#odea1 #reactions IKK_deg: {1.0}IKK = $pool cytoplasm * k_IKK_deg * IKK deg_a: {1.0}IkBa_cytoplasm = $pool cytoplasm * deg1_c * IkBa_cytoplasm deg_a_n: {1.0}IkBa_nucleus = $pool nucleus * deg1_n * IkBa_nucleus deg_ai: {1.0}IkBaIKK = {1.0}IKK cytoplasm * r1 * IkBaIKK deg_ain: {1.0}IkBaIKKNFkB = {1.0}NFkB_cytoplasm + {1.0}IKK cytoplasm * r4 * IkBaIKKNFkB deg_an: {1.0}IkBaNFkB_cytoplasm = {1.0}NFkB_cytoplasm cytoplasm * deg4_c * IkBaNFkB_cytoplasm deg_an_n: {1.0}IkBaNFkB_nucleus = {1.0}NFkB_nucleus nucleus * deg4_n * IkBaNFkB_nucleus deg_b: {1.0}IkBb_cytoplasm = $pool cytoplasm * deg2_c * IkBb_cytoplasm deg_b_n: {1.0}IkBb_nucleus = $pool nucleus * deg2_n * IkBb_nucleus deg_bi: {1.0}IkBbIKK = {1.0}IKK cytoplasm * r2 * IkBbIKK deg_bin: {1.0}IkBbIKKNFkB = {1.0}NFkB_cytoplasm + {1.0}IKK cytoplasm * r5 * IkBbIKKNFkB deg_bn: {1.0}IkBbNFkB_cytoplasm = {1.0}NFkB_cytoplasm cytoplasm * deg5_c * IkBbNFkB_cytoplasm deg_bn_n: {1.0}IkBbNFkB_nucleus = {1.0}NFkB_nucleus nucleus * deg5_n * IkBbNFkB_nucleus deg_e: {1.0}IkBe_cytoplasm = $pool cytoplasm * deg3_c * IkBe_cytoplasm deg_e_n: {1.0}IkBe_nucleus = $pool nucleus * deg3_n * IkBe_nucleus deg_ei: {1.0}IkBeIKK = {1.0}IKK cytoplasm * r3 * IkBeIKK deg_ein: {1.0}IkBeIKKNFkB = {1.0}NFkB_cytoplasm + {1.0}IKK cytoplasm * r6 * IkBeIKKNFkB deg_en: {1.0}IkBeNFkB_cytoplasm = {1.0}NFkB_cytoplasm cytoplasm * deg6_c * IkBeNFkB_cytoplasm deg_en_n: {1.0}IkBeNFkB_nucleus = {1.0}NFkB_nucleus nucleus * deg6_n * IkBeNFkB_nucleus int_2ain: {1.0}IkBaIKK + {1.0}NFkB_cytoplasm = {1.0}IkBaIKKNFkB cytoplasm * (a4_3 * IkBaIKK * NFkB_cytoplasm - d4_3 * IkBaIKKNFkB) int_2ani: {1.0}IkBaNFkB_cytoplasm + {1.0}IKK = {1.0}IkBaIKKNFkB cytoplasm * (a7 * IkBaNFkB_cytoplasm * IKK - d1_2 * IkBaIKKNFkB) int_2bin: {1.0}IkBbIKK + {1.0}NFkB_cytoplasm = {1.0}IkBbIKKNFkB cytoplasm * (a5_3 * IkBbIKK * NFkB_cytoplasm - d5_3 * IkBbIKKNFkB) int_2bni: {1.0}IkBbNFkB_cytoplasm + {1.0}IKK = {1.0}IkBbIKKNFkB cytoplasm * (a8 * IkBbNFkB_cytoplasm * IKK - d2_2 * IkBbIKKNFkB) int_2ein: {1.0}IkBeIKK + {1.0}NFkB_cytoplasm = {1.0}IkBeIKKNFkB cytoplasm * (a6_3 * IkBeIKK * NFkB_cytoplasm - d6_3 * IkBeIKKNFkB) int_2eni: {1.0}IkBeNFkB_cytoplasm + {1.0}IKK = {1.0}IkBeIKKNFkB cytoplasm * (a9 * IkBeNFkB_cytoplasm * IKK - d3_2 * IkBeIKKNFkB) int_ai: {1.0}IkBa_cytoplasm + {1.0}IKK = {1.0}IkBaIKK cytoplasm * (a1 * IkBa_cytoplasm * IKK - d1_1 * IkBaIKK) int_an: {1.0}IkBa_cytoplasm + {1.0}NFkB_cytoplasm = {1.0}IkBaNFkB_cytoplasm cytoplasm * (a4_1 * IkBa_cytoplasm * NFkB_cytoplasm - d4_1 * IkBaNFkB_cytoplasm) int_an_n: {1.0}IkBa_nucleus + {1.0}NFkB_nucleus = {1.0}IkBaNFkB_nucleus nucleus * (a4_2 * IkBa_nucleus * NFkB_nucleus - d4_2 * IkBaNFkB_nucleus) int_bi: {1.0}IkBb_cytoplasm + {1.0}IKK = {1.0}IkBbIKK cytoplasm * (a2 * IkBb_cytoplasm * IKK - d2_1 * IkBbIKK) int_bn: {1.0}IkBb_cytoplasm + {1.0}NFkB_cytoplasm = {1.0}IkBbNFkB_cytoplasm cytoplasm * (a5_1 * IkBb_cytoplasm * NFkB_cytoplasm - d5_1 * IkBbNFkB_cytoplasm) int_bn_n: {1.0}IkBb_nucleus + {1.0}NFkB_nucleus = {1.0}IkBbNFkB_nucleus nucleus * (a5_2 * IkBb_nucleus * NFkB_nucleus - d5_2 * IkBbNFkB_nucleus) int_ei: {1.0}IkBe_cytoplasm + {1.0}IKK = {1.0}IkBeIKK cytoplasm * (a3 * IkBe_cytoplasm * IKK - d3_1 * IkBeIKK) int_en: {1.0}IkBe_cytoplasm + {1.0}NFkB_cytoplasm = {1.0}IkBeNFkB_cytoplasm cytoplasm * (a6_1 * IkBe_cytoplasm * NFkB_cytoplasm - d6_1 * IkBeNFkB_cytoplasm) int_en_n: {1.0}IkBe_nucleus + {1.0}NFkB_nucleus = {1.0}IkBeNFkB_nucleus nucleus * (a6_2 * IkBe_nucleus * NFkB_nucleus - d6_2 * IkBeNFkB_nucleus) itxn_a: $pool = {1.0}IkBa_mRNA nucleus * tr2a_i * pow(NFkB_nucleus, 2) loc_a: {1.0}IkBa_cytoplasm = {1.0}IkBa_nucleus cytoplasm * tp1a * IkBa_cytoplasm - nucleus * tp2a * IkBa_nucleus loc_an: {1.0}IkBaNFkB_nucleus = {1.0}IkBaNFkB_cytoplasm nucleus * k2_a * IkBaNFkB_nucleus loc_b: {1.0}IkBb_cytoplasm = {1.0}IkBb_nucleus cytoplasm * tp1b * IkBb_cytoplasm - nucleus * tp2b * IkBb_nucleus loc_bn: {1.0}IkBbNFkB_nucleus = {1.0}IkBbNFkB_cytoplasm nucleus * k2_b * IkBbNFkB_nucleus loc_e: {1.0}IkBe_cytoplasm = {1.0}IkBe_nucleus cytoplasm * tp1e * IkBe_cytoplasm - nucleus * tp2e * IkBe_nucleus loc_en: {1.0}IkBeNFkB_nucleus = {1.0}IkBeNFkB_cytoplasm nucleus * k2_e * IkBeNFkB_nucleus loc_n: {1.0}NFkB_cytoplasm = {1.0}NFkB_nucleus cytoplasm * k1_2 * NFkB_cytoplasm - nucleus * k1_1 * NFkB_nucleus mdeg_a: {1.0}IkBa_mRNA = $pool nucleus * tr3a * IkBa_mRNA mdeg_b: {1.0}IkBb_mRNA = $pool nucleus * tr3b * IkBb_mRNA mdeg_e: {1.0}IkBe_mRNA = $pool nucleus * tr3e * IkBe_mRNA tsl_a: {1.0}IkBa_mRNA = {1.0}IkBa_mRNA + {1.0}IkBa_cytoplasm nucleus * tr1a * IkBa_mRNA tsl_b: {1.0}IkBb_mRNA = {1.0}IkBb_mRNA + {1.0}IkBb_cytoplasm nucleus * tr1b * IkBb_mRNA tsl_e: {1.0}IkBe_mRNA = {1.0}IkBe_mRNA + {1.0}IkBe_cytoplasm nucleus * tr1e * IkBe_mRNA txn_a: $pool = {1.0}IkBa_mRNA nucleus * tr2a txn_b: $pool = {1.0}IkBb_mRNA nucleus * tr2b txn_e: $pool = {1.0}IkBe_mRNA nucleus * tr2e #parameters txn_a_tr2a = 0.0001848 mdeg_a_tr3a = 0.0168 tsl_a_tr1a = 0.2448 int_ai_a1 = 1.35 int_ai_d1_1 = 0.075 int_an_a4_1 = 30.0 int_an_d4_1 = 6e-05 int_an_n_a4_2 = 30.0 int_an_n_d4_2 = 6e-05 int_2ani_a7 = 11.1 int_2ani_d1_2 = 0.075 int_2ain_a4_3 = 30.0 int_2ain_d4_3 = 6e-05 deg_a_deg1_c = 0.12 deg_a_n_deg1_n = 0.12 deg_an_n_deg4_n = 6e-05 deg_an_deg4_c = 6e-05 deg_ai_r1 = 0.072 deg_ain_r4 = 0.36 loc_a_tp1a = 0.018 loc_a_tp2a = 0.012 loc_an_k2_a = 0.828 loc_bn_k2_b = 0.414 loc_b_tp1b = 0.018 loc_b_tp2b = 0.012 deg_bin_r5 = 0.12 deg_bi_r2 = 0.024 deg_bn_deg5_c = 6e-05 deg_bn_n_deg5_n = 6e-05 deg_b_n_deg2_n = 0.18 deg_b_deg2_c = 0.18 int_2bin_a5_3 = 30.0 int_2bin_d5_3 = 6e-05 int_2bni_a8 = 2.88 int_2bni_d2_2 = 0.105 int_bn_n_a5_2 = 30.0 int_bn_n_d5_2 = 6e-05 int_bn_a5_1 = 30.0 int_bn_d5_1 = 6e-05 int_bi_a2 = 0.36 int_bi_d2_1 = 0.105 tsl_b_tr1b = 0.2448 mdeg_b_tr3b = 0.0168 txn_b_tr2b = 4.272e-05 loc_n_k1_2 = 5.4 loc_n_k1_1 = 0.0048 txn_e_tr2e = 3.048e-05 mdeg_e_tr3e = 0.0168 tsl_e_tr1e = 0.2448 int_ei_a3 = 0.54 int_ei_d3_1 = 0.105 int_en_a6_1 = 30.0 int_en_d6_1 = 6e-05 int_en_n_a6_2 = 30.0 int_en_n_d6_2 = 6e-05 int_2eni_a9 = 4.2 int_2eni_d3_2 = 0.105 int_2ein_a6_3 = 30.0 int_2ein_d6_3 = 6e-05 deg_e_deg3_c = 0.18 deg_e_n_deg3_n = 0.18 deg_en_n_deg6_n = 6e-05 deg_en_deg6_c = 6e-05 deg_ei_r3 = 0.036 deg_ein_r6 = 0.18 loc_e_tp1e = 0.018 loc_e_tp2e = 0.012 loc_en_k2_e = 0.414 IKK_deg_k_IKK_deg = 0.0 itxn_a_tr2a_i = 1.98 cytoplasm = 1.0 nucleus = 1.0 #initial values IKK = 0.001 IkBaIKK = 0.0 IkBaIKKNFkB = 0.0 IkBaNFkB_cytoplasm = 0.06 IkBaNFkB_nucleus = 0.0 IkBa_cytoplasm = 0.0 IkBa_mRNA = 0.0 IkBa_nucleus = 0.0 IkBbIKK = 0.0 IkBbIKKNFkB = 0.0 IkBbNFkB_cytoplasm = 0.03 IkBbNFkB_nucleus = 0.0 IkBb_cytoplasm = 0.0 IkBb_mRNA = 0.0 IkBb_nucleus = 0.0 IkBeIKK = 0.0 IkBeIKKNFkB = 0.0 IkBeNFkB_cytoplasm = 0.01 IkBeNFkB_nucleus = 0.0 IkBe_cytoplasm = 0.0 IkBe_mRNA = 0.0 IkBe_nucleus = 0.0 NFkB_cytoplasm = 0.0 NFkB_nucleus = 0.0 #assignment rules !F Total_IkBeps = IkBe_cytoplasm + IkBe_nucleus + IkBeIKK + IkBeIKKNFkB + IkBeNFkB_cytoplasm + IkBeNFkB_nucleus !F Total_IkBbeta = IkBb_cytoplasm + IkBb_nucleus + IkBbIKK + IkBbIKKNFkB + IkBbNFkB_cytoplasm + IkBbNFkB_nucleus !F Total_IkBalpha = IkBa_cytoplasm + IkBa_nucleus + IkBaIKK + IkBaIKKNFkB + IkBaNFkB_cytoplasm + IkBaNFkB_nucleus