#ouzounoglou1

FIX: s3

#reactions
re1:
 {1.0}s3 = {1.0}s17
  c1 * k1 * s3
re10:
 {1.0}s20 + {1.0}s17 = {1.0}s24
  c1 * k_OligomerForm * s20 * s17
re100:
 {1.0}s17 + {1.0}s499 = {1.0}s500
  k_OligomerForm * s17 * s499
re101:
 {1.0}s17 + {1.0}s500 = {1.0}s501
  k_OligomerForm * s17 * s500
re102:
 {1.0}s381 = {1.0}s35
  c1 * k_ProtOligDegr * s381
re103:
 {1.0}s383 = {1.0}s35
  c1 * k_ProtOligDegr * s383
re104:
 {1.0}s385 = {1.0}s35
  c1 * k_ProtOligDegr * s385
re105:
 {1.0}s387 = {1.0}s35
  c1 * k_ProtOligDegr * s387
re106:
 {1.0}s389 = {1.0}s35
  c1 * k_ProtOligDegr * s389
re107:
 {1.0}s391 = {1.0}s35
  c1 * k_ProtOligDegr * s391
re108:
 {1.0}s393 = {1.0}s35
  c1 * k_ProtOligDegr * s393
re109:
 {1.0}s473 = {1.0}s35
  c1 * k_ProtOligDegr * s473
re11:
 {1.0}s20 + {1.0}s35 = {1.0}s381
  c1 * k_ProteasomeBind * s20 * s35
re110:
 {1.0}s474 = {1.0}s35
  c1 * k_ProtOligDegr * s474
re111:
 {1.0}s475 = {1.0}s35
  c1 * k_ProtOligDegr * s475
re112:
 {1.0}s476 = {1.0}s35
  c1 * k_ProtOligDegr * s476
re113:
 {1.0}s477 = {1.0}s35
  c1 * k_ProtOligDegr * s477
re114:
 {1.0}s478 = {1.0}s35
  c1 * k_ProtOligDegr * s478
re115:
 {1.0}s479 = {1.0}s35
  c1 * k_ProtOligDegr * s479
re116:
 {1.0}s33 + {1.0}s35 = {1.0}s502
  c1 * k_ProteasomeBind * s33 * s35
re117:
 {1.0}s27 = {1.0}s26 + {1.0}s7
  c1 * k_DisRate * s27
re118:
 {1.0}s26 = {1.0}s25 + {1.0}s7
  c1 * k_DisRate * s26
re119:
 {1.0}s25 = {1.0}s21 + {1.0}s7
  c1 * k_DisRate * s25
re12:
 {1.0}s24 = {1.0}s517
  k_OligAutophagUptake * s24
re120:
 {1.0}s21 = {1.0}s1 + {1.0}s7
  c1 * k_DisRate * s21
re121:
 {1.0}s2 = {1.0}s5 + {1.0}s7
  c1 * k_DisRate * s2
re122:
 {1.0}s1 = {1.0}s2 + {1.0}s7
  c1 * k_DisRate * s1
re123:
 {1.0}s5 = {1.0}s6 + {1.0}s7
  c1 * k_DisRate * s5
re124:
 {1.0}s6 = {2.0}s7
  c1 * k_DisRate * s6
re125:
 {1.0}s29 = {1.0}s17 + {1.0}s30
  c1 * k_DisRate * s29
re126:
 {1.0}s30 = {1.0}s31 + {1.0}s17
  c1 * k_DisRate * s30
re127:
 {1.0}s31 = {1.0}s32 + {1.0}s17
  c1 * k_DisRate * s31
re128:
 {1.0}s32 = {1.0}s17 + {1.0}s23
  c1 * k_DisRate * s32
re129:
 {1.0}s23 = {1.0}s24 + {1.0}s17
  c1 * k_DisRate * s23
re13:
 {1.0}s24 + {1.0}s17 = {1.0}s23
  c1 * k_OligomerForm * s24 * s17
re130:
 {1.0}s24 = {1.0}s20 + {1.0}s17
  c1 * k_DisRate * s24
re131:
 {1.0}s20 = {1.0}s18 + {1.0}s17
  c1 * k_DisRate * s20
re132:
 {1.0}s18 = {2.0}s17
  c1 * k_DisRate * s18
re133:
 {1.0}s33 + {1.0}s17 = {1.0}s33
  c1 * k1 * s33 * s17
re134:
 {1.0}s17 = {1.0}s533
  k_OligAutophagUptake * s17
re135:
 {1.0}s533 = {1.0}s107
  c2 * k_M_autophagyDegr * s533
re136:
 {1.0}s7 = {1.0}s535
  k_OligAutophagUptake * s7
re137:
 {1.0}s535 = {1.0}s445
  c2 * k_M_autophagyDegr * s535
re14:
 {1.0}s24 + {1.0}s35 = {1.0}s383
  c1 * k_ProteasomeBind * s24 * s35
re15:
 {1.0}s23 = {1.0}s518
  k_OligAutophagUptake * s23
re16:
 {1.0}s23 + {1.0}s17 = {1.0}s32
  c1 * k_OligomerForm * s23 * s17
re17:
 {1.0}s23 + {1.0}s35 = {1.0}s385
  c1 * k_ProteasomeBind * s23 * s35
re18:
 {1.0}s23 + {1.0}s51 = {1.0}s496
  k_WTOligBindOnLamp * s23 * s51
re19:
 {1.0}s32 = {1.0}s519
  k_OligAutophagUptake * s32
re2:
 {1.0}s3 = {1.0}s22
  c1 * k1 * s3
re20:
 {1.0}s32 + {1.0}s17 = {1.0}s31
  c1 * k_OligomerForm * s32 * s17
re21:
 {1.0}s32 + {1.0}s35 = {1.0}s387
  c1 * k_ProteasomeBind * s32 * s35
re22:
 {1.0}s31 = {1.0}s522
  k_OligAutophagUptake * s31
re23:
 {1.0}s31 + {1.0}s17 = {1.0}s30
  c1 * k_OligomerForm * s31 * s17
re24:
 {1.0}s31 + {1.0}s35 = {1.0}s389
  c1 * k_ProteasomeBind * s31 * s35
re25:
 {1.0}s31 + {1.0}s51 = {1.0}s499
  k_WTOligBindOnLamp * s31 * s51
re26:
 {1.0}s30 = {1.0}s523
  k_OligAutophagUptake * s30
re27:
 {1.0}s30 + {1.0}s17 = {1.0}s29
  c1 * k_OligomerForm * s30 * s17
re28:
 {1.0}s30 + {1.0}s35 = {1.0}s391
  c1 * k_ProteasomeBind * s30 * s35
re29:
 {1.0}s29 + {1.0}s35 = {1.0}s393
  c1 * k_ProteasomeBind * s29 * s35
re3:
 {2.0}s17 = {1.0}s18
  c1 * k_2merForm * pow(s17, 2)
re30:
 {1.0}s29 + {1.0}s51 = {1.0}s501
  k_WTOligBindOnLamp * s29 * s51
re31:
 {1.0}s22 = {1.0}s200
  c1 * k1 * s22
re32:
 {2.0}s7 = {1.0}s6
  c1 * k_2merForm * pow(s7, 2)
re33:
 {1.0}s7 + {1.0}s536 = {1.0}s482
  k_2merForm * s7 * s536
re34:
 {1.0}s7 + {1.0}s490 = {1.0}s489
  k_OligomerForm * s7 * s490
re35:
 {1.0}s7 + {1.0}s489 = {1.0}s492
  k_OligomerForm * s7 * s489
re36:
 {1.0}s7 + {1.0}s492 = {1.0}s493
  k_OligomerForm * s7 * s492
re37:
 {1.0}s78 = {1.0}s51 + {1.0}s52
  c3 * k1 * s78
re38:
 {1.0}s85 = {1.0}s51 + {1.0}s53
  c3 * k1 * s85
re4:
 {1.0}s17 + {1.0}s22 = {1.0}s7
  c1 * k1 * s17 * s22
re40:
 {1.0}s517 = {1.0}s109
  c2 * k_M_autophagyDegr * s517
re41:
 {1.0}s523 = {1.0}s113
  c2 * k_M_autophagyDegr * s523
re42:
 {1.0}s520 = {1.0}s108
  c2 * k_M_autophagyDegr * s520
re43:
 {1.0}s521 = {1.0}s107
  c2 * k_M_autophagyDegr * s521
re44:
 {1.0}s522 = {1.0}s112
  c2 * k_M_autophagyDegr * s522
re45:
 {1.0}s518 = {1.0}s110
  c2 * k_M_autophagyDegr * s518
re46:
 {1.0}s519 = {1.0}s111
  c2 * k_M_autophagyDegr * s519
re47:
 {1.0}s29 + {1.0}s17 = {1.0}s33
  c1 * k_OligomerForm * s29 * s17
re48:
 {1.0}s6 = {1.0}s527
  k_OligAutophagUptake * s6
re49:
 {1.0}s6 + {1.0}s7 = {1.0}s5
  c1 * k_OligomerForm * s6 * s7
re5:
 {1.0}s17 + {1.0}s51 = {1.0}s78
  k_WTasyn1_2merBindOnLamp * s17 * s51
re50:
 {1.0}s5 = {1.0}s531
  k_OligAutophagUptake * s5
re51:
 {1.0}s5 + {1.0}s7 = {1.0}s2
  c1 * k_OligomerForm * s5 * s7
re52:
 {1.0}s5 + {1.0}s35 = {1.0}s473
  c1 * k_ProteasomeBind * s5 * s35
re53:
 {1.0}s2 = {1.0}s530
  k_OligAutophagUptake * s2
re54:
 {1.0}s2 + {1.0}s7 = {1.0}s1
  c1 * k_OligomerForm * s2 * s7
re55:
 {1.0}s2 + {1.0}s35 = {1.0}s474
  c1 * k_ProteasomeBind * s2 * s35
re56:
 {1.0}s1 = {1.0}s529
  k_OligAutophagUptake * s1
re57:
 {1.0}s1 + {1.0}s7 = {1.0}s21
  c1 * k_OligomerForm * s1 * s7
re58:
 {1.0}s1 + {1.0}s35 = {1.0}s475
  c1 * k_ProteasomeBind * s1 * s35
re59:
 {1.0}s21 = {1.0}s528
  k_OligAutophagUptake * s21
re6:
 {1.0}s18 = {1.0}s521
  k_OligAutophagUptake * s18
re60:
 {1.0}s21 + {1.0}s7 = {1.0}s25
  c1 * k_OligomerForm * s21 * s7
re61:
 {1.0}s21 + {1.0}s35 = {1.0}s476
  c1 * k_ProteasomeBind * s21 * s35
re62:
 {1.0}s25 = {1.0}s526
  k_OligAutophagUptake * s25
re63:
 {1.0}s25 + {1.0}s7 = {1.0}s26
  c1 * k_OligomerForm * s25 * s7
re64:
 {1.0}s25 + {1.0}s35 = {1.0}s477
  c1 * k_ProteasomeBind * s25 * s35
re65:
 {1.0}s26 = {1.0}s525
  k_OligAutophagUptake * s26
re66:
 {1.0}s26 + {1.0}s7 = {1.0}s27
  c1 * k_OligomerForm * s26 * s7
re67:
 {1.0}s26 + {1.0}s35 = {1.0}s478
  c1 * k_ProteasomeBind * s26 * s35
re68:
 {1.0}s27 + {1.0}s35 = {1.0}s479
  c1 * k_ProteasomeBind * s27 * s35
re69:
 {1.0}s53 = {1.0}s211
  c3 * k1 * s53
re7:
 {1.0}s18 + {1.0}s17 = {1.0}s20
  c1 * k_OligomerForm * s18 * s17
re70:
 {1.0}s52 = {1.0}s213
  c3 * k1 * s52
re71:
 {1.0}s501 = {1.0}s29 + {1.0}s51
  k_LampFreeWTasyn * s501
re72:
 {1.0}s482 + {1.0}s7 = {1.0}s483
  k_OligomerForm * s482 * s7
re73:
 {1.0}s483 + {1.0}s7 = {1.0}s484
  k_OligomerForm * s483 * s7
re74:
 {1.0}s484 + {1.0}s7 = {1.0}s491
  k_OligomerForm * s484 * s7
re75:
 {1.0}s491 + {1.0}s7 = {1.0}s490
  k_OligomerForm * s491 * s7
re76:
 {1.0}s494 = {1.0}s20 + {1.0}s51
  k_LampFreeWTasyn * s494
re77:
 {1.0}s495 = {1.0}s24 + {1.0}s51
  k_LampFreeWTasyn * s495
re78:
 {1.0}s496 = {1.0}s23 + {1.0}s51
  k_LampFreeWTasyn * s496
re79:
 {1.0}s498 = {1.0}s32 + {1.0}s51
  k_LampFreeWTasyn * s498
re8:
 {1.0}s18 + {1.0}s51 = {1.0}s85
  k_WTasyn1_2merBindOnLamp * s18 * s51
re80:
 {1.0}s499 = {1.0}s31 + {1.0}s51
  k_LampFreeWTasyn * s499
re81:
 {1.0}s500 = {1.0}s30 + {1.0}s51
  k_LampFreeWTasyn * s500
re82:
 {1.0}s500 + {1.0}s30 = {1.0}s51
  k_WTOligBindOnLamp * s500 * s30
re83:
 {1.0}s51 + {1.0}s20 = {1.0}s494
  k_WTOligBindOnLamp * s51 * s20
re84:
 {1.0}s51 + {1.0}s24 = {1.0}s495
  k_WTOligBindOnLamp * s51 * s24
re85:
 {1.0}s51 + {1.0}s32 = {1.0}s498
  k_WTOligBindOnLamp * s51 * s32
re86:
 {1.0}s51 + {1.0}s7 = {1.0}s536
  k_DopModWTasynLampBind * s51 * s7
re87:
 {1.0}s530 = {1.0}s447
  c2 * k_M_autophagyDegr * s530
re88:
 {1.0}s531 = {1.0}s446
  c2 * k_M_autophagyDegr * s531
re89:
 {1.0}s527 = {1.0}s445
  c2 * k_M_autophagyDegr * s527
re9:
 {1.0}s20 = {1.0}s520
  k_OligAutophagUptake * s20
re90:
 {1.0}s529 = {1.0}s448
  c2 * k_M_autophagyDegr * s529
re91:
 {1.0}s528 = {1.0}s524
  c2 * k_M_autophagyDegr * s528
re92:
 {1.0}s526 = {1.0}s524
  c2 * k_M_autophagyDegr * s526
re93:
 {1.0}s525 = {1.0}s451
  c2 * k_M_autophagyDegr * s525
re94:
 {1.0}s17 + {1.0}s78 = {1.0}s85
  k_2merForm * s17 * s78
re95:
 {1.0}s17 + {1.0}s85 = {1.0}s494
  k_OligomerForm * s17 * s85
re96:
 {1.0}s17 + {1.0}s494 = {1.0}s495
  k_OligomerForm * s17 * s494
re97:
 {1.0}s17 + {1.0}s495 = {1.0}s496
  k_OligomerForm * s17 * s495
re98:
 {1.0}s496 + {1.0}s17 = {1.0}s498
  k_OligomerForm * s496 * s17
re99:
 {1.0}s498 + {1.0}s17 = {1.0}s499
  k_OligomerForm * s498 * s17


#parameters
k_2merForm = 1.462941015e-09
k_DisRate = 4.999533748e-07
k_DopModWTasynLampBind = 7.6715997e-09
k_LampFreeWTasyn = 0.0003044571674
k_M_autophagyDegr = 0.1
k_OligAutophagUptake = 2.39034347e-08
k_OligomerForm = 3.350497192e-08
k_ProtOligDegr = 0.000370096
k_ProteasomeBind = 3.424693672e-09
k_WTOligBindOnLamp = 4e-06
k_WTasyn1_2merBindOnLamp = 6.865455081e-07
s3 = 1.0
re37_k1 = 0.00999558
re38_k1 = 0.00995312
re69_k1 = 0.1
re70_k1 = 0.1
re133_k1 = 4.90556e-07
re1_k1 = 0.0294219
re2_k1 = 0.0791823
re4_k1 = 6.74768e-07
re31_k1 = 0.00679501
c1 = 1.0
c2 = 1.0
c3 = 1.0


#initial values
s1 = 8.0
s107 = 0.0
s108 = 0.0
s109 = 0.0
s110 = 0.0
s111 = 0.0
s112 = 0.0
s113 = 0.0
s17 = 1650.0
s18 = 22.0
s2 = 8.0
s20 = 8.0
s200 = 0.0
s21 = 8.0
s211 = 0.0
s213 = 0.0
s22 = 750.0
s23 = 8.0
s24 = 8.0
s25 = 8.0
s26 = 8.0
s27 = 8.0
s29 = 8.0
s30 = 8.0
s31 = 8.0
s32 = 8.0
s33 = 0.0
s35 = 1500.0
s381 = 0.0
s383 = 0.0
s385 = 0.0
s387 = 0.0
s389 = 0.0
s391 = 0.0
s393 = 0.0
s445 = 0.0
s446 = 0.0
s447 = 0.0
s448 = 0.0
s451 = 0.0
s473 = 0.0
s474 = 0.0
s475 = 0.0
s476 = 0.0
s477 = 0.0
s478 = 0.0
s479 = 0.0
s482 = 0.0
s483 = 0.0
s484 = 0.0
s489 = 0.0
s490 = 0.0
s491 = 0.0
s492 = 0.0
s493 = 0.0
s494 = 0.0
s495 = 0.0
s496 = 0.0
s498 = 0.0
s499 = 0.0
s5 = 8.0
s500 = 0.0
s501 = 0.0
s502 = 0.0
s51 = 200.0
s517 = 0.0
s518 = 0.0
s519 = 0.0
s52 = 0.0
s520 = 0.0
s521 = 0.0
s522 = 0.0
s523 = 0.0
s524 = 0.0
s525 = 0.0
s526 = 0.0
s527 = 0.0
s528 = 0.0
s529 = 0.0
s53 = 0.0
s530 = 0.0
s531 = 0.0
s533 = 0.0
s535 = 0.0
s536 = 0.0
s6 = 0.0
s7 = 953.0
s78 = 0.0
s85 = 0.0


#assignment rules
!F Total_Cytosolic_WTASYN_Oligomers = s5 * c1 + s2 * c1 + s1 * c1 + s21 * c1 + s25 * c1 + s26 * c1 + s27 * c1 + s20 * c1 + s24 * c1 + s23 * c1 + s32 * c1 + s31 * c1 + s30 * c1 + s29 * c1
!F Total_Cytosolic_WTASYN_Monomer = s17 * c1 + s7 * c1
!F Total_Cytosolic_WTASYN_Dimer = s6 * c1 + s18 * c1