begin name
nakakuki2
end name

begin reactions
reaction1 {1.0}$EXTERNAL = {1.0}x1
reaction2 {1.0}$EXTERNAL = {1.0}x2
reaction3 {1.0}$EXTERNAL = {1.0}ppERKn
reaction4 {1.0}$EXTERNAL = {1.0}DUSP
reaction5 {1.0}$EXTERNAL = {1.0}pRSKn
reaction6 {1.0}$EXTERNAL = {1.0}cFOSp
reaction7 {1.0}$EXTERNAL = {1.0}cFOSm
reaction8 {1.0}$EXTERNAL = {1.0}cFOS
reaction9 {1.0}$EXTERNAL = {1.0}pcFOS
end reactions

begin rate equations
reaction1 = compartment*((K1*L)/tau1 - x1[t]/tau1)
reaction2 = compartment*((K2*L)/tau2 - x2[t]/tau2)
reaction3 = compartment*(ppERKc*reaction3k1 - reaction3k2*ppERKn[t] - reaction3k3*DUSP[t]*ppERKn[t])
reaction4 = compartment*reaction4k*ppERKn[t]
reaction5 = compartment*(reaction5k4*ppERKn[t] - reaction5k5*pRSKn[t])
reaction6 = compartment*(-(k7*cFOSp[t]) + (ppERKn[t]*pRSKn[t])^reaction6n/(reaction6k6^reaction6n + (ppERKn[t]*pRSKn[t])^reaction6n))
reaction7 = compartment*(-(reaction7k8*cFOSm[t]) + k7*cFOSp[t])
reaction8 = compartment*(-(k11*ppERKc*cFOS[t]) - reaction8k10*cFOS[t] + reaction8k9*cFOSm[t] + k13*pcFOS[t])
reaction9 = compartment*(k11*ppERKc*cFOS[t] - k13*pcFOS[t] - reaction9k12*pcFOS[t])
end rate equations

begin parameters
K1 = 1.09
K2 = 2.89
L = 1.0
k11 = 0.11
k13 = 0.06
k7 = 0.5
tau1 = 3.07
tau2 = 472.0
reaction3k1 = 15.0
reaction3k2 = 50.0
reaction3k3 = 14.0
reaction4k = 1.0
reaction5k4 = 0.1
reaction5k5 = 0.15
reaction6k6 = 0.13
reaction6n = 1.1
reaction7k8 = 0.08
reaction8k10 = 0.3
reaction8k9 = 0.3
reaction9k12 = 0.001
compartment = 1.0
end parameters

begin initial conditions
DUSP[0] = DUSPi
cFOS[0] = cFOSi
cFOSm[0] = cFOSmi
cFOSp[0] = cFOSpi
pRSKn[0] = pRSKni
pcFOS[0] = pcFOSi
ppERKn[0] = ppERKni
x1[0] = x1i
x2[0] = x2i
end initial conditions

begin initial values
DUSPi = 0.0
cFOSi = 0.0
cFOSmi = 0.0
cFOSpi = 0.0
pRSKni = 0.0
pcFOSi = 0.0
ppERKni = 0.0
x1i = 0.0
x2i = 0.0
end initial values

begin assignment rules
ppERKc := x1[t] - x2[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
pRSKn http://identifiers.org/reactome/REACT_13229.1
end species annotations

begin units
end units