#orfao1



#reactions
R1:
 {1.0}X = {1.0}Xa
  compartment_1 * HenriMichaelisMenten_irreversible_kcat(kcat_X, RVV, X, km_X)
R2:
 {1.0}Xa = {1.0}Xa_ATIII
  compartment_1 * ki_Xa * Xa
R3:
 {1.0}Va + {1.0}Xa + {1.0}PL = {1.0}PT
  compartment_1 * (k_PT * Va * Xa * PL - k_PL * PT)
R4:
 {1.0}V = {1.0}Va
  compartment_1 * HenriMichaelisMenten_irreversible_kcat(kcat_V, IIa, V, km_V)
R5:
 {1.0}II = {1.0}IIa
  compartment_1 * HenriMichaelisMenten_irreversible_kcat(kcat_II, PT, II, km_II)
R6:
 {1.0}II = {1.0}IIa
  compartment_1 * HenriMichaelisMenten_irreversible_kcat(kcat_2, Xa, II, km_2)
R7:
 {1.0}IIa = {1.0}IIa_alpha2M
  compartment_1 * ki_IIaAlpha2M * IIa
R8:
 {1.0}IIa = {1.0}IIa_ATIII
  compartment_1 * ki_IIaATIII * IIa


#parameters
k_PL = 801.4
k_PT = 122.9
kcat_2 = 12.4
kcat_II = 43.87
kcat_V = 7.844
kcat_X = 239.1
ki_IIaATIII = 0.7859
ki_IIaAlpha2M = 0.1762
ki_Xa = 4.531
km_2 = 0.06148
km_II = 62.25
km_V = 149.7
km_X = 23.65
compartment_1 = 1.0


#initial values
II = 1.4
IIa = 0.0
IIa_ATIII = 0.0
IIa_alpha2M = 0.0
PL = 0.04999999
PT = 0.0
RVV = 0.03
V = 0.02999999
Va = 0.0
X = 0.1999999
Xa = 0.0
Xa_ATIII = 0.0


#assignment rules
!F AmAct = IIa + 0.556 * IIa_alpha2M