begin name
obeyesekere1
end name

begin reactions
1 {1.0}$EXTERNAL = {1.0}D1
7 {1.0}RS1 = {1.0}$EXTERNAL
cycECDK2degradation1 {1.0}E1 = {1.0}$EXTERNAL
cyclebreak1 {1.0}X1 = {1.0}$EXTERNAL
cycleprogression1 {1.0}$EXTERNAL = {1.0}X1
cyclinCDK4degradation1 {1.0}D1 = {1.0}$EXTERNAL
cyclin1 {1.0}$EXTERNAL = {1.0}E1
pRBE2Fcomplexassociation1 {1.0}R1 = {1.0}RS1
pRBE2FcomplexdeassociationviacycDCDK41 {1.0}RS1 = {1.0}$EXTERNAL
pRBpdephosphorylation1 {1.0}$EXTERNAL = {1.0}R1
end reactions

begin rate equations
1 = (aD1*GF1*k1)/(1 + GF1*k1)
7 = (pE1*E1[t]*RS1[t])/(qE1 + E1[t] + RS1[t])
cycECDK2degradation1 = dE1*E1[t]*X1[t]
cyclebreak1 = dX1*X1[t]
cycleprogression1 = E2F1*f1 + aX1*E1[t] + g1*E1[t]*X1[t]^2
cyclinCDK4degradation1 = dD1*D1[t]*E1[t]
cyclin1 = aE1*(1 + af1*E2F1)
pRBE2Fcomplexassociation1 = E2F1*pS1*R1[t]
pRBE2FcomplexdeassociationviacycDCDK41 = (pD1*D1[t]*RS1[t])/(qD1 + D1[t] + RS1[t])
pRBpdephosphorylation1 = (pX1*RP1*X1[t])/(qX1 + RP1 + X1[t])
end rate equations

begin parameters
GF1 = 6.3
RT1 = 2.5
aD1 = 0.4
aE1 = 0.16
aX1 = 0.08
af1 = 0.9
dD1 = 0.4
dE1 = 0.2
dX1 = 1.04
f1 = 0.2
g1 = 0.528
k1 = 0.05
pD1 = 0.48
pE1 = 0.096
pS1 = 0.6
pX1 = 0.48
qD1 = 0.6
qE1 = 0.6
qX1 = 0.8
theta1 = 1.5
cell1 = 1.0
end parameters

begin initial conditions
D1[0] = D1i
E1[0] = E1i
RS1[0] = RS1i
R1[0] = R1i
X1[0] = X1i
end initial conditions

begin initial values
D1i = 0.1
E1i = 0.6
RS1i = 1.0
R1i = 0.5
X1i = 0.7
end initial values

begin assignment rules
RP1 := RT1 - RS1[t] - R1[t]
E2F1 := theta1 - RS1[t]
unphoRB := RS1[t] + R1[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units