_,species3_,species4_,species9_] := (k5*species4*species9)/(K5*(1 + species3/K5 + species4/K5))
function461[K6_,k6_,species3_,species4_,species9_] := (k6*species3*species9)/(K6*(1 + species3/K6 + species4/K6))
function411[K1_,KI_,V1_,species0_,species7_] := (species0*V1)/(K1*(1 + species0/K1)*(1 + species7/KI))
function441[A_,K4_,Ka_,k4_,species1_,species2_,species3_,species7_] := (k4*species1*species3*(1 + (A*species7)/Ka))/(K4*(1 + species2/K4 + species3/K4)*(1 + species7/Ka))
function471[K7_,k7_,species4_,species5_,species6_] := (k7*species4*species5)/(K7*(1 + species5/K7 + species6/K7))
function481[K8_,k8_,species4_,species5_,species6_] := (k8*species4*species6)/(K8*(1 + species5/K8 + species6/K8))
function421[K2_,k2_,species1_,species8_] := (k2*species1*species8)/(K2*(1 + species1/K2))
function491[K9_,k9_,species10_,species6_,species7_] := (k9*species10*species7)/(K9*(1 + species6/K9 + species7/K9))
function2[V12_,n12_,K12_,MPPn_] := (MPPn^n12*V12)/(K12^n12 + MPPn^n12)
function1[k11f_,ppERKc_,k11b_,ppERKn_] := k11f*ppERKc - k11b*ppERKn
function4101[K10_,k10_,species10_,species6_,species7_] := (k10*species10*species6)/(K10*(1 + species6/K10 + species7/K10))
function5[P3n_,MPn_,MPPn_,k22_,K22_,K22i_] := (k22*MPn*P3n)/(K22*(1 + MPPn/K22i + MPn/K22))
function4[MPPn_,MPn_,P3n_,k21_,K21_,K21i_] := (k21*MPPn*P3n)/(K21*(1 + MPPn/K21 + MPn/K21i))
function3[k15_,P3mRNA_] := k15*P3mRNA
function431[A_,K3_,Ka_,k3_,species1_,species2_,species3_,species7_] := (k3*species1*species2*(1 + (A*species7)/Ka))/(K3*(1 + species2/K3 + species3/K3)*(1 + species7/Ka))
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units