begin name
novak1
end name

begin reactions
R1 {1.0}$EXTERNAL = {1.0}cyclin
R10 {1.0}pdimer = {1.0}$EXTERNAL
R11 {1.0}pdimerp = {1.0}pdimer
R12 {1.0}dimerp = {1.0}pdimerp
R13 {1.0}pdimerp = {1.0}dimerp
R14 {1.0}pdimerp = {1.0}$EXTERNAL
R15 {1.0}dimerp = {1.0}$EXTERNAL
R17 {1.0}$EXTERNAL = {1.0}cdc25p
R18 {1.0}cdc25p = {1.0}$EXTERNAL
R19 {1.0}$EXTERNAL = {1.0}wee1p
R2 {1.0}cyclin = {1.0}$EXTERNAL
R20 {1.0}wee1p = {1.0}$EXTERNAL
R21 {1.0}$EXTERNAL = {1.0}IEp
R22 {1.0}IEp = {1.0}$EXTERNAL
R23 {1.0}$EXTERNAL = {1.0}UbEstar
R24 {1.0}UbEstar = {1.0}$EXTERNAL
R3 {1.0}cyclin = {1.0}dimer
R4 {1.0}dimerp = {1.0}dimer
R5 {1.0}dimer = {1.0}pdimer
R6 {1.0}dimer = {1.0}dimerp
R7 {1.0}dimer = {1.0}$EXTERNAL
R8 {1.0}pdimer = {1.0}dimer
R9 {1.0}pdimer = {1.0}pdimerp
end reactions

begin rate equations
R1 = k1AA
R10 = k2*pdimer[t]
R11 = kinh*pdimerp[t]
R12 = kwee*dimerp[t]
R13 = k25*pdimerp[t]
R14 = k2*pdimerp[t]
R15 = k2*dimerp[t]
R17 = (ka*(totalcdc25 - cdc25p[t])*dimerp[t])/(Ka + totalcdc25 - cdc25p[t])
R18 = (kbPPase*cdc25p[t])/(Kb + cdc25p[t])
R19 = (ke*dimerp[t]*(totalwee1 - wee1p[t]))/(Ke + totalwee1 - wee1p[t])
R2 = k2*cyclin[t]
R20 = (kfPPase*wee1p[t])/(Kf + wee1p[t])
R21 = (kg*dimerp[t]*(totalIE - IEp[t]))/(Kg + totalIE - IEp[t])
R22 = (khPPAse*IEp[t])/(Kh + IEp[t])
R23 = (kc*IEp[t]*(totalUbE - UbEstar[t]))/(Kc + totalUbE - UbEstar[t])
R24 = (kdantiIE*UbEstar[t])/(Kd + UbEstar[t])
R3 = cdc2*k3*cyclin[t]
R4 = kinh*dimerp[t]
R5 = kwee*dimer[t]
R6 = kcak*dimer[t]
R7 = k2*dimer[t]
R8 = k25*pdimer[t]
R9 = kcak*pdimer[t]
end rate equations

begin parameters
Ka = 0.1
Kb = 0.1
Kc = 0.01
Kd = 0.01
Ke = 0.3
Kf = 0.3
Kg = 0.01
Kh = 0.01
V25doubleprime = 2.0
V25prime = 0.1
V2doubleprime = 1.0
V2prime = 0.015
Vweedoubleprime = 1.0
Vweeprime = 0.1
k1AA = 1.0
k3 = 0.01
ka = 0.01
kbPPase = 0.125
kc = 0.1
kcak = 0.25
kdantiIE = 0.095
ke = 0.0133
kfPPase = 0.1
kg = 0.0065
khPPAse = 0.087
kinh = 0.025
totalIE = 1.0
totalUbE = 1.0
totalcdc2 = 100.0
totalcdc25 = 1.0
totalwee1 = 1.0
cytoplasm = 1.0
end parameters

begin initial conditions
IEp[0] = IEpi
UbEstar[0] = UbEstari
cdc25p[0] = cdc25pi
cyclin[0] = cyclini
dimer[0] = dimeri
dimerp[0] = dimerpi
pdimer[0] = pdimeri
pdimerp[0] = pdimerpi
wee1p[0] = wee1pi
end initial conditions

begin initial values
IEpi = 0.0
UbEstari = 0.0
cdc25pi = 0.0
cyclini = 100.0
dimeri = 0.0
dimerpi = 0.0
pdimeri = 0.0
pdimerpi = 0.0
wee1pi = 0.0
end initial values

begin assignment rules
wee1 := totalwee1 - wee1p[t]
cdc25 := totalcdc25 - cdc25p[t]
cdc2 := totalcdc2 - dimer[t] - dimerp[t] - pdimer[t] - pdimerp[t]
UbE := totalUbE - UbEstar[t]
IE := totalIE - IEp[t]
k2 := V2prime*(totalUbE - UbEstar[t]) + V2doubleprime*UbEstar[t]
kwee := Vweedoubleprime*(totalwee1 - wee1p[t]) + Vweeprime*wee1p[t]
Y15P := pdimer[t] + pdimerp[t]
totalcyclin := cyclin[t] + dimer[t] + dimerp[t] + pdimer[t] + pdimerp[t]
k25 := V25prime*(totalcdc25 - cdc25p[t]) + V25doubleprime*cdc25p[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
R19 http://identifiers.org/ec-code/2.7.11.22
R19 http://identifiers.org/go/GO:0044257
R21 http://identifiers.org/ec-code/2.7.11.22
end process annotations

begin species annotations
cyclin http://identifiers.org/interpro/IPR015454
end species annotations

begin units
end units