#roblitz1

FIX: csa1_degraded s102 s106 s107 s108 s33 s38 s62 s64 s66 s67 s69 s71 s72 s74 s76 s78 s82 s85 s87 s92 s93 s94 s95 sa1_degraded sa28_degraded sa31_degraded sa35_degraded sa3_degraded sa52_degraded sa53_degraded sa61_degraded sa75_degraded sa78_degraded sa86_degraded

#reactions
re100:
 {1.0}Ago_d = {1.0}s107
  default * function_62(Ago_d, default, p274)
re101:
 {1.0}s108 = {1.0}Ago_c
  default * function_63(Ago_d, default, p273, p274)
re102:
 {1.0}Ant_d = {1.0}s113
  default * function_64(Ant_d, default, p474)
re103:
 {1.0}s114 = {1.0}Ant_c
  default * function_65(Ant_d, default, p473, p474)
re104:
 {1.0}Ant_c = {1.0}s115
  default * function_66(Ant_c, default, p475)
re105:
 {1.0}Ant_R = {1.0}R_GnRH_a + {1.0}Ant_c
  default * function_67(Ant_R, default, p513)
re106:
 {1.0}R_GnRH_a + {1.0}Ant_c = {1.0}Ant_R
  default * function_68(Ant_c, R_GnRH_a, default, p512)
re107:
 {1.0}Ant_R = {1.0}s116
  default * function_69(Ant_R, default, p514)
re108:
 {1.0}Ant_c = {1.0}Ant_p
  default * function_70(Ant_c, default, p476)
re109:
 {1.0}Ant_p = {1.0}Ant_c
  default * function_71(Ant_p, default, p477)
re11:
 {1.0}R_GnRH_i = {1.0}sa1_degraded
  default * function_7(R_GnRH_i, default, p308)
re15:
 {1.0}GnRH_R_a = {1.0}GnRH + {1.0}R_GnRH_a
  default * function_8(GnRH_R_a, default, p303)
re2:
 {1.0}GnRH_R_a = {1.0}GnRH_R_i
  default * function_1(GnRH_R_a, default, p309)
re24:
 {1.0}GnRH = {1.0}sa3_degraded
  default * function_9(GnRH, default, p300)
re25:
 {1.0}s33 = {1.0}LH_Pit
  default * function_10(E2, P4, default, facE2, facP4, p1, p2, p3, p4, p6, p7)
re26:
 {1.0}s38 = {1.0}FSH_pit
  default * function_11(InhA_delay, InhB, default, freq, p11, p13, p21, p22, p23, p24, p25)
re28:
 {1.0}LH_Pit = {1.0}s92
  default * function_12(Ago_R_a, GnRH_R_a, LH_Pit, default, p16, p5, p8, p9)
re29:
 {1.0}FSH_pit = {1.0}s94
  default * function_13(Ago_R_a, FSH_pit, GnRH_R_a, default, p17, p18, p20, p28)
re3:
 {1.0}GnRH_R_i = {1.0}GnRH_R_a
  default * function_2(GnRH_R_i, default, p310)
re35:
 {1.0}LH_bld + {1.0}R_LH = {1.0}LH_R
  default * function_14(LH_bld, R_LH, default, facLH, p230)
re36:
 {1.0}LH_R = {1.0}R_LH_des
  default * function_15(LH_R, default, p234)
re37:
 {1.0}R_LH_des = {1.0}R_LH
  default * function_16(R_LH_des, default, p232)
re38:
 {1.0}LH_bld = {1.0}sa28_degraded
  default * function_17(LH_bld, default, p231)
re39:
 {1.0}FSH_R = {1.0}R_FSH_des
  default * function_18(FSH_R, default, p244)
re4:
 {1.0}R_GnRH_i = {1.0}R_GnRH_a
  default * function_3(R_GnRH_i, default, p307)
re40:
 {1.0}R_FSH_des = {1.0}R_FSH
  default * function_19(R_FSH_des, default, p242)
re42:
 {1.0}AF1 = {1.0}AF2
  default * function_20(AF1, FSH_R, default, p50)
re43:
 {1.0}s62 = {1.0}AF1
  default * function_21(FSH_R, default, p47, p48, p49)
re44:
 {1.0}AF2 = {1.0}AF3
  default * function_22(AF2, LH_R, R_Foll, default, p46, p51, p52)
re45:
 {1.0}AF3 = {1.0}AF4
  default * function_23(AF3, LH_R, R_Foll, default, p32, p43, p52)
re46:
 {1.0}AF4 = {1.0}PrF
  default * function_24(AF4, LH_R, R_Foll, default, p34, p52)
re49:
 {1.0}Sc1 = {1.0}Sc2
  default * function_25(Sc1, default, p37)
re5:
 {1.0}R_GnRH_a = {1.0}R_GnRH_i
  default * function_4(R_GnRH_a, default, p306)
re50:
 {1.0}Sc2 = {1.0}Lut1
  default * function_26(Sc2, default, p38)
re51:
 {1.0}Lut1 = {1.0}Lut2
  default * function_27(Ago_R_a, GnRH_R_a, Lut1, default, p39, p80, p83, p84)
re52:
 {1.0}Lut2 = {1.0}Lut3
  default * function_28(Ago_R_a, GnRH_R_a, Lut2, default, p40, p80, p83, p84)
re53:
 {1.0}Lut3 = {1.0}Lut4
  default * function_29(Ago_R_a, GnRH_R_a, Lut3, default, p41, p80, p83, p84)
re54:
 {1.0}s64 = {1.0}R_Foll
  default * function_30(FSH_bld, default, p90, p91, p94)
re56:
 {1.0}R_Foll = {1.0}sa61_degraded
  default * function_31(P4, R_Foll, default, facP4, p92, p93, p95)
re57:
 {1.0}s66 = {1.0}AF3
  default * function_32(AF3, FSH_R, default, p31, p55)
re58:
 {1.0}s67 = {1.0}AF4
  default * function_33(AF4, LH_R, default, p33, p44, p52, p55)
re59:
 {1.0}PrF = {1.0}sa52_degraded
  default * function_34(LH_R, PrF, R_Foll, default, p35, p45, p52)
re6:
 {1.0}GnRH_R_i = {1.0}R_GnRH_i
  default * function_5(GnRH_R_i, default, p305)
re60:
 {1.0}s69 = {1.0}OvF
  default * function_35(LH_R, PrF, R_Foll, default, p27, p45, p52, p53, p54)
re61:
 {1.0}OvF = {1.0}sa53_degraded
  default * function_36(OvF, default, p36)
re62:
 {1.0}s71 = {1.0}Sc1
  default * function_37(OvF, default, p26, p56, p57)
re64:
 {1.0}Lut4 = {1.0}s72
  default * function_38(Ago_R_a, GnRH_R_a, Lut4, default, p42, p80, p83, p84)
re65:
 {1.0}s74 = {1.0}E2
  default * function_39(AF2, AF3, AF4, LH_bld, Lut1, Lut4, PrF, default, facE2, p152, p158, p159, p160, p161, p164, p165)
re66:
 {1.0}E2 = {1.0}sa75_degraded
  default * function_40(E2, default, p154)
re67:
 {1.0}s76 = {1.0}P4
  default * function_41(Lut4, default, facP4, p166, p167)
re69:
 {1.0}s78 = {1.0}InhA
  default * function_42(Lut1, Lut2, Lut3, Lut4, PrF, Sc1, default, p168, p169, p170, p171, p172, p177, p178)
re71:
 {1.0}P4 = {1.0}sa78_degraded
  default * function_43(P4, default, p155)
re72:
 {1.0}s82 = {1.0}InhB
  default * function_44(AF2, Sc2, default, p173, p174, p175)
re73:
 {1.0}InhB = {1.0}sa86_degraded
  default * function_45(InhB, default, p157)
re74:
 {1.0}InhA_delay = {1.0}sa35_degraded
  default * function_46(InhA_delay, default, p30)
re75:
 {1.0}s85 = {1.0}R_GnRH_i
  default * function_47(default, p311)
re76:
 {1.0}GnRH_R_i = {1.0}csa1_degraded
  default * function_48(GnRH_R_i, default, p304)
re78:
 {1.0}s87 = {1.0}GnRH
  default * function_49(default, freq, mass)
re8:
 {1.0}GnRH + {1.0}R_GnRH_a = {1.0}GnRH_R_a
  default * function_6(GnRH, R_GnRH_a, default, p302)
re82:
 {1.0}FSH_bld = {1.0}sa31_degraded
  default * function_50(FSH_bld, default, p241)
re83:
 {1.0}s93 = {1.0}LH_bld
  default * function_51(Ago_R_a, GnRH_R_a, LH_Pit, default, facLH, p12, p16, p5, p8, p9)
re84:
 {1.0}s95 = {1.0}FSH_bld
  default * function_52(Ago_R_a, FSH_pit, GnRH_R_a, default, facFSH, p12, p17, p18, p20, p28)
re85:
 {1.0}FSH_bld + {1.0}R_FSH = {1.0}FSH_R
  default * function_53(FSH_bld, R_FSH, default, facFSH, p240)
re87:
 {1.0}InhA = {1.0}InhA_delay
  default * function_54(InhA, default, p156)
re90:
 {1.0}Ago_c = {1.0}s102
  default * function_55(Ago_c, default, p275)
re93:
 {1.0}Ago_R_a = {1.0}Ago_R_i
  default * function_56(Ago_R_a, default, p319)
re94:
 {1.0}Ago_R_i = {1.0}Ago_R_a
  default * function_57(Ago_R_i, default, p320)
re95:
 {1.0}Ago_R_i = {1.0}s106
  default * function_58(Ago_R_i, default, p314)
re97:
 {1.0}R_GnRH_a + {1.0}Ago_c = {1.0}Ago_R_a
  default * function_59(Ago_c, R_GnRH_a, default, p312)
re98:
 {1.0}Ago_R_a = {1.0}Ago_c + {1.0}R_GnRH_a
  default * function_60(Ago_R_a, default, p313)
re99:
 {1.0}Ago_R_i = {1.0}R_GnRH_i
  default * function_61(Ago_R_i, default, p315)


#parameters
facE2 = 1.0
facFSH = 1.0
facLH = 1.0
facP4 = 1.0
p1 = 7309.91587614104
p11 = 10.0
p12 = 5.0
p13 = 3.0
p152 = 2.09450510112762
p154 = 5.23500984428137
p155 = 5.12958654018257
p156 = 4.28718453552891
p157 = 172.453910864507
p158 = 51.558081260068
p159 = 9.28
p16 = 0.00476024700196886
p160 = 3480.27
p161 = 0.972
p164 = 1713.71039914086
p165 = 8675.13871487382
p166 = 0.9426346876678
p167 = 761.643100053696
p168 = 1.44522999821013
p169 = 2.28494719885448
p17 = 0.0569894397708967
p170 = 28.2110255951316
p171 = 216.85
p172 = 114.247359942724
p173 = 89.4934669769107
p174 = 447.467334884553
p175 = 134240.200465366
p177 = 60.0
p178 = 180.0
p18 = 0.0003
p2 = 7309.91587614104
p20 = 2.0
p201 = 1.0
p202 = 16.0
p203 = 1.2
p204 = 2.0
p205 = 220.0
p206 = 10.0
p208 = 220.0
p209 = 2.0
p21 = 22129.0495793807
p210 = 9.6
p211 = 1.0
p22 = 95.81
p23 = 70.0
p230 = 2.1430105602291
p231 = 74.8505459101486
p232 = 68.9493466976911
p234 = 183.363164488992
p24 = 5.0
p240 = 3.52890638983354
p241 = 114.247359942724
p242 = 61.0291748702345
p244 = 138.303203866118
p25 = 2.0
p26 = 1.20834079112225
p269 = 91.0
p27 = 7.98433864327904
p272 = 100.0
p273 = 38.12
p274 = 54.2
p275 = 2.65
p28 = 0.27201539287632
p3 = 192.2041
p30 = 0.1989
p300 = 0.447467334884553
p301 = 0.005593
p302 = 322.176481116879
p303 = 644.352962233757
p304 = 0.00894934669769107
p305 = 32.2176481116879
p306 = 3.22176481116878
p307 = 32.2176481116879
p308 = 0.0894934669769107
p309 = 32.2176481116879
p31 = 0.122060139609808
p310 = 3.222
p311 = 8.94934669769107e-05
p312 = 322.18
p313 = 644.35
p314 = 0.009
p315 = 32.22
p319 = 32.22
p32 = 122.060139609808
p320 = 3.22
p33 = 12.2060139609808
p34 = 332.754608913549
p35 = 122.060139609808
p36 = 12.2060139609808
p37 = 1.22060139609808
p38 = 0.958117057454806
p39 = 0.924735994272418
p4 = 2.3708
p40 = 0.756765706103455
p41 = 0.610291748702345
p42 = 0.542840522641847
p43 = 5.0
p44 = 2.0
p45 = 6.0
p46 = 3.68896
p469 = 34.0
p47 = 3.0
p472 = 500.0
p473 = 34.9
p474 = 45.56
p475 = 5.0
p476 = 3.216
p477 = 4.76
p48 = 0.608121
p49 = 3.66180418829425
p5 = 0.190415249686773
p50 = 1.22060139609808
p51 = 4.88231609092536
p512 = 322.18
p513 = 644.35
p514 = 0.009
p52 = 2.7262
p53 = 3.0
p54 = 10.0
p55 = 10.0
p56 = 0.02
p57 = 10.0
p6 = 10.0
p7 = 1.0
p8 = 0.0003
p80 = 20.0
p83 = 0.0008
p84 = 5.0
p9 = 5.0
p90 = 3.0
p91 = 5.0
p92 = 1.2348
p93 = 5.0
p94 = 0.2186056917845
p95 = 1.34267048505459
csa1_degraded = 1.0
s102 = 1.0
s106 = 1.0
s107 = 1.0
s108 = 1.0
s33 = 1.0
s38 = 1.0
s62 = 1.0
s64 = 1.0
s66 = 1.0
s67 = 1.0
s69 = 1.0
s71 = 1.0
s72 = 1.0
s74 = 1.0
s76 = 1.0
s78 = 1.0
s82 = 1.0
s85 = 1.0
s87 = 1.0
s92 = 1.0
s93 = 1.0
s94 = 1.0
s95 = 1.0
sa1_degraded = 1.0
sa28_degraded = 1.0
sa31_degraded = 1.0
sa35_degraded = 1.0
sa3_degraded = 1.0
sa52_degraded = 1.0
sa53_degraded = 1.0
sa61_degraded = 1.0
sa75_degraded = 1.0
sa78_degraded = 1.0
sa86_degraded = 1.0
default = 1.0


#initial values
AF1 = 2.26
AF2 = 19.92
AF3 = 0.504
AF4 = 1.604e-05
Ago_R_a = 0.0
Ago_R_i = 0.0
Ago_c = 0.0
Ago_d = 0.0
Ant_R = 0.0
Ant_c = 0.0
Ant_d = 0.0
Ant_p = 0.0
E2 = 45.0
FSH_R = 0.662
FSH_bld = 4.1
FSH_pit = 48627.2
GnRH = 0.00326
GnRH_R_a = 1.447e-05
GnRH_R_i = 1.294e-05
InhA = 1.07
InhA_delay = 86.84
InhB = 52.18
LH_Pit = 261119.0
LH_R = 0.263
LH_bld = 2.667
Lut1 = 2.762e-05
Lut2 = 0.0003772
Lut3 = 0.00334
Lut4 = 0.01385
OvF = 7.652e-19
P4 = 2.41
PrF = 0.244
R_FSH = 6.341
R_FSH_des = 1.497
R_Foll = 0.119
R_GnRH_a = 0.00928
R_GnRH_i = 0.0009409
R_LH = 8.41
R_LH_des = 0.699
Sc1 = 1.098e-08
Sc2 = 2.171e-06
s113 = 0.0
s114 = 0.0
s115 = 0.0
s116 = 0.0


#assignment rules
!F mass = p301 * (pow(E2 * p201 * default / p7 / (p208 * facE2), p209) / (1.0 + pow(E2 * p201 * default / p7 / (p208 * facE2), p209)) + 1.0 / (1.0 + pow(E2 * p201 * default / p7 / (p210 * facE2), p211)))
!F freq = p202 / (1.0 + pow(P4 * p201 * default / p7 / (p203 * facP4), p204)) * (1.0 + p201 * pow(E2 * p201 * default / p7 / (p205 * facE2), p206) / (1.0 + pow(E2 * p201 * default / p7 / (p205 * facE2), p206)))