begin name
montanez1
end name

begin reactions
Arginase {1.0}ARGin = {1.0}ORN
Argininetransport {1.0}$ARGex = {1.0}ARGin
NOS {1.0}ARGin = {1.0}$EXTERNAL
ODC {1.0}ORN = {1.0}$EXTERNAL
Ornithineefflux {1.0}ORN = {1.0}$EXTERNAL
end reactions

begin rate equations
Arginase = (ArginaseVmaxarg*cytosol*ARGin[t])/(ARGin[t] + ArginaseKmarg*(1 + ORN[t]/ArginaseKioarg))
Argininetransport = extracellular*((ARGex*ArgininetransportVmaxhat)/((ARGex + ArgininetransportKmhat)*(1 + ARGin[t]/ArgininetransportKmhat + ORN[t]/ArgininetransportKiornhat)) + (ARGex*ArgininetransportVmaxlat)/((ARGex + ArgininetransportKmlat)*(1 + ARGin[t]/ArgininetransportKmlat + ORN[t]/ArgininetransportKiornhat)))
NOS = (cytosol*NOSVmaxnos1*ARGin[t])/(NOSKmnos1 + ARGin[t])
ODC = (cytosol*ODCVmaxodc*ORN[t])/(ODCKmodc + ORN[t])
Ornithineefflux = cytosol*((OrnithineeffluxVmaxefflhat*ORN[t])/((1 + ARGex/OrnithineeffluxKmhat)*(OrnithineeffluxKiornhat*(1 + ARGin[t]/OrnithineeffluxKmhat) + ORN[t])) + (OrnithineeffluxVmaxeffllat*ORN[t])/((1 + ARGex/OrnithineeffluxKmlat)*(OrnithineeffluxKmeffllat*(1 + ARGin[t]/OrnithineeffluxKmlat) + ORN[t])))
end rate equations

begin parameters
ARGex = 330.0
ArginaseVmaxarg = 110.0
ArginaseKmarg = 1500.0
ArginaseKioarg = 1000.0
ArgininetransportKmhat = 70.0
ArgininetransportVmaxhat = 160.5
ArgininetransportKmlat = 847.0
ArgininetransportVmaxlat = 420.0
ArgininetransportKiornhat = 360.0
OrnithineeffluxKmhat = 70.0
OrnithineeffluxKmlat = 847.0
OrnithineeffluxVmaxefflhat = 160.5
OrnithineeffluxVmaxeffllat = 420.0
OrnithineeffluxKmeffllat = 847.0
OrnithineeffluxKiornhat = 360.0
NOSVmaxnos1 = 1.33
NOSKmnos1 = 16.0
ODCVmaxodc = 0.013
ODCKmodc = 90.0
cytosol = 1.0
extracellular = 1.0
end parameters

begin initial conditions
ARGin[0] = ARGini
ORN[0] = ORNi
end initial conditions

begin initial values
ARGini = 1.0
ORNi = 1.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
Arginine_transport http://identifiers.org/go/GO:0015326
Ornithine_efflux http://identifiers.org/go/GO:0015326
end process annotations

begin species annotations
ARGex http://identifiers.org/chebi/CHEBI:16467
ARGex http://identifiers.org/kegg.compound/C00062
ARGin http://identifiers.org/chebi/CHEBI:16467
ARGin http://identifiers.org/kegg.compound/C00062
ORN http://identifiers.org/chebi/CHEBI:15729
ORN http://identifiers.org/kegg.compound/C00077
end species annotations

begin units
end units