#nishio1

FIX: ATP Glc6P Glucose PEP Pyr crp crp_basal crr cyaA cyaA_basal mlcp1 mlcp2 ptsGp1 ptsGp2 ptsHp0 ptsHp1 ptsIp0 ptsIp1

#reactions
PTS2for:
 {1.0}HPr + {1.0}EI_P = {1.0}HPr_P + {1.0}EI
  cyt * kx * HPr * EI_P
PTS2rev:
 {1.0}HPr_P + {1.0}EI = {1.0}HPr + {1.0}EI_P
  cyt * kx * EI * HPr_P
PTS3for:
 {1.0}IIA + {1.0}HPr_P = {1.0}IIA_P + {1.0}HPr
  cyt * kx * IIA * HPr_P
PTS3rev:
 {1.0}IIA_P + {1.0}HPr = {1.0}IIA + {1.0}HPr_P
  cyt * kx * HPr * IIA_P
PTS4for:
 {1.0}IICB + {1.0}IIA_P = {1.0}IICB_P + {1.0}IIA
  cyt * kx * IICB * IIA_P
PTS4rev:
 {1.0}IICB_P + {1.0}IIA = {1.0}IICB + {1.0}IIA_P
  cyt * kx * IIA * IICB_P
binding_CRP_cAMP:
 {1.0}CRP + {1.0}cAMP = {1.0}CRP_cAMP
  cyt * fast * one_per_M * (pow(Kb, 2) * pow(CRP * cAMP, 2) - pow(CRP_cAMP, 2))
binding_CRP_cAMP_CRPsiteII_crp:
 {1.0}CRP_cAMP + {1.0}CRPsiteII_crp = {1.0}CRP_cAMP_CRPsiteII_crp
  cyt * fast * (Kb * CRP_cAMP * CRPsiteII_crp - CRP_cAMP_CRPsiteII_crp)
binding_CRP_cAMP_CRPsiteI_crp:
 {1.0}CRP_cAMP + {1.0}CRPsiteI_crp = {1.0}CRP_cAMP_CRPsiteI_crp
  cyt * fast * (Kb * CRP_cAMP * CRPsiteI_crp - CRP_cAMP_CRPsiteI_crp)
binding_CRP_cAMP_CRPsite_cyaA:
 {1.0}CRP_cAMP + {1.0}CRPsite_cyaA = {1.0}CRP_cAMP_CRPsite_cyaA
  cyt * fast * (Kb * CRP_cAMP * CRPsite_cyaA - CRP_cAMP_CRPsite_cyaA)
binding_CRP_cAMP_CRPsite_genome:
 {1.0}CRP_cAMP + {1.0}CRPsite_genome = {1.0}CRP_cAMP_CRPsite_genome
  cyt * fast * (Kb * CRP_cAMP * CRPsite_genome - CRP_cAMP_CRPsite_genome)
binding_CRP_cAMP_CRPsite_mlcp1:
 {1.0}CRP_cAMP + {1.0}CRPsite_mlcp1 = {1.0}CRP_cAMP_CRPsite_mlcp1
  cyt * fast * (Kb * CRP_cAMP * CRPsite_mlcp1 - CRP_cAMP_CRPsite_mlcp1)
binding_CRP_cAMP_CRPsite_mlcp2:
 {1.0}CRP_cAMP + {1.0}CRPsite_mlcp2 = {1.0}CRP_cAMP_CRPsite_mlcp2
  cyt * fast * (Kb * CRP_cAMP * CRPsite_mlcp2 - CRP_cAMP_CRPsite_mlcp2)
binding_CRP_cAMP_CRPsite_ptsGp1:
 {1.0}CRP_cAMP + {1.0}CRPsite_ptsGp1 = {1.0}CRP_cAMP_CRPsite_ptsGp1
  cyt * fast * (Kb * CRP_cAMP * CRPsite_ptsGp1 - CRP_cAMP_CRPsite_ptsGp1)
binding_CRP_cAMP_CRPsite_ptsGp2:
 {1.0}CRP_cAMP + {1.0}CRPsite_ptsGp2 = {1.0}CRP_cAMP_CRPsite_ptsGp2
  cyt * fast * (Kb * CRP_cAMP * CRPsite_ptsGp2 - CRP_cAMP_CRPsite_ptsGp2)
binding_CRP_cAMP_CRPsite_ptsHp0:
 {1.0}CRP_cAMP + {1.0}CRPsite_ptsHp0 = {1.0}CRP_cAMP_CRPsite_ptsHp0
  cyt * fast * (Kb * CRP_cAMP * CRPsite_ptsHp0 - CRP_cAMP_CRPsite_ptsHp0)
binding_CRP_cAMP_CRPsite_ptsHp1:
 {1.0}CRP_cAMP + {1.0}CRPsite_ptsHp1 = {1.0}CRP_cAMP_CRPsite_ptsHp1
  cyt * fast * (Kb * CRP_cAMP * CRPsite_ptsHp1 - CRP_cAMP_CRPsite_ptsHp1)
binding_CRP_cAMP_CRPsite_ptsIp0:
 {1.0}CRP_cAMP + {1.0}CRPsite_ptsIp0 = {1.0}CRP_cAMP_CRPsite_ptsIp0
  cyt * fast * (Kb * CRP_cAMP * CRPsite_ptsIp0 - CRP_cAMP_CRPsite_ptsIp0)
binding_CRP_cAMP_CRPsite_ptsIp1:
 {1.0}CRP_cAMP + {1.0}CRPsite_ptsIp1 = {1.0}CRP_cAMP_CRPsite_ptsIp1
  cyt * fast * (Kb * CRP_cAMP * CRPsite_ptsIp1 - CRP_cAMP_CRPsite_ptsIp1)
binding_IIA_P_CYA:
 {1.0}CYA + {1.0}IIA_P = {1.0}IIA_P_CYA
  cyt * fast * (Kb * CYA * pow(IIA_P, 2) - IIA_P_CYA)
binding_IICB_Mlc:
 {1.0}IICB + {1.0}Mlc = {1.0}IICB_Mlc
  cyt * fast * (Kb * IICB * Mlc - IICB_Mlc)
binding_Mlc_Mlcsite_mlcp1:
 {1.0}Mlc + {1.0}Mlcsite_mlcp1 = {1.0}Mlc_Mlcsite_mlcp1
  cyt * fast * (Kb * Mlc * Mlcsite_mlcp1 - Mlc_Mlcsite_mlcp1)
binding_Mlc_Mlcsite_mlcp2:
 {1.0}Mlc + {1.0}Mlcsite_mlcp2 = {1.0}Mlc_Mlcsite_mlcp2
  cyt * fast * (Kb * Mlc * Mlcsite_mlcp2 - Mlc_Mlcsite_mlcp2)
binding_Mlc_Mlcsite_ptsGp1:
 {1.0}Mlc + {1.0}Mlcsite_ptsGp1 = {1.0}Mlc_Mlcsite_ptsGp1
  cyt * fast * (Kb * Mlc * Mlcsite_ptsGp1 - Mlc_Mlcsite_ptsGp1)
binding_Mlc_Mlcsite_ptsGp2:
 {1.0}Mlc + {1.0}Mlcsite_ptsGp2 = {1.0}Mlc_Mlcsite_ptsGp2
  cyt * fast * (Kb * Mlc * Mlcsite_ptsGp2 - Mlc_Mlcsite_ptsGp2)
binding_Mlc_Mlcsite_ptsHp0:
 {1.0}Mlc + {1.0}Mlcsite_ptsHp0 = {1.0}Mlc_Mlcsite_ptsHp0
  cyt * fast * (Kb * Mlc * Mlcsite_ptsHp0 - Mlc_Mlcsite_ptsHp0)
binding_Mlc_Mlcsite_ptsIp0:
 {1.0}Mlc + {1.0}Mlcsite_ptsIp0 = {1.0}Mlc_Mlcsite_ptsIp0
  cyt * fast * (Kb * Mlc * Mlcsite_ptsIp0 - Mlc_Mlcsite_ptsIp0)
decomposition_CRP:
 {1.0}CRP = $pool
  cyt * kpd * CRP
decomposition_CRP_cAMP:
 {1.0}CRP_cAMP = $pool
  cyt * kpd * CRP_cAMP
decomposition_CRP_cAMP_CRPsiteII_crp:
 {1.0}CRP_cAMP_CRPsiteII_crp = {1.0}CRPsiteII_crp
  cyt * kpd * CRP_cAMP_CRPsiteII_crp
decomposition_CRP_cAMP_CRPsiteI_crp:
 {1.0}CRP_cAMP_CRPsiteI_crp = {1.0}CRPsiteI_crp
  cyt * kpd * CRP_cAMP_CRPsiteI_crp
decomposition_CRP_cAMP_CRPsite_cyaA:
 {1.0}CRP_cAMP_CRPsite_cyaA = {1.0}CRPsite_cyaA
  cyt * kpd * CRP_cAMP_CRPsite_cyaA
decomposition_CRP_cAMP_CRPsite_genome:
 {1.0}CRP_cAMP_CRPsite_genome = {1.0}CRPsite_genome
  cyt * kpd * CRP_cAMP_CRPsite_genome
decomposition_CRP_cAMP_CRPsite_mlcp1:
 {1.0}CRP_cAMP_CRPsite_mlcp1 = {1.0}CRPsite_mlcp1
  cyt * kpd * CRP_cAMP_CRPsite_mlcp1
decomposition_CRP_cAMP_CRPsite_mlcp2:
 {1.0}CRP_cAMP_CRPsite_mlcp2 = {1.0}CRPsite_mlcp2
  cyt * kpd * CRP_cAMP_CRPsite_mlcp2
decomposition_CRP_cAMP_CRPsite_ptsGp1:
 {1.0}CRP_cAMP_CRPsite_ptsGp1 = {1.0}CRPsite_ptsGp1
  cyt * kpd * CRP_cAMP_CRPsite_ptsGp1
decomposition_CRP_cAMP_CRPsite_ptsGp2:
 {1.0}CRP_cAMP_CRPsite_ptsGp2 = {1.0}CRPsite_ptsGp2
  cyt * kpd * CRP_cAMP_CRPsite_ptsGp2
decomposition_CRP_cAMP_CRPsite_ptsHp0:
 {1.0}CRP_cAMP_CRPsite_ptsHp0 = {1.0}CRPsite_ptsHp0
  cyt * kpd * CRP_cAMP_CRPsite_ptsHp0
decomposition_CRP_cAMP_CRPsite_ptsHp1:
 {1.0}CRP_cAMP_CRPsite_ptsHp1 = {1.0}CRPsite_ptsHp1
  cyt * kpd * CRP_cAMP_CRPsite_ptsHp1
decomposition_CRP_cAMP_CRPsite_ptsIp0:
 {1.0}CRP_cAMP_CRPsite_ptsIp0 = {1.0}CRPsite_ptsIp0
  cyt * kpd * CRP_cAMP_CRPsite_ptsIp0
decomposition_CRP_cAMP_CRPsite_ptsIp1:
 {1.0}CRP_cAMP_CRPsite_ptsIp1 = {1.0}CRPsite_ptsIp1
  cyt * kpd * CRP_cAMP_CRPsite_ptsIp1
decomposition_CYA:
 {1.0}CYA = $pool
  cyt * kpd * CYA
decomposition_EI:
 {1.0}EI = $pool
  cyt * kpd * EI
decomposition_EI_P:
 {1.0}EI_P = $pool
  cyt * kpd * EI_P
decomposition_HPr:
 {1.0}HPr = $pool
  cyt * kpd * HPr
decomposition_HPr_P:
 {1.0}HPr_P = $pool
  cyt * kpd * HPr_P
decomposition_IIA:
 {1.0}IIA = $pool
  cyt * kpd * IIA
decomposition_IIA_P:
 {1.0}IIA_P = $pool
  cyt * kpd * IIA_P
decomposition_IICB:
 {1.0}IICB = $pool
  cyt * kpd * IICB
decomposition_IICB_Mlc:
 {1.0}IICB_Mlc = $pool
  cyt * kpd * IICB_Mlc
decomposition_IICB_P:
 {1.0}IICB_P = $pool
  cyt * kpd * IICB_P
decomposition_Mlc:
 {1.0}Mlc = $pool
  cyt * kpd * Mlc
decomposition_Mlc_Mlcsite_mlcp1:
 {1.0}Mlc_Mlcsite_mlcp1 = {1.0}Mlcsite_mlcp1
  cyt * kpd * Mlc_Mlcsite_mlcp1
decomposition_Mlc_Mlcsite_mlcp2:
 {1.0}Mlc_Mlcsite_mlcp2 = {1.0}Mlcsite_mlcp2
  cyt * kpd * Mlc_Mlcsite_mlcp2
decomposition_Mlc_Mlcsite_ptsGp1:
 {1.0}Mlc_Mlcsite_ptsGp1 = {1.0}Mlcsite_ptsGp1
  cyt * kpd * Mlc_Mlcsite_ptsGp1
decomposition_Mlc_Mlcsite_ptsGp2:
 {1.0}Mlc_Mlcsite_ptsGp2 = {1.0}Mlcsite_ptsGp2
  cyt * kpd * Mlc_Mlcsite_ptsGp2
decomposition_Mlc_Mlcsite_ptsHp0:
 {1.0}Mlc_Mlcsite_ptsHp0 = {1.0}Mlcsite_ptsHp0
  cyt * kpd * Mlc_Mlcsite_ptsHp0
decomposition_Mlc_Mlcsite_ptsIp0:
 {1.0}Mlc_Mlcsite_ptsIp0 = {1.0}Mlcsite_ptsIp0
  cyt * kpd * Mlc_Mlcsite_ptsIp0
decomposition_cAMP:
 {1.0}cAMP = $pool
  cyt * kpd * cAMP
decomposition_mRNA_crp:
 {1.0}mRNA_crp = $pool
  cyt * kmd * mRNA_crp
decomposition_mRNA_crr:
 {1.0}mRNA_crr = $pool
  cyt * kmd * mRNA_crr
decomposition_mRNA_cyaA:
 {1.0}mRNA_cyaA = $pool
  cyt * kmd * mRNA_cyaA
decomposition_mRNA_mlc:
 {1.0}mRNA_mlc = $pool
  cyt * kmd * mRNA_mlc
decomposition_mRNA_ptsG:
 {1.0}mRNA_ptsG = $pool
  cyt * kmd * mRNA_ptsG
decomposition_mRNA_ptsH:
 {1.0}mRNA_ptsH = $pool
  cyt * kmd * mRNA_ptsH
decomposition_mRNA_ptsI:
 {1.0}mRNA_ptsI = $pool
  cyt * kmd * mRNA_ptsI
reaction_CYA_ATP:
 {1.0}ATP = {1.0}cAMP
  cyt * (Q * CYA * ATP / (Kmich + ATP))
reaction_EIP_Pyr:
 {1.0}EI_P + {1.0}Pyr = {1.0}EI + {1.0}PEP
  cyt * (2 * Q * EI_P * pow(Pyr, 2) / (pow(Kmich, 2) + pow(Pyr, 2)))
reaction_EI_PEP:
 {1.0}EI + {1.0}PEP = {1.0}EI_P + {1.0}Pyr
  cyt * (2 * Q * EI * pow(PEP, 2) / (pow(Kmich, 2) + pow(PEP, 2)))
reaction_IIA_P_CYA_ATP:
 {1.0}ATP = {1.0}cAMP
  cyt * (Q * IIA_P_CYA * ATP / (Kmich + ATP))
reaction_IICB_Glc6P:
 {1.0}IICB + {1.0}Glc6P = {1.0}IICB_P + {1.0}Glucose
  cyt * (Q * IICB * Glc6P / (Kmich + Glc6P))
reaction_IICB_P_Glucose:
 {1.0}IICB_P + {1.0}Glucose = {1.0}IICB + {1.0}Glc6P
  cyt * (Q * IICB_P * Glucose / (Kmich + Glucose))
transcription_CRP_cAMP_CRPsiteI_crp_CRP_cAMP_CRPsiteII_crp_crp:
 $pool = {1.0}mRNA_crp
  cyt * km * (1 + RelativeactivityatTCRPsiteII_crp * CRP_cAMP_CRPsiteII_crp / TCRPsiteII_crp - CRP_cAMP_CRPsiteI_crp / TCRPsiteI_crp) * crp
transcription_CRP_cAMP_CRPsite_cyaA_cyaA:
 $pool = {1.0}mRNA_cyaA
  cyt * km * (1 - CRP_cAMP_CRPsite_cyaA / TCRPsite_cyaA) * cyaA
transcription_CRP_cAMP_CRPsite_mlcp1_Mlc_Mlcsite_mlcp1_mlcp1:
 $pool = {1.0}mRNA_mlc
  cyt * km * (1 - CRP_cAMP_CRPsite_mlcp1 / TCRPsite_mlcp1) * (1 - Mlc_Mlcsite_mlcp1 / TMlcsite_mlcp1) * mlcp1
transcription_CRP_cAMP_CRPsite_mlcp2_Mlc_Mlcsite_mlcp2_mlcp2:
 $pool = {1.0}mRNA_mlc
  cyt * km * (CRP_cAMP_CRPsite_mlcp2 / TCRPsite_mlcp2) * (1 - Mlc_Mlcsite_mlcp2 / TMlcsite_mlcp2) * mlcp2
transcription_CRP_cAMP_CRPsite_ptsGp1_Mlc_Mlcsite_ptsGp1_ptsGp1:
 $pool = {1.0}mRNA_ptsG
  cyt * km * (CRP_cAMP_CRPsite_ptsGp1 / TCRPsite_ptsGp1) * (1 - Mlc_Mlcsite_ptsGp1 / TMlcsite_ptsGp1) * ptsGp1
transcription_CRP_cAMP_CRPsite_ptsGp2_Mlc_Mlcsite_ptsGp2_ptsGp2:
 $pool = {1.0}mRNA_ptsG
  cyt * km * (CRP_cAMP_CRPsite_ptsGp2 / TCRPsite_ptsGp2) * (1 - Mlc_Mlcsite_ptsGp2 / TMlcsite_ptsGp2) * ptsGp2
transcription_CRP_cAMP_CRPsite_ptsHp0_Mlc_Mlcsite_ptsHp0_ptsHp0:
 $pool = {1.0}mRNA_ptsH
  cyt * km * (CRP_cAMP_CRPsite_ptsHp0 / TCRPsite_ptsHp0) * (1 - Mlc_Mlcsite_ptsHp0 / TMlcsite_ptsHp0) * ptsHp0
transcription_CRP_cAMP_CRPsite_ptsHp1_ptsHp1:
 $pool = {1.0}mRNA_ptsH
  cyt * km * (CRP_cAMP_CRPsite_ptsHp1 / TCRPsite_ptsHp1) * ptsHp1
transcription_CRP_cAMP_CRPsite_ptsIp0_Mlc_Mlcsite_ptsIp0_ptsIp0:
 $pool = {1.0}mRNA_ptsI
  cyt * km * (CRP_cAMP_CRPsite_ptsIp0 / TCRPsite_ptsIp0) * (1 - Mlc_Mlcsite_ptsIp0 / TMlcsite_ptsIp0) * ptsIp0
transcription_CRP_cAMP_CRPsite_ptsIp1_ptsIp1:
 $pool = {1.0}mRNA_ptsI
  cyt * km * (CRP_cAMP_CRPsite_ptsIp1 / TCRPsite_ptsIp1) * ptsIp1
transcription_crp_basal:
 $pool = {1.0}mRNA_crp
  cyt * km * crp_basal
transcription_crr:
 $pool = {1.0}mRNA_crr
  cyt * km * crr
transcription_cyaA_basal:
 $pool = {1.0}mRNA_cyaA
  cyt * km * cyaA_basal
translation_mRNA_crp:
 $pool = {1.0}CRP
  cyt * kp * mRNA_crp
translation_mRNA_crr:
 $pool = {1.0}IIA
  cyt * kp * mRNA_crr
translation_mRNA_cyaA:
 $pool = {1.0}CYA
  cyt * kp * mRNA_cyaA
translation_mRNA_ptsG:
 $pool = {1.0}IICB
  cyt * kp * mRNA_ptsG
translation_mRNA_ptsH:
 $pool = {1.0}HPr
  cyt * kp * mRNA_ptsH
translation_mRNA_ptsI:
 $pool = {1.0}EI
  cyt * kp * mRNA_ptsI
translation_mlc:
 $pool = {1.0}Mlc
  cyt * kp * mRNA_mlc


#parameters
fast = 1000000000.0
ATP = 0.0069942
Glc6P = 0.00148
Glucose = 0.2
PEP = 0.00267
Pyr = 0.00267
crp = 2.43e-10
crp_basal = 2.43e-10
crr = 2.43e-10
cyaA = 2.43e-10
cyaA_basal = 2.43e-10
mlcp1 = 2.43e-10
mlcp2 = 2.43e-10
ptsGp1 = 2.43e-10
ptsGp2 = 2.43e-10
ptsHp0 = 2.43e-10
ptsHp1 = 2.43e-10
ptsIp0 = 2.43e-10
ptsIp1 = 2.43e-10
binding_CRP_cAMP_Kb = 40000.0
binding_CRP_cAMP_one_per_M = 1.0
binding_CRP_cAMP_CRPsite_cyaA_Kb = 66700000.0
binding_CRP_cAMP_CRPsiteI_crp_Kb = 22200000.0
binding_CRP_cAMP_CRPsiteII_crp_Kb = 2700000.0
binding_CRP_cAMP_CRPsite_ptsGp1_Kb = 10000000.0
binding_CRP_cAMP_CRPsite_ptsGp2_Kb = 10000000.0
binding_CRP_cAMP_CRPsite_ptsHp0_Kb = 10000000.0
binding_CRP_cAMP_CRPsite_ptsHp1_Kb = 10000000.0
binding_CRP_cAMP_CRPsite_ptsIp0_Kb = 10000000.0
binding_CRP_cAMP_CRPsite_ptsIp1_Kb = 10000000.0
binding_CRP_cAMP_CRPsite_mlcp1_Kb = 10000000.0
binding_CRP_cAMP_CRPsite_mlcp2_Kb = 10000000.0
binding_CRP_cAMP_CRPsite_genome_Kb = 10000000.0
binding_Mlc_Mlcsite_ptsGp1_Kb = 200000000.0
binding_Mlc_Mlcsite_ptsGp2_Kb = 200000000.0
binding_Mlc_Mlcsite_ptsHp0_Kb = 200000000.0
binding_Mlc_Mlcsite_ptsIp0_Kb = 200000000.0
binding_Mlc_Mlcsite_mlcp1_Kb = 2430000.0
binding_Mlc_Mlcsite_mlcp2_Kb = 1350000.0
binding_IICB_Mlc_Kb = 7000000.0
binding_IIA_P_CYA_Kb = 100000000.0
transcription_CRP_cAMP_CRPsite_cyaA_cyaA_km = 45.26
transcription_cyaA_basal_km = 1.281
transcription_CRP_cAMP_CRPsiteI_crp_CRP_cAMP_CRPsiteII_crp_crp_km = 20.0
transcription_CRP_cAMP_CRPsiteI_crp_CRP_cAMP_CRPsiteII_crp_crp_RelativeactivityatTCRPsiteII_crp = 5.0
transcription_crp_basal_km = 1.00886
transcription_CRP_cAMP_CRPsite_ptsGp1_Mlc_Mlcsite_ptsGp1_ptsGp1_km = 892.0
transcription_CRP_cAMP_CRPsite_ptsGp2_Mlc_Mlcsite_ptsGp2_ptsGp2_km = 2.0
transcription_CRP_cAMP_CRPsite_ptsHp0_Mlc_Mlcsite_ptsHp0_ptsHp0_km = 71.8
transcription_CRP_cAMP_CRPsite_ptsHp1_ptsHp1_km = 17.95
transcription_CRP_cAMP_CRPsite_ptsIp0_Mlc_Mlcsite_ptsIp0_ptsIp0_km = 6.244
transcription_CRP_cAMP_CRPsite_ptsIp1_ptsIp1_km = 0.892
transcription_crr_km = 334.5
transcription_CRP_cAMP_CRPsite_mlcp1_Mlc_Mlcsite_mlcp1_mlcp1_km = 1.875
transcription_CRP_cAMP_CRPsite_mlcp2_Mlc_Mlcsite_mlcp2_mlcp2_km = 1.875
decomposition_mRNA_cyaA_kmd = 0.126
decomposition_mRNA_crp_kmd = 0.139
decomposition_mRNA_ptsG_kmd = 0.217
decomposition_mRNA_ptsH_kmd = 0.0889
decomposition_mRNA_ptsI_kmd = 0.0797
decomposition_mRNA_crr_kmd = 0.0866
decomposition_mRNA_mlc_kmd = 0.3014
translation_mRNA_cyaA_kp = 11.0
translation_mRNA_crp_kp = 11.0
translation_mRNA_ptsG_kp = 11.0
translation_mRNA_ptsH_kp = 11.0
translation_mRNA_ptsI_kp = 11.0
translation_mRNA_crr_kp = 11.0
translation_mlc_kp = 11.0
decomposition_CYA_kpd = 0.1
decomposition_CRP_kpd = 0.1
decomposition_Mlc_kpd = 0.1
decomposition_cAMP_kpd = 400.0
decomposition_CRP_cAMP_kpd = 0.1
decomposition_CRP_cAMP_CRPsite_cyaA_kpd = 0.1
decomposition_CRP_cAMP_CRPsiteI_crp_kpd = 0.1
decomposition_CRP_cAMP_CRPsiteII_crp_kpd = 0.1
decomposition_CRP_cAMP_CRPsite_ptsGp1_kpd = 0.1
decomposition_CRP_cAMP_CRPsite_ptsGp2_kpd = 0.1
decomposition_CRP_cAMP_CRPsite_ptsHp0_kpd = 0.1
decomposition_CRP_cAMP_CRPsite_ptsHp1_kpd = 0.1
decomposition_CRP_cAMP_CRPsite_ptsIp0_kpd = 0.1
decomposition_CRP_cAMP_CRPsite_ptsIp1_kpd = 0.1
decomposition_CRP_cAMP_CRPsite_mlcp1_kpd = 0.1
decomposition_CRP_cAMP_CRPsite_mlcp2_kpd = 0.1
decomposition_CRP_cAMP_CRPsite_genome_kpd = 0.1
decomposition_Mlc_Mlcsite_ptsGp1_kpd = 0.1
decomposition_Mlc_Mlcsite_ptsGp2_kpd = 0.1
decomposition_Mlc_Mlcsite_ptsHp0_kpd = 0.1
decomposition_Mlc_Mlcsite_ptsIp0_kpd = 0.1
decomposition_Mlc_Mlcsite_mlcp1_kpd = 0.1
decomposition_Mlc_Mlcsite_mlcp2_kpd = 0.1
decomposition_IICB_Mlc_kpd = 0.1
decomposition_EI_P_kpd = 0.1
decomposition_EI_kpd = 0.1
decomposition_HPr_P_kpd = 0.1
decomposition_HPr_kpd = 0.1
decomposition_IIA_P_kpd = 0.1
decomposition_IIA_kpd = 0.1
decomposition_IICB_P_kpd = 0.1
decomposition_IICB_kpd = 0.1
PTS2for_kx = 12000000000.0
PTS2rev_kx = 480000000.0
PTS3for_kx = 3660000000.0
PTS3rev_kx = 2820000000.0
PTS4for_kx = 660000000.0
PTS4rev_kx = 240000000.0
reaction_CYA_ATP_Kmich = 0.001
reaction_CYA_ATP_Q = 100.0
reaction_IIA_P_CYA_ATP_Kmich = 0.001
reaction_IIA_P_CYA_ATP_Q = 9000.0
reaction_EI_PEP_Kmich = 0.0003
reaction_EI_PEP_Q = 108000.0
reaction_EIP_Pyr_Kmich = 0.002
reaction_EIP_Pyr_Q = 480000.0
reaction_IICB_P_Glucose_Kmich = 2e-05
reaction_IICB_P_Glucose_Q = 4800.0
reaction_IICB_Glc6P_Kmich = 9.61
reaction_IICB_Glc6P_Q = 389.0
cyt = 1.0


#initial values
CRP = 5.4207e-06
CRP_cAMP = 1.0214e-07
CRP_cAMP_CRPsiteII_crp = 5.2529e-11
CRP_cAMP_CRPsiteI_crp = 1.6863e-10
CRP_cAMP_CRPsite_cyaA = 2.119e-10
CRP_cAMP_CRPsite_genome = 3.7544e-09
CRP_cAMP_CRPsite_mlcp1 = 1.2279e-10
CRP_cAMP_CRPsite_mlcp2 = 1.2279e-10
CRP_cAMP_CRPsite_ptsGp1 = 1.2279e-10
CRP_cAMP_CRPsite_ptsGp2 = 1.2279e-10
CRP_cAMP_CRPsite_ptsHp0 = 1.2279e-10
CRP_cAMP_CRPsite_ptsHp1 = 1.2279e-10
CRP_cAMP_CRPsite_ptsIp0 = 1.2279e-10
CRP_cAMP_CRPsite_ptsIp1 = 1.2279e-10
CRPsiteII_crp = 1.9047e-10
CRPsiteI_crp = 7.4368e-11
CRPsite_cyaA = 3.1103e-11
CRPsite_genome = 3.6756e-09
CRPsite_mlcp1 = 1.2021e-10
CRPsite_mlcp2 = 1.2021e-10
CRPsite_ptsGp1 = 1.2021e-10
CRPsite_ptsGp2 = 1.2021e-10
CRPsite_ptsHp0 = 1.2021e-10
CRPsite_ptsHp1 = 1.2021e-10
CRPsite_ptsIp0 = 1.2021e-10
CRPsite_ptsIp1 = 1.2021e-10
CYA = 1.4934e-06
EI = 8.6098e-07
EI_P = 2.4319e-07
HPr = 1.1793e-05
HPr_P = 7.5867e-07
IIA = 9.623e-05
IIA_P = 7.0094e-06
IIA_P_CYA = 7.3371e-09
IICB = 4.2844e-05
IICB_Mlc = 1.6546e-07
IICB_P = 7.1055e-06
Mlc = 5.5172e-10
Mlc_Mlcsite_mlcp1 = 3.2535e-13
Mlc_Mlcsite_mlcp2 = 1.8086e-13
Mlc_Mlcsite_ptsGp1 = 2.4149e-11
Mlc_Mlcsite_ptsGp2 = 2.4149e-11
Mlc_Mlcsite_ptsHp0 = 2.4149e-11
Mlc_Mlcsite_ptsIp0 = 2.4149e-11
Mlcsite_mlcp1 = 2.4267e-10
Mlcsite_mlcp2 = 2.4282e-10
Mlcsite_ptsGp1 = 2.1885e-10
Mlcsite_ptsGp2 = 2.1885e-10
Mlcsite_ptsHp0 = 2.1885e-10
Mlcsite_ptsIp0 = 2.1885e-10
cAMP = 4.7107e-07
mRNA_crp = 5.0254e-08
mRNA_crr = 9.3861e-07
mRNA_cyaA = 1.3643e-08
mRNA_mlc = 1.5101e-09
mRNA_ptsG = 4.5559e-07
mRNA_ptsH = 1.1411e-07
mRNA_ptsI = 1.0038e-08


#assignment rules
!F TMlcsite_ptsIp0 = Mlcsite_ptsIp0 + Mlc_Mlcsite_ptsIp0
!F TCRPsite_cyaA = CRPsite_cyaA + CRP_cAMP_CRPsite_cyaA
!F TCRPsiteII_crp = CRPsiteII_crp + CRP_cAMP_CRPsiteII_crp
!F TCRPsite_ptsGp2 = CRPsite_ptsGp2 + CRP_cAMP_CRPsite_ptsGp2
!F TMlcsite_ptsGp2 = Mlcsite_ptsGp2 + Mlc_Mlcsite_ptsGp2
!F TCRPsite_ptsHp0 = CRPsite_ptsHp0 + CRP_cAMP_CRPsite_ptsHp0
!F TMlcsite_ptsHp0 = Mlcsite_ptsHp0 + Mlc_Mlcsite_ptsHp0
!F TCRPsite_ptsHp1 = CRPsite_ptsHp1 + CRP_cAMP_CRPsite_ptsHp1
!F TCRPsite_ptsIp0 = CRPsite_ptsIp0 + CRP_cAMP_CRPsite_ptsIp0
!F TCRPsite_ptsIp1 = CRPsite_ptsIp1 + CRP_cAMP_CRPsite_ptsIp1
!F TMlcsite_mlcp1 = Mlcsite_mlcp1 + Mlc_Mlcsite_mlcp1
!F TCRPsite_mlcp1 = CRPsite_mlcp1 + CRP_cAMP_CRPsite_mlcp1
!F TMlcsite_mlcp2 = Mlcsite_mlcp2 + Mlc_Mlcsite_mlcp2
!F TCRPsite_mlcp2 = CRPsite_mlcp2 + CRP_cAMP_CRPsite_mlcp2
!F TMlcsite_ptsGp1 = Mlcsite_ptsGp1 + Mlc_Mlcsite_ptsGp1
!F TCRPsite_ptsGp1 = CRPsite_ptsGp1 + CRP_cAMP_CRPsite_ptsGp1
!F TCRPsiteI_crp = CRPsiteI_crp + CRP_cAMP_CRPsiteI_crp