begin name
orfao1
end name

begin reactions
R1 {1.0}X = {1.0}Xa
R2 {1.0}Xa = {1.0}XaATIII
R3 {1.0}Va + {1.0}Xa + {1.0}PL = {1.0}PT
R4 {1.0}V = {1.0}Va
R5 {1.0}II = {1.0}IIa
R6 {1.0}II = {1.0}IIa
R7 {1.0}IIa = {1.0}IIaalpha2M
R8 {1.0}IIa = {1.0}IIaATIII
end reactions

begin rate equations
R1 = compartment1*HenriMichaelisMentenirreversiblekcat[kcatX, RVV[t], X[t], kmX]
R2 = compartment1*kiXa*Xa[t]
R3 = compartment1*(-(kPL*PT[t]) + kPT*PL[t]*Va[t]*Xa[t])
R4 = compartment1*HenriMichaelisMentenirreversiblekcat[kcatV, IIa[t], V[t], kmV]
R5 = compartment1*HenriMichaelisMentenirreversiblekcat[kcatII, PT[t], II[t], kmII]
R6 = compartment1*HenriMichaelisMentenirreversiblekcat[kcat2, Xa[t], II[t], km2]
R7 = compartment1*kiIIaAlpha2M*IIa[t]
R8 = compartment1*kiIIaATIII*IIa[t]
end rate equations

begin parameters
kPL = 801.4
kPT = 122.9
kcat2 = 12.4
kcatII = 43.87
kcatV = 7.844
kcatX = 239.1
kiIIaATIII = 0.7859
kiIIaAlpha2M = 0.1762
kiXa = 4.531
km2 = 0.06148
kmII = 62.25
kmV = 149.7
kmX = 23.65
compartment1 = 1.0
end parameters

begin initial conditions
II[0] = IIi
IIa[0] = IIai
IIaATIII[0] = IIaATIIIi
IIaalpha2M[0] = IIaalpha2Mi
PL[0] = PLi
PT[0] = PTi
RVV[0] = RVVi
V[0] = Vi
Va[0] = Vai
X[0] = Xi
Xa[0] = Xai
XaATIII[0] = XaATIIIi
end initial conditions

begin initial values
IIi = 1.4
IIai = 0.0
IIaATIIIi = 0.0
IIaalpha2Mi = 0.0
PLi = 0.04999999
PTi = 0.0
RVVi = 0.03
Vi = 0.02999999
Vai = 0.0
Xi = 0.1999999
Xai = 0.0
XaATIIIi = 0.0
end initial values

begin assignment rules
AmAct := IIa[t] + 0.556*IIaalpha2M[t]
end assignment rules

begin function definitions
HenriMichaelisMentenirreversiblekcat[kcat_,enzyme_,substrate_,Km_] := (enzyme*kcat*substrate)/(Km + substrate)
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
II http://identifiers.org/uniprot/P00734
IIa http://identifiers.org/uniprot/P00734
V http://identifiers.org/uniprot/P12259
Va http://identifiers.org/uniprot/P12259
X http://identifiers.org/uniprot/P00742
Xa http://identifiers.org/uniprot/P00742
end species annotations

begin units
end units