begin name nishio1 end name begin reactions PTS2for {1.0}HPr + {1.0}EIP = {1.0}HPrP + {1.0}EI PTS2rev {1.0}HPrP + {1.0}EI = {1.0}HPr + {1.0}EIP PTS3for {1.0}IIA + {1.0}HPrP = {1.0}IIAP + {1.0}HPr PTS3rev {1.0}IIAP + {1.0}HPr = {1.0}IIA + {1.0}HPrP PTS4for {1.0}IICB + {1.0}IIAP = {1.0}IICBP + {1.0}IIA PTS4rev {1.0}IICBP + {1.0}IIA = {1.0}IICB + {1.0}IIAP bindingCRPcAMP {1.0}CRP + {1.0}cAMP = {1.0}CRPcAMP bindingCRPcAMPCRPsiteIIcrp {1.0}CRPcAMP + {1.0}CRPsiteIIcrp = {1.0}CRPcAMPCRPsiteIIcrp bindingCRPcAMPCRPsiteIcrp {1.0}CRPcAMP + {1.0}CRPsiteIcrp = {1.0}CRPcAMPCRPsiteIcrp bindingCRPcAMPCRPsitecyaA {1.0}CRPcAMP + {1.0}CRPsitecyaA = {1.0}CRPcAMPCRPsitecyaA bindingCRPcAMPCRPsitegenome {1.0}CRPcAMP + {1.0}CRPsitegenome = {1.0}CRPcAMPCRPsitegenome bindingCRPcAMPCRPsitemlcp1 {1.0}CRPcAMP + {1.0}CRPsitemlcp1 = {1.0}CRPcAMPCRPsitemlcp1 bindingCRPcAMPCRPsitemlcp2 {1.0}CRPcAMP + {1.0}CRPsitemlcp2 = {1.0}CRPcAMPCRPsitemlcp2 bindingCRPcAMPCRPsiteptsGp1 {1.0}CRPcAMP + {1.0}CRPsiteptsGp1 = {1.0}CRPcAMPCRPsiteptsGp1 bindingCRPcAMPCRPsiteptsGp2 {1.0}CRPcAMP + {1.0}CRPsiteptsGp2 = {1.0}CRPcAMPCRPsiteptsGp2 bindingCRPcAMPCRPsiteptsHp0 {1.0}CRPcAMP + {1.0}CRPsiteptsHp0 = {1.0}CRPcAMPCRPsiteptsHp0 bindingCRPcAMPCRPsiteptsHp1 {1.0}CRPcAMP + {1.0}CRPsiteptsHp1 = {1.0}CRPcAMPCRPsiteptsHp1 bindingCRPcAMPCRPsiteptsIp0 {1.0}CRPcAMP + {1.0}CRPsiteptsIp0 = {1.0}CRPcAMPCRPsiteptsIp0 bindingCRPcAMPCRPsiteptsIp1 {1.0}CRPcAMP + {1.0}CRPsiteptsIp1 = {1.0}CRPcAMPCRPsiteptsIp1 bindingIIAPCYA {1.0}CYA + {1.0}IIAP = {1.0}IIAPCYA bindingIICBMlc {1.0}IICB + {1.0}Mlc = {1.0}IICBMlc bindingMlcMlcsitemlcp1 {1.0}Mlc + {1.0}Mlcsitemlcp1 = {1.0}MlcMlcsitemlcp1 bindingMlcMlcsitemlcp2 {1.0}Mlc + {1.0}Mlcsitemlcp2 = {1.0}MlcMlcsitemlcp2 bindingMlcMlcsiteptsGp1 {1.0}Mlc + {1.0}MlcsiteptsGp1 = {1.0}MlcMlcsiteptsGp1 bindingMlcMlcsiteptsGp2 {1.0}Mlc + {1.0}MlcsiteptsGp2 = {1.0}MlcMlcsiteptsGp2 bindingMlcMlcsiteptsHp0 {1.0}Mlc + {1.0}MlcsiteptsHp0 = {1.0}MlcMlcsiteptsHp0 bindingMlcMlcsiteptsIp0 {1.0}Mlc + {1.0}MlcsiteptsIp0 = {1.0}MlcMlcsiteptsIp0 decompositionCRP {1.0}CRP = {1.0}$EXTERNAL decompositionCRPcAMP {1.0}CRPcAMP = {1.0}$EXTERNAL decompositionCRPcAMPCRPsiteIIcrp {1.0}CRPcAMPCRPsiteIIcrp = {1.0}CRPsiteIIcrp decompositionCRPcAMPCRPsiteIcrp {1.0}CRPcAMPCRPsiteIcrp = {1.0}CRPsiteIcrp decompositionCRPcAMPCRPsitecyaA {1.0}CRPcAMPCRPsitecyaA = {1.0}CRPsitecyaA decompositionCRPcAMPCRPsitegenome {1.0}CRPcAMPCRPsitegenome = {1.0}CRPsitegenome decompositionCRPcAMPCRPsitemlcp1 {1.0}CRPcAMPCRPsitemlcp1 = {1.0}CRPsitemlcp1 decompositionCRPcAMPCRPsitemlcp2 {1.0}CRPcAMPCRPsitemlcp2 = {1.0}CRPsitemlcp2 decompositionCRPcAMPCRPsiteptsGp1 {1.0}CRPcAMPCRPsiteptsGp1 = {1.0}CRPsiteptsGp1 decompositionCRPcAMPCRPsiteptsGp2 {1.0}CRPcAMPCRPsiteptsGp2 = {1.0}CRPsiteptsGp2 decompositionCRPcAMPCRPsiteptsHp0 {1.0}CRPcAMPCRPsiteptsHp0 = {1.0}CRPsiteptsHp0 decompositionCRPcAMPCRPsiteptsHp1 {1.0}CRPcAMPCRPsiteptsHp1 = {1.0}CRPsiteptsHp1 decompositionCRPcAMPCRPsiteptsIp0 {1.0}CRPcAMPCRPsiteptsIp0 = {1.0}CRPsiteptsIp0 decompositionCRPcAMPCRPsiteptsIp1 {1.0}CRPcAMPCRPsiteptsIp1 = {1.0}CRPsiteptsIp1 decompositionCYA {1.0}CYA = {1.0}$EXTERNAL decompositionEI {1.0}EI = {1.0}$EXTERNAL decompositionEIP {1.0}EIP = {1.0}$EXTERNAL decompositionHPr {1.0}HPr = {1.0}$EXTERNAL decompositionHPrP {1.0}HPrP = {1.0}$EXTERNAL decompositionIIA {1.0}IIA = {1.0}$EXTERNAL decompositionIIAP {1.0}IIAP = {1.0}$EXTERNAL decompositionIICB {1.0}IICB = {1.0}$EXTERNAL decompositionIICBMlc {1.0}IICBMlc = {1.0}$EXTERNAL decompositionIICBP {1.0}IICBP = {1.0}$EXTERNAL decompositionMlc {1.0}Mlc = {1.0}$EXTERNAL decompositionMlcMlcsitemlcp1 {1.0}MlcMlcsitemlcp1 = {1.0}Mlcsitemlcp1 decompositionMlcMlcsitemlcp2 {1.0}MlcMlcsitemlcp2 = {1.0}Mlcsitemlcp2 decompositionMlcMlcsiteptsGp1 {1.0}MlcMlcsiteptsGp1 = {1.0}MlcsiteptsGp1 decompositionMlcMlcsiteptsGp2 {1.0}MlcMlcsiteptsGp2 = {1.0}MlcsiteptsGp2 decompositionMlcMlcsiteptsHp0 {1.0}MlcMlcsiteptsHp0 = {1.0}MlcsiteptsHp0 decompositionMlcMlcsiteptsIp0 {1.0}MlcMlcsiteptsIp0 = {1.0}MlcsiteptsIp0 decompositioncAMP {1.0}cAMP = {1.0}$EXTERNAL decompositionmRNAcrp {1.0}mRNAcrp = {1.0}$EXTERNAL decompositionmRNAcrr {1.0}mRNAcrr = {1.0}$EXTERNAL decompositionmRNAcyaA {1.0}mRNAcyaA = {1.0}$EXTERNAL decompositionmRNAmlc {1.0}mRNAmlc = {1.0}$EXTERNAL decompositionmRNAptsG {1.0}mRNAptsG = {1.0}$EXTERNAL decompositionmRNAptsH {1.0}mRNAptsH = {1.0}$EXTERNAL decompositionmRNAptsI {1.0}mRNAptsI = {1.0}$EXTERNAL reactionCYAATP {1.0}$ATP = {1.0}cAMP reactionEIPPyr {1.0}EIP + {1.0}$Pyr = {1.0}EI + {1.0}$PEP reactionEIPEP {1.0}EI + {1.0}$PEP = {1.0}EIP + {1.0}$Pyr reactionIIAPCYAATP {1.0}$ATP = {1.0}cAMP reactionIICBGlc6P {1.0}IICB + {1.0}$Glc6P = {1.0}IICBP + {1.0}$Glucose reactionIICBPGlucose {1.0}IICBP + {1.0}$Glucose = {1.0}IICB + {1.0}$Glc6P transcriptionCRPcAMPCRPsiteIcrpCRPcAMPCRPsiteIIcrpcrp {1.0}$EXTERNAL = {1.0}mRNAcrp transcriptionCRPcAMPCRPsitecyaAcyaA {1.0}$EXTERNAL = {1.0}mRNAcyaA transcriptionCRPcAMPCRPsitemlcp1MlcMlcsitemlcp1mlcp1 {1.0}$EXTERNAL = {1.0}mRNAmlc transcriptionCRPcAMPCRPsitemlcp2MlcMlcsitemlcp2mlcp2 {1.0}$EXTERNAL = {1.0}mRNAmlc transcriptionCRPcAMPCRPsiteptsGp1MlcMlcsiteptsGp1ptsGp1 {1.0}$EXTERNAL = {1.0}mRNAptsG transcriptionCRPcAMPCRPsiteptsGp2MlcMlcsiteptsGp2ptsGp2 {1.0}$EXTERNAL = {1.0}mRNAptsG transcriptionCRPcAMPCRPsiteptsHp0MlcMlcsiteptsHp0ptsHp0 {1.0}$EXTERNAL = {1.0}mRNAptsH transcriptionCRPcAMPCRPsiteptsHp1ptsHp1 {1.0}$EXTERNAL = {1.0}mRNAptsH transcriptionCRPcAMPCRPsiteptsIp0MlcMlcsiteptsIp0ptsIp0 {1.0}$EXTERNAL = {1.0}mRNAptsI transcriptionCRPcAMPCRPsiteptsIp1ptsIp1 {1.0}$EXTERNAL = {1.0}mRNAptsI transcriptioncrpbasal {1.0}$EXTERNAL = {1.0}mRNAcrp transcriptioncrr {1.0}$EXTERNAL = {1.0}mRNAcrr transcriptioncyaAbasal {1.0}$EXTERNAL = {1.0}mRNAcyaA translationmRNAcrp {1.0}$EXTERNAL = {1.0}CRP translationmRNAcrr {1.0}$EXTERNAL = {1.0}IIA translationmRNAcyaA {1.0}$EXTERNAL = {1.0}CYA translationmRNAptsG {1.0}$EXTERNAL = {1.0}IICB translationmRNAptsH {1.0}$EXTERNAL = {1.0}HPr translationmRNAptsI {1.0}$EXTERNAL = {1.0}EI translationmlc {1.0}$EXTERNAL = {1.0}Mlc end reactions begin rate equations PTS2for = cyt*PTS2forkx*EIP[t]*HPr[t] PTS2rev = cyt*PTS2revkx*EI[t]*HPrP[t] PTS3for = cyt*PTS3forkx*HPrP[t]*IIA[t] PTS3rev = cyt*PTS3revkx*HPr[t]*IIAP[t] PTS4for = cyt*PTS4forkx*IIAP[t]*IICB[t] PTS4rev = cyt*PTS4revkx*IIA[t]*IICBP[t] bindingCRPcAMP = bindingCRPcAMPoneperM*cyt*fast*(bindingCRPcAMPKb^2*cAMP[t]^2*CRP[t]^2 - CRPcAMP[t]^2) bindingCRPcAMPCRPsiteIIcrp = cyt*fast*(bindingCRPcAMPCRPsiteIIcrpKb*CRPsiteIIcrp[t]*CRPcAMP[t] - CRPcAMPCRPsiteIIcrp[t]) bindingCRPcAMPCRPsiteIcrp = cyt*fast*(bindingCRPcAMPCRPsiteIcrpKb*CRPsiteIcrp[t]*CRPcAMP[t] - CRPcAMPCRPsiteIcrp[t]) bindingCRPcAMPCRPsitecyaA = cyt*fast*(bindingCRPcAMPCRPsitecyaAKb*CRPsitecyaA[t]*CRPcAMP[t] - CRPcAMPCRPsitecyaA[t]) bindingCRPcAMPCRPsitegenome = cyt*fast*(bindingCRPcAMPCRPsitegenomeKb*CRPsitegenome[t]*CRPcAMP[t] - CRPcAMPCRPsitegenome[t]) bindingCRPcAMPCRPsitemlcp1 = cyt*fast*(bindingCRPcAMPCRPsitemlcp1Kb*CRPsitemlcp1[t]*CRPcAMP[t] - CRPcAMPCRPsitemlcp1[t]) bindingCRPcAMPCRPsitemlcp2 = cyt*fast*(bindingCRPcAMPCRPsitemlcp2Kb*CRPsitemlcp2[t]*CRPcAMP[t] - CRPcAMPCRPsitemlcp2[t]) bindingCRPcAMPCRPsiteptsGp1 = cyt*fast*(bindingCRPcAMPCRPsiteptsGp1Kb*CRPsiteptsGp1[t]*CRPcAMP[t] - CRPcAMPCRPsiteptsGp1[t]) bindingCRPcAMPCRPsiteptsGp2 = cyt*fast*(bindingCRPcAMPCRPsiteptsGp2Kb*CRPsiteptsGp2[t]*CRPcAMP[t] - CRPcAMPCRPsiteptsGp2[t]) bindingCRPcAMPCRPsiteptsHp0 = cyt*fast*(bindingCRPcAMPCRPsiteptsHp0Kb*CRPsiteptsHp0[t]*CRPcAMP[t] - CRPcAMPCRPsiteptsHp0[t]) bindingCRPcAMPCRPsiteptsHp1 = cyt*fast*(bindingCRPcAMPCRPsiteptsHp1Kb*CRPsiteptsHp1[t]*CRPcAMP[t] - CRPcAMPCRPsiteptsHp1[t]) bindingCRPcAMPCRPsiteptsIp0 = cyt*fast*(bindingCRPcAMPCRPsiteptsIp0Kb*CRPsiteptsIp0[t]*CRPcAMP[t] - CRPcAMPCRPsiteptsIp0[t]) bindingCRPcAMPCRPsiteptsIp1 = cyt*fast*(bindingCRPcAMPCRPsiteptsIp1Kb*CRPsiteptsIp1[t]*CRPcAMP[t] - CRPcAMPCRPsiteptsIp1[t]) bindingIIAPCYA = cyt*fast*(bindingIIAPCYAKb*CYA[t]*IIAP[t]^2 - IIAPCYA[t]) bindingIICBMlc = cyt*fast*(-IICBMlc[t] + bindingIICBMlcKb*IICB[t]*Mlc[t]) bindingMlcMlcsitemlcp1 = cyt*fast*(bindingMlcMlcsitemlcp1Kb*Mlc[t]*Mlcsitemlcp1[t] - MlcMlcsitemlcp1[t]) bindingMlcMlcsitemlcp2 = cyt*fast*(bindingMlcMlcsitemlcp2Kb*Mlc[t]*Mlcsitemlcp2[t] - MlcMlcsitemlcp2[t]) bindingMlcMlcsiteptsGp1 = cyt*fast*(bindingMlcMlcsiteptsGp1Kb*Mlc[t]*MlcsiteptsGp1[t] - MlcMlcsiteptsGp1[t]) bindingMlcMlcsiteptsGp2 = cyt*fast*(bindingMlcMlcsiteptsGp2Kb*Mlc[t]*MlcsiteptsGp2[t] - MlcMlcsiteptsGp2[t]) bindingMlcMlcsiteptsHp0 = cyt*fast*(bindingMlcMlcsiteptsHp0Kb*Mlc[t]*MlcsiteptsHp0[t] - MlcMlcsiteptsHp0[t]) bindingMlcMlcsiteptsIp0 = cyt*fast*(bindingMlcMlcsiteptsIp0Kb*Mlc[t]*MlcsiteptsIp0[t] - MlcMlcsiteptsIp0[t]) decompositionCRP = cyt*decompositionCRPkpd*CRP[t] decompositionCRPcAMP = cyt*decompositionCRPcAMPkpd*CRPcAMP[t] decompositionCRPcAMPCRPsiteIIcrp = cyt*decompositionCRPcAMPCRPsiteIIcrpkpd*CRPcAMPCRPsiteIIcrp[t] decompositionCRPcAMPCRPsiteIcrp = cyt*decompositionCRPcAMPCRPsiteIcrpkpd*CRPcAMPCRPsiteIcrp[t] decompositionCRPcAMPCRPsitecyaA = cyt*decompositionCRPcAMPCRPsitecyaAkpd*CRPcAMPCRPsitecyaA[t] decompositionCRPcAMPCRPsitegenome = cyt*decompositionCRPcAMPCRPsitegenomekpd*CRPcAMPCRPsitegenome[t] decompositionCRPcAMPCRPsitemlcp1 = cyt*decompositionCRPcAMPCRPsitemlcp1kpd*CRPcAMPCRPsitemlcp1[t] decompositionCRPcAMPCRPsitemlcp2 = cyt*decompositionCRPcAMPCRPsitemlcp2kpd*CRPcAMPCRPsitemlcp2[t] decompositionCRPcAMPCRPsiteptsGp1 = cyt*decompositionCRPcAMPCRPsiteptsGp1kpd*CRPcAMPCRPsiteptsGp1[t] decompositionCRPcAMPCRPsiteptsGp2 = cyt*decompositionCRPcAMPCRPsiteptsGp2kpd*CRPcAMPCRPsiteptsGp2[t] decompositionCRPcAMPCRPsiteptsHp0 = cyt*decompositionCRPcAMPCRPsiteptsHp0kpd*CRPcAMPCRPsiteptsHp0[t] decompositionCRPcAMPCRPsiteptsHp1 = cyt*decompositionCRPcAMPCRPsiteptsHp1kpd*CRPcAMPCRPsiteptsHp1[t] decompositionCRPcAMPCRPsiteptsIp0 = cyt*decompositionCRPcAMPCRPsiteptsIp0kpd*CRPcAMPCRPsiteptsIp0[t] decompositionCRPcAMPCRPsiteptsIp1 = cyt*decompositionCRPcAMPCRPsiteptsIp1kpd*CRPcAMPCRPsiteptsIp1[t] decompositionCYA = cyt*decompositionCYAkpd*CYA[t] decompositionEI = cyt*decompositionEIkpd*EI[t] decompositionEIP = cyt*decompositionEIPkpd*EIP[t] decompositionHPr = cyt*decompositionHPrkpd*HPr[t] decompositionHPrP = cyt*decompositionHPrPkpd*HPrP[t] decompositionIIA = cyt*decompositionIIAkpd*IIA[t] decompositionIIAP = cyt*decompositionIIAPkpd*IIAP[t] decompositionIICB = cyt*decompositionIICBkpd*IICB[t] decompositionIICBMlc = cyt*decompositionIICBMlckpd*IICBMlc[t] decompositionIICBP = cyt*decompositionIICBPkpd*IICBP[t] decompositionMlc = cyt*decompositionMlckpd*Mlc[t] decompositionMlcMlcsitemlcp1 = cyt*decompositionMlcMlcsitemlcp1kpd*MlcMlcsitemlcp1[t] decompositionMlcMlcsitemlcp2 = cyt*decompositionMlcMlcsitemlcp2kpd*MlcMlcsitemlcp2[t] decompositionMlcMlcsiteptsGp1 = cyt*decompositionMlcMlcsiteptsGp1kpd*MlcMlcsiteptsGp1[t] decompositionMlcMlcsiteptsGp2 = cyt*decompositionMlcMlcsiteptsGp2kpd*MlcMlcsiteptsGp2[t] decompositionMlcMlcsiteptsHp0 = cyt*decompositionMlcMlcsiteptsHp0kpd*MlcMlcsiteptsHp0[t] decompositionMlcMlcsiteptsIp0 = cyt*decompositionMlcMlcsiteptsIp0kpd*MlcMlcsiteptsIp0[t] decompositioncAMP = cyt*decompositioncAMPkpd*cAMP[t] decompositionmRNAcrp = cyt*decompositionmRNAcrpkmd*mRNAcrp[t] decompositionmRNAcrr = cyt*decompositionmRNAcrrkmd*mRNAcrr[t] decompositionmRNAcyaA = cyt*decompositionmRNAcyaAkmd*mRNAcyaA[t] decompositionmRNAmlc = cyt*decompositionmRNAmlckmd*mRNAmlc[t] decompositionmRNAptsG = cyt*decompositionmRNAptsGkmd*mRNAptsG[t] decompositionmRNAptsH = cyt*decompositionmRNAptsHkmd*mRNAptsH[t] decompositionmRNAptsI = cyt*decompositionmRNAptsIkmd*mRNAptsI[t] reactionCYAATP = (ATP*cyt*reactionCYAATPQ*CYA[t])/(ATP + reactionCYAATPKmich) reactionEIPPyr = (2*cyt*Pyr^2*reactionEIPPyrQ*EIP[t])/(Pyr^2 + reactionEIPPyrKmich^2) reactionEIPEP = (2*cyt*PEP^2*reactionEIPEPQ*EI[t])/(PEP^2 + reactionEIPEPKmich^2) reactionIIAPCYAATP = (ATP*cyt*reactionIIAPCYAATPQ*IIAPCYA[t])/(ATP + reactionIIAPCYAATPKmich) reactionIICBGlc6P = (cyt*Glc6P*reactionIICBGlc6PQ*IICB[t])/(Glc6P + reactionIICBGlc6PKmich) reactionIICBPGlucose = (cyt*Glucose*reactionIICBPGlucoseQ*IICBP[t])/(Glucose + reactionIICBPGlucoseKmich) transcriptionCRPcAMPCRPsiteIcrpCRPcAMPCRPsiteIIcrpcrp = crp*cyt*transcriptionCRPcAMPCRPsiteIcrpCRPcAMPCRPsiteIIcrpcrpkm*(1 + (transcriptionCRPcAMPCRPsiteIcrpCRPcAMPCRPsiteIIcrpcrpRelativeactivityatTCRPsiteIIcrp*CRPcAMPCRPsiteIIcrp[t])/TCRPsiteIIcrp - CRPcAMPCRPsiteIcrp[t]/TCRPsiteIcrp) transcriptionCRPcAMPCRPsitecyaAcyaA = cyaA*cyt*transcriptionCRPcAMPCRPsitecyaAcyaAkm*(1 - CRPcAMPCRPsitecyaA[t]/TCRPsitecyaA) transcriptionCRPcAMPCRPsitemlcp1MlcMlcsitemlcp1mlcp1 = cyt*mlcp1*transcriptionCRPcAMPCRPsitemlcp1MlcMlcsitemlcp1mlcp1km*(1 - CRPcAMPCRPsitemlcp1[t]/TCRPsitemlcp1)*(1 - MlcMlcsitemlcp1[t]/TMlcsitemlcp1) transcriptionCRPcAMPCRPsitemlcp2MlcMlcsitemlcp2mlcp2 = (cyt*mlcp2*transcriptionCRPcAMPCRPsitemlcp2MlcMlcsitemlcp2mlcp2km*CRPcAMPCRPsitemlcp2[t]*(1 - MlcMlcsitemlcp2[t]/TMlcsitemlcp2))/TCRPsitemlcp2 transcriptionCRPcAMPCRPsiteptsGp1MlcMlcsiteptsGp1ptsGp1 = (cyt*ptsGp1*transcriptionCRPcAMPCRPsiteptsGp1MlcMlcsiteptsGp1ptsGp1km*CRPcAMPCRPsiteptsGp1[t]*(1 - MlcMlcsiteptsGp1[t]/TMlcsiteptsGp1))/TCRPsiteptsGp1 transcriptionCRPcAMPCRPsiteptsGp2MlcMlcsiteptsGp2ptsGp2 = (cyt*ptsGp2*transcriptionCRPcAMPCRPsiteptsGp2MlcMlcsiteptsGp2ptsGp2km*CRPcAMPCRPsiteptsGp2[t]*(1 - MlcMlcsiteptsGp2[t]/TMlcsiteptsGp2))/TCRPsiteptsGp2 transcriptionCRPcAMPCRPsiteptsHp0MlcMlcsiteptsHp0ptsHp0 = (cyt*ptsHp0*transcriptionCRPcAMPCRPsiteptsHp0MlcMlcsiteptsHp0ptsHp0km*CRPcAMPCRPsiteptsHp0[t]*(1 - MlcMlcsiteptsHp0[t]/TMlcsiteptsHp0))/TCRPsiteptsHp0 transcriptionCRPcAMPCRPsiteptsHp1ptsHp1 = (cyt*ptsHp1*transcriptionCRPcAMPCRPsiteptsHp1ptsHp1km*CRPcAMPCRPsiteptsHp1[t])/TCRPsiteptsHp1 transcriptionCRPcAMPCRPsiteptsIp0MlcMlcsiteptsIp0ptsIp0 = (cyt*ptsIp0*transcriptionCRPcAMPCRPsiteptsIp0MlcMlcsiteptsIp0ptsIp0km*CRPcAMPCRPsiteptsIp0[t]*(1 - MlcMlcsiteptsIp0[t]/TMlcsiteptsIp0))/TCRPsiteptsIp0 transcriptionCRPcAMPCRPsiteptsIp1ptsIp1 = (cyt*ptsIp1*transcriptionCRPcAMPCRPsiteptsIp1ptsIp1km*CRPcAMPCRPsiteptsIp1[t])/TCRPsiteptsIp1 transcriptioncrpbasal = crpbasal*cyt*transcriptioncrpbasalkm transcriptioncrr = crr*cyt*transcriptioncrrkm transcriptioncyaAbasal = cyaAbasal*cyt*transcriptioncyaAbasalkm translationmRNAcrp = cyt*translationmRNAcrpkp*mRNAcrp[t] translationmRNAcrr = cyt*translationmRNAcrrkp*mRNAcrr[t] translationmRNAcyaA = cyt*translationmRNAcyaAkp*mRNAcyaA[t] translationmRNAptsG = cyt*translationmRNAptsGkp*mRNAptsG[t] translationmRNAptsH = cyt*translationmRNAptsHkp*mRNAptsH[t] translationmRNAptsI = cyt*translationmRNAptsIkp*mRNAptsI[t] translationmlc = cyt*translationmlckp*mRNAmlc[t] end rate equations begin parameters fast = 1000000000.0 ATP = 0.0069942 Glc6P = 0.00148 Glucose = 0.2 PEP = 0.00267 Pyr = 0.00267 crp = "2.43e-10" crpbasal = "2.43e-10" crr = "2.43e-10" cyaA = "2.43e-10" cyaAbasal = "2.43e-10" mlcp1 = "2.43e-10" mlcp2 = "2.43e-10" ptsGp1 = "2.43e-10" ptsGp2 = "2.43e-10" ptsHp0 = "2.43e-10" ptsHp1 = "2.43e-10" ptsIp0 = "2.43e-10" ptsIp1 = "2.43e-10" bindingCRPcAMPKb = 40000.0 bindingCRPcAMPoneperM = 1.0 bindingCRPcAMPCRPsitecyaAKb = 66700000.0 bindingCRPcAMPCRPsiteIcrpKb = 22200000.0 bindingCRPcAMPCRPsiteIIcrpKb = 2700000.0 bindingCRPcAMPCRPsiteptsGp1Kb = 10000000.0 bindingCRPcAMPCRPsiteptsGp2Kb = 10000000.0 bindingCRPcAMPCRPsiteptsHp0Kb = 10000000.0 bindingCRPcAMPCRPsiteptsHp1Kb = 10000000.0 bindingCRPcAMPCRPsiteptsIp0Kb = 10000000.0 bindingCRPcAMPCRPsiteptsIp1Kb = 10000000.0 bindingCRPcAMPCRPsitemlcp1Kb = 10000000.0 bindingCRPcAMPCRPsitemlcp2Kb = 10000000.0 bindingCRPcAMPCRPsitegenomeKb = 10000000.0 bindingMlcMlcsiteptsGp1Kb = 200000000.0 bindingMlcMlcsiteptsGp2Kb = 200000000.0 bindingMlcMlcsiteptsHp0Kb = 200000000.0 bindingMlcMlcsiteptsIp0Kb = 200000000.0 bindingMlcMlcsitemlcp1Kb = 2430000.0 bindingMlcMlcsitemlcp2Kb = 1350000.0 bindingIICBMlcKb = 7000000.0 bindingIIAPCYAKb = 100000000.0 transcriptionCRPcAMPCRPsitecyaAcyaAkm = 45.26 transcriptioncyaAbasalkm = 1.281 transcriptionCRPcAMPCRPsiteIcrpCRPcAMPCRPsiteIIcrpcrpkm = 20.0 transcriptionCRPcAMPCRPsiteIcrpCRPcAMPCRPsiteIIcrpcrpRelativeactivityatTCRPsiteIIcrp = 5.0 transcriptioncrpbasalkm = 1.00886 transcriptionCRPcAMPCRPsiteptsGp1MlcMlcsiteptsGp1ptsGp1km = 892.0 transcriptionCRPcAMPCRPsiteptsGp2MlcMlcsiteptsGp2ptsGp2km = 2.0 transcriptionCRPcAMPCRPsiteptsHp0MlcMlcsiteptsHp0ptsHp0km = 71.8 transcriptionCRPcAMPCRPsiteptsHp1ptsHp1km = 17.95 transcriptionCRPcAMPCRPsiteptsIp0MlcMlcsiteptsIp0ptsIp0km = 6.244 transcriptionCRPcAMPCRPsiteptsIp1ptsIp1km = 0.892 transcriptioncrrkm = 334.5 transcriptionCRPcAMPCRPsitemlcp1MlcMlcsitemlcp1mlcp1km = 1.875 transcriptionCRPcAMPCRPsitemlcp2MlcMlcsitemlcp2mlcp2km = 1.875 decompositionmRNAcyaAkmd = 0.126 decompositionmRNAcrpkmd = 0.139 decompositionmRNAptsGkmd = 0.217 decompositionmRNAptsHkmd = 0.0889 decompositionmRNAptsIkmd = 0.0797 decompositionmRNAcrrkmd = 0.0866 decompositionmRNAmlckmd = 0.3014 translationmRNAcyaAkp = 11.0 translationmRNAcrpkp = 11.0 translationmRNAptsGkp = 11.0 translationmRNAptsHkp = 11.0 translationmRNAptsIkp = 11.0 translationmRNAcrrkp = 11.0 translationmlckp = 11.0 decompositionCYAkpd = 0.1 decompositionCRPkpd = 0.1 decompositionMlckpd = 0.1 decompositioncAMPkpd = 400.0 decompositionCRPcAMPkpd = 0.1 decompositionCRPcAMPCRPsitecyaAkpd = 0.1 decompositionCRPcAMPCRPsiteIcrpkpd = 0.1 decompositionCRPcAMPCRPsiteIIcrpkpd = 0.1 decompositionCRPcAMPCRPsiteptsGp1kpd = 0.1 decompositionCRPcAMPCRPsiteptsGp2kpd = 0.1 decompositionCRPcAMPCRPsiteptsHp0kpd = 0.1 decompositionCRPcAMPCRPsiteptsHp1kpd = 0.1 decompositionCRPcAMPCRPsiteptsIp0kpd = 0.1 decompositionCRPcAMPCRPsiteptsIp1kpd = 0.1 decompositionCRPcAMPCRPsitemlcp1kpd = 0.1 decompositionCRPcAMPCRPsitemlcp2kpd = 0.1 decompositionCRPcAMPCRPsitegenomekpd = 0.1 decompositionMlcMlcsiteptsGp1kpd = 0.1 decompositionMlcMlcsiteptsGp2kpd = 0.1 decompositionMlcMlcsiteptsHp0kpd = 0.1 decompositionMlcMlcsiteptsIp0kpd = 0.1 decompositionMlcMlcsitemlcp1kpd = 0.1 decompositionMlcMlcsitemlcp2kpd = 0.1 decompositionIICBMlckpd = 0.1 decompositionEIPkpd = 0.1 decompositionEIkpd = 0.1 decompositionHPrPkpd = 0.1 decompositionHPrkpd = 0.1 decompositionIIAPkpd = 0.1 decompositionIIAkpd = 0.1 decompositionIICBPkpd = 0.1 decompositionIICBkpd = 0.1 PTS2forkx = 12000000000.0 PTS2revkx = 480000000.0 PTS3forkx = 3660000000.0 PTS3revkx = 2820000000.0 PTS4forkx = 660000000.0 PTS4revkx = 240000000.0 reactionCYAATPKmich = 0.001 reactionCYAATPQ = 100.0 reactionIIAPCYAATPKmich = 0.001 reactionIIAPCYAATPQ = 9000.0 reactionEIPEPKmich = 0.0003 reactionEIPEPQ = 108000.0 reactionEIPPyrKmich = 0.002 reactionEIPPyrQ = 480000.0 reactionIICBPGlucoseKmich = "2e-05" reactionIICBPGlucoseQ = 4800.0 reactionIICBGlc6PKmich = 9.61 reactionIICBGlc6PQ = 389.0 cyt = 1.0 end parameters begin initial conditions CRP[0] = CRPi CRPcAMP[0] = CRPcAMPi CRPcAMPCRPsiteIIcrp[0] = CRPcAMPCRPsiteIIcrpi CRPcAMPCRPsiteIcrp[0] = CRPcAMPCRPsiteIcrpi CRPcAMPCRPsitecyaA[0] = CRPcAMPCRPsitecyaAi CRPcAMPCRPsitegenome[0] = CRPcAMPCRPsitegenomei CRPcAMPCRPsitemlcp1[0] = CRPcAMPCRPsitemlcp1i CRPcAMPCRPsitemlcp2[0] = CRPcAMPCRPsitemlcp2i CRPcAMPCRPsiteptsGp1[0] = CRPcAMPCRPsiteptsGp1i CRPcAMPCRPsiteptsGp2[0] = CRPcAMPCRPsiteptsGp2i CRPcAMPCRPsiteptsHp0[0] = CRPcAMPCRPsiteptsHp0i CRPcAMPCRPsiteptsHp1[0] = CRPcAMPCRPsiteptsHp1i CRPcAMPCRPsiteptsIp0[0] = CRPcAMPCRPsiteptsIp0i CRPcAMPCRPsiteptsIp1[0] = CRPcAMPCRPsiteptsIp1i CRPsiteIIcrp[0] = CRPsiteIIcrpi CRPsiteIcrp[0] = CRPsiteIcrpi CRPsitecyaA[0] = CRPsitecyaAi CRPsitegenome[0] = CRPsitegenomei CRPsitemlcp1[0] = CRPsitemlcp1i CRPsitemlcp2[0] = CRPsitemlcp2i CRPsiteptsGp1[0] = CRPsiteptsGp1i CRPsiteptsGp2[0] = CRPsiteptsGp2i CRPsiteptsHp0[0] = CRPsiteptsHp0i CRPsiteptsHp1[0] = CRPsiteptsHp1i CRPsiteptsIp0[0] = CRPsiteptsIp0i CRPsiteptsIp1[0] = CRPsiteptsIp1i CYA[0] = CYAi EI[0] = EIi EIP[0] = EIPi HPr[0] = HPri HPrP[0] = HPrPi IIA[0] = IIAi IIAP[0] = IIAPi IIAPCYA[0] = IIAPCYAi IICB[0] = IICBi IICBMlc[0] = IICBMlci IICBP[0] = IICBPi Mlc[0] = Mlci MlcMlcsitemlcp1[0] = MlcMlcsitemlcp1i MlcMlcsitemlcp2[0] = MlcMlcsitemlcp2i MlcMlcsiteptsGp1[0] = MlcMlcsiteptsGp1i MlcMlcsiteptsGp2[0] = MlcMlcsiteptsGp2i MlcMlcsiteptsHp0[0] = MlcMlcsiteptsHp0i MlcMlcsiteptsIp0[0] = MlcMlcsiteptsIp0i Mlcsitemlcp1[0] = Mlcsitemlcp1i Mlcsitemlcp2[0] = Mlcsitemlcp2i MlcsiteptsGp1[0] = MlcsiteptsGp1i MlcsiteptsGp2[0] = MlcsiteptsGp2i MlcsiteptsHp0[0] = MlcsiteptsHp0i MlcsiteptsIp0[0] = MlcsiteptsIp0i cAMP[0] = cAMPi mRNAcrp[0] = mRNAcrpi mRNAcrr[0] = mRNAcrri mRNAcyaA[0] = mRNAcyaAi mRNAmlc[0] = mRNAmlci mRNAptsG[0] = mRNAptsGi mRNAptsH[0] = mRNAptsHi mRNAptsI[0] = mRNAptsIi end initial conditions begin initial values CRPi = 5.4207e-06 CRPcAMPi = 1.0214e-07 CRPcAMPCRPsiteIIcrpi = 5.2529e-11 CRPcAMPCRPsiteIcrpi = 1.6863e-10 CRPcAMPCRPsitecyaAi = 2.119e-10 CRPcAMPCRPsitegenomei = 3.7544e-09 CRPcAMPCRPsitemlcp1i = 1.2279e-10 CRPcAMPCRPsitemlcp2i = 1.2279e-10 CRPcAMPCRPsiteptsGp1i = 1.2279e-10 CRPcAMPCRPsiteptsGp2i = 1.2279e-10 CRPcAMPCRPsiteptsHp0i = 1.2279e-10 CRPcAMPCRPsiteptsHp1i = 1.2279e-10 CRPcAMPCRPsiteptsIp0i = 1.2279e-10 CRPcAMPCRPsiteptsIp1i = 1.2279e-10 CRPsiteIIcrpi = 1.9047e-10 CRPsiteIcrpi = 7.4368e-11 CRPsitecyaAi = 3.1103e-11 CRPsitegenomei = 3.6756e-09 CRPsitemlcp1i = 1.2021e-10 CRPsitemlcp2i = 1.2021e-10 CRPsiteptsGp1i = 1.2021e-10 CRPsiteptsGp2i = 1.2021e-10 CRPsiteptsHp0i = 1.2021e-10 CRPsiteptsHp1i = 1.2021e-10 CRPsiteptsIp0i = 1.2021e-10 CRPsiteptsIp1i = 1.2021e-10 CYAi = 1.4934e-06 EIi = 8.6098e-07 EIPi = 2.4319e-07 HPri = 1.1793e-05 HPrPi = 7.5867e-07 IIAi = 9.623e-05 IIAPi = 7.0094e-06 IIAPCYAi = 7.3371e-09 IICBi = 4.2844e-05 IICBMlci = 1.6546e-07 IICBPi = 7.1055e-06 Mlci = 5.5172e-10 MlcMlcsitemlcp1i = 3.2535e-13 MlcMlcsitemlcp2i = 1.8086e-13 MlcMlcsiteptsGp1i = 2.4149e-11 MlcMlcsiteptsGp2i = 2.4149e-11 MlcMlcsiteptsHp0i = 2.4149e-11 MlcMlcsiteptsIp0i = 2.4149e-11 Mlcsitemlcp1i = 2.4267e-10 Mlcsitemlcp2i = 2.4282e-10 MlcsiteptsGp1i = 2.1885e-10 MlcsiteptsGp2i = 2.1885e-10 MlcsiteptsHp0i = 2.1885e-10 MlcsiteptsIp0i = 2.1885e-10 cAMPi = 4.7107e-07 mRNAcrpi = 5.0254e-08 mRNAcrri = 9.3861e-07 mRNAcyaAi = 1.3643e-08 mRNAmlci = 1.5101e-09 mRNAptsGi = 4.5559e-07 mRNAptsHi = 1.1411e-07 mRNAptsIi = 1.0038e-08 end initial values begin assignment rules TMlcsiteptsIp0 := MlcsiteptsIp0[t] + MlcMlcsiteptsIp0[t] TCRPsitecyaA := CRPsitecyaA[t] + CRPcAMPCRPsitecyaA[t] TCRPsiteIIcrp := CRPsiteIIcrp[t] + CRPcAMPCRPsiteIIcrp[t] TCRPsiteptsGp2 := CRPsiteptsGp2[t] + CRPcAMPCRPsiteptsGp2[t] TMlcsiteptsGp2 := MlcsiteptsGp2[t] + MlcMlcsiteptsGp2[t] TCRPsiteptsHp0 := CRPsiteptsHp0[t] + CRPcAMPCRPsiteptsHp0[t] TMlcsiteptsHp0 := MlcsiteptsHp0[t] + MlcMlcsiteptsHp0[t] TCRPsiteptsHp1 := CRPsiteptsHp1[t] + CRPcAMPCRPsiteptsHp1[t] TCRPsiteptsIp0 := CRPsiteptsIp0[t] + CRPcAMPCRPsiteptsIp0[t] TCRPsiteptsIp1 := CRPsiteptsIp1[t] + CRPcAMPCRPsiteptsIp1[t] TMlcsitemlcp1 := Mlcsitemlcp1[t] + MlcMlcsitemlcp1[t] TCRPsitemlcp1 := CRPsitemlcp1[t] + CRPcAMPCRPsitemlcp1[t] TMlcsitemlcp2 := Mlcsitemlcp2[t] + MlcMlcsitemlcp2[t] TCRPsitemlcp2 := CRPsitemlcp2[t] + CRPcAMPCRPsitemlcp2[t] TMlcsiteptsGp1 := MlcsiteptsGp1[t] + MlcMlcsiteptsGp1[t] TCRPsiteptsGp1 := CRPsiteptsGp1[t] + CRPcAMPCRPsiteptsGp1[t] TCRPsiteIcrp := CRPsiteIcrp[t] + CRPcAMPCRPsiteIcrp[t] end assignment rules begin function definitions end function definitions begin events unnamed = (t >= 500, {Glucose -> 1/500000000}, 0) end events begin process annotations end process annotations begin species annotations ATP http://identifiers.org/chebi/CHEBI:15422 CRP http://identifiers.org/uniprot/P0ACJ8 CYA http://identifiers.org/uniprot/P00936 EI http://identifiers.org/uniprot/P08839 Glc6P http://identifiers.org/chebi/CHEBI:4170 Glucose http://identifiers.org/chebi/CHEBI:4167 HPr http://identifiers.org/uniprot/P0AA04 IIA_P http://identifiers.org/uniprot/P69783 IICB http://identifiers.org/uniprot/C3TDU2 Mlc http://identifiers.org/uniprot/P50456 PEP http://identifiers.org/chebi/CHEBI:44897 Pyr http://identifiers.org/chebi/CHEBI:32816 cAMP http://identifiers.org/chebi/CHEBI:17489 crr http://identifiers.org/uniprot/P69783 cyaA http://identifiers.org/uniprot/P00936 end species annotations begin units end units