begin name
santolini1
end name

begin reactions
r1 {1.0}FeIII + {1.0}$NADPH = {1.0}FeII + {1.0}$NADPplus
r10 {1.0}FeIINO + {1.0}$O2 = {1.0}FeIII + {1.0}$NO3
r2 {1.0}FeII + {1.0}$O2 = {1.0}FeIIO2
r3 {1.0}FeIIO2 = {1.0}FeIIIstar
r4 {1.0}FeIIIstar + {0.5}$NADPH = {1.0}FeIIstar + {0.5}$NADPplus
r5 {1.0}FeIIstar + {1.0}$O2 = {1.0}FeIIstarO2
r6 {1.0}FeIIstarO2 = {1.0}FeIIINO + {1.0}$citrulline
r9 {1.0}FeIINO = {1.0}FeII + {1.0}$NO
rF {1.0}FeIIINO = {1.0}FeIII + {1.0}$NO
rG {1.0}FeIIINO + {0.5}$NADPH = {1.0}FeIINO + {0.5}$NADPplus
end reactions

begin rate equations
r1 = cytosol*k1*FeIII[t]
r10 = cytosol*k10*O2*FeIINO[t]
r2 = cytosol*k2*O2*FeII[t]
r3 = cytosol*k3*FeIIO2[t]
r4 = cytosol*k4*FeIIIstar[t]
r5 = cytosol*k5*O2*FeIIstar[t]
r6 = cytosol*k6*FeIIstarO2[t]
r9 = cytosol*k9*FeIINO[t]
rF = cytosol*k7*FeIIINO[t]
rG = cytosol*k8*FeIIINO[t]
end rate equations

begin parameters
k1 = 2.6
k10 = 0.0013
k2 = 0.9
k3 = 26.0
k4 = 2.6
k5 = 0.9
k6 = 26.0
k7 = 5.0
k8 = 2.6
k9 = 0.0001
NADPH = 40.0
NADPplus = 0.0
NO = 0.0
NO3 = 0.0
O2 = 140.0
citrulline = 0.0
cytosol = 1.0
end parameters

begin initial conditions
FeII[0] = FeIIi
FeIII[0] = FeIIIi
FeIIINO[0] = FeIIINOi
FeIIIstar[0] = FeIIIstari
FeIINO[0] = FeIINOi
FeIIO2[0] = FeIIO2i
FeIIstar[0] = FeIIstari
FeIIstarO2[0] = FeIIstarO2i
end initial conditions

begin initial values
FeIIi = 0.0
FeIIIi = 1.0
FeIIINOi = 0.0
FeIIIstari = 0.0
FeIINOi = 0.0
FeIIO2i = 0.0
FeIIstari = 0.0
FeIIstarO2i = 0.0
end initial values

begin assignment rules
FeIIIt := FeIII[t] + FeIIIstar[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
NO http://identifiers.org/chebi/CHEBI:16480
NO http://identifiers.org/kegg.compound/C00533
NO3 http://identifiers.org/chebi/CHEBI:17632
NO3 http://identifiers.org/kegg.compound/C00244
end species annotations

begin units
end units