begin name perelson2 end name begin reactions CD4TproductionV {1.0}$EXTERNAL = {1.0}V VinfectionCD4T {1.0}V + {1.0}T = {1.0}Tstar activationCD4T {1.0}Tstar = {1.0}Tstarstar clearanceV {1.0}V = {1.0}$EXTERNAL deathCD4TactiveInfected {1.0}Ttot + {1.0}Tstarstar = {1.0}$EXTERNAL deathCD4Tplain {1.0}T + {1.0}Ttot = {1.0}$EXTERNAL deathCD4TrestingInfected {1.0}Ttot + {1.0}Tstar = {1.0}$EXTERNAL growthCD4T {1.0}$EXTERNAL = {1.0}T + {1.0}Ttot sourceCD4T {1.0}$EXTERNAL = {1.0}T + {1.0}Ttot end reactions begin rate equations CD4TproductionV = muB*N0*Tstarstar[t] VinfectionCD4T = k1*T[t]*V[t] activationCD4T = k2*Tstar[t] clearanceV = muV*V[t] deathCD4TactiveInfected = muB*Tstarstar[t] deathCD4Tplain = muT*T[t] deathCD4TrestingInfected = muT*Tstar[t] growthCD4T = r*T[t]*(1 - Ttot[t]/Tmax) sourceCD4T = s end rate equations begin parameters N0 = 1000.0 Tmax = 1500.0 k1 = "2.4e-05" k2 = 0.003 muB = 0.24 muT = 0.02 muV = 2.4 r = 0.03 s = 10.0 theta = 1.0 default = 1.0 end parameters begin initial conditions T[0] = Ti Tstar[0] = Tstari Tstarstar[0] = Tstarstari Ttot[0] = Ttoti V[0] = Vi end initial conditions begin initial values Ti = 1000.0 Tstari = 0.0 Tstarstari = 0.0 Ttoti = 1000.0 Vi = 0.001 end initial values begin assignment rules end assignment rules begin function definitions end function definitions begin events end events begin process annotations end process annotations begin species annotations end species annotations begin units end units