#middleton1

FIX: s11 s15 s3 s33 s34 s35 s5 s6 s66 s67 s68 s69 s7 s70 s71

#reactions
re1:
 {1.0}s1 + {1.0}s2 = {1.0}s65
  la * s1 * s2
re10:
 {1.0}s24 + {1.0}s27 = {1.0}s31
  ka15 * s24 * s27
re11:
 {1.0}s31 = {1.0}s24 + {1.0}s27
  kd15 * s31
re12:
 {1.0}s31 = {1.0}s27 + {1.0}s25
  km15 * s31
re13:
 {1.0}s25 + {1.0}s27 = {1.0}s30
  ka24 * s25 * s27
re14:
 {1.0}s30 = {1.0}s25 + {1.0}s27
  kd24 * s30
re15:
 {1.0}s30 = {1.0}s27 + {1.0}s26
  km24 * s30
re16:
 {1.0}s26 + {1.0}s28 = {1.0}s29
  ka9 * s26 * s28
re17:
 {1.0}s29 = {1.0}s26 + {1.0}s28
  kd9 * s29
re18:
 {1.0}s29 = {1.0}s28 + {1.0}s1
  km9 * s29
re19:
 {1.0}s65 = {1.0}s62
  q * s65
re2:
 {1.0}s65 = {1.0}s2 + {1.0}s1
  ld * s65
re20:
 {1.0}s62 = {1.0}s65
  p * s62
re21:
 {1.0}s7 = {1.0}s16
  deltaDELLA * s40
re22:
 {1.0}s6 = {1.0}s27
  deltaGA20ox * s39
re23:
 {1.0}s5 = {1.0}s28
  deltaGA3ox * s41
re24:
 {1.0}s33 = {1.0}s2
  deltaGID * s42
re27:
 {1.0}s11 = {1.0}s39
  muGA20ox * s16 / (s16 + thetaGA20ox)
re28:
 {1.0}s15 = {1.0}s42
  muGID * s16 / (s16 + thetaGID)
re29:
 {1.0}s34 = {1.0}s40
  muDELLA * thetaDELLA / (s16 + thetaDELLA)
re3:
 {1.0}s62 + {1.0}s16 = {1.0}s45
  ua1 * s62 * s16
re30:
 {1.0}s35 = {1.0}s41
  muGA3ox * s16 / (s16 + thetaGA3ox)
re31:
 {1.0}s40 = {1.0}s34
  muDELLA * s40
re32:
 {1.0}s42 = {1.0}s15
  muGID * s42
re33:
 {1.0}s39 = {1.0}s11
  muGA20ox * s39
re34:
 {1.0}s41 = {1.0}s35
  muGA3ox * s41
re35:
 {1.0}s27 = {1.0}s6
  gammaGA20ox * s27
re37:
 {1.0}s2 = {1.0}s33
  gammaGID * s2
re38:
 {1.0}s28 = {1.0}s5
  gammaGA3ox * s28
re39:
 {1.0}s62 + {1.0}s16 = {1.0}s36
  ua2 * s62 * s16
re4:
 {1.0}s45 = {1.0}s62 + {1.0}s16
  ud1 * s45
re40:
 {1.0}s36 = {1.0}s62 + {1.0}s16
  ud2 * s36
re41:
 {1.0}s66 = {1.0}s1
  Pmem * A1 * omegaGA4
re42:
 {1.0}s23 = {1.0}s67
  muGA * s23
re43:
 {1.0}s24 = {1.0}s68
  muGA * s24
re44:
 {1.0}s25 = {1.0}s69
  muGA * s25
re45:
 {1.0}s26 = {1.0}s70
  muGA * s26
re46:
 {1.0}s1 = {1.0}s71
  (muGA + Pmem * B1) * s1
re5:
 {1.0}s45 = {1.0}s62 + {1.0}s22
  um * s45
re6:
 {1.0}s3 = {1.0}s23
  omegaGA12
re7:
 {1.0}s23 + {1.0}s27 = {1.0}s32
  ka12 * s23 * s27
re8:
 {1.0}s32 = {1.0}s23 + {1.0}s27
  kd12 * s32
re9:
 {1.0}s32 = {1.0}s27 + {1.0}s24
  km12 * s32


#parameters
Pmem = 2.66664
R = 1.0
appliedGA4 = 2.0
muDELLA = 0.070794578438414
muGA = 0.290804218727464
muGA20ox = 0.047770755070625
muGA3ox = 0.102600014140148
muGID = 0.045708818961487
omegaGA12ga13 = 0.006602803853512
omegaGA4 = 0.0
tGA4off = 620.0
tGA4on = 500.0
s11 = 0.0
s15 = 0.0
s3 = 0.0
s33 = 0.0
s34 = 0.0
s35 = 0.0
s5 = 0.0
s6 = 0.0
s66 = 0.0
s67 = 0.0
s68 = 0.0
s69 = 0.0
s7 = 0.0
s70 = 0.0
s71 = 0.0
re1_la = 1.35
re2_ld = 2.84315148627376
re3_ua1 = 10.0
re4_ud1 = 0.133045441797809
re5_um = 6.92208879449283
re7_ka12 = 2904.11853677638
re8_kd12 = 2.67298621993027
re9_km12 = 198.80427707769
re10_ka15 = 2073.22402517968
re11_kd15 = 0.008827838388125
re12_km15 = 763.777072066507
re13_ka24 = 3099.18915892587
re14_kd24 = 0.01588492846351
re15_km24 = 2.58846077319221
re16_ka9 = 2073.22402517968
re17_kd9 = 0.008827838388125
re18_km9 = 763.777072066507
re19_q = 0.025118864315096
re20_p = 0.077624711662869
re21_deltaDELLA = 0.000527749140286577
re22_deltaGA20ox = 0.192990314378105
re23_deltaGA3ox = 0.019299031437811
re24_deltaGID = 19.2990314378105
re27_thetaGA20ox = 0.6383
re28_thetaGID = 0.00055995
re29_thetaDELLA = 0.01
re30_thetaGA3ox = 0.0082
re35_gammaGA20ox = 3.514
re37_gammaGID = 3.514
re38_gammaGA3ox = 3.514
re39_ua2 = 316.2278
re40_ud2 = 2.8184
re41_A1 = 0.0307
re46_B1 = 0.00039795
default = 1.0


#initial values
s1 = 0.01
s16 = 0.01
s2 = 0.01
s22 = 0.01
s23 = 0.01
s24 = 0.01
s25 = 0.01
s26 = 0.01
s27 = 0.01
s28 = 0.01
s29 = 0.01
s30 = 0.01
s31 = 0.01
s32 = 0.01
s36 = 0.01
s39 = 0.01
s40 = 0.01
s41 = 0.01
s42 = 0.01
s45 = 0.01
s62 = 0.01
s65 = 0.01


#assignment rules
!F omegaGA12 = R * omegaGA12ga13