#passos1

FIX: Sink Source

#reactions
ATMInactivation:
 {1.0}ATMA = {1.0}ATMI
  kinactATM * ATMA
ATMactivation:
 {1.0}damDNA + {1.0}ATMI = {1.0}damDNA + {1.0}ATMA
  kactATM * damDNA * ATMI
DNAdamage:
 {1.0}IR = {1.0}IR + {1.0}damDNA
  kdam * IR
DNArepair:
 {1.0}damDNA = {1.0}Sink
  krepair * damDNA
GADD45activation2:
 {1.0}p21 = {1.0}p21 + {1.0}GADD45
  kGADD45 * p21
GADD45degradation:
 {1.0}GADD45 = {1.0}Sink
  kdegGADD45 * GADD45
Mdm2Degradation:
 {1.0}Mdm2 = {1.0}Sink
  kdegMdm2 * Mdm2
Mdm2Pdegradation:
 {1.0}Mdm2_P = {1.0}Sink
  kdegATMMdm2 * Mdm2_P
Mdm2Synthesis:
 {1.0}Mdm2_mRNA = {1.0}Mdm2_mRNA + {1.0}Mdm2
  ksynMdm2 * Mdm2_mRNA
Mdm2dephosorylation:
 {1.0}Mdm2_P = {1.0}Mdm2
  kdephosMdm2 * Mdm2_P
Mdm2mRNADegradation:
 {1.0}Mdm2_mRNA = {1.0}Sink
  kdegMdm2mRNA * Mdm2_mRNA
Mdm2mRNASynthesis1:
 {1.0}p53 = {1.0}p53 + {1.0}Mdm2_mRNA
  ksynMdm2mRNA * p53
Mdm2mRNASynthesis2:
 {1.0}p53_P = {1.0}p53_P + {1.0}Mdm2_mRNA
  ksynMdm2mRNA * p53_P
Mdm2phoshorylation:
 {1.0}Mdm2 + {1.0}ATMA = {1.0}Mdm2_P + {1.0}ATMA
  kphosMdm2 * Mdm2 * ATMA
P53_Mdm2Binding:
 {1.0}p53 + {1.0}Mdm2 = {1.0}Mdm2_p53
  kbinMdm2p53 * p53 * Mdm2
P53_Mdm2Release:
 {1.0}Mdm2_p53 = {1.0}p53 + {1.0}Mdm2
  krelMdm2p53 * Mdm2_p53
ROSDNAdamage:
 {1.0}ROS = {1.0}ROS + {1.0}damDNA
  kdamROS * ROS
ROSgenerationP38:
 {1.0}p38_P = {1.0}p38_P + {1.0}ROS
  kgenROSp38 * p38_P * kp38ROS
ROSremoval:
 {1.0}ROS = {1.0}Sink
  kremROS * ROS
basalROSDNAdamage:
 {1.0}basalROS = {1.0}basalROS + {1.0}damDNA
  kdamBasalROS * basalROS
p21Synthesis1:
 {1.0}p21_mRNA = {1.0}p21_mRNA + {1.0}p21step1
  ksynp21step1 * p21_mRNA
p21Synthesis2:
 {1.0}p21step1 = {1.0}p21step2
  ksynp21step2 * p21step1
p21Synthesis3:
 {1.0}p21step2 = {1.0}p21
  ksynp21step3 * p21step2
p21degradation:
 {1.0}p21 = {1.0}Sink
  kdegp21 * p21
p21mRNADegradation:
 {1.0}p21_mRNA = {1.0}Sink
  kdegp21mRNA * p21_mRNA
p21mRNASynthesis1:
 {1.0}p53 = {1.0}p53 + {1.0}p21_mRNA
  ksynp21mRNAp53 * p53
p21mRNASynthesis2:
 {1.0}p53_P = {1.0}p53_P + {1.0}p21_mRNA
  ksynp21mRNAp53P * p53_P
p38activation:
 {1.0}p38 + {1.0}GADD45 = {1.0}p38_P + {1.0}GADD45
  kphosp38 * p38 * GADD45
p38inactivation:
 {1.0}p38_P = {1.0}p38
  kdephosp38 * p38_P
p53Degradation:
 {1.0}Mdm2_p53 = {1.0}Mdm2
  kdegp53 * Mdm2_p53
p53Mdm2IndepDegradation1:
 {1.0}p53_P = {1.0}Sink
  kdegp53mdm2ind * p53_P
p53Mdm2IndepDegradation2:
 {1.0}p53 = {1.0}Sink
  kdegp53mdm2ind * p53
p53Synthesis:
 {1.0}p53_mRNA = {1.0}p53 + {1.0}p53_mRNA
  ksynp53 * p53_mRNA
p53dephosorylation:
 {1.0}p53_P = {1.0}p53
  kdephosp53 * p53_P
p53mRNADegradation:
 {1.0}p53_mRNA = {1.0}Sink
  kdegp53mRNA * p53_mRNA
p53mRNASynthesis:
 {1.0}Source = {1.0}p53_mRNA
  ksynp53mRNA * Source
p53phoshorylation:
 {1.0}p53 + {1.0}ATMA = {1.0}p53_P + {1.0}ATMA
  kphosp53 * p53 * ATMA


#parameters
kGADD45 = 4e-06
kactATM = 2e-05
kbinMdm2p53 = 0.001155
kdam = 0.007
kdamBasalROS = 1e-09
kdamROS = 1e-05
kdegATMMdm2 = 0.0004
kdegGADD45 = 1e-05
kdegMdm2 = 0.000433
kdegMdm2mRNA = 0.0001
kdegp21 = 0.00019
kdegp21mRNA = 2.4e-05
kdegp53 = 0.000825
kdegp53mRNA = 0.0001
kdegp53mdm2ind = 8.25e-07
kdephosMdm2 = 0.5
kdephosp38 = 0.1
kdephosp53 = 0.5
kgenROSp38 = 0.00045
kinactATM = 0.0005
kp38ROS = 1.0
kphosMdm2 = 2.0
kphosp38 = 0.008
kphosp53 = 0.006
krelMdm2p53 = 1.155e-06
kremROS = 0.000383
krepair = 6e-05
ksynMdm2 = 0.000495
ksynMdm2mRNA = 0.0001
ksynp21mRNAp53 = 6e-08
ksynp21mRNAp53P = 6e-06
ksynp21step1 = 0.0004
ksynp21step2 = 4e-05
ksynp21step3 = 4e-05
ksynp53 = 0.006
ksynp53mRNA = 0.001
Sink = 1.0
Source = 1.0
cell = 1.0


#initial values
ATMA = 0.0
ATMI = 200.0
GADD45 = 0.0
IR = 0.0
Mdm2 = 5.0
Mdm2_P = 0.0
Mdm2_mRNA = 10.0
Mdm2_p53 = 95.0
ROS = 0.0
basalROS = 10.0
damDNA = 0.0
p21 = 0.0
p21_basal = 7.0
p21_mRNA = 1.0
p21step1 = 0.0
p21step2 = 0.0
p38 = 100.0
p38_P = 0.0
p53 = 5.0
p53_P = 0.0
p53_mRNA = 10.0


#assignment rules