(* Generated by JWS Online *)

(* This is an experimental feature of JWS Online. Please report any mistakes.*)

(* Note that the following notable SBML entities or features are not supported in notebook outputyet: *)
    (* Events *)
    (* Constraints *)
    (* Units and UnitDefinitions *)
    (* AlgebraicRules *)
    (* conversionFactors *)

variables = {
S1[t], S10[t], S11[t], S12[t], S13[t], S14[t], S15[t], S16[t], S17[t], S18[t], S19[t], S2[t], S20[t], S21[t], S22[t], S23[t], S24[t], S25[t], S26[t], S27[t], S28[t], S3[t], S4[t], S5[t]
};

initialValues = {
S1[0] == 25.5914, S10[0] == 0.0, S11[0] == 0.0, S12[0] == 0.0, S13[0] == 0.0, S14[0] == 0.0, S15[0] == 0.0, S16[0] == 0.0, S17[0] == 0.0, S18[0] == 0.0, S19[0] == 0.0, S2[0] == 0.0601, S20[0] == 0.0, S21[0] == 0.0, S22[0] == 0.0, S23[0] == 0.0, S24[0] == 0.0, S25[0] == 0.0, S26[0] == 0.0, S27[0] == 0.0, S28[0] == 0.0, S3[0] == 6.2223, S4[0] == 0.415, S5[0] == 1.0
};

rates = {
reaction\[LetterSpace]1, reaction\[LetterSpace]10, reaction\[LetterSpace]11, reaction\[LetterSpace]12, reaction\[LetterSpace]13, reaction\[LetterSpace]14, reaction\[LetterSpace]15, reaction\[LetterSpace]16, reaction\[LetterSpace]17, reaction\[LetterSpace]18, reaction\[LetterSpace]19, reaction\[LetterSpace]2, reaction\[LetterSpace]20, reaction\[LetterSpace]21, reaction\[LetterSpace]22, reaction\[LetterSpace]23, reaction\[LetterSpace]24, reaction\[LetterSpace]25, reaction\[LetterSpace]26, reaction\[LetterSpace]27, reaction\[LetterSpace]28, reaction\[LetterSpace]29, reaction\[LetterSpace]3, reaction\[LetterSpace]30, reaction\[LetterSpace]31, reaction\[LetterSpace]32, reaction\[LetterSpace]33, reaction\[LetterSpace]34, reaction\[LetterSpace]35, reaction\[LetterSpace]36, reaction\[LetterSpace]37, reaction\[LetterSpace]38, reaction\[LetterSpace]39, reaction\[LetterSpace]4, reaction\[LetterSpace]40, reaction\[LetterSpace]41, reaction\[LetterSpace]42, reaction\[LetterSpace]43, reaction\[LetterSpace]44, reaction\[LetterSpace]45, reaction\[LetterSpace]46, reaction\[LetterSpace]47, reaction\[LetterSpace]48, reaction\[LetterSpace]49, reaction\[LetterSpace]5, reaction\[LetterSpace]50, reaction\[LetterSpace]51, reaction\[LetterSpace]52, reaction\[LetterSpace]53, reaction\[LetterSpace]54, reaction\[LetterSpace]55, reaction\[LetterSpace]56, reaction\[LetterSpace]57, reaction\[LetterSpace]58, reaction\[LetterSpace]59, reaction\[LetterSpace]6, reaction\[LetterSpace]60, reaction\[LetterSpace]61, reaction\[LetterSpace]62, reaction\[LetterSpace]63, reaction\[LetterSpace]64, reaction\[LetterSpace]65, reaction\[LetterSpace]66, reaction\[LetterSpace]67, reaction\[LetterSpace]68, reaction\[LetterSpace]69, reaction\[LetterSpace]7, reaction\[LetterSpace]8, reaction\[LetterSpace]9
};

rateEquations = {
reaction\[LetterSpace]1 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]1\[LetterSpace]0[cell, ks\[LetterSpace]c4, tf], reaction\[LetterSpace]10 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]10\[LetterSpace]0[S2[t], cell, kdeg\[LetterSpace]rbbound], reaction\[LetterSpace]11 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]11\[LetterSpace]0[S1[t], S11[t], cell, kdeg\[LetterSpace]rbp21], reaction\[LetterSpace]12 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]12\[LetterSpace]0[S11[t], S2[t], cell, kdeg\[LetterSpace]rbp21], reaction\[LetterSpace]13 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]13\[LetterSpace]0[S14[t], cell, ks\[LetterSpace]e2fe2f, ks\[LetterSpace]e2fmyc, tf], reaction\[LetterSpace]14 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]14\[LetterSpace]0[S2[t], cell, kdeg\[LetterSpace]e2fbound], reaction\[LetterSpace]15 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]15\[LetterSpace]0[S2[t], cell, kd\[LetterSpace]rbe2f], reaction\[LetterSpace]16 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]16\[LetterSpace]0[Km\[LetterSpace]prb, S1[t], S24[t], cell, kcatp\[LetterSpace]rbc4, nrb], reaction\[LetterSpace]17 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]17\[LetterSpace]0[Km\[LetterSpace]prb, S2[t], S24[t], cell, kcatp\[LetterSpace]rbc4, nrb], reaction\[LetterSpace]18 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]18\[LetterSpace]0[S14[t], S18[t], S5[t], cell, k\[LetterSpace]dna], reaction\[LetterSpace]19 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]19\[LetterSpace]0[S10[t], cell, gsk3b, kdeg\[LetterSpace]c4, kdeg\[LetterSpace]c4gsk3b], reaction\[LetterSpace]2 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]2\[LetterSpace]0[S14[t], S16[t], cell, ks\[LetterSpace]c2e2f, ks\[LetterSpace]c2myc, tf], reaction\[LetterSpace]20 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]20\[LetterSpace]0[S13[t], cell, gsk3b, kdeg\[LetterSpace]c2, kdeg\[LetterSpace]c2gsk3b], reaction\[LetterSpace]21 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]21\[LetterSpace]0[S13[t], cell, kp\[LetterSpace]c2cak], reaction\[LetterSpace]22 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]22\[LetterSpace]0[S10[t], S12[t], cell, kb\[LetterSpace]p21c4], reaction\[LetterSpace]23 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]23\[LetterSpace]0[S12[t], S4[t], cell, kb\[LetterSpace]p21c2], reaction\[LetterSpace]24 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]24\[LetterSpace]0[S11[t], S13[t], cell, kb\[LetterSpace]p21c2], reaction\[LetterSpace]25 -> Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]25\[LetterSpace]0[S12[t], Vratio, cell, kimport], reaction\[LetterSpace]26 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]26\[LetterSpace]0[S12[t], Vratio, cell, kimport], reaction\[LetterSpace]27 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]27\[LetterSpace]0[S11[t], cell, erk, gsk3b, kdeg\[LetterSpace]p21erk, kdeg\[LetterSpace]p21gsk3b], reaction\[LetterSpace]28 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]28\[LetterSpace]0[S12[t], cell, erk, gsk3b, kdeg\[LetterSpace]p21erk, kdeg\[LetterSpace]p21gsk3b], reaction\[LetterSpace]29 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]29\[LetterSpace]0[S15[t], cell, kdeg\[LetterSpace]rbfree], reaction\[LetterSpace]3 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]3\[LetterSpace]0[S3[t], cell, gsk3b, kdeg\[LetterSpace]c2, kdeg\[LetterSpace]c2gsk3b], reaction\[LetterSpace]30 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]30\[LetterSpace]0[S16[t], cell, kdeg\[LetterSpace]rbbound], reaction\[LetterSpace]31 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]31\[LetterSpace]0[S11[t], S15[t], cell, kdeg\[LetterSpace]rbp21], reaction\[LetterSpace]32 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]32\[LetterSpace]0[S11[t], S16[t], cell, kdeg\[LetterSpace]rbp21], reaction\[LetterSpace]33 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]33\[LetterSpace]0[S14[t], cell, kdeg\[LetterSpace]e2ffree], reaction\[LetterSpace]34 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]34\[LetterSpace]0[S16[t], cell, kdeg\[LetterSpace]e2fbound], reaction\[LetterSpace]35 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]35\[LetterSpace]0[S1[t], S14[t], cell, kb\[LetterSpace]rbe2f], reaction\[LetterSpace]36 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]36\[LetterSpace]0[S14[t], S15[t], cell, kb\[LetterSpace]rbpe2f], reaction\[LetterSpace]37 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]37\[LetterSpace]0[S16[t], cell, kd\[LetterSpace]rbpe2f], reaction\[LetterSpace]38 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]38\[LetterSpace]0[Km\[LetterSpace]prb, S15[t], S18[t], cell, kcatp\[LetterSpace]rbc2, nrb], reaction\[LetterSpace]39 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]39\[LetterSpace]0[Km\[LetterSpace]prb, S16[t], S18[t], cell, kcatp\[LetterSpace]rbc2, nrb], reaction\[LetterSpace]4 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]4\[LetterSpace]0[S4[t], cell, gsk3b, kdeg\[LetterSpace]c2, kdeg\[LetterSpace]c2gsk3b], reaction\[LetterSpace]40 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]40\[LetterSpace]0[Km\[LetterSpace]dprb, S15[t], S18[t], cell, kcatdp\[LetterSpace]rbc4, kinh\[LetterSpace]pp1, nrb], reaction\[LetterSpace]41 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]41\[LetterSpace]0[Km\[LetterSpace]dprb, S16[t], S18[t], cell, kcatdp\[LetterSpace]rbc4, kinh\[LetterSpace]pp1, nrb], reaction\[LetterSpace]42 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]42\[LetterSpace]0[S17[t], cell, k\[LetterSpace]delay], reaction\[LetterSpace]43 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]43\[LetterSpace]0[S19[t], cell, gsk3b, kdeg\[LetterSpace]c4, kdeg\[LetterSpace]c4gsk3b], reaction\[LetterSpace]44 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]44\[LetterSpace]0[S18[t], cell, gsk3b, kdeg\[LetterSpace]c2, kdeg\[LetterSpace]c2gsk3b], reaction\[LetterSpace]45 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]45\[LetterSpace]0[S20[t], cell, gsk3b, kdeg\[LetterSpace]c2, kdeg\[LetterSpace]c2gsk3b], reaction\[LetterSpace]46 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]46\[LetterSpace]0[S18[t], cell, gsk3b, kdeg\[LetterSpace]c2c2gsk3b], reaction\[LetterSpace]47 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]47\[LetterSpace]0[S18[t], cell, kdp\[LetterSpace]c2cak], reaction\[LetterSpace]48 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]48\[LetterSpace]0[S19[t], cell, kd\[LetterSpace]p21c4], reaction\[LetterSpace]49 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]49\[LetterSpace]0[S11[t], S18[t], cell, kb\[LetterSpace]p21c2], reaction\[LetterSpace]5 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]5\[LetterSpace]0[S14[t], cell, ks\[LetterSpace]p21e2f, ks\[LetterSpace]p21p53, tfp21], reaction\[LetterSpace]50 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]50\[LetterSpace]0[S20[t], cell, kd\[LetterSpace]p21c2], reaction\[LetterSpace]51 -> Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]51\[LetterSpace]0[S19[t], Vratio, cell, kimport], reaction\[LetterSpace]52 -> Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]52\[LetterSpace]0[S20[t], Vratio, cell, kimport], reaction\[LetterSpace]53 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]53\[LetterSpace]0[S19[t], Vratio, cell, kimport], reaction\[LetterSpace]54 -> cell*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]54\[LetterSpace]0[S20[t], Vratio, cell, kimport], reaction\[LetterSpace]55 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]55\[LetterSpace]0[S21[t], cell, kdeg\[LetterSpace]rbfree], reaction\[LetterSpace]56 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]56\[LetterSpace]0[S11[t], S21[t], cell, kdeg\[LetterSpace]rbp21], reaction\[LetterSpace]57 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]57\[LetterSpace]0[Km\[LetterSpace]dprb, S18[t], S21[t], cell, kcatdp\[LetterSpace]rbc2, kinh\[LetterSpace]pp1, nrb], reaction\[LetterSpace]58 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]58\[LetterSpace]0[S22[t], cell, k\[LetterSpace]delay], reaction\[LetterSpace]59 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]59\[LetterSpace]0[S24[t], cell, kdeg\[LetterSpace]c4], reaction\[LetterSpace]6 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]6\[LetterSpace]0[S3[t], cell, kd\[LetterSpace]p21c2], reaction\[LetterSpace]60 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]60\[LetterSpace]0[S23[t], cell, gsk3b, kdeg\[LetterSpace]c2, kdeg\[LetterSpace]c2gsk3b], reaction\[LetterSpace]61 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]61\[LetterSpace]0[S24[t], cell, kd\[LetterSpace]p21c4], reaction\[LetterSpace]62 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]62\[LetterSpace]0[S23[t], cell, kd\[LetterSpace]p21c2], reaction\[LetterSpace]63 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]63\[LetterSpace]0[S14[t], S18[t], S23[t], cell, erk, kdeg\[LetterSpace]p21c2skp2, kdeg\[LetterSpace]p21erkskp2, kdeg\[LetterSpace]p21skp2], reaction\[LetterSpace]64 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]64\[LetterSpace]0[S14[t], S18[t], S24[t], cell, erk, kdeg\[LetterSpace]p21c2skp2, kdeg\[LetterSpace]p21erkskp2, kdeg\[LetterSpace]p21skp2], reaction\[LetterSpace]65 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]65\[LetterSpace]0[S25[t], cell, k\[LetterSpace]delay], reaction\[LetterSpace]66 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]66\[LetterSpace]0[S26[t], cell, gsk3b, kdeg\[LetterSpace]c4, kdeg\[LetterSpace]c4gsk3b], reaction\[LetterSpace]67 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]67\[LetterSpace]0[S11[t], S26[t], cell, kb\[LetterSpace]p21c4], reaction\[LetterSpace]68 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]68\[LetterSpace]0[S27[t], cell, k\[LetterSpace]delay], reaction\[LetterSpace]69 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]69\[LetterSpace]0[S28[t], cell, k\[LetterSpace]delay], reaction\[LetterSpace]7 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]7\[LetterSpace]0[S14[t], S18[t], S3[t], cell, erk, kdeg\[LetterSpace]p21c2skp2, kdeg\[LetterSpace]p21erkskp2, kdeg\[LetterSpace]p21skp2], reaction\[LetterSpace]8 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]8\[LetterSpace]0[S14[t], cell, ks\[LetterSpace]rb, ks\[LetterSpace]rbe2f], reaction\[LetterSpace]9 -> Nucleus*Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]9\[LetterSpace]0[S1[t], cell, kdeg\[LetterSpace]rbfree]
};

parameters = {
Kd\[LetterSpace]p21c2 -> 0.0100024233821379, Kd\[LetterSpace]p21c4 -> 99.9965429570432, Kd\[LetterSpace]rb\[LetterSpace]e2f -> 50.002528361226, Kd\[LetterSpace]rbp\[LetterSpace]e2f -> 481.484530572552, Km\[LetterSpace]dprb -> 0.118988383643671, Km\[LetterSpace]prb -> 2.03458881189349, Vcyto -> 12.67, Vnuc -> 0.25, aakt -> 0.53, aerk -> 0.16, atf -> 0.601288203846636, k\[LetterSpace]delay -> 23.6658781343201, k\[LetterSpace]dna -> 0.00949790539669408, kb\[LetterSpace]p21c2 -> 997.938141166465, kb\[LetterSpace]p21c4 -> 14.3083360067931, kb\[LetterSpace]rbe2f -> 229.976400323907, kb\[LetterSpace]rbpe2f -> 182.218452288549, kc2cak -> 0.316993285134466, kcatdp\[LetterSpace]rbc2 -> 0.00313841707547858, kcatdp\[LetterSpace]rbc4 -> 2892.0219338341, kcatp\[LetterSpace]rbc2 -> 7142308.07232621, kcatprbc4 -> 2797.82326282727, kdeg\[LetterSpace]c2 -> 0.225746618767114, kdeg\[LetterSpace]c2c2gsk3b -> 5.58835572681068, kdeg\[LetterSpace]c2gsk3b -> 1.55090179808215*^-05, kdeg\[LetterSpace]c4 -> 1.01433121526038, kdeg\[LetterSpace]c4gsk3b -> 0.107637073030656, kdeg\[LetterSpace]e2fbound -> 0.0999954023364359, kdeg\[LetterSpace]p21c2skp2 -> 0.040108041739907, kdeg\[LetterSpace]p21erk -> 0.736488746268804, kdeg\[LetterSpace]p21erkskp2 -> 0.000282976267377082, kdeg\[LetterSpace]p21gsk3b -> 0.00464010657330714, kdeg\[LetterSpace]p21skp2 -> 0.750574831653576, kdeg\[LetterSpace]rbbound -> 0.0889964132806627, kdeg\[LetterSpace]rbp21 -> 0.863570809432207, kdege2fplus -> 4.18153340918872*^-05, kdegrbplus -> 0.257763482477731, kdp\[LetterSpace]c2cak -> 101.282119534273, ki -> 0.0918326575000322, kinh\[LetterSpace]p21akt -> 0.439662894183616, kinh\[LetterSpace]pp1 -> 16634.9400020267, ks\[LetterSpace]c2e2f -> 2.19944932286058, ks\[LetterSpace]c2myc -> 0.157511710670132, ks\[LetterSpace]c4 -> 14298.6715905912, ks\[LetterSpace]e2fe2f -> 0.459601740303536, ks\[LetterSpace]e2fmyc -> 2.49174531457788*^-06, ks\[LetterSpace]p21e2f -> 0.811617200647839, ks\[LetterSpace]p21p53 -> 3.84136205729286*^-06, ks\[LetterSpace]rb -> 72.5245257602228, ks\[LetterSpace]rbe2f -> 20.0129834334888, nakt -> 1.0957, nerk -> 1.14663416967514, nrb -> 3.0, pakt -> 0.0348, perk -> 0.00857314138104046, scale\[LetterSpace]PhosRbS788 -> 0.673907327042472, scale\[LetterSpace]PhosRbS800 -> 0.82377467648995, scale\[LetterSpace]TotCDK2T160 -> 2.728395741944, scale\[LetterSpace]TotE2F -> 28.7418, scale\[LetterSpace]TotRb -> 0.2605, scale\[LetterSpace]TotcycDCDK4 -> 0.5651, scale\[LetterSpace]TotcycECDK2 -> 0.1889, scale\[LetterSpace]Totp21 -> 0.1728, scale\[LetterSpace]Totp21CDK2 -> 0.339790715037712, Nucleus -> 1.0, cell -> 1.0
};

assignments = {
Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]23\[LetterSpace]0[S12_,S4_,cell_,kb\[LetterSpace]p21c2_] -> (kb\[LetterSpace]p21c2*S12*S4)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]1\[LetterSpace]0[cell_,ks\[LetterSpace]c4_,tf_] -> (ks\[LetterSpace]c4*tf)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]2\[LetterSpace]0[S14_,S16_,cell_,ks\[LetterSpace]c2e2f_,ks\[LetterSpace]c2myc_,tf_] -> (ks\[LetterSpace]c2e2f*(S14 + S16) + ks\[LetterSpace]c2myc*tf)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]58\[LetterSpace]0[S22_,cell_,k\[LetterSpace]delay_] -> (k\[LetterSpace]delay*S22)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]59\[LetterSpace]0[S24_,cell_,kdeg\[LetterSpace]c4_] -> (kdeg\[LetterSpace]c4*S24)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]3\[LetterSpace]0[S3_,cell_,gsk3b_,kdeg\[LetterSpace]c2_,kdeg\[LetterSpace]c2gsk3b_] -> ((kdeg\[LetterSpace]c2 + gsk3b*kdeg\[LetterSpace]c2gsk3b)*S3)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]4\[LetterSpace]0[S4_,cell_,gsk3b_,kdeg\[LetterSpace]c2_,kdeg\[LetterSpace]c2gsk3b_] -> ((kdeg\[LetterSpace]c2 + gsk3b*kdeg\[LetterSpace]c2gsk3b)*S4)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]5\[LetterSpace]0[S14_,cell_,ks\[LetterSpace]p21e2f_,ks\[LetterSpace]p21p53_,tfp21_] -> ((ks\[LetterSpace]p21p53 + ks\[LetterSpace]p21e2f*S14)*tfp21)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]6\[LetterSpace]0[S3_,cell_,kd\[LetterSpace]p21c2_] -> (kd\[LetterSpace]p21c2*S3)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]9\[LetterSpace]0[S1_,cell_,kdeg\[LetterSpace]rbfree_] -> (kdeg\[LetterSpace]rbfree*S1)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]10\[LetterSpace]0[S2_,cell_,kdeg\[LetterSpace]rbbound_] -> (kdeg\[LetterSpace]rbbound*S2)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]11\[LetterSpace]0[S1_,S11_,cell_,kdeg\[LetterSpace]rbp21_] -> (kdeg\[LetterSpace]rbp21*S1*S11)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]12\[LetterSpace]0[S11_,S2_,cell_,kdeg\[LetterSpace]rbp21_] -> (kdeg\[LetterSpace]rbp21*S11*S2)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]13\[LetterSpace]0[S14_,cell_,ks\[LetterSpace]e2fe2f_,ks\[LetterSpace]e2fmyc_,tf_] -> ((ks\[LetterSpace]e2fmyc + ks\[LetterSpace]e2fe2f*S14)*tf)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]14\[LetterSpace]0[S2_,cell_,kdeg\[LetterSpace]e2fbound_] -> (kdeg\[LetterSpace]e2fbound*S2)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]15\[LetterSpace]0[S2_,cell_,kd\[LetterSpace]rbe2f_] -> (kd\[LetterSpace]rbe2f*S2)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]17\[LetterSpace]0[Km\[LetterSpace]prb_,S2_,S24_,cell_,kcatp\[LetterSpace]rbc4_,nrb_] -> (kcatp\[LetterSpace]rbc4*S2^nrb*S24)/(cell*(Km\[LetterSpace]prb^nrb + S2^nrb)), Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]18\[LetterSpace]0[S14_,S18_,S5_,cell_,k\[LetterSpace]dna_] -> (k\[LetterSpace]dna*S14*S18*S5)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]19\[LetterSpace]0[S10_,cell_,gsk3b_,kdeg\[LetterSpace]c4_,kdeg\[LetterSpace]c4gsk3b_] -> ((kdeg\[LetterSpace]c4 + gsk3b*kdeg\[LetterSpace]c4gsk3b)*S10)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]21\[LetterSpace]0[S13_,cell_,kp\[LetterSpace]c2cak_] -> (kp\[LetterSpace]c2cak*S13)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]22\[LetterSpace]0[S10_,S12_,cell_,kb\[LetterSpace]p21c4_] -> (kb\[LetterSpace]p21c4*S10*S12)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]24\[LetterSpace]0[S11_,S13_,cell_,kb\[LetterSpace]p21c2_] -> (kb\[LetterSpace]p21c2*S11*S13)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]25\[LetterSpace]0[S12_,Vratio_,cell_,kimport_] -> (kimport*S12)/(cell*Vratio), Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]26\[LetterSpace]0[S12_,Vratio_,cell_,kimport_] -> (kimport*S12*(1 - Vratio^(-1)))/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]28\[LetterSpace]0[S12_,cell_,erk_,gsk3b_,kdeg\[LetterSpace]p21erk_,kdeg\[LetterSpace]p21gsk3b_] -> ((erk*kdeg\[LetterSpace]p21erk + gsk3b*kdeg\[LetterSpace]p21gsk3b)*S12)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]29\[LetterSpace]0[S15_,cell_,kdeg\[LetterSpace]rbfree_] -> (kdeg\[LetterSpace]rbfree*S15)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]31\[LetterSpace]0[S11_,S15_,cell_,kdeg\[LetterSpace]rbp21_] -> (kdeg\[LetterSpace]rbp21*S11*S15)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]32\[LetterSpace]0[S11_,S16_,cell_,kdeg\[LetterSpace]rbp21_] -> (kdeg\[LetterSpace]rbp21*S11*S16)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]33\[LetterSpace]0[S14_,cell_,kdeg\[LetterSpace]e2ffree_] -> (kdeg\[LetterSpace]e2ffree*S14)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]34\[LetterSpace]0[S16_,cell_,kdeg\[LetterSpace]e2fbound_] -> (kdeg\[LetterSpace]e2fbound*S16)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]35\[LetterSpace]0[S1_,S14_,cell_,kb\[LetterSpace]rbe2f_] -> (kb\[LetterSpace]rbe2f*S1*S14)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]37\[LetterSpace]0[S16_,cell_,kd\[LetterSpace]rbpe2f_] -> (kd\[LetterSpace]rbpe2f*S16)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]38\[LetterSpace]0[Km\[LetterSpace]prb_,S15_,S18_,cell_,kcatp\[LetterSpace]rbc2_,nrb_] -> (kcatp\[LetterSpace]rbc2*S15^nrb*S18)/(cell*(Km\[LetterSpace]prb^nrb + S15^nrb)), Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]39\[LetterSpace]0[Km\[LetterSpace]prb_,S16_,S18_,cell_,kcatp\[LetterSpace]rbc2_,nrb_] -> (kcatp\[LetterSpace]rbc2*S16^nrb*S18)/(cell*(Km\[LetterSpace]prb^nrb + S16^nrb)), Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]40\[LetterSpace]0[Km\[LetterSpace]dprb_,S15_,S18_,cell_,kcatdp\[LetterSpace]rbc4_,kinh\[LetterSpace]pp1_,nrb_] -> (kcatdp\[LetterSpace]rbc4*S15^nrb)/(cell*(Km\[LetterSpace]dprb^nrb + S15^nrb)*(1 + kinh\[LetterSpace]pp1*S18)), Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]42\[LetterSpace]0[S17_,cell_,k\[LetterSpace]delay_] -> (k\[LetterSpace]delay*S17)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]41\[LetterSpace]0[Km\[LetterSpace]dprb_,S16_,S18_,cell_,kcatdp\[LetterSpace]rbc4_,kinh\[LetterSpace]pp1_,nrb_] -> (kcatdp\[LetterSpace]rbc4*S16^nrb)/(cell*(Km\[LetterSpace]dprb^nrb + S16^nrb)*(1 + kinh\[LetterSpace]pp1*S18)), Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]50\[LetterSpace]0[S20_,cell_,kd\[LetterSpace]p21c2_] -> (kd\[LetterSpace]p21c2*S20)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]49\[LetterSpace]0[S11_,S18_,cell_,kb\[LetterSpace]p21c2_] -> (kb\[LetterSpace]p21c2*S11*S18)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]48\[LetterSpace]0[S19_,cell_,kd\[LetterSpace]p21c4_] -> (kd\[LetterSpace]p21c4*S19)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]47\[LetterSpace]0[S18_,cell_,kdp\[LetterSpace]c2cak_] -> (kdp\[LetterSpace]c2cak*S18)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]46\[LetterSpace]0[S18_,cell_,gsk3b_,kdeg\[LetterSpace]c2c2gsk3b_] -> (gsk3b*kdeg\[LetterSpace]c2c2gsk3b*S18)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]45\[LetterSpace]0[S20_,cell_,gsk3b_,kdeg\[LetterSpace]c2_,kdeg\[LetterSpace]c2gsk3b_] -> ((kdeg\[LetterSpace]c2 + gsk3b*kdeg\[LetterSpace]c2gsk3b)*S20)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]44\[LetterSpace]0[S18_,cell_,gsk3b_,kdeg\[LetterSpace]c2_,kdeg\[LetterSpace]c2gsk3b_] -> ((kdeg\[LetterSpace]c2 + gsk3b*kdeg\[LetterSpace]c2gsk3b)*S18)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]43\[LetterSpace]0[S19_,cell_,gsk3b_,kdeg\[LetterSpace]c4_,kdeg\[LetterSpace]c4gsk3b_] -> ((kdeg\[LetterSpace]c4 + gsk3b*kdeg\[LetterSpace]c4gsk3b)*S19)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]62\[LetterSpace]0[S23_,cell_,kd\[LetterSpace]p21c2_] -> (kd\[LetterSpace]p21c2*S23)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]61\[LetterSpace]0[S24_,cell_,kd\[LetterSpace]p21c4_] -> (kd\[LetterSpace]p21c4*S24)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]60\[LetterSpace]0[S23_,cell_,gsk3b_,kdeg\[LetterSpace]c2_,kdeg\[LetterSpace]c2gsk3b_] -> ((kdeg\[LetterSpace]c2 + gsk3b*kdeg\[LetterSpace]c2gsk3b)*S23)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]57\[LetterSpace]0[Km\[LetterSpace]dprb_,S18_,S21_,cell_,kcatdp\[LetterSpace]rbc2_,kinh\[LetterSpace]pp1_,nrb_] -> (kcatdp\[LetterSpace]rbc2*S21^nrb)/(cell*(1 + kinh\[LetterSpace]pp1*S18)*(Km\[LetterSpace]dprb^nrb + S21^nrb)), Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]56\[LetterSpace]0[S11_,S21_,cell_,kdeg\[LetterSpace]rbp21_] -> (kdeg\[LetterSpace]rbp21*S11*S21)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]55\[LetterSpace]0[S21_,cell_,kdeg\[LetterSpace]rbfree_] -> (kdeg\[LetterSpace]rbfree*S21)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]54\[LetterSpace]0[S20_,Vratio_,cell_,kimport_] -> (kimport*S20*(1 - Vratio^(-1)))/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]69\[LetterSpace]0[S28_,cell_,k\[LetterSpace]delay_] -> (k\[LetterSpace]delay*S28)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]68\[LetterSpace]0[S27_,cell_,k\[LetterSpace]delay_] -> (k\[LetterSpace]delay*S27)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]67\[LetterSpace]0[S11_,S26_,cell_,kb\[LetterSpace]p21c4_] -> (kb\[LetterSpace]p21c4*S11*S26)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]66\[LetterSpace]0[S26_,cell_,gsk3b_,kdeg\[LetterSpace]c4_,kdeg\[LetterSpace]c4gsk3b_] -> ((kdeg\[LetterSpace]c4 + gsk3b*kdeg\[LetterSpace]c4gsk3b)*S26)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]65\[LetterSpace]0[S25_,cell_,k\[LetterSpace]delay_] -> (k\[LetterSpace]delay*S25)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]64\[LetterSpace]0[S14_,S18_,S24_,cell_,erk_,kdeg\[LetterSpace]p21c2skp2_,kdeg\[LetterSpace]p21erkskp2_,kdeg\[LetterSpace]p21skp2_] -> (S14*(erk*kdeg\[LetterSpace]p21erkskp2 + kdeg\[LetterSpace]p21skp2 + kdeg\[LetterSpace]p21c2skp2*S18)*S24)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]63\[LetterSpace]0[S14_,S18_,S23_,cell_,erk_,kdeg\[LetterSpace]p21c2skp2_,kdeg\[LetterSpace]p21erkskp2_,kdeg\[LetterSpace]p21skp2_] -> (S14*(erk*kdeg\[LetterSpace]p21erkskp2 + kdeg\[LetterSpace]p21skp2 + kdeg\[LetterSpace]p21c2skp2*S18)*S23)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]53\[LetterSpace]0[S19_,Vratio_,cell_,kimport_] -> (kimport*S19*(1 - Vratio^(-1)))/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]52\[LetterSpace]0[S20_,Vratio_,cell_,kimport_] -> (kimport*S20)/(cell*Vratio), Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]51\[LetterSpace]0[S19_,Vratio_,cell_,kimport_] -> (kimport*S19)/(cell*Vratio), Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]36\[LetterSpace]0[S14_,S15_,cell_,kb\[LetterSpace]rbpe2f_] -> (kb\[LetterSpace]rbpe2f*S14*S15)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]30\[LetterSpace]0[S16_,cell_,kdeg\[LetterSpace]rbbound_] -> (kdeg\[LetterSpace]rbbound*S16)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]27\[LetterSpace]0[S11_,cell_,erk_,gsk3b_,kdeg\[LetterSpace]p21erk_,kdeg\[LetterSpace]p21gsk3b_] -> ((erk*kdeg\[LetterSpace]p21erk + gsk3b*kdeg\[LetterSpace]p21gsk3b)*S11)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]20\[LetterSpace]0[S13_,cell_,gsk3b_,kdeg\[LetterSpace]c2_,kdeg\[LetterSpace]c2gsk3b_] -> ((kdeg\[LetterSpace]c2 + gsk3b*kdeg\[LetterSpace]c2gsk3b)*S13)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]16\[LetterSpace]0[Km\[LetterSpace]prb_,S1_,S24_,cell_,kcatp\[LetterSpace]rbc4_,nrb_] -> (kcatp\[LetterSpace]rbc4*S1^nrb*S24)/(cell*(Km\[LetterSpace]prb^nrb + S1^nrb)), Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]8\[LetterSpace]0[S14_,cell_,ks\[LetterSpace]rb_,ks\[LetterSpace]rbe2f_] -> (ks\[LetterSpace]rb + ks\[LetterSpace]rbe2f*S14)/cell, Function\[LetterSpace]for\[LetterSpace]reaction\[LetterSpace]7\[LetterSpace]0[S14_,S18_,S3_,cell_,erk_,kdeg\[LetterSpace]p21c2skp2_,kdeg\[LetterSpace]p21erkskp2_,kdeg\[LetterSpace]p21skp2_] -> (S14*(erk*kdeg\[LetterSpace]p21erkskp2 + kdeg\[LetterSpace]p21skp2 + kdeg\[LetterSpace]p21c2skp2*S18)*S3)/cell, kdeg\[LetterSpace]e2ffree -> kdege2fplus + kdeg\[LetterSpace]e2fbound, kcatp\[LetterSpace]rbc4 -> (1 - inhc4d1)*kcatprbc4, kd\[LetterSpace]rbpe2f -> kb\[LetterSpace]rbpe2f*Kd\[LetterSpace]rbp\[LetterSpace]e2f, kd\[LetterSpace]rbe2f -> kb\[LetterSpace]rbe2f*Kd\[LetterSpace]rb\[LetterSpace]e2f, hgf -> Piecewise[{{0, t < -1}}, Piecewise[{{0, t < 24}}, 1]], inhp53 -> 0, inherk -> 0, inhakt -> 0, inhc4d1 -> 0, ObsTotE2F\[LetterSpace]obs -> ((scale\[LetterSpace]TotE2F + scale\[LetterSpace]TotRb)*Vnuc*(S14[t] + S16[t] + S2[t]))/(Vcyto + Vnuc), ObsTotCDK2T160\[LetterSpace]obs -> (scale\[LetterSpace]TotCDK2T160*Vnuc*(S18[t] + S23[t]))/(Vcyto + Vnuc), ObsTotCycDCDK4\[LetterSpace]obs -> (scale\[LetterSpace]TotcycDCDK4*(Vcyto*S19[t] + Vnuc*S24[t]))/(Vcyto + Vnuc), ObsPhosRbS788\[LetterSpace]obs -> (scale\[LetterSpace]PhosRbS788*Vnuc*(S15[t] + S16[t] + S21[t]))/(Vcyto + Vnuc), ObsPhosRbS800\[LetterSpace]obs -> (scale\[LetterSpace]PhosRbS800*Vnuc*S21[t])/(Vcyto + Vnuc), ObsDNAContent\[LetterSpace]obs -> 2 - S17[t] - S22[t] - S25[t] - S27[t] - S28[t] - S5[t], Vratio -> Vnuc/Vcyto, gsk3b -> 1 - akt, tf -> atf + (1 - atf)*erk*(1 - gsk3b), kp\[LetterSpace]c2cak -> kc2cak + kdp\[LetterSpace]c2cak, kd\[LetterSpace]p21c4 -> kb\[LetterSpace]p21c4*Kd\[LetterSpace]p21c4, kd\[LetterSpace]p21c2 -> kb\[LetterSpace]p21c2*Kd\[LetterSpace]p21c2, kdeg\[LetterSpace]rbfree -> kdegrbplus + kdeg\[LetterSpace]rbbound, kimport -> ki/(1 + akt*kinh\[LetterSpace]p21akt), tfp21 -> (1 - inhp53)*tf, akt -> (1 - inhakt)*(aakt + ((1 - aakt)*hgf^nakt*(1 + pakt^nakt))/(hgf^nakt + pakt^nakt)), erk -> (1 - inherk)*(aerk + ((1 - aerk)*hgf^nerk*(1 + perk^nerk))/(hgf^nerk + perk^nerk)), ObsTotRb\[LetterSpace]obs -> (scale\[LetterSpace]TotRb*Vnuc*(S1[t] + S15[t] + S16[t] + S2[t] + S21[t]))/(Vcyto + Vnuc), ObsTotP21\[LetterSpace]obs -> (scale\[LetterSpace]Totp21*(Vcyto*(S12[t] + S19[t] + S20[t]) + Vnuc*(S11[t] + S23[t] + S24[t] + S3[t])))/(Vcyto + Vnuc), ObsTotCycECDK2\[LetterSpace]obs -> (scale\[LetterSpace]TotcycECDK2*(Vnuc*(S13[t] + S18[t] + S23[t] + S3[t]) + Vcyto*(S20[t] + S4[t])))/(Vcyto + Vnuc), ObsCDK2P21\[LetterSpace]obs -> (scale\[LetterSpace]Totp21CDK2*(Vcyto*S20[t] + Vnuc*(S23[t] + S3[t])))/(Vcyto + Vnuc)
};

events = {

};

speciesAnnotations = {
ObsDNAContent\[LetterSpace]obs[t]->"http://identifiers.org/chebi/CHEBI:16991", ObsTotCycDCDK4\[LetterSpace]obs[t]->"http://identifiers.org/go/GO:0097128", ObsTotCycECDK2\[LetterSpace]obs[t]->"http://identifiers.org/go/GO:0097134", ObsTotE2F\[LetterSpace]obs[t]->"http://identifiers.org/uniprot/Q61501", ObsTotP21\[LetterSpace]obs[t]->"http://identifiers.org/uniprot/P46414", ObsTotRb\[LetterSpace]obs[t]->"http://identifiers.org/uniprot/P13405", S10[t]->"http://identifiers.org/go/GO:0097128", S11[t]->"http://identifiers.org/uniprot/P46414", S12[t]->"http://identifiers.org/uniprot/P46414", S14[t]->"http://identifiers.org/uniprot/Q61501", S17[t]->"http://identifiers.org/go/GO:0036387", S22[t]->"http://identifiers.org/go/GO:0036387", S25[t]->"http://identifiers.org/go/GO:0036387", S26[t]->"http://identifiers.org/go/GO:0097128", S27[t]->"http://identifiers.org/go/GO:0036387", S28[t]->"http://identifiers.org/go/GO:0036387", S5[t]->"http://identifiers.org/go/GO:0036387", hgf[t]->"http://identifiers.org/uniprot/Q08048", inhakt[t]->"http://identifiers.org/uniprot/P31750", inhc4d1[t]->"http://identifiers.org/go/GO:0097128", inherk[t]->"http://identifiers.org/uniprot/Q63844", inhp53[t]->"http://identifiers.org/uniprot/P02340"
};

reactionAnnotations = {

};

units = {
{"time" -> "", "metabolite" -> "", "extent" -> ""}
};

(* Time evolution *)
odes = {
S1'[t] == 1.0*reaction\[LetterSpace]8 +1.0*reaction\[LetterSpace]14 +1.0*reaction\[LetterSpace]15 +1.0*reaction\[LetterSpace]40 -1.0*reaction\[LetterSpace]9 -1.0*reaction\[LetterSpace]11 -1.0*reaction\[LetterSpace]16 -1.0*reaction\[LetterSpace]35, S10'[t] == 1.0*reaction\[LetterSpace]1 +1.0*reaction\[LetterSpace]48 -1.0*reaction\[LetterSpace]19 -1.0*reaction\[LetterSpace]22, S11'[t] == 1.0*reaction\[LetterSpace]25 +1.0*reaction\[LetterSpace]3 +1.0*reaction\[LetterSpace]6 +1.0*reaction\[LetterSpace]60 +1.0*reaction\[LetterSpace]61 +1.0*reaction\[LetterSpace]62 -1.0*reaction\[LetterSpace]24 -1.0*reaction\[LetterSpace]27 -1.0*reaction\[LetterSpace]49 -1.0*reaction\[LetterSpace]67, S12'[t] == 1.0*reaction\[LetterSpace]5 +1.0*reaction\[LetterSpace]43 +1.0*reaction\[LetterSpace]45 +1.0*reaction\[LetterSpace]48 +1.0*reaction\[LetterSpace]50 -1.0*reaction\[LetterSpace]22 -1.0*reaction\[LetterSpace]23 -1.0*reaction\[LetterSpace]25 -1.0*reaction\[LetterSpace]26 -1.0*reaction\[LetterSpace]28, S13'[t] == 1.0*reaction\[LetterSpace]6 +1.0*reaction\[LetterSpace]7 +1.0*reaction\[LetterSpace]47 -1.0*reaction\[LetterSpace]20 -1.0*reaction\[LetterSpace]21 -1.0*reaction\[LetterSpace]24, S14'[t] == 1.0*reaction\[LetterSpace]10 +1.0*reaction\[LetterSpace]12 +1.0*reaction\[LetterSpace]13 +1.0*reaction\[LetterSpace]15 +1.0*reaction\[LetterSpace]30 +1.0*reaction\[LetterSpace]32 +1.0*reaction\[LetterSpace]37 +1.0*reaction\[LetterSpace]39 -1.0*reaction\[LetterSpace]33 -1.0*reaction\[LetterSpace]35 -1.0*reaction\[LetterSpace]36, S15'[t] == 1.0*reaction\[LetterSpace]16 +1.0*reaction\[LetterSpace]34 +1.0*reaction\[LetterSpace]37 +1.0*reaction\[LetterSpace]57 -1.0*reaction\[LetterSpace]29 -1.0*reaction\[LetterSpace]31 -1.0*reaction\[LetterSpace]36 -1.0*reaction\[LetterSpace]38 -1.0*reaction\[LetterSpace]40, S16'[t] == 1.0*reaction\[LetterSpace]17 +1.0*reaction\[LetterSpace]36 -1.0*reaction\[LetterSpace]30 -1.0*reaction\[LetterSpace]32 -1.0*reaction\[LetterSpace]34 -1.0*reaction\[LetterSpace]37 -1.0*reaction\[LetterSpace]39 -1.0*reaction\[LetterSpace]41, S17'[t] == 1.0*reaction\[LetterSpace]18 -1.0*reaction\[LetterSpace]42, S18'[t] == 1.0*reaction\[LetterSpace]21 +1.0*reaction\[LetterSpace]62 +1.0*reaction\[LetterSpace]63 -1.0*reaction\[LetterSpace]44 -1.0*reaction\[LetterSpace]46 -1.0*reaction\[LetterSpace]47 -1.0*reaction\[LetterSpace]49, S19'[t] == 1.0*reaction\[LetterSpace]22 -1.0*reaction\[LetterSpace]43 -1.0*reaction\[LetterSpace]48 -1.0*reaction\[LetterSpace]51 -1.0*reaction\[LetterSpace]53, S2'[t] == 1.0*reaction\[LetterSpace]35 +1.0*reaction\[LetterSpace]41 -1.0*reaction\[LetterSpace]12 -1.0*reaction\[LetterSpace]14 -1.0*reaction\[LetterSpace]15 -1.0*reaction\[LetterSpace]10 -1.0*reaction\[LetterSpace]17, S20'[t] == 1.0*reaction\[LetterSpace]23 -1.0*reaction\[LetterSpace]45 -1.0*reaction\[LetterSpace]50 -1.0*reaction\[LetterSpace]52 -1.0*reaction\[LetterSpace]54, S21'[t] == 1.0*reaction\[LetterSpace]38 +1.0*reaction\[LetterSpace]39 -1.0*reaction\[LetterSpace]55 -1.0*reaction\[LetterSpace]56 -1.0*reaction\[LetterSpace]57, S22'[t] == 1.0*reaction\[LetterSpace]42 -1.0*reaction\[LetterSpace]58, S23'[t] == 1.0*reaction\[LetterSpace]49 -1.0*reaction\[LetterSpace]60 -1.0*reaction\[LetterSpace]62 -1.0*reaction\[LetterSpace]63, S24'[t] == 1.0*reaction\[LetterSpace]51 +1.0*reaction\[LetterSpace]67 -1.0*reaction\[LetterSpace]59 -1.0*reaction\[LetterSpace]61 -1.0*reaction\[LetterSpace]64, S25'[t] == 1.0*reaction\[LetterSpace]58 -1.0*reaction\[LetterSpace]65, S26'[t] == 1.0*reaction\[LetterSpace]61 +1.0*reaction\[LetterSpace]64 -1.0*reaction\[LetterSpace]66 -1.0*reaction\[LetterSpace]67, S27'[t] == 1.0*reaction\[LetterSpace]65 -1.0*reaction\[LetterSpace]68, S28'[t] == 1.0*reaction\[LetterSpace]68 -1.0*reaction\[LetterSpace]69, S3'[t] == 1.0*reaction\[LetterSpace]24 +1.0*reaction\[LetterSpace]52 -1.0*reaction\[LetterSpace]3 -1.0*reaction\[LetterSpace]6 -1.0*reaction\[LetterSpace]7, S4'[t] == 1.0*reaction\[LetterSpace]2 +1.0*reaction\[LetterSpace]50 -1.0*reaction\[LetterSpace]4 -1.0*reaction\[LetterSpace]23, S5'[t] ==  -1.0*reaction\[LetterSpace]18
};
timeCourse = NDSolve[Join[odes, initialValues]//.rateEquations//.assignments//.parameters, variables, {t, 0, 100}];

(* Steady-state solution initialized with result of time evolution *)
findRootEquations = odes /.D[_[t],t]->0;
findRootVariables = Partition[Flatten[{#, #/.timeCourse/.t->100} &/@variables],2];
steadyStateVariables = FindRoot[findRootEquations//.rateEquations//.assignments//.parameters, findRootVariables, MaxIterations->100]
fluxes = #//.assignments//.parameters/.steadyStateVariables&/@rateEquations

(* Plot the time evolution of the variables *)
plotTable=Table[Plot[variables[[i]]/.parameters/.timeCourse,{t,0,100},PlotLegends->variables[[i]],PlotRange->Full],{i,Length[variables]}]