begin name romond1 end name begin reactions R1 {1.0}$EXTERNAL = {1.0}C1 R10 {1.0}C2 = {1.0}$EXTERNAL R2 {1.0}C1 = {1.0}$EXTERNAL R3 {1.0}C1 = {1.0}$EXTERNAL R8 {1.0}$EXTERNAL = {1.0}C2 R9 {1.0}C2 = {1.0}$EXTERNAL end reactions begin rate equations R1 = (compartment*Kim1*vi1)/(Kim1 + M2[t]) R10 = compartment*kd2*C2[t] R2 = (compartment*vd1*C1[t]*X1[t])/(Kd1 + C1[t]) R3 = compartment*kd1*C1[t] R8 = (compartment*Kim2*vi2)/(Kim2 + M1[t]) R9 = (compartment*vd2*C2[t]*X2[t])/(Kd2 + C2[t]) end rate equations begin parameters H1 = 0.01 H2 = 0.01 H3 = 0.01 H4 = 0.01 K1 = 0.01 K2 = 0.01 K3 = 0.01 K4 = 0.01 Kd1 = 0.02 Kd2 = 0.02 Kc1 = 0.5 Kc2 = 0.5 Kim1 = 0.03 Kim2 = 0.03 U2 = 0.15 U4 = 0.05 UM1 = 0.3 UM3 = 0.1 V2 = 0.15 V4 = 0.05 VM1 = 0.3 VM3 = 0.1 kd1 = 0.001 kd2 = 0.001 vd1 = 0.025 vd2 = 0.025 vi1 = 0.05 vi2 = 0.05 compartment = 1.0 end parameters begin initial conditions C1[0] = C1i C2[0] = C2i M1[0] = M1i M2[0] = M2i X1[0] = X1i X2[0] = X2i X2[0] = X2i M2[0] = M2i X1[0] = X1i M1[0] = M1i end initial conditions begin initial values C1i = 2.0 C2i = 0.0 M1i = 1.0 M2i = 0.0 X1i = 0.0 X2i = 0.0 X2i = 0.0 M2i = 0.0 X1i = 0.0 M1i = 1.0 end initial values begin assignment rules U3 := UM3*M2[t] U1 := (UM1*C2[t])/(Kc2 + C2[t]) V3 := VM3*M1[t] V1 := (VM1*C1[t])/(Kc1 + C1[t]) end assignment rules begin function definitions end function definitions begin events end events begin process annotations end process annotations begin species annotations end species annotations begin units end units