begin name
maheshvare1
end name

begin reactions
ATPADPCHANGE {1.0}$EXTERNAL = {1.0}atp
ATPconsumption {1.0}atp + {1.0}$h2o = {1.0}adp + {1.0}$h
ATPformation {1.0}adp + {1.0}$h = {1.0}atp + {1.0}$h2o
ENO {1.0}pg2 = {1.0}pep + {1.0}$h2o
FBA {1.0}fbp = {1.0}dhap + {1.0}grap
FBP {1.0}fbp + {1.0}$h2o = {1.0}f6p
FBP26 {1.0}f26bp + {1.0}$h2o = {1.0}f6p
GAPD {1.0}grap = {1.0}bpg13 + {1.0}$h
GLCt1r {1.0}$glcext = {1.0}glc
HEX1 {1.0}glc + {1.0}atp = {1.0}g6p + {1.0}adp + {1.0}$h
IRS {1.0}$EXTERNAL = {1.0}$insext + {1.0}$cpepext
LDHL {1.0}pyr + {1.0}$h = {1.0}lac
LLACt2r {1.0}lac = {1.0}$lacext
PFK {1.0}f6p + {1.0}atp = {1.0}adp + {1.0}fbp + {1.0}$h
PFK26 {1.0}atp + {1.0}f6p = {1.0}adp + {1.0}f26bp + {1.0}$h
PGI {1.0}g6p = {1.0}f6p
PGK {1.0}adp + {1.0}bpg13 = {1.0}atp + {1.0}pg3
PGM {1.0}pg3 = {1.0}pg2
PYK {1.0}pep + {1.0}adp + {1.0}$h = {1.0}pyr + {1.0}atp
PYRt2r {1.0}pyr = {1.0}$pyrmito
TPI {1.0}dhap = {1.0}grap
end reactions

begin rate equations
ATPADPCHANGE = (-atpadp + atpadpss)*cyto*NUCLEOTIDECHANGEVm
ATPconsumption = (ATPconsumptionVm*cyto*atp[t])/(ATPconsumptionKMatp*(1 + atp[t]/ATPconsumptionKMatp))
ATPformation = (ATPformationVm*cyto*phos*adp[t])/(ATPformationKMadp*ATPformationKMphos*(1 + phos/ATPformationKMphos)*(1 + adp[t]/ATPformationKMadp))
ENO = (cyto*ENOVm*(-(pep[t]/ENOKeq) + pg2[t]))/(ENOKMpg2*(1 + pep[t]/ENOKMpep + pg2[t]/ENOKMpg2))
FBA = (cyto*FBAVm*(fbp[t] - (dhap[t]*grap[t])/FBAKeq))/(FBAKMfbp*(fbp[t]/FBAKMfbp + (1 + dhap[t]/FBAKMdhap)*(1 + grap[t]/FBAKMgrap)))
FBP = (cyto*FBPVm*fbp[t])/(FBPKMfbp*(1 + fbp[t]/FBPKMfbp))
FBP26 = (cyto*FBP26Vm*f26bp[t])/(FBP26KMf26bp*(1 + f26bp[t]/FBP26KMf26bp))
GAPD = (cyto*GAPDVm*(-((nadh*bpg13[t])/GAPDKeq) + nad*phos*grap[t]))/(GAPDKMgrap*GAPDKMnad*GAPDKMphos*(-1 + (1 + nadh/GAPDKMnadh)*(1 + bpg13[t]/GAPDKMbpg13) + (1 + nad/GAPDKMnad)*(1 + phos/GAPDKMphos)*(1 + grap[t]/GAPDKMgrap)))
GLCt1r = (cyto*GLCt1rVm*(glcext - glc[t]/GLCt1rKeq))/(GLCt1rKMglcext*(1 + glcext/GLCt1rKMglcext + glc[t]/GLCt1rKMglc))
HEX1 = (cyto*HEX1Vm*(-((adp[t]*g6p[t])/HEX1Keq) + atp[t]*glc[t]))/(HEX1KMatp*HEX1KMglc*(-1 + (1 + adp[t]/HEX1KMadp)*(1 + g6p[t]/HEX1KMg6p) + (1 + atp[t]/HEX1KMatp)*(1 + glc[t]/HEX1KMglc)))
IRS = cyto*(IRSfp + IRSss)
LDHL = (cyto*LDHLVm*(-((nad*lac[t])/LDHLKeq) + nadh*pyr[t]))/(LDHLKMnadh*LDHLKMpyr*(-1 + (1 + nad/LDHLKMnad)*(1 + lac[t]/LDHLKMlac) + (1 + nadh/LDHLKMnadh)*(1 + pyr[t]/LDHLKMpyr)))
LLACt2r = (cyto*LLACt2rVm*lac[t])/(LLACt2rKMlac*(1 + lac[t]/LLACt2rKMlac))
PFK = (cyto*PFKVm*atp[t]*f6p[t])/(PFKKMatp*PFKKMf6p*(1 + atp[t]/PFKKMatp)*(1 + f6p[t]/PFKKMf6p))
PFK26 = (cyto*PFK26Vm*atp[t]*f6p[t])/(PFK26KMatp*PFK26KMf6p*(1 + atp[t]/PFK26KMatp)*(1 + f6p[t]/PFK26KMf6p))
PGI = (cyto*PGIVm*(-(f6p[t]/PGIKeq) + g6p[t]))/(PGIKMg6p*(1 + f6p[t]/PGIKMf6p + g6p[t]/PGIKMg6p))
PGK = (cyto*PGKVm*(adp[t]*bpg13[t] - (atp[t]*pg3[t])/PGKKeq))/(PGKKMadp*PGKKMbpg13*(-1 + (1 + adp[t]/PGKKMadp)*(1 + bpg13[t]/PGKKMbpg13) + (1 + atp[t]/PGKKMatp)*(1 + pg3[t]/PGKKMpg3)))
PGM = (cyto*PGMVm*(-(pg2[t]/PGMKeq) + pg3[t]))/(PGMKMpg3*(1 + pg2[t]/PGMKMpg2 + pg3[t]/PGMKMpg3))
PYK = (cyto*PYKVm*(adp[t]*pep[t] - (atp[t]*pyr[t])/PYKKeq))/(PYKKMadp*PYKKMpep*(-1 + (1 + adp[t]/PYKKMadp)*(1 + pep[t]/PYKKMpep) + (1 + atp[t]/PYKKMatp)*(1 + pyr[t]/PYKKMpyr)))
PYRt2r = (cyto*PYRt2rVm*pyr[t])/(PYRt2rKMpyr*(1 + pyr[t]/PYRt2rKMpyr))
TPI = (cyto*TPIVm*(dhap[t] - grap[t]/TPIKeq))/(TPIKMdhap*(1 + dhap[t]/TPIKMdhap + grap[t]/TPIKMgrap))
end rate equations

begin parameters
ATPconsumptionKMatp = 2.0
ATPconsumptionVm = 5.58245
ATPformationKMadp = 5.6
ATPformationKMphos = 3.4
ATPformationVm = 42.6819
ENOKMpep = 0.089
ENOKMpg2 = 0.3
ENOKeq = 4.38534496525434
ENOVm = 191.263
FBAKMdhap = 0.38
FBAKMfbp = 0.027
FBAKMgrap = 0.32
FBAKeq = 0.000133163971260293
FBAVm = 500.562
FBP26KMf26bp = 0.013
FBP26Vm = 8.05946
FBPKMfbp = 0.1
FBPVm = 0.01
GAPDKMbpg13 = 0.018
GAPDKMgrap = 0.07
GAPDKMnad = 0.75
GAPDKMnadh = 0.012
GAPDKMphos = 3.4
GAPDKeq = 0.497383227406177
GAPDVm = 4950.28
GLCt1rKMglc = 17.0
GLCt1rKMglcext = 17.0
GLCt1rKeq = 1.0
GLCt1rVm = 1000.0
HEX1KMadp = 0.63
HEX1KMatp = 0.63
HEX1KMg6p = 19.9
HEX1KMglc = 5.0
HEX1Keq = 2255.52682196071
HEX1Vm = 2.71005
IRSfpKdatpdt = 0.0003
IRSfpVm = 0.05
IRSssKatpratio = 5.13347666690148
IRSssVm = 0.02
IRSsshillatpratio = 7.10527645078065
LDHLKMlac = 3.0
LDHLKMnad = 0.211
LDHLKMnadh = 0.0107
LDHLKMpyr = 0.398
LDHLKeq = 100.0
LDHLVm = 7.26844
LLACt2rKMlac = 0.8
LLACt2rVm = 5.21331
NUCLEOTIDECHANGEVm = 0.2
PFK26KMatp = 0.328
PFK26KMf6p = 0.017
PFK26Vm = 4.19328
PFKKMatp = 0.063
PFKKMf6p = 0.35
PFKVm = 7.48024
PGIKMf6p = 0.12
PGIKMg6p = 0.35
PGIKeq = 0.364659218171184
PGIVm = 4525.64
PGKKMadp = 0.126
PGKKMatp = 0.24
PGKKMbpg13 = 0.042
PGKKMpg3 = 0.27
PGKKeq = 1931.283
PGKVm = 4912.9
PGMKMpg2 = 0.139
PGMKMpg3 = 0.22
PGMKeq = 0.174472843901766
PGMVm = 5000.0
PYKKMadp = 0.22
PYKKMatp = 0.86
PYKKMpep = 0.18
PYKKMpyr = 3.0
PYKKeq = 20593.3056361955
PYKVm = 7.44078
PYRt2rKMpyr = 0.15
PYRt2rVm = 0.0575902
TPIKMdhap = 0.62
TPIKMgrap = 0.55
TPIKeq = 0.113860326083997
TPIVm = 4572.25
fscale = 1.0
presimduration = 60.0
presimglcext = 3.0
simglcext = 3.0
cpepext = 0.0
glcext = 2.8
h = 1.0
h2o = 1.0
insext = "6e-08"
lacext = 1.0
pyrmito = 1.0
cell = 0.001321
mm = 1.0
pm = 1.0
end parameters

begin initial conditions
adp[0] = adpi
atp[0] = atpi
bpg13[0] = bpg13i
dhap[0] = dhapi
f26bp[0] = f26bpi
f6p[0] = f6pi
fbp[0] = fbpi
g6p[0] = g6pi
glc[0] = glci
grap[0] = grapi
lac[0] = laci
pep[0] = pepi
pg2[0] = pg2i
pg3[0] = pg3i
pyr[0] = pyri
end initial conditions

begin initial values
adpi = 1.199
atpi = 3.921
bpg13i = 0.018
dhapi = 0.011
f26bpi = 0.002
f6pi = 0.008
fbpi = 0.019
g6pi = 0.113
glci = 2.571
grapi = 0.003
laci = 1.083
pepi = 0.477
pg2i = 0.14
pg3i = 0.669
pyri = 0.392
end initial values

begin assignment rules
ext := 1000*cell
cyto := 0.95*cell
mito := 0.05*cell
atpadp := adp[t] + atp[t]
atpratio := atp[t]/(1/100000000 + adp[t])
nadhnad := nad + nadh
nadhratio := nadh/(1/100000000 + nad)
fbpgrap := fbp[t] + grap[t]
fbpdhapgrap := dhap[t] + fbp[t] + grap[t]
fbpdhap := dhap[t] + fbp[t]
lacpyrratio := lac[t]/pyr[t]
phos := Piecewise[{{10.1746465657385, glcext < 2.4}, {10.1746465657385 - 0.184822580052604*(-2.4 + glcext), glcext >= 2.4 && glcext < 4}, {9.87893043765431 - 0.184822580052604*(-4 + glcext), glcext >= 4 && glcext < 8.6}, {9.02874656941233 - 0.184822580052604*(-8.6 + glcext), glcext >= 8.6 && glcext < 14.5}, {7.93829334710197 - 0.184822580052604*(-14.5 + glcext), glcext >= 14.5 && glcext < 16}, {7.66105947702306, glcext >= 16}}, 0]
nad := 0.59 + (0.3*glcext^1.39)/(10.20979845132981 + glcext^1.39)
nadh := 0.13 + (0.23*glcext^1.53)/(29.47951197523888 + glcext^1.53)
datpdt := -ATPconsumption + ATPformation + ATPADPCHANGE - HEX1 - PFK - PFK26 + PGK + PYK
IRSpervol := IRS/cell
atpadpss := 4.66 + (1.87*glcext^2.03)/(16.764209380544166 + glcext^2.03)
IRSss := (IRSssVm*(atp[t]/adp[t])^IRSsshillatpratio)/(IRSssKatpratio^IRSsshillatpratio + (atp[t]/adp[t])^IRSsshillatpratio)
IRSfp := Piecewise[{{(datpdt*IRSfpVm)/(datpdt + IRSfpKdatpdt), datpdt > 0}}, 0]
end assignment rules

begin function definitions
end function definitions

begin events
event_simulation = (t >= presimduration, {glcext -> simglcext}, 0)
event_presimulation = (presimduration > 0 && t < presimduration, {glcext -> presimglcext}, 0)
end events

begin process annotations
ATP_ADP_CHANGE http://identifiers.org/SBO:0000176
ATPconsumption http://identifiers.org/SBO:0000176
ATPformation http://identifiers.org/SBO:0000176
ENO http://identifiers.org/SBO:0000176
ENO http://identifiers.org/vmhreaction/ENO
ENO http://identifiers.org/rhea/10167
ENO http://identifiers.org/rhea/10164
ENO http://identifiers.org/metanetx.reaction/MNXR97932
ENO http://identifiers.org/seed/rxn00459
ENO http://identifiers.org/bigg.reaction/ENO
ENO http://identifiers.org/biocyc/META:2PGADEHYDRAT-RXN
ENO http://identifiers.org/ec-code/4.2.1.11
ENO http://identifiers.org/kegg.reaction/R00658
ENO http://identifiers.org/uniprot/P06733
ENO http://identifiers.org/uniprot/P13929
ENO http://identifiers.org/uniprot/P09104
FBA http://identifiers.org/SBO:0000176
FBA http://identifiers.org/vmhreaction/FBA
FBA http://identifiers.org/rhea/14729
FBA http://identifiers.org/rhea/14732
FBA http://identifiers.org/metanetx.reaction/MNXR99459
FBA http://identifiers.org/seed/rxn00786
FBA http://identifiers.org/bigg.reaction/FBA
FBA http://identifiers.org/ec-code/4.1.2.13
FBA http://identifiers.org/kegg.reaction/R01068
FBA http://identifiers.org/uniprot/P09972
FBA http://identifiers.org/uniprot/P04075
FBA http://identifiers.org/uniprot/P05062
FBP http://identifiers.org/SBO:0000176
FBP http://identifiers.org/vmhreaction/FBP
FBP http://identifiers.org/metanetx.reaction/MNXR99465
FBP http://identifiers.org/seed/rxn00549
FBP http://identifiers.org/bigg.reaction/FBP
FBP http://identifiers.org/ec-code/3.1.3.11
FBP http://identifiers.org/rhea/11064
FBP http://identifiers.org/uniprot/P09467
FBP http://identifiers.org/uniprot/Q9UMQ9
FBP http://identifiers.org/uniprot/O00757
FBP http://identifiers.org/uniprot/Q9UJ73
FBP http://identifiers.org/uniprot/Q9UMR0
FBP26 http://identifiers.org/SBO:0000176
FBP26 http://identifiers.org/vmhreaction/FBP26
FBP26 http://identifiers.org/metanetx.reaction/MNXR99466
FBP26 http://identifiers.org/bigg.reaction/FBP26
FBP26 http://identifiers.org/biocyc/META:3.1.3.46-RXN
FBP26 http://identifiers.org/ec-code/3.1.3.46
FBP26 http://identifiers.org/kegg.reaction/R02731
FBP26 http://identifiers.org/rhea/17289
FBP26 http://identifiers.org/uniprot/Q16875
FBP26 http://identifiers.org/uniprot/Q9NQ88
FBP26 http://identifiers.org/uniprot/Q16877
FBP26 http://identifiers.org/uniprot/P16118
FBP26 http://identifiers.org/uniprot/O60825
GAPD http://identifiers.org/SBO:0000176
GAPD http://identifiers.org/vmhreaction/GAPD
GAPD http://identifiers.org/rhea/10303
GAPD http://identifiers.org/rhea/10300
GAPD http://identifiers.org/metanetx.reaction/MNXR100040
GAPD http://identifiers.org/seed/rxn00781
GAPD http://identifiers.org/bigg.reaction/GAPD
GAPD http://identifiers.org/biocyc/META:GAPOXNPHOSPHN-RXN
GAPD http://identifiers.org/ec-code/1.2.1.12
GAPD http://identifiers.org/kegg.reaction/R01061
GAPD http://identifiers.org/uniprot/P04406
GAPD http://identifiers.org/uniprot/O14556
GLCt1r http://identifiers.org/SBO:0000655
GLCt1r http://identifiers.org/vmhreaction/GLCt1r
GLCt1r http://identifiers.org/bigg.reaction/GLCt1
GLCt1r http://identifiers.org/biocyc/META:TRANS-RXN0-574
GLCt1r http://identifiers.org/metanetx.reaction/MNXR100188
HEX1 http://identifiers.org/SBO:0000176
HEX1 http://identifiers.org/vmhreaction/HEX1
HEX1 http://identifiers.org/rhea/17825
HEX1 http://identifiers.org/rhea/17828
HEX1 http://identifiers.org/metanetx.reaction/MNXR100612
HEX1 http://identifiers.org/seed/rxn00216
HEX1 http://identifiers.org/bigg.reaction/HEX1
HEX1 http://identifiers.org/biocyc/META:GLUCOKIN-RXN
HEX1 http://identifiers.org/ec-code/2.7.1.1
HEX1 http://identifiers.org/kegg.reaction/R00299
HEX1 http://identifiers.org/uniprot/P35557
IRS http://identifiers.org/SBO:0000655
IRS http://identifiers.org/GO:0030073
LDH_L http://identifiers.org/SBO:0000176
LDH_L http://identifiers.org/vmhreaction/LDH_L
LDH_L http://identifiers.org/rhea/23444
LDH_L http://identifiers.org/rhea/23447
LDH_L http://identifiers.org/metanetx.reaction/MNXR101040
LDH_L http://identifiers.org/seed/rxn00499
LDH_L http://identifiers.org/bigg.reaction/LDH_L
LDH_L http://identifiers.org/biocyc/META:L-LACTATE-DEHYDROGENASE-RXN
LDH_L http://identifiers.org/ec-code/1.1.1.27
LDH_L http://identifiers.org/kegg.reaction/R00703
LDH_L http://identifiers.org/uniprot/P00338
LDH_L http://identifiers.org/uniprot/P07864
LDH_L http://identifiers.org/uniprot/P07195
LDH_L http://identifiers.org/uniprot/Q9BYZ2
L_LACt2r http://identifiers.org/SBO:0000655
L_LACt2r http://identifiers.org/vmhreaction/L_LACt2r
L_LACt2r http://identifiers.org/metanetx.reaction/MNXR101277
L_LACt2r http://identifiers.org/seed/rxn05602
L_LACt2r http://identifiers.org/bigg.reaction/L_LACt2r
L_LACt2r http://identifiers.org/biocyc/META:TRANS-RXN-104
L_LACt2r http://identifiers.org/rhea/29415
PFK http://identifiers.org/SBO:0000176
PFK http://identifiers.org/vmhreaction/PFK
PFK http://identifiers.org/metanetx.reaction/MNXR102507
PFK http://identifiers.org/seed/rxn00545
PFK http://identifiers.org/bigg.reaction/PFK
PFK http://identifiers.org/ec-code/2.7.1.11
PFK http://identifiers.org/rhea/16109
PFK http://identifiers.org/uniprot/P17858
PFK http://identifiers.org/uniprot/P08237
PFK http://identifiers.org/uniprot/Q01813
PFK26 http://identifiers.org/SBO:0000176
PFK26 http://identifiers.org/vmhreaction/PFK26
PFK26 http://identifiers.org/rhea/15656
PFK26 http://identifiers.org/rhea/15653
PFK26 http://identifiers.org/metanetx.reaction/MNXR102508
PFK26 http://identifiers.org/seed/rxn01971
PFK26 http://identifiers.org/bigg.reaction/PFK26
PFK26 http://identifiers.org/biocyc/META:6-PHOSPHOFRUCTO-2-KINASE-RXN
PFK26 http://identifiers.org/ec-code/2.7.1.105
PFK26 http://identifiers.org/kegg.reaction/R02732
PFK26 http://identifiers.org/uniprot/Q16877
PFK26 http://identifiers.org/uniprot/Q16875
PFK26 http://identifiers.org/uniprot/P16118
PFK26 http://identifiers.org/uniprot/O60825
PGI http://identifiers.org/SBO:0000176
PGI http://identifiers.org/vmhreaction/PGI
PGI http://identifiers.org/metanetx.reaction/MNXR102535
PGI http://identifiers.org/seed/rxn00558
PGI http://identifiers.org/bigg.reaction/PGI
PGI http://identifiers.org/biocyc/META:PGLUCISOM-RXN
PGI http://identifiers.org/ec-code/5.3.1.9
PGI http://identifiers.org/uniprot/P06744
PGK http://identifiers.org/SBO:0000176
PGK http://identifiers.org/vmhreaction/PGK
PGK http://identifiers.org/rhea/14801
PGK http://identifiers.org/rhea/14804
PGK http://identifiers.org/metanetx.reaction/MNXR102538
PGK http://identifiers.org/seed/rxn01100
PGK http://identifiers.org/bigg.reaction/PGK
PGK http://identifiers.org/biocyc/META:PHOSGLYPHOS-RXN
PGK http://identifiers.org/ec-code/2.7.2.3
PGK http://identifiers.org/kegg.reaction/R01512
PGK http://identifiers.org/uniprot/P00558
PGK http://identifiers.org/uniprot/P07205
PGM http://identifiers.org/SBO:0000176
PGM http://identifiers.org/vmhreaction/PGM
PGM http://identifiers.org/rhea/15901
PGM http://identifiers.org/rhea/15904
PGM http://identifiers.org/metanetx.reaction/MNXR102547
PGM http://identifiers.org/seed/rxn01106
PGM http://identifiers.org/bigg.reaction/PGM
PGM http://identifiers.org/biocyc/META:3PGAREARR-RXN
PGM http://identifiers.org/ec-code/5.4.2.1
PGM http://identifiers.org/kegg.reaction/R01518
PGM http://identifiers.org/uniprot/P15259
PGM http://identifiers.org/uniprot/P07738
PGM http://identifiers.org/uniprot/P18669
PYK http://identifiers.org/SBO:0000176
PYK http://identifiers.org/vmhreaction/PYK
PYK http://identifiers.org/rhea/18160
PYK http://identifiers.org/rhea/18157
PYK http://identifiers.org/metanetx.reaction/MNXR103371
PYK http://identifiers.org/seed/rxn00148
PYK http://identifiers.org/bigg.reaction/PYK
PYK http://identifiers.org/biocyc/META:PEPDEPHOS-RXN
PYK http://identifiers.org/ec-code/2.7.1.40
PYK http://identifiers.org/kegg.reaction/R00200
PYK http://identifiers.org/uniprot/P14618
PYK http://identifiers.org/uniprot/P30613
PYRt2r http://identifiers.org/SBO:0000655
PYRt2r http://identifiers.org/vmhreaction/PYRt2r
PYRt2r http://identifiers.org/bigg.reaction/PYRt2
PYRt2r http://identifiers.org/metanetx.reaction/MNXR103385
TPI http://identifiers.org/SBO:0000176
TPI http://identifiers.org/vmhreaction/TPI
TPI http://identifiers.org/metanetx.reaction/MNXR104918
TPI http://identifiers.org/seed/rxn00747
TPI http://identifiers.org/bigg.reaction/TPI
TPI http://identifiers.org/biocyc/META:TRIOSEPISOMERIZATION-RXN
TPI http://identifiers.org/ec-code/5.3.1.1
TPI http://identifiers.org/kegg.reaction/R01015
TPI http://identifiers.org/rhea/18585
TPI http://identifiers.org/uniprot/P60174
end process annotations

begin species annotations
adp http://identifiers.org/SBO:0000247
adp http://identifiers.org/inchikey/XTWYTFMLZFPYCI-KQYNXXCUSA-N
adp http://identifiers.org/vmhmetabolite/adp
adp http://identifiers.org/bigg.metabolite/adp
adp http://identifiers.org/kegg.compound/C00008
adp http://identifiers.org/hmdb/HMDB01341
adp http://identifiers.org/hmdb/HMDB0001341
adp http://identifiers.org/biocyc/META:ADP
adp http://identifiers.org/CHEBI:40553
adp http://identifiers.org/CHEBI:456216
adp http://identifiers.org/CHEBI:13222
adp http://identifiers.org/CHEBI:16761
adp http://identifiers.org/CHEBI:2342
adp http://identifiers.org/CHEBI:87518
adp http://identifiers.org/CHEBI:22244
adp http://identifiers.org/metanetx.chemical/MNXM7
adp http://identifiers.org/seed.compound/cpd00008
atp http://identifiers.org/SBO:0000247
atp http://identifiers.org/inchikey/ZKHQWZAMYRWXGA-KQYNXXCUSA-J
atp http://identifiers.org/vmhmetabolite/atp
atp http://identifiers.org/bigg.metabolite/atp
atp http://identifiers.org/kegg.compound/C00002
atp http://identifiers.org/hmdb/HMDB00538
atp http://identifiers.org/hmdb/HMDB0000538
atp http://identifiers.org/biocyc/META:ATP
atp http://identifiers.org/CHEBI:30616
atp http://identifiers.org/CHEBI:57299
atp http://identifiers.org/CHEBI:40938
atp http://identifiers.org/CHEBI:10841
atp http://identifiers.org/CHEBI:10789
atp http://identifiers.org/CHEBI:22249
atp http://identifiers.org/CHEBI:2359
atp http://identifiers.org/CHEBI:13236
atp http://identifiers.org/CHEBI:15422
atp http://identifiers.org/CHEBI:237958
atp http://identifiers.org/metanetx.chemical/MNXM3
atp http://identifiers.org/seed.compound/cpd00002
bpg13 http://identifiers.org/SBO:0000247
bpg13 http://identifiers.org/inchikey/LJQLQCAXBUHEAZ-UWTATZPHSA-N
bpg13 http://identifiers.org/vmhmetabolite/13dpg
bpg13 http://identifiers.org/bigg.metabolite/13dpg
bpg13 http://identifiers.org/kegg.compound/C00236
bpg13 http://identifiers.org/hmdb/HMDB62758
bpg13 http://identifiers.org/hmdb/HMDB0001270
bpg13 http://identifiers.org/biocyc/META:DPG
bpg13 http://identifiers.org/CHEBI:11881
bpg13 http://identifiers.org/CHEBI:57604
bpg13 http://identifiers.org/CHEBI:1658
bpg13 http://identifiers.org/CHEBI:20189
bpg13 http://identifiers.org/CHEBI:16001
bpg13 http://identifiers.org/metanetx.chemical/MNXM261
bpg13 http://identifiers.org/seed.compound/cpd00203
cpep_ext http://identifiers.org/SBO:0000245
cpep_ext http://identifiers.org/CHEBI:80332
cpep_ext http://identifiers.org/ncit/C94608
dhap http://identifiers.org/SBO:0000247
dhap http://identifiers.org/inchikey/GNGACRATGGDKBX-UHFFFAOYSA-N
dhap http://identifiers.org/vmhmetabolite/dhap
dhap http://identifiers.org/bigg.metabolite/dhap
dhap http://identifiers.org/kegg.compound/C00111
dhap http://identifiers.org/hmdb/HMDB0001473
dhap http://identifiers.org/hmdb/HMDB11735
dhap http://identifiers.org/hmdb/HMDB01473
dhap http://identifiers.org/biocyc/META:DIHYDROXY-ACETONE-PHOSPHATE
dhap http://identifiers.org/CHEBI:24355
dhap http://identifiers.org/CHEBI:16108
dhap http://identifiers.org/CHEBI:14342
dhap http://identifiers.org/CHEBI:57642
dhap http://identifiers.org/CHEBI:5454
dhap http://identifiers.org/CHEBI:39571
dhap http://identifiers.org/CHEBI:14341
dhap http://identifiers.org/metanetx.chemical/MNXM77
dhap http://identifiers.org/seed.compound/cpd00095
f26bp http://identifiers.org/SBO:0000247
f26bp http://identifiers.org/inchikey/YXWOAJXNVLXPMU-ZXXMMSQZSA-N
f26bp http://identifiers.org/vmhmetabolite/f26bp
f26bp http://identifiers.org/bigg.metabolite/f26bp
f26bp http://identifiers.org/kegg.compound/C00665
f26bp http://identifiers.org/hmdb/HMDB01047
f26bp http://identifiers.org/hmdb/HMDB0001047
f26bp http://identifiers.org/biocyc/META:CPD-535
f26bp http://identifiers.org/CHEBI:42586
f26bp http://identifiers.org/CHEBI:20933
f26bp http://identifiers.org/CHEBI:28602
f26bp http://identifiers.org/CHEBI:12351
f26bp http://identifiers.org/CHEBI:58579
f26bp http://identifiers.org/CHEBI:4122
f26bp http://identifiers.org/metanetx.chemical/MNXM651
f26bp http://identifiers.org/seed.compound/cpd00503
f6p http://identifiers.org/SBO:0000247
f6p http://identifiers.org/inchikey/BGWGXPAPYGQALX-ARQDHWQXSA-N
f6p http://identifiers.org/vmhmetabolite/f6p
f6p http://identifiers.org/bigg.metabolite/f6p
f6p http://identifiers.org/kegg.compound/C00085
f6p http://identifiers.org/kegg.compound/C05345
f6p http://identifiers.org/hmdb/HMDB03971
f6p http://identifiers.org/hmdb/HMDB0000124
f6p http://identifiers.org/biocyc/META:FRUCTOSE-6P
f6p http://identifiers.org/CHEBI:16084
f6p http://identifiers.org/CHEBI:42378
f6p http://identifiers.org/CHEBI:10375
f6p http://identifiers.org/CHEBI:57634
f6p http://identifiers.org/CHEBI:22768
f6p http://identifiers.org/CHEBI:12352
f6p http://identifiers.org/metanetx.chemical/MNXM89621
f6p http://identifiers.org/seed.compound/cpd19035
fbp http://identifiers.org/SBO:0000247
fbp http://identifiers.org/inchikey/RNBGYGVWRKECFJ-VRPWFDPXSA-N
fbp http://identifiers.org/vmhmetabolite/fdp
fbp http://identifiers.org/bigg.metabolite/fdp
fbp http://identifiers.org/kegg.compound/C00354
fbp http://identifiers.org/hmdb/HMDB0001058
fbp http://identifiers.org/CHEBI:37736
fbp http://identifiers.org/CHEBI:49299
fbp http://identifiers.org/metanetx.chemical/MNXM417
fbp http://identifiers.org/seed.compound/cpd00290
g6p http://identifiers.org/SBO:0000247
g6p http://identifiers.org/inchikey/YXWOAJXNVLXPMU-ZXXMMSQZSA-N
g6p http://identifiers.org/vmhmetabolite/g6p
g6p http://identifiers.org/bigg.metabolite/g6p
g6p http://identifiers.org/kegg.compound/C00092
g6p http://identifiers.org/hmdb/HMDB01401
g6p http://identifiers.org/hmdb/HMDB06793
g6p http://identifiers.org/hmdb/HMDB0001401
g6p http://identifiers.org/hmdb/HMDB01549
g6p http://identifiers.org/biocyc/META:D-glucopyranose-6-phosphate
g6p http://identifiers.org/CHEBI:14314
g6p http://identifiers.org/CHEBI:4170
g6p http://identifiers.org/CHEBI:61548
g6p http://identifiers.org/metanetx.chemical/MNXM160
g6p http://identifiers.org/seed.compound/cpd26836
g6p http://identifiers.org/seed.compound/cpd00079
glc http://identifiers.org/SBO:0000247
glc http://identifiers.org/inchikey/NBSCHQHZLSJFNQ-GASJEMHNSA-N
glc http://identifiers.org/vmhmetabolite/glc_D
glc http://identifiers.org/bigg.metabolite/glc__D
glc http://identifiers.org/kegg.compound/C00031
glc http://identifiers.org/hmdb/HMDB0000122
glc http://identifiers.org/hmdb/HMDB06564
glc http://identifiers.org/hmdb/HMDB00122
glc http://identifiers.org/biocyc/META:Glucopyranose
glc http://identifiers.org/CHEBI:12965
glc http://identifiers.org/CHEBI:20999
glc http://identifiers.org/CHEBI:17634
glc http://identifiers.org/CHEBI:4167
glc http://identifiers.org/metanetx.chemical/MNXM41
glc http://identifiers.org/seed.compound/cpd26821
glc http://identifiers.org/seed.compound/cpd00027
glc_ext http://identifiers.org/SBO:0000247
glc_ext http://identifiers.org/inchikey/WQZGKKKJIJFFOK-GASJEMHNSA-N
glc_ext http://identifiers.org/vmhmetabolite/glc_D
glc_ext http://identifiers.org/bigg.metabolite/glc__D
glc_ext http://identifiers.org/kegg.compound/C00031
glc_ext http://identifiers.org/hmdb/HMDB0000122
glc_ext http://identifiers.org/hmdb/HMDB06564
glc_ext http://identifiers.org/hmdb/HMDB00122
glc_ext http://identifiers.org/biocyc/META:Glucopyranose
glc_ext http://identifiers.org/CHEBI:12965
glc_ext http://identifiers.org/CHEBI:20999
glc_ext http://identifiers.org/CHEBI:17634
glc_ext http://identifiers.org/CHEBI:4167
glc_ext http://identifiers.org/metanetx.chemical/MNXM41
glc_ext http://identifiers.org/seed.compound/cpd26821
glc_ext http://identifiers.org/seed.compound/cpd00027
grap http://identifiers.org/SBO:0000247
grap http://identifiers.org/inchikey/LXJXRIRHZLFYRP-UHFFFAOYSA-N
grap http://identifiers.org/vmhmetabolite/g3p
grap http://identifiers.org/bigg.metabolite/g3p
grap http://identifiers.org/kegg.compound/C00118
grap http://identifiers.org/kegg.compound/C00661
grap http://identifiers.org/biocyc/META:GAP
grap http://identifiers.org/CHEBI:17138
grap http://identifiers.org/CHEBI:12984
grap http://identifiers.org/CHEBI:18324
grap http://identifiers.org/CHEBI:29052
grap http://identifiers.org/CHEBI:58027
grap http://identifiers.org/CHEBI:5446
grap http://identifiers.org/CHEBI:181
grap http://identifiers.org/CHEBI:14333
grap http://identifiers.org/CHEBI:59776
grap http://identifiers.org/CHEBI:12983
grap http://identifiers.org/CHEBI:21026
grap http://identifiers.org/hmdb/HMDB01112
grap http://identifiers.org/metanetx.chemical/MNXM74
grap http://identifiers.org/seed.compound/cpd00102
grap http://identifiers.org/seed.compound/cpd19005
h http://identifiers.org/SBO:0000247
h http://identifiers.org/inchikey/GPRLSGONYQIRFK-UHFFFAOYSA-N
h http://identifiers.org/vmhmetabolite/h
h http://identifiers.org/bigg.metabolite/h
h http://identifiers.org/kegg.compound/C00080
h http://identifiers.org/hmdb/HMDB59597
h http://identifiers.org/hmdb/HMDB0059597
h http://identifiers.org/biocyc/META:PROTON
h http://identifiers.org/CHEBI:15378
h http://identifiers.org/CHEBI:10744
h http://identifiers.org/CHEBI:5584
h http://identifiers.org/CHEBI:13357
h http://identifiers.org/metanetx.chemical/MNXM1
h http://identifiers.org/seed.compound/cpd00067
h2o http://identifiers.org/SBO:0000247
h2o http://identifiers.org/inchikey/XLYOFNOQVPJJNP-UHFFFAOYSA-M
h2o http://identifiers.org/vmhmetabolite/h2o
h2o http://identifiers.org/bigg.metabolite/h2o
h2o http://identifiers.org/kegg.compound/C01328
h2o http://identifiers.org/kegg.compound/C00001
h2o http://identifiers.org/hmdb/HMDB01039
h2o http://identifiers.org/hmdb/HMDB0002111
h2o http://identifiers.org/hmdb/HMDB02111
h2o http://identifiers.org/biocyc/META:CPD-15815
h2o http://identifiers.org/biocyc/META:HYDROXYL-GROUP
h2o http://identifiers.org/biocyc/META:WATER
h2o http://identifiers.org/biocyc/META:OXONIUM
h2o http://identifiers.org/biocyc/META:OH
h2o http://identifiers.org/CHEBI:16234
h2o http://identifiers.org/CHEBI:10743
h2o http://identifiers.org/CHEBI:44292
h2o http://identifiers.org/CHEBI:13419
h2o http://identifiers.org/CHEBI:44641
h2o http://identifiers.org/CHEBI:15377
h2o http://identifiers.org/CHEBI:30490
h2o http://identifiers.org/CHEBI:5594
h2o http://identifiers.org/CHEBI:5585
h2o http://identifiers.org/CHEBI:44819
h2o http://identifiers.org/CHEBI:13352
h2o http://identifiers.org/CHEBI:27313
h2o http://identifiers.org/CHEBI:43228
h2o http://identifiers.org/CHEBI:42857
h2o http://identifiers.org/CHEBI:29412
h2o http://identifiers.org/CHEBI:13365
h2o http://identifiers.org/CHEBI:42043
h2o http://identifiers.org/CHEBI:44701
h2o http://identifiers.org/CHEBI:33813
h2o http://identifiers.org/CHEBI:29356
h2o http://identifiers.org/metanetx.chemical/MNXM2
h2o http://identifiers.org/seed.compound/cpd15275
h2o http://identifiers.org/seed.compound/cpd27222
h2o http://identifiers.org/seed.compound/cpd00001
ins_ext http://identifiers.org/SBO:0000245
ins_ext http://identifiers.org/uniprot/P01308
ins_ext http://identifiers.org/CHEBI:145810
ins_ext http://identifiers.org/ncit/C2271
ins_ext http://identifiers.org/vmhmetabolite/M03169
ins_ext http://identifiers.org/kegg.compound/C00723
lac http://identifiers.org/SBO:0000247
lac http://identifiers.org/inchikey/JVTAAEKCZFNVCJ-REOHCLBHSA-M
lac http://identifiers.org/vmhmetabolite/lac_L
lac http://identifiers.org/bigg.metabolite/lac__L
lac http://identifiers.org/kegg.compound/C00186
lac http://identifiers.org/hmdb/HMDB03328
lac http://identifiers.org/hmdb/HMDB0000190
lac http://identifiers.org/hmdb/HMDB00190
lac http://identifiers.org/hmdb/HMDB62492
lac http://identifiers.org/biocyc/META:L-LACTATE
lac http://identifiers.org/CHEBI:18783
lac http://identifiers.org/CHEBI:11065
lac http://identifiers.org/CHEBI:422
lac http://identifiers.org/CHEBI:16651
lac http://identifiers.org/CHEBI:12411
lac http://identifiers.org/metanetx.chemical/MNXM179
lac http://identifiers.org/seed.compound/cpd00159
lac_ext http://identifiers.org/SBO:0000247
lac_ext http://identifiers.org/inchikey/JVTAAEKCZFNVCJ-REOHCLBHSA-M
lac_ext http://identifiers.org/vmhmetabolite/lac_L
lac_ext http://identifiers.org/bigg.metabolite/lac__L
lac_ext http://identifiers.org/kegg.compound/C00186
lac_ext http://identifiers.org/hmdb/HMDB03328
lac_ext http://identifiers.org/hmdb/HMDB0000190
lac_ext http://identifiers.org/hmdb/HMDB00190
lac_ext http://identifiers.org/hmdb/HMDB62492
lac_ext http://identifiers.org/biocyc/META:L-LACTATE
lac_ext http://identifiers.org/CHEBI:18783
lac_ext http://identifiers.org/CHEBI:11065
lac_ext http://identifiers.org/CHEBI:422
lac_ext http://identifiers.org/CHEBI:16651
lac_ext http://identifiers.org/CHEBI:12411
lac_ext http://identifiers.org/metanetx.chemical/MNXM179
lac_ext http://identifiers.org/seed.compound/cpd00159
nad http://identifiers.org/SBO:0000247
nad http://identifiers.org/inchikey/BAWFJGJZGIEFAR-NNYOXOHSSA-N
nad http://identifiers.org/vmhmetabolite/nad
nad http://identifiers.org/bigg.metabolite/nad
nad http://identifiers.org/kegg.compound/C00003
nad http://identifiers.org/hmdb/HMDB0000902
nad http://identifiers.org/hmdb/HMDB00902
nad http://identifiers.org/biocyc/META:NAD
nad http://identifiers.org/CHEBI:13393
nad http://identifiers.org/CHEBI:21901
nad http://identifiers.org/CHEBI:15846
nad http://identifiers.org/CHEBI:29867
nad http://identifiers.org/CHEBI:7422
nad http://identifiers.org/CHEBI:57540
nad http://identifiers.org/CHEBI:44281
nad http://identifiers.org/CHEBI:44215
nad http://identifiers.org/CHEBI:44214
nad http://identifiers.org/CHEBI:13394
nad http://identifiers.org/metanetx.chemical/MNXM8
nad http://identifiers.org/seed.compound/cpd00003
nadh http://identifiers.org/SBO:0000247
nadh http://identifiers.org/inchikey/BOPGDPNILDQYTO-NNYOXOHSSA-L
nadh http://identifiers.org/vmhmetabolite/nadh
nadh http://identifiers.org/bigg.metabolite/nadh
nadh http://identifiers.org/kegg.compound/C00004
nadh http://identifiers.org/hmdb/HMDB0001487
nadh http://identifiers.org/hmdb/HMDB01487
nadh http://identifiers.org/biocyc/META:NADH
nadh http://identifiers.org/CHEBI:57945
nadh http://identifiers.org/CHEBI:21902
nadh http://identifiers.org/CHEBI:44216
nadh http://identifiers.org/CHEBI:7423
nadh http://identifiers.org/CHEBI:13395
nadh http://identifiers.org/CHEBI:13396
nadh http://identifiers.org/CHEBI:16908
nadh http://identifiers.org/metanetx.chemical/MNXM10
nadh http://identifiers.org/seed.compound/cpd00004
pep http://identifiers.org/SBO:0000247
pep http://identifiers.org/inchikey/DTBNBXWJWCWCIK-UHFFFAOYSA-M
pep http://identifiers.org/vmhmetabolite/pep
pep http://identifiers.org/bigg.metabolite/pep
pep http://identifiers.org/kegg.compound/C00074
pep http://identifiers.org/hmdb/HMDB0000263
pep http://identifiers.org/hmdb/HMDB00263
pep http://identifiers.org/biocyc/META:PHOSPHO-ENOL-PYRUVATE
pep http://identifiers.org/CHEBI:8147
pep http://identifiers.org/CHEBI:18021
pep http://identifiers.org/CHEBI:44897
pep http://identifiers.org/CHEBI:58702
pep http://identifiers.org/CHEBI:14812
pep http://identifiers.org/CHEBI:26055
pep http://identifiers.org/CHEBI:44894
pep http://identifiers.org/CHEBI:26054
pep http://identifiers.org/metanetx.chemical/MNXM73
pep http://identifiers.org/seed.compound/cpd00061
pg2 http://identifiers.org/SBO:0000247
pg2 http://identifiers.org/inchikey/GXIURPTVHJPJLF-UWTATZPHSA-K
pg2 http://identifiers.org/vmhmetabolite/2pg
pg2 http://identifiers.org/bigg.metabolite/2pg
pg2 http://identifiers.org/kegg.compound/C00631
pg2 http://identifiers.org/hmdb/HMDB03391
pg2 http://identifiers.org/hmdb/HMDB00362
pg2 http://identifiers.org/hmdb/HMDB0003391
pg2 http://identifiers.org/hmdb/HMDB62707
pg2 http://identifiers.org/biocyc/META:2-PG
pg2 http://identifiers.org/CHEBI:58289
pg2 http://identifiers.org/CHEBI:39868
pg2 http://identifiers.org/CHEBI:11651
pg2 http://identifiers.org/CHEBI:24344
pg2 http://identifiers.org/CHEBI:17835
pg2 http://identifiers.org/CHEBI:12986
pg2 http://identifiers.org/CHEBI:21028
pg2 http://identifiers.org/CHEBI:1267
pg2 http://identifiers.org/CHEBI:88350
pg2 http://identifiers.org/metanetx.chemical/MNXM275
pg2 http://identifiers.org/seed.compound/cpd00482
pg3 http://identifiers.org/SBO:0000247
pg3 http://identifiers.org/inchikey/OSJPPGNTCRNQQC-UWTATZPHSA-N
pg3 http://identifiers.org/vmhmetabolite/3pg
pg3 http://identifiers.org/bigg.metabolite/3pg
pg3 http://identifiers.org/kegg.compound/C00197
pg3 http://identifiers.org/hmdb/HMDB60180
pg3 http://identifiers.org/hmdb/HMDB0060180
pg3 http://identifiers.org/biocyc/META:G3P
pg3 http://identifiers.org/CHEBI:11879
pg3 http://identifiers.org/CHEBI:17794
pg3 http://identifiers.org/CHEBI:12987
pg3 http://identifiers.org/CHEBI:58272
pg3 http://identifiers.org/CHEBI:11880
pg3 http://identifiers.org/CHEBI:21029
pg3 http://identifiers.org/CHEBI:1657
pg3 http://identifiers.org/metanetx.chemical/MNXM126
pg3 http://identifiers.org/seed.compound/cpd00169
phos http://identifiers.org/SBO:0000247
phos http://identifiers.org/inchikey/NBIIXXVUZAFLBC-UHFFFAOYSA-K
phos http://identifiers.org/vmhmetabolite/pi
phos http://identifiers.org/bigg.metabolite/pi
phos http://identifiers.org/kegg.compound/C00009
phos http://identifiers.org/hmdb/HMDB02105
phos http://identifiers.org/hmdb/HMDB00973
phos http://identifiers.org/hmdb/HMDB05947
phos http://identifiers.org/hmdb/HMDB0001429
phos http://identifiers.org/hmdb/HMDB02142
phos http://identifiers.org/hmdb/HMDB01429
phos http://identifiers.org/biocyc/META:PHOSPHATE-GROUP
phos http://identifiers.org/biocyc/META:CPD-16459
phos http://identifiers.org/biocyc/META:Pi
phos http://identifiers.org/CHEBI:26020
phos http://identifiers.org/CHEBI:45024
phos http://identifiers.org/CHEBI:18367
phos http://identifiers.org/CHEBI:39745
phos http://identifiers.org/CHEBI:7793
phos http://identifiers.org/CHEBI:14791
phos http://identifiers.org/CHEBI:43470
phos http://identifiers.org/CHEBI:29139
phos http://identifiers.org/CHEBI:26078
phos http://identifiers.org/CHEBI:39739
phos http://identifiers.org/CHEBI:43474
phos http://identifiers.org/CHEBI:35780
phos http://identifiers.org/CHEBI:29137
phos http://identifiers.org/metanetx.chemical/MNXM9
phos http://identifiers.org/seed.compound/cpd00009
phos http://identifiers.org/seed.compound/cpd27787
pyr http://identifiers.org/SBO:0000247
pyr http://identifiers.org/inchikey/LCTONWCANYUPML-UHFFFAOYSA-M
pyr http://identifiers.org/vmhmetabolite/pyr
pyr http://identifiers.org/bigg.metabolite/pyr
pyr http://identifiers.org/kegg.compound/C00022
pyr http://identifiers.org/hmdb/HMDB0000243
pyr http://identifiers.org/hmdb/HMDB00243
pyr http://identifiers.org/biocyc/META:PYRUVATE
pyr http://identifiers.org/CHEBI:15361
pyr http://identifiers.org/CHEBI:32816
pyr http://identifiers.org/CHEBI:26466
pyr http://identifiers.org/CHEBI:45253
pyr http://identifiers.org/CHEBI:8685
pyr http://identifiers.org/CHEBI:14987
pyr http://identifiers.org/CHEBI:26462
pyr http://identifiers.org/metanetx.chemical/MNXM23
pyr http://identifiers.org/seed.compound/cpd00020
pyr_mito http://identifiers.org/SBO:0000247
pyr_mito http://identifiers.org/inchikey/LCTONWCANYUPML-UHFFFAOYSA-M
pyr_mito http://identifiers.org/vmhmetabolite/pyr
pyr_mito http://identifiers.org/bigg.metabolite/pyr
pyr_mito http://identifiers.org/kegg.compound/C00022
pyr_mito http://identifiers.org/hmdb/HMDB0000243
pyr_mito http://identifiers.org/hmdb/HMDB00243
pyr_mito http://identifiers.org/biocyc/META:PYRUVATE
pyr_mito http://identifiers.org/CHEBI:15361
pyr_mito http://identifiers.org/CHEBI:32816
pyr_mito http://identifiers.org/CHEBI:26466
pyr_mito http://identifiers.org/CHEBI:45253
pyr_mito http://identifiers.org/CHEBI:8685
pyr_mito http://identifiers.org/CHEBI:14987
pyr_mito http://identifiers.org/CHEBI:26462
pyr_mito http://identifiers.org/metanetx.chemical/MNXM23
pyr_mito http://identifiers.org/seed.compound/cpd00020
end species annotations

begin units
end units