begin name
ouzounoglou1
end name

begin reactions
re1 {1.0}$s3 = {1.0}s17
re10 {1.0}s20 + {1.0}s17 = {1.0}s24
re100 {1.0}s17 + {1.0}s499 = {1.0}s500
re101 {1.0}s17 + {1.0}s500 = {1.0}s501
re102 {1.0}s381 = {1.0}s35
re103 {1.0}s383 = {1.0}s35
re104 {1.0}s385 = {1.0}s35
re105 {1.0}s387 = {1.0}s35
re106 {1.0}s389 = {1.0}s35
re107 {1.0}s391 = {1.0}s35
re108 {1.0}s393 = {1.0}s35
re109 {1.0}s473 = {1.0}s35
re11 {1.0}s20 + {1.0}s35 = {1.0}s381
re110 {1.0}s474 = {1.0}s35
re111 {1.0}s475 = {1.0}s35
re112 {1.0}s476 = {1.0}s35
re113 {1.0}s477 = {1.0}s35
re114 {1.0}s478 = {1.0}s35
re115 {1.0}s479 = {1.0}s35
re116 {1.0}s33 + {1.0}s35 = {1.0}s502
re117 {1.0}s27 = {1.0}s26 + {1.0}s7
re118 {1.0}s26 = {1.0}s25 + {1.0}s7
re119 {1.0}s25 = {1.0}s21 + {1.0}s7
re12 {1.0}s24 = {1.0}s517
re120 {1.0}s21 = {1.0}s1 + {1.0}s7
re121 {1.0}s2 = {1.0}s5 + {1.0}s7
re122 {1.0}s1 = {1.0}s2 + {1.0}s7
re123 {1.0}s5 = {1.0}s6 + {1.0}s7
re124 {1.0}s6 = {2.0}s7
re125 {1.0}s29 = {1.0}s17 + {1.0}s30
re126 {1.0}s30 = {1.0}s31 + {1.0}s17
re127 {1.0}s31 = {1.0}s32 + {1.0}s17
re128 {1.0}s32 = {1.0}s17 + {1.0}s23
re129 {1.0}s23 = {1.0}s24 + {1.0}s17
re13 {1.0}s24 + {1.0}s17 = {1.0}s23
re130 {1.0}s24 = {1.0}s20 + {1.0}s17
re131 {1.0}s20 = {1.0}s18 + {1.0}s17
re132 {1.0}s18 = {2.0}s17
re133 {1.0}s33 + {1.0}s17 = {1.0}s33
re134 {1.0}s17 = {1.0}s533
re135 {1.0}s533 = {1.0}s107
re136 {1.0}s7 = {1.0}s535
re137 {1.0}s535 = {1.0}s445
re14 {1.0}s24 + {1.0}s35 = {1.0}s383
re15 {1.0}s23 = {1.0}s518
re16 {1.0}s23 + {1.0}s17 = {1.0}s32
re17 {1.0}s23 + {1.0}s35 = {1.0}s385
re18 {1.0}s23 + {1.0}s51 = {1.0}s496
re19 {1.0}s32 = {1.0}s519
re2 {1.0}$s3 = {1.0}s22
re20 {1.0}s32 + {1.0}s17 = {1.0}s31
re21 {1.0}s32 + {1.0}s35 = {1.0}s387
re22 {1.0}s31 = {1.0}s522
re23 {1.0}s31 + {1.0}s17 = {1.0}s30
re24 {1.0}s31 + {1.0}s35 = {1.0}s389
re25 {1.0}s31 + {1.0}s51 = {1.0}s499
re26 {1.0}s30 = {1.0}s523
re27 {1.0}s30 + {1.0}s17 = {1.0}s29
re28 {1.0}s30 + {1.0}s35 = {1.0}s391
re29 {1.0}s29 + {1.0}s35 = {1.0}s393
re3 {2.0}s17 = {1.0}s18
re30 {1.0}s29 + {1.0}s51 = {1.0}s501
re31 {1.0}s22 = {1.0}s200
re32 {2.0}s7 = {1.0}s6
re33 {1.0}s7 + {1.0}s536 = {1.0}s482
re34 {1.0}s7 + {1.0}s490 = {1.0}s489
re35 {1.0}s7 + {1.0}s489 = {1.0}s492
re36 {1.0}s7 + {1.0}s492 = {1.0}s493
re37 {1.0}s78 = {1.0}s51 + {1.0}s52
re38 {1.0}s85 = {1.0}s51 + {1.0}s53
re4 {1.0}s17 + {1.0}s22 = {1.0}s7
re40 {1.0}s517 = {1.0}s109
re41 {1.0}s523 = {1.0}s113
re42 {1.0}s520 = {1.0}s108
re43 {1.0}s521 = {1.0}s107
re44 {1.0}s522 = {1.0}s112
re45 {1.0}s518 = {1.0}s110
re46 {1.0}s519 = {1.0}s111
re47 {1.0}s29 + {1.0}s17 = {1.0}s33
re48 {1.0}s6 = {1.0}s527
re49 {1.0}s6 + {1.0}s7 = {1.0}s5
re5 {1.0}s17 + {1.0}s51 = {1.0}s78
re50 {1.0}s5 = {1.0}s531
re51 {1.0}s5 + {1.0}s7 = {1.0}s2
re52 {1.0}s5 + {1.0}s35 = {1.0}s473
re53 {1.0}s2 = {1.0}s530
re54 {1.0}s2 + {1.0}s7 = {1.0}s1
re55 {1.0}s2 + {1.0}s35 = {1.0}s474
re56 {1.0}s1 = {1.0}s529
re57 {1.0}s1 + {1.0}s7 = {1.0}s21
re58 {1.0}s1 + {1.0}s35 = {1.0}s475
re59 {1.0}s21 = {1.0}s528
re6 {1.0}s18 = {1.0}s521
re60 {1.0}s21 + {1.0}s7 = {1.0}s25
re61 {1.0}s21 + {1.0}s35 = {1.0}s476
re62 {1.0}s25 = {1.0}s526
re63 {1.0}s25 + {1.0}s7 = {1.0}s26
re64 {1.0}s25 + {1.0}s35 = {1.0}s477
re65 {1.0}s26 = {1.0}s525
re66 {1.0}s26 + {1.0}s7 = {1.0}s27
re67 {1.0}s26 + {1.0}s35 = {1.0}s478
re68 {1.0}s27 + {1.0}s35 = {1.0}s479
re69 {1.0}s53 = {1.0}s211
re7 {1.0}s18 + {1.0}s17 = {1.0}s20
re70 {1.0}s52 = {1.0}s213
re71 {1.0}s501 = {1.0}s29 + {1.0}s51
re72 {1.0}s482 + {1.0}s7 = {1.0}s483
re73 {1.0}s483 + {1.0}s7 = {1.0}s484
re74 {1.0}s484 + {1.0}s7 = {1.0}s491
re75 {1.0}s491 + {1.0}s7 = {1.0}s490
re76 {1.0}s494 = {1.0}s20 + {1.0}s51
re77 {1.0}s495 = {1.0}s24 + {1.0}s51
re78 {1.0}s496 = {1.0}s23 + {1.0}s51
re79 {1.0}s498 = {1.0}s32 + {1.0}s51
re8 {1.0}s18 + {1.0}s51 = {1.0}s85
re80 {1.0}s499 = {1.0}s31 + {1.0}s51
re81 {1.0}s500 = {1.0}s30 + {1.0}s51
re82 {1.0}s500 + {1.0}s30 = {1.0}s51
re83 {1.0}s51 + {1.0}s20 = {1.0}s494
re84 {1.0}s51 + {1.0}s24 = {1.0}s495
re85 {1.0}s51 + {1.0}s32 = {1.0}s498
re86 {1.0}s51 + {1.0}s7 = {1.0}s536
re87 {1.0}s530 = {1.0}s447
re88 {1.0}s531 = {1.0}s446
re89 {1.0}s527 = {1.0}s445
re9 {1.0}s20 = {1.0}s520
re90 {1.0}s529 = {1.0}s448
re91 {1.0}s528 = {1.0}s524
re92 {1.0}s526 = {1.0}s524
re93 {1.0}s525 = {1.0}s451
re94 {1.0}s17 + {1.0}s78 = {1.0}s85
re95 {1.0}s17 + {1.0}s85 = {1.0}s494
re96 {1.0}s17 + {1.0}s494 = {1.0}s495
re97 {1.0}s17 + {1.0}s495 = {1.0}s496
re98 {1.0}s496 + {1.0}s17 = {1.0}s498
re99 {1.0}s498 + {1.0}s17 = {1.0}s499
end reactions

begin rate equations
re1 = c1*re1k1*s3
re10 = c1*kOligomerForm*s17[t]*s20[t]
re100 = kOligomerForm*s17[t]*s499[t]
re101 = kOligomerForm*s17[t]*s500[t]
re102 = c1*kProtOligDegr*s381[t]
re103 = c1*kProtOligDegr*s383[t]
re104 = c1*kProtOligDegr*s385[t]
re105 = c1*kProtOligDegr*s387[t]
re106 = c1*kProtOligDegr*s389[t]
re107 = c1*kProtOligDegr*s391[t]
re108 = c1*kProtOligDegr*s393[t]
re109 = c1*kProtOligDegr*s473[t]
re11 = c1*kProteasomeBind*s20[t]*s35[t]
re110 = c1*kProtOligDegr*s474[t]
re111 = c1*kProtOligDegr*s475[t]
re112 = c1*kProtOligDegr*s476[t]
re113 = c1*kProtOligDegr*s477[t]
re114 = c1*kProtOligDegr*s478[t]
re115 = c1*kProtOligDegr*s479[t]
re116 = c1*kProteasomeBind*s33[t]*s35[t]
re117 = c1*kDisRate*s27[t]
re118 = c1*kDisRate*s26[t]
re119 = c1*kDisRate*s25[t]
re12 = kOligAutophagUptake*s24[t]
re120 = c1*kDisRate*s21[t]
re121 = c1*kDisRate*s2[t]
re122 = c1*kDisRate*s1[t]
re123 = c1*kDisRate*s5[t]
re124 = c1*kDisRate*s6[t]
re125 = c1*kDisRate*s29[t]
re126 = c1*kDisRate*s30[t]
re127 = c1*kDisRate*s31[t]
re128 = c1*kDisRate*s32[t]
re129 = c1*kDisRate*s23[t]
re13 = c1*kOligomerForm*s17[t]*s24[t]
re130 = c1*kDisRate*s24[t]
re131 = c1*kDisRate*s20[t]
re132 = c1*kDisRate*s18[t]
re133 = c1*re133k1*s17[t]*s33[t]
re134 = kOligAutophagUptake*s17[t]
re135 = c2*kMautophagyDegr*s533[t]
re136 = kOligAutophagUptake*s7[t]
re137 = c2*kMautophagyDegr*s535[t]
re14 = c1*kProteasomeBind*s24[t]*s35[t]
re15 = kOligAutophagUptake*s23[t]
re16 = c1*kOligomerForm*s17[t]*s23[t]
re17 = c1*kProteasomeBind*s23[t]*s35[t]
re18 = kWTOligBindOnLamp*s23[t]*s51[t]
re19 = kOligAutophagUptake*s32[t]
re2 = c1*re2k1*s3
re20 = c1*kOligomerForm*s17[t]*s32[t]
re21 = c1*kProteasomeBind*s32[t]*s35[t]
re22 = kOligAutophagUptake*s31[t]
re23 = c1*kOligomerForm*s17[t]*s31[t]
re24 = c1*kProteasomeBind*s31[t]*s35[t]
re25 = kWTOligBindOnLamp*s31[t]*s51[t]
re26 = kOligAutophagUptake*s30[t]
re27 = c1*kOligomerForm*s17[t]*s30[t]
re28 = c1*kProteasomeBind*s30[t]*s35[t]
re29 = c1*kProteasomeBind*s29[t]*s35[t]
re3 = c1*k2merForm*s17[t]^2
re30 = kWTOligBindOnLamp*s29[t]*s51[t]
re31 = c1*re31k1*s22[t]
re32 = c1*k2merForm*s7[t]^2
re33 = k2merForm*s536[t]*s7[t]
re34 = kOligomerForm*s490[t]*s7[t]
re35 = kOligomerForm*s489[t]*s7[t]
re36 = kOligomerForm*s492[t]*s7[t]
re37 = c3*re37k1*s78[t]
re38 = c3*re38k1*s85[t]
re4 = c1*re4k1*s17[t]*s22[t]
re40 = c2*kMautophagyDegr*s517[t]
re41 = c2*kMautophagyDegr*s523[t]
re42 = c2*kMautophagyDegr*s520[t]
re43 = c2*kMautophagyDegr*s521[t]
re44 = c2*kMautophagyDegr*s522[t]
re45 = c2*kMautophagyDegr*s518[t]
re46 = c2*kMautophagyDegr*s519[t]
re47 = c1*kOligomerForm*s17[t]*s29[t]
re48 = kOligAutophagUptake*s6[t]
re49 = c1*kOligomerForm*s6[t]*s7[t]
re5 = kWTasyn12merBindOnLamp*s17[t]*s51[t]
re50 = kOligAutophagUptake*s5[t]
re51 = c1*kOligomerForm*s5[t]*s7[t]
re52 = c1*kProteasomeBind*s35[t]*s5[t]
re53 = kOligAutophagUptake*s2[t]
re54 = c1*kOligomerForm*s2[t]*s7[t]
re55 = c1*kProteasomeBind*s2[t]*s35[t]
re56 = kOligAutophagUptake*s1[t]
re57 = c1*kOligomerForm*s1[t]*s7[t]
re58 = c1*kProteasomeBind*s1[t]*s35[t]
re59 = kOligAutophagUptake*s21[t]
re6 = kOligAutophagUptake*s18[t]
re60 = c1*kOligomerForm*s21[t]*s7[t]
re61 = c1*kProteasomeBind*s21[t]*s35[t]
re62 = kOligAutophagUptake*s25[t]
re63 = c1*kOligomerForm*s25[t]*s7[t]
re64 = c1*kProteasomeBind*s25[t]*s35[t]
re65 = kOligAutophagUptake*s26[t]
re66 = c1*kOligomerForm*s26[t]*s7[t]
re67 = c1*kProteasomeBind*s26[t]*s35[t]
re68 = c1*kProteasomeBind*s27[t]*s35[t]
re69 = c3*re69k1*s53[t]
re7 = c1*kOligomerForm*s17[t]*s18[t]
re70 = c3*re70k1*s52[t]
re71 = kLampFreeWTasyn*s501[t]
re72 = kOligomerForm*s482[t]*s7[t]
re73 = kOligomerForm*s483[t]*s7[t]
re74 = kOligomerForm*s484[t]*s7[t]
re75 = kOligomerForm*s491[t]*s7[t]
re76 = kLampFreeWTasyn*s494[t]
re77 = kLampFreeWTasyn*s495[t]
re78 = kLampFreeWTasyn*s496[t]
re79 = kLampFreeWTasyn*s498[t]
re8 = kWTasyn12merBindOnLamp*s18[t]*s51[t]
re80 = kLampFreeWTasyn*s499[t]
re81 = kLampFreeWTasyn*s500[t]
re82 = kWTOligBindOnLamp*s30[t]*s500[t]
re83 = kWTOligBindOnLamp*s20[t]*s51[t]
re84 = kWTOligBindOnLamp*s24[t]*s51[t]
re85 = kWTOligBindOnLamp*s32[t]*s51[t]
re86 = kDopModWTasynLampBind*s51[t]*s7[t]
re87 = c2*kMautophagyDegr*s530[t]
re88 = c2*kMautophagyDegr*s531[t]
re89 = c2*kMautophagyDegr*s527[t]
re9 = kOligAutophagUptake*s20[t]
re90 = c2*kMautophagyDegr*s529[t]
re91 = c2*kMautophagyDegr*s528[t]
re92 = c2*kMautophagyDegr*s526[t]
re93 = c2*kMautophagyDegr*s525[t]
re94 = k2merForm*s17[t]*s78[t]
re95 = kOligomerForm*s17[t]*s85[t]
re96 = kOligomerForm*s17[t]*s494[t]
re97 = kOligomerForm*s17[t]*s495[t]
re98 = kOligomerForm*s17[t]*s496[t]
re99 = kOligomerForm*s17[t]*s498[t]
end rate equations

begin parameters
k2merForm = "1.462941015e-09"
kDisRate = "4.999533748e-07"
kDopModWTasynLampBind = "7.6715997e-09"
kLampFreeWTasyn = 0.0003044571674
kMautophagyDegr = 0.1
kOligAutophagUptake = "2.39034347e-08"
kOligomerForm = "3.350497192e-08"
kProtOligDegr = 0.000370096
kProteasomeBind = "3.424693672e-09"
kWTOligBindOnLamp = "4e-06"
kWTasyn12merBindOnLamp = "6.865455081e-07"
s3 = 1.0
re37k1 = 0.00999558
re38k1 = 0.00995312
re69k1 = 0.1
re70k1 = 0.1
re133k1 = "4.90556e-07"
re1k1 = 0.0294219
re2k1 = 0.0791823
re4k1 = "6.74768e-07"
re31k1 = 0.00679501
c1 = 1.0
c2 = 1.0
c3 = 1.0
end parameters

begin initial conditions
s1[0] = s1i
s107[0] = s107i
s108[0] = s108i
s109[0] = s109i
s110[0] = s110i
s111[0] = s111i
s112[0] = s112i
s113[0] = s113i
s17[0] = s17i
s18[0] = s18i
s2[0] = s2i
s20[0] = s20i
s200[0] = s200i
s21[0] = s21i
s211[0] = s211i
s213[0] = s213i
s22[0] = s22i
s23[0] = s23i
s24[0] = s24i
s25[0] = s25i
s26[0] = s26i
s27[0] = s27i
s29[0] = s29i
s30[0] = s30i
s31[0] = s31i
s32[0] = s32i
s33[0] = s33i
s35[0] = s35i
s381[0] = s381i
s383[0] = s383i
s385[0] = s385i
s387[0] = s387i
s389[0] = s389i
s391[0] = s391i
s393[0] = s393i
s445[0] = s445i
s446[0] = s446i
s447[0] = s447i
s448[0] = s448i
s451[0] = s451i
s473[0] = s473i
s474[0] = s474i
s475[0] = s475i
s476[0] = s476i
s477[0] = s477i
s478[0] = s478i
s479[0] = s479i
s482[0] = s482i
s483[0] = s483i
s484[0] = s484i
s489[0] = s489i
s490[0] = s490i
s491[0] = s491i
s492[0] = s492i
s493[0] = s493i
s494[0] = s494i
s495[0] = s495i
s496[0] = s496i
s498[0] = s498i
s499[0] = s499i
s5[0] = s5i
s500[0] = s500i
s501[0] = s501i
s502[0] = s502i
s51[0] = s51i
s517[0] = s517i
s518[0] = s518i
s519[0] = s519i
s52[0] = s52i
s520[0] = s520i
s521[0] = s521i
s522[0] = s522i
s523[0] = s523i
s524[0] = s524i
s525[0] = s525i
s526[0] = s526i
s527[0] = s527i
s528[0] = s528i
s529[0] = s529i
s53[0] = s53i
s530[0] = s530i
s531[0] = s531i
s533[0] = s533i
s535[0] = s535i
s536[0] = s536i
s6[0] = s6i
s7[0] = s7i
s78[0] = s78i
s85[0] = s85i
end initial conditions

begin initial values
s1i = 8.0
s107i = 0.0
s108i = 0.0
s109i = 0.0
s110i = 0.0
s111i = 0.0
s112i = 0.0
s113i = 0.0
s17i = 1650.0
s18i = 22.0
s2i = 8.0
s20i = 8.0
s200i = 0.0
s21i = 8.0
s211i = 0.0
s213i = 0.0
s22i = 750.0
s23i = 8.0
s24i = 8.0
s25i = 8.0
s26i = 8.0
s27i = 8.0
s29i = 8.0
s30i = 8.0
s31i = 8.0
s32i = 8.0
s33i = 0.0
s35i = 1500.0
s381i = 0.0
s383i = 0.0
s385i = 0.0
s387i = 0.0
s389i = 0.0
s391i = 0.0
s393i = 0.0
s445i = 0.0
s446i = 0.0
s447i = 0.0
s448i = 0.0
s451i = 0.0
s473i = 0.0
s474i = 0.0
s475i = 0.0
s476i = 0.0
s477i = 0.0
s478i = 0.0
s479i = 0.0
s482i = 0.0
s483i = 0.0
s484i = 0.0
s489i = 0.0
s490i = 0.0
s491i = 0.0
s492i = 0.0
s493i = 0.0
s494i = 0.0
s495i = 0.0
s496i = 0.0
s498i = 0.0
s499i = 0.0
s5i = 8.0
s500i = 0.0
s501i = 0.0
s502i = 0.0
s51i = 200.0
s517i = 0.0
s518i = 0.0
s519i = 0.0
s52i = 0.0
s520i = 0.0
s521i = 0.0
s522i = 0.0
s523i = 0.0
s524i = 0.0
s525i = 0.0
s526i = 0.0
s527i = 0.0
s528i = 0.0
s529i = 0.0
s53i = 0.0
s530i = 0.0
s531i = 0.0
s533i = 0.0
s535i = 0.0
s536i = 0.0
s6i = 0.0
s7i = 953.0
s78i = 0.0
s85i = 0.0
end initial values

begin assignment rules
TotalCytosolicWTASYNOligomers := c1*s1[t] + c1*s2[t] + c1*s20[t] + c1*s21[t] + c1*s23[t] + c1*s24[t] + c1*s25[t] + c1*s26[t] + c1*s27[t] + c1*s29[t] + c1*s30[t] + c1*s31[t] + c1*s32[t] + c1*s5[t]
TotalCytosolicWTASYNMonomer := c1*s17[t] + c1*s7[t]
TotalCytosolicWTASYNDimer := c1*s18[t] + c1*s6[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
s17 http://identifiers.org/uniprot/P37840
s22 http://identifiers.org/chebi/CHEBI:18243
s51 http://identifiers.org/uniprot/P13473
s517 http://identifiers.org/uniprot/P37840
s518 http://identifiers.org/uniprot/P37840
s519 http://identifiers.org/uniprot/P37840
s520 http://identifiers.org/uniprot/P37840
s521 http://identifiers.org/uniprot/P37840
s522 http://identifiers.org/uniprot/P37840
s523 http://identifiers.org/uniprot/P37840
s533 http://identifiers.org/uniprot/P37840
end species annotations

begin units
end units