#mulquiney1 #reactions v_RBCvAK: {1.0}mgadpRBC + {1.0}adpRBC = {1.0}mgatpRBC + {1.0}ampRBC TsRBC * Vrbc * (K1appRBCvAK * adpRBC / Vrbc * mgadpRBC / Vrbc - K2appRBCvAK * ampRBC / Vrbc * mgatpRBC / Vrbc) v_RBCvALD: {1.0}f16p2RBC = {1.0}dhapRBC + {1.0}gapRBC TsRBC * Vrbc * (VRBCvALD * (f16p2RBC / Vrbc * KcatfRBCvALD / Kmf16p2RBCvALD - gapRBC / Vrbc * dhapRBC / Vrbc * KcatrRBCvALD / (KidhapRBCvALD * KmgapRBCvALD)) / (1 + dhapRBC / Vrbc / KidhapRBCvALD + f16p2RBC / Vrbc / Kmf16p2RBCvALD + gapRBC / Vrbc * dhapRBC / Vrbc / (KidhapRBCvALD * KmgapRBCvALD) + f16p2RBC / Vrbc * gapRBC / Vrbc * KmdhapRBCvALD / (Kif16p2RBCvALD * KidhapRBCvALD * KmgapRBCvALD) + (b23pgRBC / Vrbc + mgb23pgRBC / Vrbc) / Kib23pgRBCvALD + gapRBC / Vrbc * KmdhapRBCvALD * (1 + (b23pgRBC / Vrbc + mgb23pgRBC / Vrbc) / Kib23pgRBCvALD) / (KidhapRBCvALD * KmgapRBCvALD))) v_RBCvATPASE: {1.0}mgatpRBC = {1.0}mgadpRBC + {1.0}phosRBC TsRBC * Vrbc * (KRBCvATPASE * mgatpRBC / Vrbc) v_RBCvBPGSP1: {1.0}b13pgRBC + {1.0}bpgspRBC = {1.0}bpgspb13pgRBC TsRBC * Vrbc * (K1appRBCvBPGSP1 * b13pgRBC / Vrbc * bpgspRBC / Vrbc - K2RBCvBPGSP1 * bpgspb13pgRBC / Vrbc) v_RBCvBPGSP2: {1.0}bpgspb13pgRBC = {1.0}bpgsppRBC + {1.0}p3gRBC TsRBC * Vrbc * (K3appRBCvBPGSP2 * bpgspb13pgRBC / Vrbc) v_RBCvBPGSP3: {1.0}bpgsppRBC + {1.0}p3gRBC = {1.0}bpgsppp3gRBC TsRBC * Vrbc * (-K5RBCvBPGSP3 * bpgsppp3gRBC / Vrbc + K4appRBCvBPGSP3 * bpgsppRBC / Vrbc * p3gRBC / Vrbc) v_RBCvBPGSP4: {1.0}bpgsppRBC + {1.0}p2gRBC = {1.0}bpgsppp2gRBC TsRBC * Vrbc * (-K7RBCvBPGSP4 * bpgsppp2gRBC / Vrbc + K6appRBCvBPGSP4 * bpgsppRBC / Vrbc * p2gRBC / Vrbc) v_RBCvBPGSP5: {1.0}bpgsppp3gRBC = {1.0}bpgspb23pgRBC TsRBC * Vrbc * (K8RBCvBPGSP5 * bpgsppp3gRBC / Vrbc - K9RBCvBPGSP5 * bpgspb23pgRBC / Vrbc) v_RBCvBPGSP6: {1.0}bpgsppp2gRBC = {1.0}bpgspb23pgRBC TsRBC * Vrbc * (K10RBCvBPGSP6 * bpgsppp2gRBC / Vrbc - K11RBCvBPGSP6 * bpgspb23pgRBC / Vrbc) v_RBCvBPGSP7: {1.0}bpgspb23pgRBC = {1.0}bpgspRBC + {1.0}b23pgRBC TsRBC * Vrbc * (-K13appRBCvBPGSP7 * b23pgRBC / Vrbc * bpgspRBC / Vrbc + K12RBCvBPGSP7 * bpgspb23pgRBC / Vrbc) v_RBCvBPGSP8: {1.0}bpgsppRBC + {1.0}phosRBC = {1.0}bpgsppphosRBC TsRBC * Vrbc * (K14RBCvBPGSP8 * bpgsppRBC / Vrbc * phosRBC / Vrbc - K15RBCvBPGSP8 * bpgsppphosRBC / Vrbc) v_RBCvBPGSP9: {1.0}bpgsppphosRBC = {1.0}bpgspRBC + {2.0}phosRBC TsRBC * Vrbc * (K16RBCvBPGSP9 * bpgsppphosRBC / Vrbc) v_RBCvENO: {1.0}p2gRBC = {1.0}pepRBC TsRBC * Vrbc * (VRBCvENO * (KcatfRBCvENO * mgRBC / Vrbc * p2gRBC / Vrbc / (KimgRBCvENO * Kmp2gRBCvENO) - KcatrRBCvENO * mgRBC / Vrbc * pepRBC / Vrbc / (KipepRBCvENO * KmmgRBCvENO)) / (1 + mgRBC / Vrbc / KimgRBCvENO + p2gRBC / Vrbc / Kip2gRBCvENO + mgRBC / Vrbc * p2gRBC / Vrbc / (KimgRBCvENO * Kmp2gRBCvENO) + pepRBC / Vrbc / KipepRBCvENO + mgRBC / Vrbc * pepRBC / Vrbc / (KipepRBCvENO * KmmgRBCvENO))) v_RBCvG6PDH: {1.0}g6pRBC + {1.0}nadpRBC = {1.0}nadphRBC + {1.0}p6glRBC TsRBC * Vrbc * (VRBCvG6PDH * (g6pRBC / Vrbc * K1RBCvG6PDH * K3RBCvG6PDH * K5RBCvG6PDH * K7RBCvG6PDH * K9RBCvG6PDH * nadpRBC / Vrbc - K2RBCvG6PDH * K4RBCvG6PDH * K6RBCvG6PDH * K8RBCvG6PDH * K10RBCvG6PDH * nadphRBC / Vrbc * p6glRBC / Vrbc) / (g6pRBC / Vrbc * K3RBCvG6PDH * K5RBCvG6PDH * K7RBCvG6PDH * K9RBCvG6PDH + K2RBCvG6PDH * (K4RBCvG6PDH * K6RBCvG6PDH + K4RBCvG6PDH * K7RBCvG6PDH + K5RBCvG6PDH * K7RBCvG6PDH) * K9RBCvG6PDH + K1RBCvG6PDH * (K4RBCvG6PDH * K6RBCvG6PDH + K4RBCvG6PDH * K7RBCvG6PDH + K5RBCvG6PDH * K7RBCvG6PDH) * K9RBCvG6PDH * nadpRBC / Vrbc + g6pRBC / Vrbc * K1RBCvG6PDH * K3RBCvG6PDH * (K5RBCvG6PDH * K7RBCvG6PDH + K5RBCvG6PDH * K9RBCvG6PDH + K6RBCvG6PDH * K9RBCvG6PDH + K7RBCvG6PDH * K9RBCvG6PDH) * nadpRBC / Vrbc + g6pRBC / Vrbc * K3RBCvG6PDH * K5RBCvG6PDH * K7RBCvG6PDH * K10RBCvG6PDH * nadphRBC / Vrbc + K2RBCvG6PDH * (K4RBCvG6PDH * K6RBCvG6PDH + K5RBCvG6PDH * K6RBCvG6PDH + K5RBCvG6PDH * K7RBCvG6PDH) * K10RBCvG6PDH * nadphRBC / Vrbc + K2RBCvG6PDH * K4RBCvG6PDH * K6RBCvG6PDH * K8RBCvG6PDH * p6glRBC / Vrbc + K1RBCvG6PDH * K4RBCvG6PDH * K6RBCvG6PDH * K8RBCvG6PDH * nadpRBC / Vrbc * p6glRBC / Vrbc + g6pRBC / Vrbc * K1RBCvG6PDH * K3RBCvG6PDH * (K5RBCvG6PDH + K6RBCvG6PDH) * K8RBCvG6PDH * nadpRBC / Vrbc * p6glRBC / Vrbc + g6pRBC / Vrbc * K3RBCvG6PDH * (K5RBCvG6PDH + K6RBCvG6PDH) * K8RBCvG6PDH * K10RBCvG6PDH * nadphRBC / Vrbc * p6glRBC / Vrbc + (K2RBCvG6PDH * K4RBCvG6PDH + K2RBCvG6PDH * K5RBCvG6PDH + K2RBCvG6PDH * K6RBCvG6PDH + K4RBCvG6PDH * K6RBCvG6PDH) * K8RBCvG6PDH * K10RBCvG6PDH * nadphRBC / Vrbc * p6glRBC / Vrbc)) v_RBCvGAPDH: {1.0}gapRBC + {1.0}phosRBC + {1.0}nadRBC = {1.0}nadhRBC + {1.0}b13pgRBC TsRBC * Vrbc * VRBCvGAPDH / (gapRBC / Vrbc / KiappgapRBCvGAPDH * (1 + gapRBC / Vrbc / KidgapRBCvGAPDH) + b13pgRBC / Vrbc / Kiappb13pgRBCvGAPDH * (1 + gapRBC / Vrbc / KidgapRBCvGAPDH) + Kmb13pgRBCvGAPDH * nadhRBC / Vrbc / (Kiappb13pgRBCvGAPDH * KmappnadhRBCvGAPDH) + KmgapRBCvGAPDH * nadRBC / Vrbc * phosRBC / Vrbc / (KiappgapRBCvGAPDH * KmnadRBCvGAPDH * KiphosRBCvGAPDH) + nadRBC / Vrbc * gapRBC / Vrbc / (KinadRBCvGAPDH * KiappgapRBCvGAPDH) + phosRBC / Vrbc * gapRBC / Vrbc / (KiphosRBCvGAPDH * KiappgapRBCvGAPDH) * (1 + gapRBC / Vrbc / KidgapRBCvGAPDH) + nadRBC / Vrbc * b13pgRBC / Vrbc / (KinadRBCvGAPDH * Kiappb13pgRBCvGAPDH) + Kmb13pgRBCvGAPDH * phosRBC / Vrbc * nadhRBC / Vrbc / (KiphosRBCvGAPDH * Kiappb13pgRBCvGAPDH * KmappnadhRBCvGAPDH) + gapRBC / Vrbc * nadhRBC / Vrbc / (KiappgapRBCvGAPDH * KiappnadhRBCvGAPDH) + b13pgRBC / Vrbc * nadhRBC / Vrbc / (Kiappb13pgRBCvGAPDH * KmappnadhRBCvGAPDH) + nadRBC / Vrbc * phosRBC / Vrbc * gapRBC / Vrbc / (KmnadRBCvGAPDH * KiphosRBCvGAPDH * KiappgapRBCvGAPDH) + KmgapRBCvGAPDH * nadRBC / Vrbc * phosRBC / Vrbc * b13pgRBC / Vrbc / (KiappgapRBCvGAPDH * KmnadRBCvGAPDH * KiphosRBCvGAPDH * Kidb13pgRBCvGAPDH) + phosRBC / Vrbc * gapRBC / Vrbc * nadhRBC / Vrbc / (KiphosRBCvGAPDH * KiappgapRBCvGAPDH * KiappnadhRBCvGAPDH) + Kmb13pgRBCvGAPDH * phosRBC / Vrbc * b13pgRBC / Vrbc * nadhRBC / Vrbc / (Kiappb13pgRBCvGAPDH * KmappnadhRBCvGAPDH * KiphosRBCvGAPDH * Kidb13pgRBCvGAPDH)) * (KcatfappRBCvGAPDH * gapRBC / Vrbc * nadRBC / Vrbc * phosRBC / Vrbc / (KmnadRBCvGAPDH * KiphosRBCvGAPDH * KiappgapRBCvGAPDH) - KcatrappRBCvGAPDH * b13pgRBC / Vrbc * nadhRBC / Vrbc / (Kiappb13pgRBCvGAPDH * KmappnadhRBCvGAPDH)) v_RBCvGSSGR: {1.0}nadphRBC + {1.0}gssgRBC = {2.0}gshRBC + {1.0}nadpRBC TsRBC * Vrbc * (VRBCvGSSGR * (-gshRBC * gshRBC / Vrbc / Vrbc * K2RBCvGSSGR * K4RBCvGSSGR * K6RBCvGSSGR * K8RBCvGSSGR * K10RBCvGSSGR * K12RBCvGSSGR * nadpRBC / Vrbc + gssgRBC / Vrbc * K1RBCvGSSGR * K3RBCvGSSGR * K5RBCvGSSGR * K7RBCvGSSGR * K9RBCvGSSGR * K11RBCvGSSGR * nadphRBC / Vrbc) / (gshRBC * gshRBC / Vrbc / Vrbc * K2RBCvGSSGR * K4RBCvGSSGR * K6RBCvGSSGR * K8RBCvGSSGR * K10RBCvGSSGR + gshRBC / Vrbc * K2RBCvGSSGR * K4RBCvGSSGR * K6RBCvGSSGR * K8RBCvGSSGR * K11RBCvGSSGR + gssgRBC / Vrbc * K3RBCvGSSGR * K5RBCvGSSGR * K7RBCvGSSGR * K9RBCvGSSGR * K11RBCvGSSGR + K2RBCvGSSGR * (K4RBCvGSSGR * K6RBCvGSSGR + K4RBCvGSSGR * K7RBCvGSSGR + K5RBCvGSSGR * K7RBCvGSSGR) * K9RBCvGSSGR * K11RBCvGSSGR + gshRBC / Vrbc * K2RBCvGSSGR * K4RBCvGSSGR * K6RBCvGSSGR * K8RBCvGSSGR * K12RBCvGSSGR * nadpRBC / Vrbc + gssgRBC / Vrbc * K3RBCvGSSGR * K5RBCvGSSGR * K7RBCvGSSGR * K9RBCvGSSGR * K12RBCvGSSGR * nadpRBC / Vrbc + K2RBCvGSSGR * (K4RBCvGSSGR * K6RBCvGSSGR + K4RBCvGSSGR * K7RBCvGSSGR + K5RBCvGSSGR * K7RBCvGSSGR) * K9RBCvGSSGR * K12RBCvGSSGR * nadpRBC / Vrbc + gshRBC / Vrbc * gssgRBC / Vrbc * K3RBCvGSSGR * K5RBCvGSSGR * K7RBCvGSSGR * K10RBCvGSSGR * K12RBCvGSSGR * nadpRBC / Vrbc + gshRBC / Vrbc * K2RBCvGSSGR * (K4RBCvGSSGR * K6RBCvGSSGR + K4RBCvGSSGR * K7RBCvGSSGR + K5RBCvGSSGR * K7RBCvGSSGR) * K10RBCvGSSGR * K12RBCvGSSGR * nadpRBC / Vrbc + gshRBC * gshRBC / Vrbc / Vrbc * gssgRBC / Vrbc * K3RBCvGSSGR * (K5RBCvGSSGR + K6RBCvGSSGR) * K8RBCvGSSGR * K10RBCvGSSGR * K12RBCvGSSGR * nadpRBC / Vrbc + gshRBC * gshRBC / Vrbc / Vrbc * (K2RBCvGSSGR * K4RBCvGSSGR + K2RBCvGSSGR * K5RBCvGSSGR + K2RBCvGSSGR * K6RBCvGSSGR + K4RBCvGSSGR * K6RBCvGSSGR) * K8RBCvGSSGR * K10RBCvGSSGR * K12RBCvGSSGR * nadpRBC / Vrbc + gshRBC / Vrbc * gssgRBC / Vrbc * K1RBCvGSSGR * K3RBCvGSSGR * K5RBCvGSSGR * K7RBCvGSSGR * K10RBCvGSSGR * nadphRBC / Vrbc + gshRBC * gshRBC / Vrbc / Vrbc * K1RBCvGSSGR * K4RBCvGSSGR * K6RBCvGSSGR * K8RBCvGSSGR * K10RBCvGSSGR * nadphRBC / Vrbc + gshRBC * gshRBC / Vrbc / Vrbc * gssgRBC / Vrbc * K1RBCvGSSGR * K3RBCvGSSGR * (K5RBCvGSSGR + K6RBCvGSSGR) * K8RBCvGSSGR * K10RBCvGSSGR * nadphRBC / Vrbc + gshRBC / Vrbc * K1RBCvGSSGR * K4RBCvGSSGR * K6RBCvGSSGR * K8RBCvGSSGR * K11RBCvGSSGR * nadphRBC / Vrbc + gshRBC / Vrbc * gssgRBC / Vrbc * K1RBCvGSSGR * K3RBCvGSSGR * (K5RBCvGSSGR + K6RBCvGSSGR) * K8RBCvGSSGR * K11RBCvGSSGR * nadphRBC / Vrbc + K1RBCvGSSGR * (K4RBCvGSSGR * K6RBCvGSSGR + K4RBCvGSSGR * K7RBCvGSSGR + K5RBCvGSSGR * K7RBCvGSSGR) * K9RBCvGSSGR * K11RBCvGSSGR * nadphRBC / Vrbc + gssgRBC / Vrbc * K1RBCvGSSGR * K3RBCvGSSGR * (K5RBCvGSSGR * K7RBCvGSSGR * K9RBCvGSSGR + K5RBCvGSSGR * K7RBCvGSSGR * K11RBCvGSSGR + K5RBCvGSSGR * K9RBCvGSSGR * K11RBCvGSSGR + K6RBCvGSSGR * K9RBCvGSSGR * K11RBCvGSSGR + K7RBCvGSSGR * K9RBCvGSSGR * K11RBCvGSSGR) * nadphRBC / Vrbc)) v_RBCvHBADP: {1.0}hbRBC + {1.0}adpRBC = {1.0}hbadpRBC TsRBC * Vrbc * (-hbadpRBC / Vrbc * KdRBCvHBADP + KaappRBCvHBADP * adpRBC / Vrbc * hbRBC / Vrbc) v_RBCvHBATP: {1.0}hbRBC + {1.0}atpRBC = {1.0}hbatpRBC TsRBC * Vrbc * (-hbatpRBC / Vrbc * KdRBCvHBATP + KaappRBCvHBATP * atpRBC / Vrbc * hbRBC / Vrbc) v_RBCvHBB13PG: {1.0}hbRBC + {1.0}b13pgRBC = {1.0}hbb13pgRBC TsRBC * Vrbc * (-hbb13pgRBC / Vrbc * KdRBCvHBB13PG + KaappRBCvHBB13PG * b13pgRBC / Vrbc * hbRBC / Vrbc) v_RBCvHBB23PG: {1.0}hbRBC + {1.0}b23pgRBC = {1.0}hbb23pgRBC TsRBC * Vrbc * (-hbb23pgRBC / Vrbc * KdRBCvHBBPG + KaappRBCvHBBPG * b23pgRBC / Vrbc * hbRBC / Vrbc) v_RBCvHBMGATP: {1.0}mgatpRBC + {1.0}hbRBC = {1.0}hbmgatpRBC TsRBC * Vrbc * (-hbmgatpRBC / Vrbc * KdRBCvHBMGATP + KaappRBCvHBMGATP * hbRBC / Vrbc * mgatpRBC / Vrbc) v_RBCvHK: {1.0}mgatpRBC = {1.0}g6pRBC + {1.0}mgadpRBC TsRBC * Vrbc * (-KcatrappRBCvHK * ERBCvHK * g6pRBC / Vrbc * mgadpRBC / Vrbc / (Kig6pRBCvHK * KmmgadpRBCvHK) + KcatfappRBCvHK * ERBCvHK * glcRBC / Vrbc * mgatpRBC / Vrbc / (KiglcRBCvHK * KmmgatpRBCvHK)) / (1 + glcRBC / Vrbc / KiglcRBCvHK + glcRBC / Vrbc * b23pgRBC / Vrbc / (KdibpgRBCvHK * KiglcRBCvHK) + glcRBC / Vrbc * g16p2RBC / Vrbc / (Kdig16p2RBCvHK * KiglcRBCvHK) + glcRBC / Vrbc * g6pRBC / Vrbc / (Kdig6pRBCvHK * KiglcRBCvHK) + g6pRBC / Vrbc / Kig6pRBCvHK + glcRBC / Vrbc * gshRBC / Vrbc / (KdigshRBCvHK * KiglcRBCvHK) + mgadpRBC / Vrbc / KimgadpRBCvHK + g6pRBC / Vrbc * mgadpRBC / Vrbc / (Kig6pRBCvHK * KmmgadpRBCvHK) + mgatpRBC / Vrbc / KimgatpRBCvHK + glcRBC / Vrbc * mgatpRBC / Vrbc / (KiglcRBCvHK * KmmgatpRBCvHK)) v_RBCvLACTRANSPORT: {1.0}lacRBC = $pool TsRBC * vBld * (-KiRBCvLACTRANSPORT * lacEXT / vBld + KoRBCvLACTRANSPORT * lacRBC / Vrbc) v_RBCvLDH: {1.0}nadhRBC + {1.0}pyrRBC = {1.0}lacRBC + {1.0}nadRBC TsRBC * Vrbc * VRBCvLDH * (-(KcatrRBCvLDH * lacRBC / Vrbc * nadRBC / Vrbc / (KinadRBCvLDH * KmapplacRBCvLDH)) + KcatfRBCvLDH * nadhRBC / Vrbc * pyrRBC / Vrbc / (KinadhRBCvLDH * KmapppyrRBCvLDH)) / (nadRBC / Vrbc / KinadRBCvLDH + lacRBC / Vrbc * nadRBC / Vrbc / (KinadRBCvLDH * KmapplacRBCvLDH) + nadhRBC / Vrbc / KinadhRBCvLDH + KmnadRBCvLDH * lacRBC / Vrbc * nadhRBC / Vrbc / (KinadRBCvLDH * KinadhRBCvLDH * KmapplacRBCvLDH) + KmnadhRBCvLDH * nadRBC / Vrbc * pyrRBC / Vrbc / (KinadRBCvLDH * KinadhRBCvLDH * KmapppyrRBCvLDH) + lacRBC / Vrbc * nadRBC / Vrbc * pyrRBC / Vrbc / (KinadRBCvLDH * KiapppyrRBCvLDH * KmapplacRBCvLDH) + nadhRBC / Vrbc * pyrRBC / Vrbc / (KinadhRBCvLDH * KmapppyrRBCvLDH) + lacRBC / Vrbc * nadhRBC / Vrbc * pyrRBC / Vrbc / (KiapplacRBCvLDH * KinadhRBCvLDH * KmapppyrRBCvLDH) + (1 + pyrRBC / Vrbc / KidpyrRBCvLDH) * (1 + KmnadRBCvLDH * lacRBC / Vrbc / (KinadRBCvLDH * KmapplacRBCvLDH) + KmnadhRBCvLDH * pyrRBC / Vrbc / (KinadhRBCvLDH * KmapppyrRBCvLDH))) v_RBCvLDHP: {1.0}nadphRBC + {1.0}pyrRBC = {1.0}lacRBC + {1.0}nadpRBC TsRBC * Vrbc * ((-(KrRBCvLDHP * lacRBC / Vrbc * nadpRBC / Vrbc / KmlacRBCvLDHP) + KfRBCvLDHP * nadphRBC / Vrbc * pyrRBC / Vrbc / KmpyrRBCvLDHP) / (1 + lacRBC / Vrbc / KmlacRBCvLDHP + pyrRBC / Vrbc / KmpyrRBCvLDHP)) v_RBCvMGADP: {1.0}mgRBC + {1.0}adpRBC = {1.0}mgadpRBC TsRBC * Vrbc * (KaappRBCvMGADP * adpRBC / Vrbc * mgRBC / Vrbc - KdRBCvMGADP * mgadpRBC / Vrbc) v_RBCvMGATP: {1.0}mgRBC + {1.0}atpRBC = {1.0}mgatpRBC TsRBC * Vrbc * (KaappRBCvMGATP * atpRBC / Vrbc * mgRBC / Vrbc - KdRBCvMGATP * mgatpRBC / Vrbc) v_RBCvMGB13PG: {1.0}mgRBC + {1.0}b13pgRBC = {1.0}mgb13pgRBC TsRBC * Vrbc * (KaappRBCvMGB13PG * b13pgRBC / Vrbc * mgRBC / Vrbc - KdRBCvMGB13PG * mgb13pgRBC / Vrbc) v_RBCvMGB23PG: {1.0}mgRBC + {1.0}b23pgRBC = {1.0}mgb23pgRBC TsRBC * Vrbc * (KaappRBCvMGB23PG * b23pgRBC / Vrbc * mgRBC / Vrbc - KdRBCvMGB23PG * mgb23pgRBC / Vrbc) v_RBCvMGF16P2: {1.0}mgRBC + {1.0}f16p2RBC = {1.0}mgf16p2RBC TsRBC * Vrbc * (KaappRBCvMGF16P2 * f16p2RBC / Vrbc * mgRBC / Vrbc - KdRBCvMGF16P2 * mgf16p2RBC / Vrbc) v_RBCvMGG16P2: {1.0}mgRBC + {1.0}g16p2RBC = {1.0}mgg16p2RBC TsRBC * Vrbc * (KaappRBCvMGG16P2 * g16p2RBC / Vrbc * mgRBC / Vrbc - KdRBCvMGG16P2 * mgg16p2RBC / Vrbc) v_RBCvMGPHOS: {1.0}mgRBC + {1.0}phosRBC = {1.0}mgphosRBC TsRBC * Vrbc * (-KdRBCvMGPHOS * mgphosRBC / Vrbc + KaappRBCvMGPHOS * mgRBC / Vrbc * phosRBC / Vrbc) v_RBCvOX: {2.0}gshRBC = {1.0}gssgRBC TsRBC * Vrbc * (KRBCvOX * gshRBC / Vrbc) v_RBCvOXNADH: {1.0}nadhRBC = {1.0}nadRBC TsRBC * Vrbc * (KRBCvOXNADH * nadhRBC / Vrbc) v_RBCvP6GDH: {1.0}p6gRBC + {1.0}nadpRBC = {1.0}nadphRBC + {1.0}ru5pRBC TsRBC * Vrbc * (VRBCvP6GDH * (K1RBCvP6GDH * K3RBCvP6GDH * K5RBCvP6GDH * K7RBCvP6GDH * K9RBCvP6GDH * K11RBCvP6GDH * nadpRBC / Vrbc * p6gRBC / Vrbc - co2RBC / Vrbc * K2RBCvP6GDH * K4RBCvP6GDH * K6RBCvP6GDH * K8RBCvP6GDH * K10RBCvP6GDH * K12RBCvP6GDH * nadphRBC / Vrbc * ru5pRBC / Vrbc) / (co2RBC / Vrbc * K2RBCvP6GDH * K4RBCvP6GDH * K6RBCvP6GDH * K8RBCvP6GDH * K11RBCvP6GDH + K2RBCvP6GDH * (K4RBCvP6GDH * K6RBCvP6GDH + K4RBCvP6GDH * K7RBCvP6GDH + K5RBCvP6GDH * K7RBCvP6GDH) * K9RBCvP6GDH * K11RBCvP6GDH + co2RBC / Vrbc * K1RBCvP6GDH * K4RBCvP6GDH * K6RBCvP6GDH * K8RBCvP6GDH * K11RBCvP6GDH * nadpRBC / Vrbc + K1RBCvP6GDH * (K4RBCvP6GDH * K6RBCvP6GDH + K4RBCvP6GDH * K7RBCvP6GDH + K5RBCvP6GDH * K7RBCvP6GDH) * K9RBCvP6GDH * K11RBCvP6GDH * nadpRBC / Vrbc + co2RBC / Vrbc * K2RBCvP6GDH * K4RBCvP6GDH * K6RBCvP6GDH * K8RBCvP6GDH * K12RBCvP6GDH * nadphRBC / Vrbc + K2RBCvP6GDH * (K4RBCvP6GDH * K6RBCvP6GDH + K4RBCvP6GDH * K7RBCvP6GDH + K5RBCvP6GDH * K7RBCvP6GDH) * K9RBCvP6GDH * K12RBCvP6GDH * nadphRBC / Vrbc + K3RBCvP6GDH * K5RBCvP6GDH * K7RBCvP6GDH * K9RBCvP6GDH * K11RBCvP6GDH * p6gRBC / Vrbc + co2RBC / Vrbc * K1RBCvP6GDH * K3RBCvP6GDH * (K5RBCvP6GDH + K6RBCvP6GDH) * K8RBCvP6GDH * K11RBCvP6GDH * nadpRBC / Vrbc * p6gRBC / Vrbc + K1RBCvP6GDH * K3RBCvP6GDH * (K5RBCvP6GDH * K7RBCvP6GDH * K9RBCvP6GDH + K5RBCvP6GDH * K7RBCvP6GDH * K11RBCvP6GDH + K5RBCvP6GDH * K9RBCvP6GDH * K11RBCvP6GDH + K6RBCvP6GDH * K9RBCvP6GDH * K11RBCvP6GDH + K7RBCvP6GDH * K9RBCvP6GDH * K11RBCvP6GDH) * nadpRBC / Vrbc * p6gRBC / Vrbc + K3RBCvP6GDH * K5RBCvP6GDH * K7RBCvP6GDH * K9RBCvP6GDH * K12RBCvP6GDH * nadphRBC / Vrbc * p6gRBC / Vrbc + co2RBC / Vrbc * K2RBCvP6GDH * K4RBCvP6GDH * K6RBCvP6GDH * K8RBCvP6GDH * K10RBCvP6GDH * ru5pRBC / Vrbc + co2RBC / Vrbc * K1RBCvP6GDH * K4RBCvP6GDH * K6RBCvP6GDH * K8RBCvP6GDH * K10RBCvP6GDH * nadpRBC / Vrbc * ru5pRBC / Vrbc + K2RBCvP6GDH * (K4RBCvP6GDH * K6RBCvP6GDH + K4RBCvP6GDH * K7RBCvP6GDH + K5RBCvP6GDH * K7RBCvP6GDH) * K10RBCvP6GDH * K12RBCvP6GDH * nadphRBC / Vrbc * ru5pRBC / Vrbc + co2RBC / Vrbc * (K2RBCvP6GDH * K4RBCvP6GDH + K2RBCvP6GDH * K5RBCvP6GDH + K2RBCvP6GDH * K6RBCvP6GDH + K4RBCvP6GDH * K6RBCvP6GDH) * K8RBCvP6GDH * K10RBCvP6GDH * K12RBCvP6GDH * nadphRBC / Vrbc * ru5pRBC / Vrbc + K1RBCvP6GDH * K3RBCvP6GDH * K5RBCvP6GDH * K7RBCvP6GDH * K10RBCvP6GDH * nadpRBC / Vrbc * p6gRBC / Vrbc * ru5pRBC / Vrbc + co2RBC / Vrbc * K1RBCvP6GDH * K3RBCvP6GDH * (K5RBCvP6GDH + K6RBCvP6GDH) * K8RBCvP6GDH * K10RBCvP6GDH * nadpRBC / Vrbc * p6gRBC / Vrbc * ru5pRBC / Vrbc + K3RBCvP6GDH * K5RBCvP6GDH * K7RBCvP6GDH * K10RBCvP6GDH * K12RBCvP6GDH * nadphRBC / Vrbc * p6gRBC / Vrbc * ru5pRBC / Vrbc + co2RBC / Vrbc * K3RBCvP6GDH * (K5RBCvP6GDH + K6RBCvP6GDH) * K8RBCvP6GDH * K10RBCvP6GDH * K12RBCvP6GDH * nadphRBC / Vrbc * p6gRBC / Vrbc * ru5pRBC / Vrbc)) v_RBCvPFK: {1.0}mgatpRBC + {1.0}f6pRBC = {1.0}f16p2RBC + {1.0}mgadpRBC TsRBC * Vrbc * (VRBCvPFK * (-(f16p2RBC / Vrbc * KcatfRBCvPFK * mgadpRBC / Vrbc / (Kmf16p2RBCvPFK * KmmgadpRBCvPFK)) + f6pRBC / Vrbc * KcatfRBCvPFK * mgatpRBC / Vrbc / (Kmf6pRBCvPFK * KmmgatpRBCvPFK)) / ((1 + f16p2RBC / Vrbc / Kmf16p2RBCvPFK + f6pRBC / Vrbc / Kmf6pRBCvPFK + mgadpRBC / Vrbc / KmmgadpRBCvPFK + f16p2RBC / Vrbc * mgadpRBC / Vrbc / (Kmf16p2RBCvPFK * KmmgadpRBCvPFK) + mgatpRBC / Vrbc / KmmgatpRBCvPFK + f6pRBC / Vrbc * mgatpRBC / Vrbc / (Kmf6pRBCvPFK * KmmgatpRBCvPFK)) * (1 + pow(hRBC / KaRBCvPFK, nRBCvPFK) * pow(1 + atpRBC / Vrbc / KtatpRBCvPFK, 4) * pow(1 + b23pgRBC / Vrbc / Ktb23pgRBCvPFK, 4) * pow(1 + mgRBC / Vrbc / KtmgRBCvPFK, 4) / (pow(1 + f16p2RBC / Vrbc / Kmf16p2RBCvPFK + f6pRBC / Vrbc / Kmf6pRBCvPFK, 4) * pow(1 + ampRBC / Vrbc / KrampRBCvPFK, 4) * pow(1 + g16p2RBC / Vrbc / Krg16p2RBCvPFK, 4) * pow(1 + phosRBC / Vrbc / KrphosRBCvPFK, 4))))) v_RBCvPGI: {1.0}g6pRBC = {1.0}f6pRBC TsRBC * Vrbc * (ERBCvPGI * (-(f6pRBC / Vrbc * KcatrRBCvPGI / Kmf6pRBCvPGI) + g6pRBC / Vrbc * KcatfRBCvPGI / Kmg6pRBCvPGI) / (1 + f6pRBC / Vrbc / Kmf6pRBCvPGI + g6pRBC / Vrbc / Kmg6pRBCvPGI)) v_RBCvPGK: {1.0}b13pgRBC + {1.0}mgadpRBC = {1.0}mgatpRBC + {1.0}p3gRBC TsRBC * Vrbc * (VRBCvPGK * (b13pgRBC / Vrbc * KcatfRBCvPGK * mgadpRBC / Vrbc / (KimgadpRBCvPGK * Kmb13pgRBCvPGK) - KcatrRBCvPGK * mgatpRBC / Vrbc * p3gRBC / Vrbc / (KimgatpRBCvPGK * Kmp3gRBCvPGK)) / (1 + b13pgRBC / Vrbc / Kib13pgRBCvPGK + mgadpRBC / Vrbc / KimgadpRBCvPGK + b13pgRBC / Vrbc * mgadpRBC / Vrbc / (KimgadpRBCvPGK * Kmb13pgRBCvPGK) + mgatpRBC / Vrbc / KimgatpRBCvPGK + p3gRBC / Vrbc / Kip3gRBCvPGK + mgatpRBC / Vrbc * p3gRBC / Vrbc / (KimgatpRBCvPGK * Kmp3gRBCvPGK))) v_RBCvPGLHYDROLYSIS: {1.0}p6glRBC = {1.0}p6gRBC TsRBC * Vrbc * (KhydrolRBCvPGLHYDROLYSIS * p6glRBC / Vrbc + VRBCvPGLHYDROLYSIS * Klactonase3RBCvPGLHYDROLYSIS * p6glRBC / Vrbc / ((Klactonase2RBCvPGLHYDROLYSIS + Klactonase3RBCvPGLHYDROLYSIS) / Klactonase1RBCvPGLHYDROLYSIS + p6glRBC / Vrbc)) v_RBCvPGM: {1.0}p3gRBC = {1.0}p2gRBC TsRBC * Vrbc * (VRBCvPGM * (-(KcatrRBCvPGM * p2gRBC / Vrbc / Kmp2gRBCvPGM) + KcatfRBCvPGM * p3gRBC / Vrbc / Kmp3gRBCvPGM) / (1 + p2gRBC / Vrbc / Kmp2gRBCvPGM + p3gRBC / Vrbc / Kmp3gRBCvPGM)) v_RBCvPHOSTRANSPORT: {1.0}phosRBC = $pool TsRBC * vBld * (-KiRBCvPHOSTRANSPORT * phosEXT / vBld + KoRBCvPHOSTRANSPORT * phosRBC / Vrbc) v_RBCvPK: {1.0}pepRBC + {1.0}mgadpRBC = {1.0}pyrRBC + {1.0}mgatpRBC TsRBC * Vrbc * (VRBCvPK * (KcatfRBCvPK * mgadpRBC / Vrbc * pepRBC / Vrbc / (KrmgadpRBCvPK * KrpepRBCvPK) - KcatrRBCvPK * mgatpRBC / Vrbc * pyrRBC / Vrbc / (KrmgatpRBCvPK * KrpyrRBCvPK)) / ((1 + mgadpRBC / Vrbc / KrmgadpRBCvPK + mgatpRBC / Vrbc / KrmgatpRBCvPK + pepRBC / Vrbc / KrpepRBCvPK + mgadpRBC / Vrbc * pepRBC / Vrbc / (KrmgadpRBCvPK * KrpepRBCvPK) + pyrRBC / Vrbc / KrpyrRBCvPK + mgatpRBC / Vrbc * pyrRBC / Vrbc / (KrmgatpRBCvPK * KrpyrRBCvPK)) * (1 + LRBCvPK))) v_RBCvPYRTRANSPORT: {1.0}pyrRBC = $pool TsRBC * vBld * (-KiRBCvPYRTRANSPORT * pyrEXT / vBld + KoRBCvPYRTRANSPORT * pyrRBC / Vrbc) v_RBCvR5PI: {1.0}ru5pRBC = {1.0}rib5pRBC TsRBC * Vrbc * (VRBCvR5PI * (-(K2RBCvR5PI * K4RBCvR5PI * rib5pRBC / Vrbc / (K2RBCvR5PI + K3RBCvR5PI)) + K1RBCvR5PI * K3RBCvR5PI * ru5pRBC / Vrbc / (K2RBCvR5PI + K3RBCvR5PI)) / (1 + K1RBCvR5PI * ru5pRBC / Vrbc / (K2RBCvR5PI + K3RBCvR5PI) + K4RBCvR5PI * xu5pRBC / Vrbc / (K2RBCvR5PI + K3RBCvR5PI))) v_RBCvRu5PE: {1.0}ru5pRBC = {1.0}xu5pRBC TsRBC * Vrbc * (VRBCvRu5PE * (K1RBCvRu5PE * K3RBCvRu5PE * ru5pRBC / Vrbc / (K2RBCvRu5PE + K3RBCvRu5PE) - K2RBCvRu5PE * K4RBCvRu5PE * xu5pRBC / Vrbc / (K2RBCvRu5PE + K3RBCvRu5PE)) / (1 + K1RBCvRu5PE * ru5pRBC / Vrbc / (K2RBCvRu5PE + K3RBCvRu5PE) + K4RBCvRu5PE * xu5pRBC / Vrbc / (K2RBCvRu5PE + K3RBCvRu5PE))) v_RBCvTA: {1.0}sed7pRBC + {1.0}gapRBC = {1.0}ery4pRBC + {1.0}f6pRBC TsRBC * Vrbc * (VRBCvTA * (-ery4pRBC / Vrbc * f6pRBC / Vrbc * K2RBCvTA * K4RBCvTA * K6RBCvTA * K8RBCvTA + gapRBC / Vrbc * K1RBCvTA * K3RBCvTA * K5RBCvTA * K7RBCvTA * sed7pRBC / Vrbc) / (gapRBC / Vrbc * (K2RBCvTA + K3RBCvTA) * K5RBCvTA * K7RBCvTA + ery4pRBC / Vrbc * K2RBCvTA * K4RBCvTA * (K6RBCvTA + K7RBCvTA) + f6pRBC / Vrbc * gapRBC / Vrbc * (K2RBCvTA + K3RBCvTA) * K5RBCvTA * K8RBCvTA + f6pRBC / Vrbc * (K2RBCvTA + K3RBCvTA) * K6RBCvTA * K8RBCvTA + ery4pRBC / Vrbc * f6pRBC / Vrbc * K4RBCvTA * (K2RBCvTA + K6RBCvTA) * K8RBCvTA + gapRBC / Vrbc * K1RBCvTA * K5RBCvTA * (K3RBCvTA + K7RBCvTA) * sed7pRBC / Vrbc + K1RBCvTA * K3RBCvTA * (K6RBCvTA + K7RBCvTA) * sed7pRBC / Vrbc + ery4pRBC / Vrbc * K1RBCvTA * K4RBCvTA * (K6RBCvTA + K7RBCvTA) * sed7pRBC / Vrbc)) v_RBCvTIM: {1.0}gapRBC = {1.0}dhapRBC TsRBC * Vrbc * (VRBCvTIM * (gapRBC / Vrbc * KcatfRBCvTIM / KmgapRBCvTIM - dhapRBC / Vrbc * KcatrRBCvTIM / KmdhapRBCvTIM) / (1 + gapRBC / Vrbc / KmgapRBCvTIM + dhapRBC / Vrbc / KmdhapRBCvTIM)) v_RBCvTK1: {1.0}xu5pRBC + {1.0}tkRBC = {1.0}tkxu5pRBC TsRBC * Vrbc * (K1RBCvTK1 * tkRBC / Vrbc * xu5pRBC / Vrbc - K2RBCvTK1 * tkxu5pRBC / Vrbc) v_RBCvTK2: {1.0}tkxu5pRBC = {1.0}tkgRBC + {1.0}gapRBC TsRBC * Vrbc * (K3RBCvTK2 * tkxu5pRBC / Vrbc - K4RBCvTK2 * tkgRBC / Vrbc * gapRBC / Vrbc) v_RBCvTK3: {1.0}tkgRBC + {1.0}rib5pRBC = {1.0}tkgrib5pRBC TsRBC * Vrbc * (K5RBCvTK3 * tkgRBC / Vrbc * rib5pRBC / Vrbc - K6RBCvTK3 * tkgrib5pRBC / Vrbc) v_RBCvTK4: {1.0}tkgrib5pRBC = {1.0}tkRBC + {1.0}sed7pRBC TsRBC * Vrbc * (K7RBCvTK4 * tkgrib5pRBC / Vrbc - K8RBCvTK4 * tkRBC / Vrbc * sed7pRBC / Vrbc) v_RBCvTK5: {1.0}tkgRBC + {1.0}ery4pRBC = {1.0}tkgery4pRBC TsRBC * Vrbc * (K9RBCvTK5 * tkgRBC / Vrbc * ery4pRBC / Vrbc - K10RBCvTK5 * tkgery4pRBC / Vrbc) v_RBCvTK6: {1.0}tkgery4pRBC = {1.0}tkRBC + {1.0}f6pRBC TsRBC * Vrbc * (K11RBCvTK6 * tkgery4pRBC / Vrbc - K12RBCvTK6 * tkRBC / Vrbc * f6pRBC / Vrbc) #parameters AlphaCellWaterFraction = 0.7 CRBCvMGADP = 0.00062 CRBCvMGATP = 8.4e-05 CRBCvMGB13PG = 0.0032 CRBCvMGB23PG = 0.0032 CRBCvMGF16P2 = 0.0083 CRBCvMGG16P2 = 0.0083 CRBCvMGPHOS = 40800.0 ConcADPRBC = 0.00031 ConcAMPRBC = 3e-05 ConcATPRBC = 0.0021 ConcB13PGRBC = 7e-07 ConcB23PGRBC = 0.0067 ConcBPGSPB13PGRBC = 0.0 ConcBPGSPB23PGRBC = 0.0 ConcBPGSPPP2GRBC = 0.0 ConcBPGSPPP3GRBC = 0.0 ConcBPGSPPRBC = 0.0 ConcBPGSPRBC = 3.8e-06 ConcBpgsppphosRBC = 0.0 ConcCo2RBC = 0.0012 ConcDhapRBC = 1.9e-05 ConcEry4PRBC = 1e-05 ConcF16P2RBC = 2.7e-06 ConcF6PRBC = 1.3e-05 ConcG16P2RBC = 0.000122 ConcG6PRBC = 4e-05 ConcGSHRBC = 0.0032 ConcGapRBC = 5.7e-06 ConcGlcRBC = 0.005 ConcGssgRBC = 9e-08 ConcHbADPRBC = 0.0 ConcHbATPRBC = 0.0 ConcHbB13PGRBC = 0.0 ConcHbB23PGRBC = 0.0 ConcHbRBC = 0.007 ConcHbmgatpRBC = 0.0 ConcLacEXT = 0.00182 ConcLacRBC = 0.0014 ConcMgADPRBC = 0.0 ConcMgB13PGRBC = 0.0 ConcMgB23PGRBC = 0.0 ConcMgF16P2RBC = 0.0 ConcMgRBC = 0.003 ConcMgatpRBC = 0.0 ConcMgg16p2RBC = 0.0 ConcMgphosRBC = 0.0 ConcNADPRBC = 1.25e-07 ConcNADRBC = 6e-05 ConcNadhRBC = 1.4e-07 ConcNadphRBC = 6.4e-05 ConcP2GARBC = 1e-05 ConcP3GARBC = 6.4e-05 ConcP6GLRBC = 1.4e-10 ConcP6GRBC = 1.4e-07 ConcPEPRBC = 2.3e-05 ConcPhosEXT = 0.00192 ConcPhosRBC = 0.001 ConcPyrEXT = 8.5e-05 ConcPyrRBC = 6e-05 ConcRib5PRBC = 1e-05 ConcRu5PRBC = 1e-05 ConcSed7PRBC = 1e-05 ConcTKGEry4PRBC = 0.0 ConcTKGRBC = 0.0 ConcTKGRib5PRBC = 0.0 ConcTKRBC = 3.3e-07 ConcTkxu5pRBC = 0.0 ConcXu5PRBC = 1e-06 ERBCvHK = 2.5e-08 ERBCvPGI = 2.18e-07 K10RBCvBPGSP6 = 1979.0 K10RBCvG6PDH = 1400000000.0 K10RBCvGSSGR = 50000000.0 K10RBCvP6GDH = 225000.0 K10RBCvTK5 = 175.0 K11RBCvBPGSP6 = 0.01 K11RBCvGSSGR = 7000.0 K11RBCvP6GDH = 300.0 K11RBCvTK6 = 40.0 K12RBCvBPGSP7 = 1000.0 K12RBCvGSSGR = 100000000.0 K12RBCvP6GDH = 4950000.0 K12RBCvTK6 = 21300.0 K13RBCvBPGSP7 = 1800000.0 K14RBCvBPGSP8 = 1000000000.0 K15RBCvBPGSP8 = 610000.0 K16RBCvBPGSP9 = 0.19 K1RBCvAK = 4300.0 K1RBCvBPGSP1 = 80000000.0 K1RBCvG6PDH = 110000000.0 K1RBCvGSSGR = 85000000.0 K1RBCvP6GDH = 2400000.0 K1RBCvR5PI = 60900.0 K1RBCvRu5PE = 3910000.0 K1RBCvTA = 580000.0 K1RBCvTK1 = 216000.0 K2RBCvAK = 1400.0 K2RBCvBPGSP1 = 400.0 K2RBCvG6PDH = 870.0 K2RBCvGSSGR = 510.0 K2RBCvP6GDH = 410.0 K2RBCvR5PI = 33.3 K2RBCvRu5PE = 438.0 K2RBCvTA = 45.3 K2RBCvTK1 = 38.0 K3RBCvBPGSP2 = 9.9 K3RBCvG6PDH = 26000000.0 K3RBCvGSSGR = 1000000000.0 K3RBCvP6GDH = 2000000000.0 K3RBCvR5PI = 14.2 K3RBCvRu5PE = 305.0 K3RBCvTA = 16.3 K3RBCvTK2 = 34.0 K4RBCvBPGSP3 = 185000000.0 K4RBCvG6PDH = 300.0 K4RBCvGSSGR = 72000.0 K4RBCvP6GDH = 26000.0 K4RBCvR5PI = 21600.0 K4RBCvRu5PE = 1490000.0 K4RBCvTA = 1010000.0 K4RBCvTK2 = 156000.0 K5RBCvBPGSP3 = 100000000.0 K5RBCvG6PDH = 750.0 K5RBCvGSSGR = 810.0 K5RBCvP6GDH = 48.0 K5RBCvTA = 490000.0 K5RBCvTK3 = 329000.0 K6RBCvBPGSP4 = 1000.0 K6RBCvG6PDH = 2000.0 K6RBCvGSSGR = 1000.0 K6RBCvP6GDH = 30.0 K6RBCvTA = 60.0 K6RBCvTK3 = 175.0 K7RBCvBPGSP4 = 1000.0 K7RBCvG6PDH = 220000.0 K7RBCvGSSGR = 1000000.0 K7RBCvP6GDH = 630.0 K7RBCvTA = 17.0 K7RBCvTK4 = 40.0 K8RBCvBPGSP5 = 10000.0 K8RBCvG6PDH = 1100000000.0 K8RBCvGSSGR = 50000000.0 K8RBCvP6GDH = 36000.0 K8RBCvTA = 79000.0 K8RBCvTK4 = 44800.0 K9RBCvBPGSP5 = 0.55 K9RBCvG6PDH = 10000.0 K9RBCvGSSGR = 1000000.0 K9RBCvP6GDH = 800.0 K9RBCvTK5 = 2240000.0 KRBCvATPASE = 0.000585 KRBCvMGADP = 3290.0 KRBCvMGATP = 43200.0 KRBCvMGB13PG = 7410.0 KRBCvMGB23PG = 7410.0 KRBCvMGF16P2 = 363.0 KRBCvMGG16P2 = 363.0 KRBCvOX = 3.4e-05 KRBCvOXNADH = 0.0163 KaRBCvHBADP = 300000.0 KaRBCvHBATP = 432000.0 KaRBCvHBB13PG = 380000.0 KaRBCvHBBPG = 300000.0 KaRBCvHBMGATP = 46800.0 KaRBCvMGADP = 2760000.0 KaRBCvMGATP = 31200000.0 KaRBCvMGB13PG = 228000.0 KaRBCvMGB23PG = 804000.0 KaRBCvMGF16P2 = 480000.0 KaRBCvMGG16P2 = 480000.0 KaRBCvMGPHOS = 40800.0 KaRBCvPFK = 8.91251e-08 KahbRBC = 2.51189e-07 KcatfRBCvALD = 68.0 KcatfRBCvENO = 190.0 KcatfRBCvGAPDH = 695.304 KcatfRBCvHK = 299.16 KcatfRBCvLDH = 458.0 KcatfRBCvPFK = 822.0 KcatfRBCvPGI = 1470.0 KcatfRBCvPGK = 2290.0 KcatfRBCvPGM = 795.0 KcatfRBCvPK = 1386.0 KcatfRBCvTIM = 14560.0 KcatrRBCvALD = 234.0 KcatrRBCvENO = 50.0 KcatrRBCvGAPDH = 512.487 KcatrRBCvHK = 1.92792 KcatrRBCvLDH = 115.0 KcatrRBCvPFK = 36.0 KcatrRBCvPGI = 1760.0 KcatrRBCvPGK = 917.0 KcatrRBCvPGM = 714.0 KcatrRBCvPK = 3.26 KcatrRBCvTIM = 1280.0 KdRBCvHBADP = 1200.0 KdRBCvHBATP = 1200.0 KdRBCvHBB13PG = 1200.0 KdRBCvHBBPG = 1200.0 KdRBCvHBMGATP = 1200.0 KdRBCvMGADP = 1200.0 KdRBCvMGATP = 1200.0 KdRBCvMGB13PG = 1200.0 KdRBCvMGB23PG = 1200.0 KdRBCvMGF16P2 = 1200.0 KdRBCvMGG16P2 = 1200.0 KdRBCvMGPHOS = 1200.0 KdibpgRBCvHK = 0.004 Kdig16p2RBCvHK = 3e-05 Kdig6pRBCvHK = 1e-05 KdigshRBCvHK = 0.003 KfRBCvLDHP = 0.00346 Kh2bpgRBCvMGB13PG = 4270000.0 Kh2bpgRBCvMGB23PG = 4270000.0 Kh2fRBCvMGF16P2 = 1120000.0 Kh2fRBCvMGG16P2 = 1120000.0 KhadpRBCvAK = 5420000.0 KhadpRBCvMGADP = 5420000.0 KhampRBCvAK = 3090000.0 KhatpRBCvMGATP = 9070000.0 KhbpgRBCvMGB13PG = 162000000.0 KhbpgRBCvMGB23PG = 162000000.0 KhfRBCvMGF16P2 = 7560000.0 KhfRBCvMGG16P2 = 7560000.0 KhphosRBCvMGPHOS = 5680000.0 KhydrolRBCvPGLHYDROLYSIS = 0.00071 KiRBCvLACTRANSPORT = 0.0036 KiRBCvPHOSTRANSPORT = 0.00056 KiRBCvPYRTRANSPORT = 0.018 Kib13pgRBCvGAPDH = 4.55544e-21 Kib13pgRBCvPGK = 1.6e-06 Kib23pgRBCvALD = 0.0015 Kidb13pgRBCvGAPDH = 1e-06 KidgapRBCvGAPDH = 3.1e-05 KidhapRBCvALD = 1.1e-05 KidpyrRBCvLDH = 0.000101 Kif16p2RBCvALD = 1.98e-05 Kig6pRBCvHK = 4.7e-05 KigapRBCvGAPDH = 4.76523e-19 KiglcRBCvHK = 4.7e-05 KilacRBCvLDH = 0.00733 KimgRBCvENO = 4.6e-05 KimgadpRBCvHK = 0.001 KimgadpRBCvPGK = 8e-05 KimgatpRBCvHK = 0.001 KimgatpRBCvPGK = 0.000186 KinadRBCvGAPDH = 4.5e-05 KinadRBCvLDH = 0.000503 KinadhRBCvGAPDH = 1e-05 KinadhRBCvLDH = 2.45e-06 Kip2gRBCvENO = 0.00014 Kip3gRBCvPGK = 0.000205 KipepRBCvENO = 0.0001105 KiphosRBCvGAPDH = 0.00316 KipyrRBCvLDH = 0.000228 KkadpRBCvAK = 4.8 KkadpRBCvMGADP = 4.8 KkampRBCvAK = 1.8 KkatpRBCvMGATP = 14.0 KkbpgRBCvMGB13PG = 85.1 KkbpgRBCvMGB23PG = 85.1 KkfRBCvMGF16P2 = 10.7 KkfRBCvMGG16P2 = 10.7 KkhbpgRBCvMGB13PG = 8.9 KkhbpgRBCvMGB23PG = 8.9 KkhfRBCvMGF16P2 = 3.3 KkhfRBCvMGG16P2 = 3.3 KkphosRBCvMGPHOS = 3.0 Klactonase1RBCvPGLHYDROLYSIS = 13000000.0 Klactonase2RBCvPGLHYDROLYSIS = 1000.0 Klactonase3RBCvPGLHYDROLYSIS = 29.0 Kmb13pgRBCvGAPDH = 6.71e-07 Kmb13pgRBCvPGK = 2e-06 KmdhapRBCvALD = 3.5e-05 KmdhapRBCvTIM = 0.0001624 Kmf16p2RBCvALD = 7.1e-06 Kmf16p2RBCvPFK = 0.0005 Kmf6pRBCvPFK = 7.5e-05 Kmf6pRBCvPGI = 7.1e-05 Kmg6pRBCvPGI = 0.000181 KmgapRBCvALD = 0.000189 KmgapRBCvGAPDH = 9.5e-05 KmgapRBCvTIM = 0.000446 KmghadpRBCvMGADP = 107.0 KmghatpRBCvMGATP = 748.0 KmghbpgRBCvMGB13PG = 513.0 KmghbpgRBCvMGB23PG = 513.0 KmghfRBCvMGF16P2 = 89.0 KmghfRBCvMGG16P2 = 89.0 KmlacRBCvLDH = 0.00107 KmlacRBCvLDHP = 0.000414 KmmgRBCvENO = 4.6e-05 KmmgadpRBCvHK = 0.001 KmmgadpRBCvPFK = 0.00054 KmmgadpRBCvPGK = 0.0001 KmmgatpRBCvHK = 0.001 KmmgatpRBCvPFK = 6.8e-05 KmmgatpRBCvPGK = 0.001 KmnadRBCvGAPDH = 4.5e-05 KmnadRBCvLDH = 0.000107 KmnadhRBCvGAPDH = 3.3e-06 KmnadhRBCvLDH = 8.44e-06 Kmp2gRBCvENO = 0.00014 Kmp2gRBCvPGM = 2.56e-05 Kmp3gRBCvPGK = 0.0011 Kmp3gRBCvPGM = 0.000168 KmpepRBCvENO = 0.0001105 KmphosRBCvGAPDH = 0.00316 KmpyrRBCvLDH = 0.000137 KmpyrRBCvLDHP = 0.000414 KrRBCvLDHP = 5.43e-07 KrampRBCvPFK = 0.0003 Krf16p2RBCvPK = 5e-06 Krg16p2RBCvPFK = 0.01 Krg16p2RBCvPK = 0.0001 KrmgadpRBCvPK = 0.000474 KrmgatpRBCvPK = 0.003 KrpepRBCvPK = 0.000225 KrphosRBCvPFK = 0.03 KrpyrRBCvPK = 0.002 KtatpRBCvPFK = 0.0001 KtatpRBCvPK = 0.00339 Ktb23pgRBCvPFK = 0.005 KtmgRBCvPFK = 0.004 RtvRBC = 0.69 TsRBC = 60.0 VRBCvALD = 3.7e-07 VRBCvENO = 2.2e-07 VRBCvG6PDH = 9.3e-08 VRBCvGAPDH = 7.66e-06 VRBCvGSSGR = 1.25e-07 VRBCvLDH = 3.43e-06 VRBCvP6GDH = 2.1e-06 VRBCvPFK = 1.1e-07 VRBCvPGK = 2.74e-06 VRBCvPGLHYDROLYSIS = 1.4e-05 VRBCvPGM = 4.1e-07 VRBCvPK = 8.7e-08 VRBCvR5PI = 1.42e-05 VRBCvRu5PE = 4.22e-06 VRBCvTA = 6.9e-07 VRBCvTIM = 1.14e-06 bpgxRBC = 3.8e-06 gssgxRBC = 0.00160009 hbxRBC = 0.007 kRBC = 0.15 nRBCvPFK = 5.0 nadpxRBC = 6.4125e-05 pHConversionFactor = 1.0 phRBC = 7.2 tkxRBC = 3.3e-07 xatpRBC = -0.00456 xg16p2RBC = 0.000122 xphosRBC = 0.000438 Vrbc = 90.0 vBld = 128.5 #initial values adpRBC = 0.0279 ampRBC = 27/10000 atpRBC = 0.189 b13pgRBC = 63/1000000 b23pgRBC = 0.603 bpgspRBC = 0.00034199999999999996 bpgspb13pgRBC = 0 bpgspb23pgRBC = 0 bpgsppRBC = 0 bpgsppp2gRBC = 0 bpgsppp3gRBC = 0 bpgsppphosRBC = 0 dhapRBC = 0.0017100000000000001 ery4pRBC = 9/10000 f16p2RBC = 0.00024300000000000002 f6pRBC = 0.00117 g16p2RBC = 0.01098 g6pRBC = 9/2500 gapRBC = 0.000513 gshRBC = 0.28800000000000003 gssgRBC = 81/10000000 hbRBC = 0.63 hbadpRBC = 0 hbatpRBC = 0 hbb13pgRBC = 0 hbb23pgRBC = 0 hbmgatpRBC = 0 lacRBC = 0.126 mgRBC = 0.27 mgadpRBC = 0 mgatpRBC = 0 mgb13pgRBC = 0 mgb23pgRBC = 0 mgf16p2RBC = 0 mgg16p2RBC = 0 mgphosRBC = 0 nadRBC = 27/5000 nadhRBC = 0.000012599999999999998 nadpRBC = 0.000011249999999999999 nadphRBC = 0.00576 p2gRBC = 9/10000 p3gRBC = 0.00576 p6gRBC = 0.000012599999999999998 p6glRBC = 1.2599999999999999*^-8 pepRBC = 0.00207 phosRBC = 0.09 pyrRBC = 27/5000 rib5pRBC = 9/10000 ru5pRBC = 9/10000 sed7pRBC = 9/10000 tkRBC = 0.0000297 tkgRBC = 0 tkgery4pRBC = 0 tkgrib5pRBC = 0 tkxu5pRBC = 0 xu5pRBC = 9/100000 #assignment rules !F KiappgapRBCvGAPDH = KigapRBCvGAPDH / (1.0 + pow(10.0, -phRBC) / pow(10.0, -7.5) + pow(10.0, -10.0) / pow(10.0, -phRBC)) !F K13appRBCvBPGSP7 = K13RBCvBPGSP7 * ((1.0 + pow(pow(10.0, -7.2) / pow(10.0, -7.17), 4.0)) / (1.0 + pow(pow(10.0, -phRBC) / pow(10.0, -7.17), 4.0))) !F KaappRBCvMGB23PG = KaRBCvMGB23PG * CRBCvMGB23PG * (KRBCvMGB23PG + KhbpgRBCvMGB23PG * KmghbpgRBCvMGB23PG * hRBC) / (1.0 + KhbpgRBCvMGB23PG * hRBC + Kh2bpgRBCvMGB23PG * KhbpgRBCvMGB23PG * hRBC * hRBC + kRBC * KkbpgRBCvMGB23PG + kRBC * KhbpgRBCvMGB23PG * KkhbpgRBCvMGB23PG * hRBC) !F KaappRBCvMGF16P2 = KaRBCvMGF16P2 * CRBCvMGF16P2 * (KRBCvMGF16P2 + KhfRBCvMGF16P2 * KmghfRBCvMGF16P2 * hRBC) / (1.0 + KhfRBCvMGF16P2 * hRBC + Kh2fRBCvMGF16P2 * KhfRBCvMGF16P2 * hRBC * hRBC + kRBC * KkfRBCvMGF16P2 + kRBC * KhfRBCvMGF16P2 * KkhfRBCvMGF16P2 * hRBC) !F K6appRBCvBPGSP4 = K6RBCvBPGSP4 * ((1.0 + pow(pow(10.0, -7.2) / pow(10.0, -7.17), 4.0)) / (1.0 + pow(pow(10.0, -phRBC) / pow(10.0, -7.17), 4.0))) !F K1appRBCvAK = K1RBCvAK * (1.0 + pHConversionFactor * pow(10.0, -phRBC) * KhadpRBCvAK + kRBC * KkadpRBCvAK) !F KaappRBCvMGATP = KaRBCvMGATP * CRBCvMGATP * ((KRBCvMGATP + KhatpRBCvMGATP * KmghatpRBCvMGATP * hRBC) / (1.0 + KhatpRBCvMGATP / pHConversionFactor / pow(10.0, phRBC) + kRBC * KkatpRBCvMGATP)) !F KaappRBCvMGG16P2 = KaRBCvMGG16P2 * CRBCvMGG16P2 * (KRBCvMGG16P2 + KhfRBCvMGG16P2 * KmghfRBCvMGG16P2 * hRBC) / (1.0 + KhfRBCvMGG16P2 * hRBC + Kh2fRBCvMGG16P2 * KhfRBCvMGG16P2 * hRBC * hRBC + kRBC * KkfRBCvMGG16P2 + kRBC * KhfRBCvMGG16P2 * KkhfRBCvMGG16P2 * hRBC) !F K2appRBCvAK = K2RBCvAK * (1.0 + hRBC * KhampRBCvAK + kRBC * KkampRBCvAK) !F KaappRBCvMGB13PG = KaRBCvMGB13PG * CRBCvMGB13PG * (KRBCvMGB13PG + KhbpgRBCvMGB13PG * KmghbpgRBCvMGB13PG * hRBC) / (1.0 + KhbpgRBCvMGB13PG * hRBC + Kh2bpgRBCvMGB13PG * KhbpgRBCvMGB13PG * hRBC * hRBC + kRBC * KkbpgRBCvMGB13PG + kRBC * KhbpgRBCvMGB13PG * KkhbpgRBCvMGB13PG * hRBC) !F KaappRBCvMGPHOS = KaRBCvMGPHOS * (1.0 + pHConversionFactor * pow(10.0, -7.2) * KhphosRBCvMGPHOS + kRBC * KkphosRBCvMGPHOS) / (1.0 + hRBC * KhphosRBCvMGPHOS + kRBC * KkphosRBCvMGPHOS) !F KoRBCvPHOSTRANSPORT = KiRBCvPHOSTRANSPORT / KeqRBCvPHOSTRANSPORT !F KaappRBCvMGADP = KaRBCvMGADP * CRBCvMGADP * ((KRBCvMGADP + KhadpRBCvMGADP * KmghadpRBCvMGADP * hRBC) / (1.0 + KhadpRBCvMGADP * hRBC + kRBC * KkadpRBCvMGADP)) !F KiapppyrRBCvLDH = KipyrRBCvLDH * ((1.0 + pow(10.0, -6.8) / pow(10.0, -phRBC)) / (1.0 + pow(10.0, -6.8) / pow(10.0, -7.2))) !F KcatrappRBCvGAPDH = KcatrRBCvGAPDH / (1.0 + pow(10.0, -phRBC) / pow(10.0, -7.5) + pow(10.0, -10.0) / pow(10.0, -phRBC)) !F KmapplacRBCvLDH = KmlacRBCvLDH * ((1.0 + pow(10.0, -phRBC) / pow(10.0, -6.8)) / (1.0 + pow(10.0, -7.2) / pow(10.0, -6.8))) !F KeqRBCvLACTRANSPORT = (1.0 + pow(10.0, phRBC - 3.73)) / (1.0 + pow(10.0, phRBC - 3.73) / RtvRBC) !F KmappnadhRBCvGAPDH = KmnadhRBCvGAPDH * (pow(10.0, -7.2) / pow(10.0, -phRBC)) !F KmapppyrRBCvLDH = KmpyrRBCvLDH * ((1.0 + pow(10.0, -6.8) / pow(10.0, -phRBC)) / (1.0 + pow(10.0, -6.8) / pow(10.0, -7.2))) !F KcatrappRBCvHK = KcatrRBCvHK / (1.0 + pow(10.0, -phRBC) / pow(10.0, -7.02) + pow(10.0, -9.55) / pow(10.0, -phRBC)) !F HbpHRBC = (1.0 + 2.0 * KahbRBC / (pHConversionFactor * pow(10.0, -7.2)) + pow(KahbRBC / (pHConversionFactor * pow(10.0, -7.2)), 2.0)) / (1.0 + 2.0 * KahbRBC / hRBC + KahbRBC / hRBC * KahbRBC / hRBC) !F KeqRBCvPHOSTRANSPORT = (1.0 + pow(10.0, phRBC - 6.75)) / (1.0 / RtvRBC + pow(10.0, phRBC - 6.75) / (RtvRBC * RtvRBC)) !F KcatfappRBCvHK = KcatfRBCvHK / (1.0 + pow(10.0, -phRBC) / pow(10.0, -7.02) + pow(10.0, -9.55) / pow(10.0, -phRBC)) !F KaappRBCvHBB13PG = KaRBCvHBB13PG * HbpHRBC !F KiapplacRBCvLDH = KilacRBCvLDH * ((1.0 + pow(10.0, -phRBC) / pow(10.0, -6.8)) / (1.0 + pow(10.0, -7.2) / pow(10.0, -6.8))) !F K4appRBCvBPGSP3 = K4RBCvBPGSP3 * ((1.0 + pow(pow(10.0, -7.2) / pow(10.0, -7.17), 4.0)) / (1.0 + pow(pow(10.0, -phRBC) / pow(10.0, -7.17), 4.0))) !F KcatfappRBCvGAPDH = KcatfRBCvGAPDH / (1.0 + pow(10.0, -phRBC) / pow(10.0, -7.5) + pow(10.0, -10.0) / pow(10.0, -phRBC)) !F atpRBCsum = atpRBC+adpRBC+ampRBC !F KoRBCvPYRTRANSPORT = KiRBCvPYRTRANSPORT / RtvRBC !F hRBC = pHConversionFactor / pow(10.0, phRBC) !F KaappRBCvHBATP = KaRBCvHBATP * HbpHRBC !F KaappRBCvHBADP = KaRBCvHBADP * HbpHRBC !F KoRBCvLACTRANSPORT = KiRBCvLACTRANSPORT / KeqRBCvLACTRANSPORT !F K3appRBCvBPGSP2 = K3RBCvBPGSP2 * ((1.0 + pow(pow(10.0, -7.2) / pow(10.0, -7.17), 4.0)) / (1.0 + pow(pow(10.0, -phRBC) / pow(10.0, -7.17), 4.0))) !F KaappRBCvHBBPG = KaRBCvHBBPG * HbpHRBC !F KiappnadhRBCvGAPDH = KinadhRBCvGAPDH * (pow(10.0, -7.2) / pow(10.0, -phRBC)) !F KaappRBCvHBMGATP = KaRBCvHBMGATP * HbpHRBC !F K1appRBCvBPGSP1 = K1RBCvBPGSP1 * ((1.0 + pow(10.0, -6.8) / pow(10.0, -7.2)) / (1.0 + pow(10.0, -6.8) / pow(10.0, -phRBC))) !F testsum = adpRBC+atpRBC+ampRBC+mgRBC +mgadpRBC + mgatpRBC +mgb13pgRBC + mgb23pgRBC + mgf16p2RBC + mgg16p2RBC + mgphosRBC !F Kiappb13pgRBCvGAPDH = Kib13pgRBCvGAPDH / (1.0 + pow(10.0, -phRBC) / pow(10.0, -7.5) + pow(10.0, -10.0) / pow(10.0, -phRBC)) !F LRBCvPK = pHConversionFactor * pow(10.0, -6.8) / hRBC * pow(1.0 + atpRBC / Vrbc / KtatpRBCvPK, 4.0) / (pow(1.0 + f16p2RBC / Vrbc / Krf16p2RBCvPK + g16p2RBC / Vrbc / Krg16p2RBCvPK, 4.0) * pow(1.0 + pepRBC / Vrbc / KrpepRBCvPK + pyrRBC / Vrbc / KrpyrRBCvPK, 4.0)) !F lacEXT = ConcLacEXT*vBld !F phosEXT = ConcPhosEXT*vBld !F pyrEXT = ConcPyrEXT*vBld !F glcRBC = ConcGlcRBC*Vrbc !F co2RBC = ConcCo2RBC * Vrbc