begin name
queralt1
end name

begin reactions
securinseparasesecurindegradation {1.0}securinseparase = {1.0}$EXTERNAL
securinseparaseseparasedegradation {1.0}securinseparase = {1.0}$EXTERNAL
v1 {1.0}$AA = {1.0}Clb2
v10 {1.0}separaseT = {1.0}$degr
v11 {1.0}$EXTERNAL = {1.0}securinseparase
v13 {1.0}$EXTERNAL = {1.0}Net1
v14 {1.0}Net1 = {1.0}$EXTERNAL
v15 {1.0}Net1 = {1.0}Net1Cdc14
v16 {1.0}Net1Cdc14 = {1.0}Net1
v17 {1.0}Net1Cdc14 = {1.0}$EXTERNAL
v18 {1.0}$AA = {1.0}PoloT
v19 {1.0}PoloT = {1.0}$degr
v2 {1.0}Clb2 = {1.0}$degr
v20 {1.0}$EXTERNAL = {1.0}Polo
v21 {1.0}Polo = {1.0}$EXTERNAL
v22 {1.0}Polo = {1.0}$degr
v23 {1.0}$EXTERNAL = {1.0}Tem1
v24 {1.0}Tem1 = {1.0}$EXTERNAL
v25 {1.0}$EXTERNAL = {1.0}Cdc15
v26 {1.0}Cdc15 = {1.0}$EXTERNAL
v27 {1.0}$AA = {1.0}MEN
v28 {1.0}MEN = {1.0}$degr
v29 {1.0}MEN = {1.0}$EXTERNAL
v3 {1.0}$AA = {1.0}Cdc20
v30 {1.0}MEN = {1.0}$EXTERNAL
v4 {1.0}Cdc20 = {1.0}$degr
v5 {1.0}$EXTERNAL = {1.0}Cdh1
v6 {1.0}Cdh1 = {1.0}$EXTERNAL
v7 {1.0}$AA = {1.0}securinT
v8 {1.0}securinT = {1.0}$degr
v9 {1.0}$AA = {1.0}separaseT
end reactions

begin rate equations
securinseparasesecurindegradation = (kdsecurin + kadsecurin*Cdc20[t])*securinseparase[t]
securinseparaseseparasedegradation = kdseparase*securinseparase[t]
v1 = ksclb2
v10 = kdseparase*separaseT[t]
v11 = lasecurin*securin*separase - ldsecurin*securinseparase[t]
v13 = (Net1P*(Cdc14*kad + kd*PP2A))/(Jnet + Net1P)
v14 = ((Cdk*kp + kap*MEN[t])*Net1[t])/(Jnet + Net1[t] + Net1Cdc14[t])
v15 = Cdc14*lanet*Net1[t]
v16 = ldnet*Net1Cdc14[t]
v17 = ((Cdk*kp + kap*MEN[t])*Net1Cdc14[t])/(Jnet + Net1[t] + Net1Cdc14[t])
v18 = kspolo
v19 = (kdpolo + kadpolo*Cdh1[t])*PoloT[t]
v2 = (kdclb2 + kadclb2*Cdc20[t] + kaadclb2*Cdh1[t])*Clb2[t]
v20 = ((Cdk*kaapolo + kapolo)*(-Polo[t] + PoloT[t]))/(Jpolo - Polo[t] + PoloT[t])
v21 = (kipolo*Polo[t])/(Jpolo + Polo[t])
v22 = (kdpolo + kadpolo*Cdh1[t])*Polo[t]
v23 = ((katem + kaatem*Polo[t])*(Tem1T - Tem1[t]))/(Jtem1 + Tem1T - Tem1[t])
v24 = ((kitem + kaitem*PP2A)*Tem1[t])/(Jtem1 + Tem1[t])
v25 = ((Cdc14*kaacdc15 + kacdc15)*(Cdc15T - Cdc15[t]))/(Cdc15T + Jcdc15 - Cdc15[t])
v26 = ((Cdk*kaicdc15 + kicdc15)*Cdc15[t])/(Jcdc15 + Cdc15[t])
v27 = lamen*(Cdc15[t] - MEN[t])*(-MEN[t] + Tem1[t])
v28 = ldmen*MEN[t]
v29 = ((kitem + kaitem*PP2A)*MEN[t])/(Jtem1 + Tem1[t])
v3 = kscdc20
v30 = ((Cdk*kaicdc15 + kicdc15)*MEN[t])/(Jcdc15 + Cdc15[t])
v4 = Cdc20[t]*(kdcdc20 + kadcdc20*Cdh1[t])
v5 = ((Cdc14*kadcdh + kdcdh)*(Cdh1T - Cdh1[t]))/(Cdh1T + Jcdh - Cdh1[t])
v6 = (Cdk*kapcdh*Cdh1[t])/(Jcdh + Cdh1[t])
v7 = kssecurin
v8 = (kdsecurin + kadsecurin*Cdc20[t])*securinT[t]
v9 = ksseparase
end rate equations

begin parameters
Cdc14T = 0.5
Cdc15T = 1.0
Cdh1T = 1.0
Inh = 0.0
Jcdc15 = 0.2
Jcdh = 0.0015
Jnet = 0.2
Jpolo = 0.25
Jtem1 = 0.005
Net1T = 1.0
PP2AT = 1.0
Tem1T = 1.0
kaacdc15 = 0.5
kaadclb2 = 2.0
kaapolo = 0.5
kaatem = 0.5
kacdc15 = 0.02
kad = 0.1
kadcdc20 = 2.0
kadcdh = 1.0
kadclb2 = 0.2
kadpolo = 0.25
kadsecurin = 2.0
kaicdc15 = 0.2
kaitem = 1.0
kap = 2.0
kapcdh = 1.0
kapolo = 0.0
katem = 0.0
kd = 0.45
kdcdc20 = 0.05
kdcdh = 0.01
kdclb2 = 0.03
kdpolo = 0.01
kdsecurin = 0.05
kdseparase = 0.004
ki = 20.0
kicdc15 = 0.0
kipolo = 0.1
kitem = 0.1
kp = 0.4
kpp = 0.1
kscdc20 = 0.015
ksclb2 = 0.03
kspolo = 0.01
kssecurin = 0.03
ksseparase = 0.001
lamen = 10.0
lanet = 500.0
lasecurin = 500.0
ldmen = 0.1
ldnet = 1.0
ldsecurin = 1.0
AA = 1.0
degr = 1.0
compartment = 1.0
end parameters

begin initial conditions
Cdc15[0] = Cdc15i
Cdc20[0] = Cdc20i
Cdh1[0] = Cdh1i
Clb2[0] = Clb2i
MEN[0] = MENi
Net1[0] = Net1i
Net1Cdc14[0] = Net1Cdc14i
Polo[0] = Poloi
PoloT[0] = PoloTi
Tem1[0] = Tem1i
securinT[0] = securinTi
securinseparase[0] = securinseparasei
separaseT[0] = separaseTi
end initial conditions

begin initial values
Cdc15i = 0.0257
Cdc20i = 0.0
Cdh1i = 3.8e-05
Clb2i = 0.997
MENi = 8e-06
Net1i = 0.098
Net1Cdc14i = 0.485
Poloi = 0.945
PoloTi = 0.99
Tem1i = 0.00389
securinTi = 0.6
securinseparasei = 0.248
separaseTi = 0.25
end initial values

begin assignment rules
PP2A := (PP2AT*(1 + ki*kpp*separase))/(1 + ki*separase)
Cdc15i := Cdc15T - Cdc15[t]
Cdc14 := Cdc14T - Net1Cdc14[t]
Net1P := Net1T - Net1[t] - Net1Cdc14[t]
Cdk := Clb2[t]/(1 + Inh)
Poloi := -Polo[t] + PoloT[t]
securin := -securinseparase[t] + securinT[t]
Tem1i := Tem1T - Tem1[t]
Cdh1i := Cdh1T - Cdh1[t]
separase := -securinseparase[t] + separaseT[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units