begin name
odea1
end name

begin reactions
IKKdeg {1.0}IKK = {1.0}$EXTERNAL
dega {1.0}IkBacytoplasm = {1.0}$EXTERNAL
degan {1.0}IkBanucleus = {1.0}$EXTERNAL
degai {1.0}IkBaIKK = {1.0}IKK
degain {1.0}IkBaIKKNFkB = {1.0}NFkBcytoplasm + {1.0}IKK
degan {1.0}IkBaNFkBcytoplasm = {1.0}NFkBcytoplasm
degann {1.0}IkBaNFkBnucleus = {1.0}NFkBnucleus
degb {1.0}IkBbcytoplasm = {1.0}$EXTERNAL
degbn {1.0}IkBbnucleus = {1.0}$EXTERNAL
degbi {1.0}IkBbIKK = {1.0}IKK
degbin {1.0}IkBbIKKNFkB = {1.0}NFkBcytoplasm + {1.0}IKK
degbn {1.0}IkBbNFkBcytoplasm = {1.0}NFkBcytoplasm
degbnn {1.0}IkBbNFkBnucleus = {1.0}NFkBnucleus
dege {1.0}IkBecytoplasm = {1.0}$EXTERNAL
degen {1.0}IkBenucleus = {1.0}$EXTERNAL
degei {1.0}IkBeIKK = {1.0}IKK
degein {1.0}IkBeIKKNFkB = {1.0}NFkBcytoplasm + {1.0}IKK
degen {1.0}IkBeNFkBcytoplasm = {1.0}NFkBcytoplasm
degenn {1.0}IkBeNFkBnucleus = {1.0}NFkBnucleus
int2ain {1.0}IkBaIKK + {1.0}NFkBcytoplasm = {1.0}IkBaIKKNFkB
int2ani {1.0}IkBaNFkBcytoplasm + {1.0}IKK = {1.0}IkBaIKKNFkB
int2bin {1.0}IkBbIKK + {1.0}NFkBcytoplasm = {1.0}IkBbIKKNFkB
int2bni {1.0}IkBbNFkBcytoplasm + {1.0}IKK = {1.0}IkBbIKKNFkB
int2ein {1.0}IkBeIKK + {1.0}NFkBcytoplasm = {1.0}IkBeIKKNFkB
int2eni {1.0}IkBeNFkBcytoplasm + {1.0}IKK = {1.0}IkBeIKKNFkB
intai {1.0}IkBacytoplasm + {1.0}IKK = {1.0}IkBaIKK
intan {1.0}IkBacytoplasm + {1.0}NFkBcytoplasm = {1.0}IkBaNFkBcytoplasm
intann {1.0}IkBanucleus + {1.0}NFkBnucleus = {1.0}IkBaNFkBnucleus
intbi {1.0}IkBbcytoplasm + {1.0}IKK = {1.0}IkBbIKK
intbn {1.0}IkBbcytoplasm + {1.0}NFkBcytoplasm = {1.0}IkBbNFkBcytoplasm
intbnn {1.0}IkBbnucleus + {1.0}NFkBnucleus = {1.0}IkBbNFkBnucleus
intei {1.0}IkBecytoplasm + {1.0}IKK = {1.0}IkBeIKK
inten {1.0}IkBecytoplasm + {1.0}NFkBcytoplasm = {1.0}IkBeNFkBcytoplasm
intenn {1.0}IkBenucleus + {1.0}NFkBnucleus = {1.0}IkBeNFkBnucleus
itxna {1.0}$EXTERNAL = {1.0}IkBamRNA
loca {1.0}IkBacytoplasm = {1.0}IkBanucleus
locan {1.0}IkBaNFkBnucleus = {1.0}IkBaNFkBcytoplasm
locb {1.0}IkBbcytoplasm = {1.0}IkBbnucleus
locbn {1.0}IkBbNFkBnucleus = {1.0}IkBbNFkBcytoplasm
loce {1.0}IkBecytoplasm = {1.0}IkBenucleus
locen {1.0}IkBeNFkBnucleus = {1.0}IkBeNFkBcytoplasm
locn {1.0}NFkBcytoplasm = {1.0}NFkBnucleus
mdega {1.0}IkBamRNA = {1.0}$EXTERNAL
mdegb {1.0}IkBbmRNA = {1.0}$EXTERNAL
mdege {1.0}IkBemRNA = {1.0}$EXTERNAL
tsla {1.0}IkBamRNA = {1.0}IkBamRNA + {1.0}IkBacytoplasm
tslb {1.0}IkBbmRNA = {1.0}IkBbmRNA + {1.0}IkBbcytoplasm
tsle {1.0}IkBemRNA = {1.0}IkBemRNA + {1.0}IkBecytoplasm
txna {1.0}$EXTERNAL = {1.0}IkBamRNA
txnb {1.0}$EXTERNAL = {1.0}IkBbmRNA
txne {1.0}$EXTERNAL = {1.0}IkBemRNA
end reactions

begin rate equations
IKKdeg = cytoplasm*IKKdegkIKKdeg*IKK[t]
dega = cytoplasm*degadeg1c*IkBacytoplasm[t]
degan = degandeg1n*nucleus*IkBanucleus[t]
degai = cytoplasm*degair1*IkBaIKK[t]
degain = cytoplasm*degainr4*IkBaIKKNFkB[t]
degan = cytoplasm*degandeg4c*IkBaNFkBcytoplasm[t]
degann = deganndeg4n*nucleus*IkBaNFkBnucleus[t]
degb = cytoplasm*degbdeg2c*IkBbcytoplasm[t]
degbn = degbndeg2n*nucleus*IkBbnucleus[t]
degbi = cytoplasm*degbir2*IkBbIKK[t]
degbin = cytoplasm*degbinr5*IkBbIKKNFkB[t]
degbn = cytoplasm*degbndeg5c*IkBbNFkBcytoplasm[t]
degbnn = degbnndeg5n*nucleus*IkBbNFkBnucleus[t]
dege = cytoplasm*degedeg3c*IkBecytoplasm[t]
degen = degendeg3n*nucleus*IkBenucleus[t]
degei = cytoplasm*degeir3*IkBeIKK[t]
degein = cytoplasm*degeinr6*IkBeIKKNFkB[t]
degen = cytoplasm*degendeg6c*IkBeNFkBcytoplasm[t]
degenn = degenndeg6n*nucleus*IkBeNFkBnucleus[t]
int2ain = cytoplasm*(-(int2aind43*IkBaIKKNFkB[t]) + int2aina43*IkBaIKK[t]*NFkBcytoplasm[t])
int2ani = cytoplasm*(-(int2anid12*IkBaIKKNFkB[t]) + int2ania7*IkBaNFkBcytoplasm[t]*IKK[t])
int2bin = cytoplasm*(-(int2bind53*IkBbIKKNFkB[t]) + int2bina53*IkBbIKK[t]*NFkBcytoplasm[t])
int2bni = cytoplasm*(-(int2bnid22*IkBbIKKNFkB[t]) + int2bnia8*IkBbNFkBcytoplasm[t]*IKK[t])
int2ein = cytoplasm*(-(int2eind63*IkBeIKKNFkB[t]) + int2eina63*IkBeIKK[t]*NFkBcytoplasm[t])
int2eni = cytoplasm*(-(int2enid32*IkBeIKKNFkB[t]) + int2enia9*IkBeNFkBcytoplasm[t]*IKK[t])
intai = cytoplasm*(-(intaid11*IkBaIKK[t]) + intaia1*IkBacytoplasm[t]*IKK[t])
intan = cytoplasm*(-(intand41*IkBaNFkBcytoplasm[t]) + intana41*IkBacytoplasm[t]*NFkBcytoplasm[t])
intann = nucleus*(-(intannd42*IkBaNFkBnucleus[t]) + intanna42*IkBanucleus[t]*NFkBnucleus[t])
intbi = cytoplasm*(-(intbid21*IkBbIKK[t]) + intbia2*IkBbcytoplasm[t]*IKK[t])
intbn = cytoplasm*(-(intbnd51*IkBbNFkBcytoplasm[t]) + intbna51*IkBbcytoplasm[t]*NFkBcytoplasm[t])
intbnn = nucleus*(-(intbnnd52*IkBbNFkBnucleus[t]) + intbnna52*IkBbnucleus[t]*NFkBnucleus[t])
intei = cytoplasm*(-(inteid31*IkBeIKK[t]) + inteia3*IkBecytoplasm[t]*IKK[t])
inten = cytoplasm*(-(intend61*IkBeNFkBcytoplasm[t]) + intena61*IkBecytoplasm[t]*NFkBcytoplasm[t])
intenn = nucleus*(-(intennd62*IkBeNFkBnucleus[t]) + intenna62*IkBenucleus[t]*NFkBnucleus[t])
itxna = itxnatr2ai*nucleus*NFkBnucleus[t]^2
loca = cytoplasm*locatp1a*IkBacytoplasm[t] - locatp2a*nucleus*IkBanucleus[t]
locan = locank2a*nucleus*IkBaNFkBnucleus[t]
locb = cytoplasm*locbtp1b*IkBbcytoplasm[t] - locbtp2b*nucleus*IkBbnucleus[t]
locbn = locbnk2b*nucleus*IkBbNFkBnucleus[t]
loce = cytoplasm*locetp1e*IkBecytoplasm[t] - locetp2e*nucleus*IkBenucleus[t]
locen = locenk2e*nucleus*IkBeNFkBnucleus[t]
locn = cytoplasm*locnk12*NFkBcytoplasm[t] - locnk11*nucleus*NFkBnucleus[t]
mdega = mdegatr3a*nucleus*IkBamRNA[t]
mdegb = mdegbtr3b*nucleus*IkBbmRNA[t]
mdege = mdegetr3e*nucleus*IkBemRNA[t]
tsla = nucleus*tslatr1a*IkBamRNA[t]
tslb = nucleus*tslbtr1b*IkBbmRNA[t]
tsle = nucleus*tsletr1e*IkBemRNA[t]
txna = nucleus*txnatr2a
txnb = nucleus*txnbtr2b
txne = nucleus*txnetr2e
end rate equations

begin parameters
txnatr2a = 0.0001848
mdegatr3a = 0.0168
tslatr1a = 0.2448
intaia1 = 1.35
intaid11 = 0.075
intana41 = 30.0
intand41 = "6e-05"
intanna42 = 30.0
intannd42 = "6e-05"
int2ania7 = 11.1
int2anid12 = 0.075
int2aina43 = 30.0
int2aind43 = "6e-05"
degadeg1c = 0.12
degandeg1n = 0.12
deganndeg4n = "6e-05"
degandeg4c = "6e-05"
degair1 = 0.072
degainr4 = 0.36
locatp1a = 0.018
locatp2a = 0.012
locank2a = 0.828
locbnk2b = 0.414
locbtp1b = 0.018
locbtp2b = 0.012
degbinr5 = 0.12
degbir2 = 0.024
degbndeg5c = "6e-05"
degbnndeg5n = "6e-05"
degbndeg2n = 0.18
degbdeg2c = 0.18
int2bina53 = 30.0
int2bind53 = "6e-05"
int2bnia8 = 2.88
int2bnid22 = 0.105
intbnna52 = 30.0
intbnnd52 = "6e-05"
intbna51 = 30.0
intbnd51 = "6e-05"
intbia2 = 0.36
intbid21 = 0.105
tslbtr1b = 0.2448
mdegbtr3b = 0.0168
txnbtr2b = "4.272e-05"
locnk12 = 5.4
locnk11 = 0.0048
txnetr2e = "3.048e-05"
mdegetr3e = 0.0168
tsletr1e = 0.2448
inteia3 = 0.54
inteid31 = 0.105
intena61 = 30.0
intend61 = "6e-05"
intenna62 = 30.0
intennd62 = "6e-05"
int2enia9 = 4.2
int2enid32 = 0.105
int2eina63 = 30.0
int2eind63 = "6e-05"
degedeg3c = 0.18
degendeg3n = 0.18
degenndeg6n = "6e-05"
degendeg6c = "6e-05"
degeir3 = 0.036
degeinr6 = 0.18
locetp1e = 0.018
locetp2e = 0.012
locenk2e = 0.414
IKKdegkIKKdeg = 0.0
itxnatr2ai = 1.98
cytoplasm = 1.0
nucleus = 1.0
end parameters

begin initial conditions
IKK[0] = IKKi
IkBaIKK[0] = IkBaIKKi
IkBaIKKNFkB[0] = IkBaIKKNFkBi
IkBaNFkBcytoplasm[0] = IkBaNFkBcytoplasmi
IkBaNFkBnucleus[0] = IkBaNFkBnucleusi
IkBacytoplasm[0] = IkBacytoplasmi
IkBamRNA[0] = IkBamRNAi
IkBanucleus[0] = IkBanucleusi
IkBbIKK[0] = IkBbIKKi
IkBbIKKNFkB[0] = IkBbIKKNFkBi
IkBbNFkBcytoplasm[0] = IkBbNFkBcytoplasmi
IkBbNFkBnucleus[0] = IkBbNFkBnucleusi
IkBbcytoplasm[0] = IkBbcytoplasmi
IkBbmRNA[0] = IkBbmRNAi
IkBbnucleus[0] = IkBbnucleusi
IkBeIKK[0] = IkBeIKKi
IkBeIKKNFkB[0] = IkBeIKKNFkBi
IkBeNFkBcytoplasm[0] = IkBeNFkBcytoplasmi
IkBeNFkBnucleus[0] = IkBeNFkBnucleusi
IkBecytoplasm[0] = IkBecytoplasmi
IkBemRNA[0] = IkBemRNAi
IkBenucleus[0] = IkBenucleusi
NFkBcytoplasm[0] = NFkBcytoplasmi
NFkBnucleus[0] = NFkBnucleusi
end initial conditions

begin initial values
IKKi = 0.001
IkBaIKKi = 0.0
IkBaIKKNFkBi = 0.0
IkBaNFkBcytoplasmi = 0.06
IkBaNFkBnucleusi = 0.0
IkBacytoplasmi = 0.0
IkBamRNAi = 0.0
IkBanucleusi = 0.0
IkBbIKKi = 0.0
IkBbIKKNFkBi = 0.0
IkBbNFkBcytoplasmi = 0.03
IkBbNFkBnucleusi = 0.0
IkBbcytoplasmi = 0.0
IkBbmRNAi = 0.0
IkBbnucleusi = 0.0
IkBeIKKi = 0.0
IkBeIKKNFkBi = 0.0
IkBeNFkBcytoplasmi = 0.01
IkBeNFkBnucleusi = 0.0
IkBecytoplasmi = 0.0
IkBemRNAi = 0.0
IkBenucleusi = 0.0
NFkBcytoplasmi = 0.0
NFkBnucleusi = 0.0
end initial values

begin assignment rules
TotalIkBeps := IkBeIKK[t] + IkBeIKKNFkB[t] + IkBeNFkBcytoplasm[t] + IkBeNFkBnucleus[t] + IkBecytoplasm[t] + IkBenucleus[t]
TotalIkBbeta := IkBbIKK[t] + IkBbIKKNFkB[t] + IkBbNFkBcytoplasm[t] + IkBbNFkBnucleus[t] + IkBbcytoplasm[t] + IkBbnucleus[t]
TotalIkBalpha := IkBaIKK[t] + IkBaIKKNFkB[t] + IkBaNFkBcytoplasm[t] + IkBaNFkBnucleus[t] + IkBacytoplasm[t] + IkBanucleus[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
deg_ai http://identifiers.org/ec-code/2.7.11.10
deg_ai http://identifiers.org/go/GO:0008384
deg_ain http://identifiers.org/ec-code/2.7.11.10
deg_ain http://identifiers.org/go/GO:0051092
deg_ain http://identifiers.org/go/GO:0008384
deg_bi http://identifiers.org/ec-code/2.7.11.10
deg_bi http://identifiers.org/go/GO:0008384
deg_bin http://identifiers.org/ec-code/2.7.11.10
deg_bin http://identifiers.org/go/GO:0051092
deg_bin http://identifiers.org/go/GO:0008384
deg_ei http://identifiers.org/ec-code/2.7.11.10
deg_ei http://identifiers.org/go/GO:0008384
deg_ein http://identifiers.org/ec-code/2.7.11.10
deg_ein http://identifiers.org/go/GO:0008384
deg_ein http://identifiers.org/go/GO:0051092
txn_a http://identifiers.org/go/GO:0006351
txn_b http://identifiers.org/go/GO:0006351
txn_e http://identifiers.org/go/GO:0006351
end process annotations

begin species annotations
end species annotations

begin units
end units