#montanez1

FIX: ARGex

#reactions
Arginase:
 {1.0}ARGin = {1.0}ORN
  cytosol * (Vmaxarg * ARGin / (Kmarg * (1 + ORN / Kioarg) + ARGin))
Arginine_transport:
 {1.0}ARGex = {1.0}ARGin
  extracellular * (ARGex / (Kmhat + ARGex) * (Vmaxhat / (1 + ORN / Kiornhat + ARGin / Kmhat)) + ARGex / (Kmlat + ARGex) * (Vmaxlat / (1 + ORN / Kiornhat + ARGin / Kmlat)))
NOS:
 {1.0}ARGin = $pool
  cytosol * (Vmaxnos1 * ARGin / (Kmnos1 + ARGin))
ODC:
 {1.0}ORN = $pool
  cytosol * (Vmaxodc * ORN / (Kmodc + ORN))
Ornithine_efflux:
 {1.0}ORN = $pool
  cytosol * (Vmaxefflhat / (1 + ARGex / Kmhat) * (ORN / (Kiornhat * (1 + ARGin / Kmhat) + ORN)) + Vmaxeffllat / (1 + ARGex / Kmlat) * (ORN / (Kmeffllat * (1 + ARGin / Kmlat) + ORN)))


#parameters
ARGex = 330.0
Arginase_Vmaxarg = 110.0
Arginase_Kmarg = 1500.0
Arginase_Kioarg = 1000.0
Arginine_transport_Kmhat = 70.0
Arginine_transport_Vmaxhat = 160.5
Arginine_transport_Kmlat = 847.0
Arginine_transport_Vmaxlat = 420.0
Arginine_transport_Kiornhat = 360.0
Ornithine_efflux_Kmhat = 70.0
Ornithine_efflux_Kmlat = 847.0
Ornithine_efflux_Vmaxefflhat = 160.5
Ornithine_efflux_Vmaxeffllat = 420.0
Ornithine_efflux_Kmeffllat = 847.0
Ornithine_efflux_Kiornhat = 360.0
NOS_Vmaxnos1 = 1.33
NOS_Kmnos1 = 16.0
ODC_Vmaxodc = 0.013
ODC_Kmodc = 90.0
cytosol = 1.0
extracellular = 1.0


#initial values
ARGin = 1.0
ORN = 1.0


#assignment rules