begin name
palini1
end name

begin reactions
Adegradation {1.0}A = {1.0}$EXTERNAL
CIbinding {1.0}C + {1.0}I = {1.0}X
Cdegradation {1.0}C = {1.0}$EXTERNAL
Iactivation {1.0}X = {1.0}C + {1.0}A
Idegradation {1.0}I = {1.0}$EXTERNAL
Iexpression {1.0}$EXTERNAL = {1.0}I
RLbinding {1.0}R + {1.0}$L = {1.0}C
Rdegradation {1.0}R = {1.0}$EXTERNAL
Rexpression {1.0}$EXTERNAL = {1.0}R
Xdegradation {1.0}X = {1.0}$EXTERNAL
end reactions

begin rate equations
Adegradation = cell*kdegA*A[t]
CIbinding = cell*(k1*C[t]*I[t] - k2*X[t])
Cdegradation = cell*kdegC*C[t]
Iactivation = cell*k3*X[t]
Idegradation = cell*kdegI*I[t]
Iexpression = cell*(BI + (TFs*A[t])/(KD + A[t]))
RLbinding = cell*(-(koff*C[t]) + kon*L*R[t])
Rdegradation = cell*kdegR*R[t]
Rexpression = cell*(BR + (Rs*A[t])/(KD + A[t]))
Xdegradation = cell*kdegX*X[t]
end rate equations

begin parameters
BI = 0.005
BR = 0.005
KD = 200.0
Rs = 3.0
TFs = 3.0
k1 = 1.0
k2 = 5.0
k3 = 45.0
kdegA = 0.005
kdegC = 0.01
kdegI = 0.005
kdegR = 0.005
kdegX = 0.005
koff = 0.05
kon = 0.001
L = 0.1
cell = 1.0
end parameters

begin initial conditions
A[0] = Ai
C[0] = Ci
I[0] = Ii
R[0] = Ri
X[0] = Xi
end initial conditions

begin initial values
Ai = 0.0
Ci = 0.0
Ii = 1.0
Ri = 1.0
Xi = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units