begin name
leloup1
end name

begin reactions
Mpdegradation {1.0}Mp = {1.0}$EXTERNAL
Mpproduction {1.0}$EXTERNAL = {1.0}Mp
Mtdegradation {1.0}Mt = {1.0}$EXTERNAL
Mtproduction {1.0}$EXTERNAL = {1.0}Mt
P0degradation {1.0}P0 = {1.0}$EXTERNAL
P0production {1.0}$EXTERNAL = {1.0}P0
P0toP1 {1.0}P0 = {1.0}P1
P1degradation {1.0}P1 = {1.0}$EXTERNAL
P1toP0 {1.0}P1 = {1.0}P0
P1toP2 {1.0}P1 = {1.0}P2
P2degradation {1.0}P2 = {1.0}$EXTERNAL
P2toP1 {1.0}P2 = {1.0}P1
PTcomplexdegradation {1.0}CC = {1.0}$EXTERNAL
PTcomplexformation {1.0}P2 + {1.0}T2 = {1.0}CC
PTcomplexnucleation {1.0}CC = {1.0}Cn
PTnuclcomplexdegradation {1.0}Cn = {1.0}$EXTERNAL
T0degradation {1.0}T0 = {1.0}$EXTERNAL
T0production {1.0}$EXTERNAL = {1.0}T0
T0toT1 {1.0}T0 = {1.0}T1
T1degradation {1.0}T1 = {1.0}$EXTERNAL
T1toT0 {1.0}T1 = {1.0}T0
T1toT2 {1.0}T1 = {1.0}T2
T2degradation {1.0}T2 = {1.0}$EXTERNAL
T2toT1 {1.0}T2 = {1.0}T1
end reactions

begin rate equations
Mpdegradation = Cell*Mpdegradationkd*Mp[t] + (Cell*MpdegradationVmP*Mp[t])/(MpdegradationKmP + Mp[t])
Mpproduction = (Cell*MpproductionKIP^Mpproductionn*MpproductionvsP)/(MpproductionKIP^Mpproductionn + Cn[t]^Mpproductionn)
Mtdegradation = Cell*Mtdegradationkd*Mt[t] + (Cell*VmT*Mt[t])/(MtdegradationKmT + Mt[t])
Mtproduction = (Cell*MtproductionKIT^Mtproductionn*MtproductionVsT)/(MtproductionKIT^Mtproductionn + Cn[t]^Mtproductionn)
P0degradation = Cell*P0degradationkd*P0[t]
P0production = Cell*P0productionksP*Mp[t]
P0toP1 = (Cell*P0toP1V1P*P0[t])/(P0toP1K1P + P0[t])
P1degradation = Cell*P1degradationkd*P1[t]
P1toP0 = (Cell*P1toP0V2P*P1[t])/(P1toP0K2P + P1[t])
P1toP2 = (Cell*P1toP2V3P*P1[t])/(P1toP2K3P + P1[t])
P2degradation = Cell*P2degradationkd*P2[t] + (Cell*P2degradationVdP*P2[t])/(P2degradationKdP + P2[t])
P2toP1 = (Cell*P2toP1V4P*P2[t])/(P2toP1K4P + P2[t])
PTcomplexdegradation = Cell*PTcomplexdegradationkdC*CC[t]
PTcomplexformation = -(Cell*PTcomplexformationk4*CC[t]) + Cell*PTcomplexformationk3*P2[t]*T2[t]
PTcomplexnucleation = Cell*PTcomplexnucleationk1*CC[t] - compartment0000002*PTcomplexnucleationk2*Cn[t]
PTnuclcomplexdegradation = compartment0000002*PTnuclcomplexdegradationkdN*Cn[t]
T0degradation = Cell*T0degradationkd*T0[t]
T0production = Cell*T0productionksT*Mt[t]
T0toT1 = (Cell*T0toT1V1T*T0[t])/(T0toT1K1T + T0[t])
T1degradation = Cell*T1degradationkd*T1[t]
T1toT0 = (Cell*T1toT0V2T*T1[t])/(T1toT0K2T + T1[t])
T1toT2 = (Cell*T1toT2V3T*T1[t])/(T1toT2K3T + T1[t])
T2degradation = Cell*T2degradationkd*T2[t] + (Cell*VdT*T2[t])/(T2degradationKdT + T2[t])
T2toT1 = (Cell*T2toT1V4T*T2[t])/(T2toT1K4T + T2[t])
end rate equations

begin parameters
VdT = 2.0
VmT = 0.7
P1toP2K3P = 2.0
P0toP1K1P = 2.0
P0toP1V1P = 8.0
T0toT1K1T = 2.0
T0toT1V1T = 8.0
P1toP0K2P = 2.0
P1toP0V2P = 1.0
T1toT0K2T = 2.0
T1toT0V2T = 1.0
P1toP2V3P = 8.0
T1toT2K3T = 2.0
T1toT2V3T = 8.0
P2toP1K4P = 2.0
P2toP1V4P = 1.0
T2toT1K4T = 2.0
T2toT1V4T = 1.0
P0degradationkd = 0.01
T0degradationkd = 0.01
P1degradationkd = 0.01
T1degradationkd = 0.01
P2degradationkd = 0.01
P2degradationVdP = 2.0
P2degradationKdP = 0.2
T2degradationkd = 0.01
T2degradationKdT = 0.2
PTcomplexformationk3 = 1.2
PTcomplexformationk4 = 0.6
PTcomplexnucleationk1 = 0.6
PTcomplexnucleationk2 = 0.2
PTcomplexdegradationkdC = 0.01
PTnuclcomplexdegradationkdN = 0.01
MpproductionvsP = 1.0
MpproductionKIP = 1.0
Mpproductionn = 4.0
MtproductionVsT = 1.0
MtproductionKIT = 1.0
Mtproductionn = 4.0
P0productionksP = 0.9
T0productionksT = 0.9
Mpdegradationkd = 0.01
MpdegradationVmP = 0.7
MpdegradationKmP = 0.2
Mtdegradationkd = 0.01
MtdegradationKmT = 0.2
Cell = 1.0
compartment0000002 = 1.0
end parameters

begin initial conditions
CC[0] = CCi
Cn[0] = Cni
Mp[0] = Mpi
Mt[0] = Mti
P0[0] = P0i
P1[0] = P1i
P2[0] = P2i
T0[0] = T0i
T1[0] = T1i
T2[0] = T2i
end initial conditions

begin initial values
CCi = 0.0
Cni = 0.0
Mpi = 0.0
Mti = 0.0
P0i = 0.0
P1i = 0.0
P2i = 0.0
T0i = 0.0
T1i = 0.0
T2i = 0.0
end initial values

begin assignment rules
Tt := CC[t] + Cn[t] + T0[t] + T1[t] + T2[t]
Pt := CC[t] + Cn[t] + P0[t] + P1[t] + P2[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units