begin name mayya1 end name begin reactions PstatDimerimport {1.0}PstatDimersol = {1.0}PstatDimernuc PstatDimerisation {2.0}Pstatsol = {1.0}PstatDimersol PstatDimerisationNuc {2.0}Pstatnuc = {1.0}PstatDimernuc statDephosphorylation {1.0}Pstatnuc = {1.0}statnuc statPhosphorylation {1.0}statsol = {1.0}Pstatsol + {1.0}speciestest statexport {1.0}statsol = {1.0}statnuc statimport {1.0}statsol = {1.0}statnuc end reactions begin rate equations PstatDimerimport = (nm*PstatDimerimportPstatDimerimpMax*PstatDimersol[t])/(PstatDimerimportKpsdimp + PstatDimersol[t]) PstatDimerisation = sol*(-(PstatDimerisationKrPstatDimerisation*PstatDimersol[t]) + PstatDimerisationKfPstatDimerisation*Pstatsol[t]^2) PstatDimerisationNuc = nuc*(-(PstatDimerisationNucKrPstatDimerisation*PstatDimernuc[t]) + PstatDimerisationNucKfPstatDimerisation*Pstatnuc[t]^2) statDephosphorylation = (nuc*statDephosphorylationKcatdephos*Pstatnuc[t]*statPhosphatasenuc[t])/(statDephosphorylationKmdephos + Pstatnuc[t]) statPhosphorylation = (sol*statKinasesol*statPhosphorylationKcatphos*statsol[t])/(statPhosphorylationKmphos + statsol[t]) statexport = (nm*nuc*statexportstatexpMax*statnuc[t])/(statexportKsexp + statnuc[t]) statimport = (nm*nuc*statimportstatimpMax*statsol[t])/(statimportKsimp + statsol[t]) end rate equations begin parameters PstatDimerisationKfPstatDimerisation = 0.6 PstatDimerisationKrPstatDimerisation = 0.03 statDephosphorylationKcatdephos = 1.0 statDephosphorylationKmdephos = 2.0 statPhosphorylationKcatphos = 1.0 statPhosphorylationKmphos = 4.0 PstatDimerisationNucKfPstatDimerisation = 0.6 PstatDimerisationNucKrPstatDimerisation = 0.03 PstatDimerimportPstatDimerimpMax = 0.045 PstatDimerimportKpsdimp = 0.3 statexportstatexpMax = -0.06 statexportKsexp = 0.6 statimportstatimpMax = 0.003 statimportKsimp = 3.0 nm = 1.0 nuc = 1.0 sol = 14.625 end parameters begin initial conditions PstatDimernuc[0] = PstatDimernuci PstatDimersol[0] = PstatDimersoli Pstatnuc[0] = Pstatnuci Pstatsol[0] = Pstatsoli speciestest[0] = speciestesti statPhosphatasenuc[0] = statPhosphatasenuci statnuc[0] = statnuci statsol[0] = statsoli end initial conditions begin initial values PstatDimernuci = 0.0 PstatDimersoli = 0.0 Pstatnuci = 0.0 Pstatsoli = 0.0 speciestesti = 0.0 statPhosphatasenuci = 0.05 statnuci = 0.0 statsoli = 1.0 end initial values begin assignment rules statKinasesol := Piecewise[{{0.01*Sin[0.001571*(-500 + t)], t > 500 && t < 2502.54614894971}}, 0] end assignment rules begin function definitions end function definitions begin events end events begin process annotations end process annotations begin species annotations end species annotations begin units end units