begin name montagne1 end name begin reactions assaal {1.0}T1 + {1.0}alpha = {1.0}alphaT1 assabl {1.0}alpha + {1.0}T2 = {1.0}alphaT2 assbcl {1.0}beta + {1.0}T3 = {1.0}betaT3 assbcr {1.0}T3 + {1.0}Inh = {1.0}T3Inh assbcrl {1.0}beta + {1.0}T3Inh = {1.0}betaT3Inh disaa {1.0}alphaT1alpha = {1.0}alpha + {1.0}alphaalphaT1 disab {1.0}alphaT2beta = {1.0}beta + {1.0}alphabetaT2 disbc {1.0}betaT3Inh = {1.0}Inh + {1.0}betaInhT3 exoa {1.0}alpha = {1.0}$empty exob {1.0}beta = {1.0}$empty exoc {1.0}Inh = {1.0}$empty inhac {1.0}T1 + {1.0}Inh = {1.0}InhT1 inhdisplac {1.0}T1alpha + {1.0}Inh = {1.0}alpha + {1.0}InhT1 massaalr {1.0}alphaT1alpha = {1.0}alpha + {1.0}alphaT1 massaar {1.0}T1alpha = {1.0}T1 + {1.0}alpha massaarl {1.0}alphaT1alpha = {1.0}alpha + {1.0}T1alpha massablr {1.0}alphaT2beta = {1.0}alphaT2 + {1.0}beta massabr {1.0}T2beta = {1.0}T2 + {1.0}beta massabrl {1.0}alphaT2beta = {1.0}alpha + {1.0}T2beta massbclr {1.0}betaT3Inh = {1.0}betaT3 + {1.0}Inh minhdisplca {1.0}alpha + {1.0}InhT1 = {1.0}alphaT1 + {1.0}Inh nickaa {1.0}alphaalphaT1 = {1.0}alphaT1alpha nickab {1.0}alphabetaT2 = {1.0}alphaT2beta nickbc {1.0}betaInhT3 = {1.0}betaT3Inh polaa {1.0}alphaT1 = {1.0}alphaalphaT1 polab {1.0}alphaT2 = {1.0}alphabetaT2 polbc {1.0}betaT3 = {1.0}betaInhT3 end reactions begin rate equations assaal = sample*(-(k0r*alphaT1[t]) + k0d*alpha[t]*T1[t]) assabl = sample*(-(k7r*alphaT2[t]) + k7d*alpha[t]*T2[t]) assbcl = sample*(-(k14r*betaT3[t]) + k14d*beta[t]*T3[t]) assbcr = sample*(k16d*Inh[t]*T3[t] - k16r*T3Inh[t]) assbcrl = sample*(-(k17r*betaT3Inh[t]) + k17d*beta[t]*T3Inh[t]) disaa = k5d*sample*alphaT1alpha[t] disab = k12d*sample*alphaT2beta[t] disbc = k19d*sample*betaT3Inh[t] exoa = k24d*sample*alpha[t] exob = k25d*sample*beta[t] exoc = k26d*sample*Inh[t] inhac = sample*(-(k21r*InhT1[t]) + k21d*Inh[t]*T1[t]) inhdisplac = sample*(-(k22r*alpha[t]*InhT1[t]) + k22d*Inh[t]*T1alpha[t]) massaalr = sample*(-(k1r*alpha[t]*alphaT1[t]) + k1d*alphaT1alpha[t]) massaar = sample*(-(k2r*alpha[t]*T1[t]) + k2d*T1alpha[t]) massaarl = sample*(k3d*alphaT1alpha[t] - k3r*alpha[t]*T1alpha[t]) massablr = sample*(k8d*alphaT2beta[t] - k8r*alphaT2[t]*beta[t]) massabr = sample*(-(k9r*beta[t]*T2[t]) + k9d*T2beta[t]) massabrl = sample*(k10d*alphaT2beta[t] - k10r*alpha[t]*T2beta[t]) massbclr = sample*(k15d*betaT3Inh[t] - k15r*betaT3[t]*Inh[t]) minhdisplca = sample*(-(k23r*alphaT1[t]*Inh[t]) + k23d*alpha[t]*InhT1[t]) nickaa = k6d*sample*alphaalphaT1[t] nickab = k13d*sample*alphabetaT2[t] nickbc = k20d*sample*betaInhT3[t] polaa = k4d*sample*alphaT1[t] polab = k11d*sample*alphaT2[t] polbc = k18d*sample*betaT3[t] end rate equations begin parameters k0d = 0.0294 k0r = 3.43457943925 k10d = 3.43457943925 k10r = 0.0294 k11d = 11.8408 k12d = 9.2239832 k13d = 2.60186 k14d = 0.0171 k14r = 0.610714285714 k15d = 0.00186296832954 k15r = 0.027 k16d = 0.027 k16r = 0.00186296832954 k17d = 0.0171 k17r = 0.610714285714 k18d = 17.024 k19d = 5.566848 k1d = 3.43457943925 k1r = 0.0294 k20d = 3.2064 k21d = 0.027 k21r = 0.00608108108108 k22d = 0.021546 k22r = "4.15391351351e-05" k23d = "4.15391351351e-05" k23r = 0.021546 k24d = 0.411 k25d = 0.485802 k26d = 1.7262 k2d = 3.43457943925 k2r = 0.0294 k3d = 3.43457943925 k3r = 0.0294 k4d = 15.2 k5d = 11.8408 k6d = 3.34 k7d = 0.0294 k7r = 3.43457943925 k8d = 0.610714285714 k8r = 0.0171 k9d = 0.610714285714 k9r = 0.0171 empty = 0.0 sample = 1.0 end parameters begin initial conditions Inh[0] = Inhi InhT1[0] = InhT1i T1[0] = T1i T1alpha[0] = T1alphai T2[0] = T2i T2beta[0] = T2betai T3[0] = T3i T3Inh[0] = T3Inhi alpha[0] = alphai alphaT1[0] = alphaT1i alphaT1alpha[0] = alphaT1alphai alphaT2[0] = alphaT2i alphaT2beta[0] = alphaT2betai alphaalphaT1[0] = alphaalphaT1i alphabetaT2[0] = alphabetaT2i beta[0] = betai betaInhT3[0] = betaInhT3i betaT3[0] = betaT3i betaT3Inh[0] = betaT3Inhi end initial conditions begin initial values Inhi = 0.0 InhT1i = 0.0 T1i = 38.5 T1alphai = 0.0 T2i = 3.89 T2betai = 0.0 T3i = 38.5 T3Inhi = 0.0 alphai = 10.0 alphaT1i = 0.0 alphaT1alphai = 0.0 alphaT2i = 0.0 alphaT2betai = 0.0 alphaalphaT1i = 0.0 alphabetaT2i = 0.0 betai = 0.0 betaInhT3i = 0.0 betaT3i = 0.0 betaT3Inhi = 0.0 end initial values begin assignment rules alphatotal := alpha[t] + alphaT1[t] + 2*alphaT1alpha[t] + 2*alphaT2[t] + alphaT2beta[t] + T1alpha[t] betatotal := alphaT2beta[t] + beta[t] + betaT3[t] + betaT3Inh[t] + T2beta[t] Inhtotal := betaT3Inh[t] + Inh[t] + InhT1[t] + T3Inh[t] fluorescence := -0.38 + 0.00093*(22*(alphaalphaT1[t] + alphabetaT2[t] + alphaT1alpha[t] + alphaT2beta[t]) + 27*(betaInhT3[t] + betaT3Inh[t]) + 11*(alphaT1[t] + alphaT2[t] + betaT3[t] + T1alpha[t] + T2beta[t]) + 16*(InhT1[t] + T3Inh[t])) Bpconcentration := 22*(alphaalphaT1[t] + alphabetaT2[t] + alphaT1alpha[t] + alphaT2beta[t]) + 27*(betaInhT3[t] + betaT3Inh[t]) + 11*(alphaT1[t] + alphaT2[t] + betaT3[t] + T1alpha[t] + T2beta[t]) + 16*(InhT1[t] + T3Inh[t]) end assignment rules begin function definitions end function definitions begin events end events begin process annotations end process annotations begin species annotations end species annotations begin units end units