begin name
koo4
end name

begin reactions
re10 {1.0}s11 = {1.0}s3
re102 {1.0}s95 = {1.0}s93
re103 {1.0}s94 = {1.0}s92
re104 {1.0}s91 + {1.0}s93 = {1.0}s110
re105 {1.0}s110 = {1.0}s112
re106 {1.0}s112 + {1.0}s111 = {1.0}s113
re107 {1.0}s113 = {1.0}s114 + {1.0}s93
re108 {1.0}s98 = {1.0}s91
re109 {1.0}s114 = {1.0}s98 + {1.0}s111
re11 {1.0}s13 = {1.0}s12
re110 {1.0}s115 = {1.0}s106
re111 {1.0}s108 = {1.0}s115
re112 {1.0}s103 = {1.0}s102
re113 {1.0}s102 = {1.0}s103
re114 {1.0}s97 = {1.0}s101
re115 {1.0}s101 = {1.0}s97
re116 {1.0}s96 = {1.0}s100
re117 {1.0}s100 = {1.0}s96
re118 {1.0}s99 = {1.0}s104
re119 {1.0}s104 = {1.0}s99
re12 {1.0}s3 = {1.0}s9
re120 {1.0}s106 = {1.0}s35
re121 {1.0}s37 = {1.0}s51
re122 {1.0}s38 = {1.0}s39
re123 {1.0}s43 = {1.0}s100
re124 {1.0}s100 = {1.0}s43
re125 {1.0}s44 = {1.0}s104
re126 {1.0}s104 = {1.0}s44
re127 {1.0}s42 = {1.0}s107
re128 {1.0}s107 = {1.0}s42
re129 {1.0}s105 = {1.0}s49
re131 {1.0}s51 = {1.0}s116
re132 {1.0}s45 = {1.0}s117 + {1.0}s47
re133 {1.0}s50 = {1.0}s117 + {1.0}s48
re134 {1.0}s66 = {1.0}s57 + {1.0}s118
re135 {1.0}s65 = {1.0}s118 + {1.0}s57
re136 {1.0}s61 = {1.0}s57 + {1.0}s48
re137 {1.0}s62 = {1.0}s57 + {1.0}s48
re138 {1.0}s58 = {1.0}s57 + {1.0}s47
re139 {1.0}s60 = {1.0}s57 + {1.0}s47
re3 {1.0}s4 = {1.0}s3
re37 {1.0}s51 + {1.0}s47 = {1.0}s45
re38 {1.0}s48 + {1.0}s51 = {1.0}s50
re4 {1.0}s5 = {1.0}s2
re41 {1.0}s52 = {1.0}s48
re42 {1.0}s48 = {1.0}s47
re5 {1.0}s7 = {1.0}s6
re50 {1.0}s45 = {1.0}s50
re51 {1.0}s45 + {1.0}s57 = {1.0}s58
re52 {1.0}s58 = {1.0}s61
re53 {1.0}s61 = {1.0}s50 + {1.0}s57
re54 {1.0}s60 = {1.0}s62
re55 {1.0}s58 = {1.0}s60
re56 {1.0}s61 = {1.0}s62
re57 {1.0}s22 = {1.0}s20
re58 {1.0}s19 = {1.0}s17
re59 {1.0}s17 = {1.0}s19
re6 {1.0}s6 = {1.0}s8
re60 {1.0}s17 + {1.0}s16 = {1.0}s28
re61 {1.0}s28 = {1.0}s26
re62 {1.0}s26 = {1.0}s27
re63 {1.0}s26 = {1.0}s28
re64 {1.0}s27 = {1.0}s26
re65 {1.0}s27 = {1.0}s17 + {1.0}s16
re66 {1.0}s25 = {1.0}s14
re67 {1.0}s14 = {1.0}s25
re68 {1.0}s21 = {1.0}s23
re69 {1.0}s63 = {1.0}s64
re7 {1.0}s2 = {1.0}s3
re70 {1.0}s65 = {1.0}s66
re71 {1.0}s66 = {1.0}s51 + {1.0}s57
re72 {1.0}s62 = {1.0}s65 + {1.0}s48
re8 {1.0}s3 = {1.0}s9
re9 {1.0}s3 = {1.0}s10
end reactions

begin rate equations
re10 = 0.5*dotqinpass
re102 = (E^(re102unity - (s39[t]/re102tf)^0.35)*re102normal*(re102unity - (s39[t]/re102tf)^0.35))/((re102tinynum + s39[t])/re102unimol)^0.65
re103 = E^(re103unity - (s39[t]/re103tf)^1.3)*re103normal*(s39[t]/re103unimol)^0.3*(re103unity - (s39[t]/re103tf)^1.3)
re104 = -(re104k105*s110[t]) + re104k105*s91[t]*s93[t]
re105 = -(re105k6*s112[t]) + re105kcatsrc*s110[t]*s92[t]
re106 = re106k107*s111[t]*s112[t] - re106k107*s113[t]
re107 = re107k108*s113[t] - re107k108*s114[t]*s93[t]
re108 = (re108V10*s98[t])/(re108K10 + s98[t])
re109 = re109k9*s114[t]
re11 = 0.5*re11unisec
re110 = re110kT*s115[t]
re111 = re111ktr1*s107[t] + re111ktr1k2*s49[t]
re112 = (re112k111*s103[t]*s114[t])/(re112K111 + s103[t])
re113 = (re113V12*s102[t])/(re113K12 + s102[t])
re114 = (re114k113*s102[t]*s97[t])/(re114K113 + s97[t])
re115 = (re115V18*s101[t])/(re115K18 + s101[t])
re116 = (re116k19*s101[t]*s96[t])/(re116K19 + s96[t])
re117 = (re117V20*s100[t])/(re117K20 + s100[t])
re118 = (re118k21*s43[t]*s99[t])/(re118K21 + s99[t])
re119 = (re119V22*s104[t])/(re119K22 + s104[t])
re12 = (0.5*dotVp*s3[t]^2)/(K4^2 + s3[t]^2)
re120 = re120kD*s106[t]
re121 = (re121kP*s106[t])/(re121K30 + s106[t])
re122 = re122unitime
re123 = (re123V37*s43[t])/(re123K37 + s43[t])
re124 = (re124k38*s100[t]*s101[t])/(re124K38 + s100[t])
re125 = (re125V39*s44[t])/(re125K39 + s44[t])
re126 = (re126k40*s104[t]*s43[t])/(re126K40 + s104[t])
re127 = (re127k43*s42[t]*s44[t])/(re127K43 + s42[t])
re128 = (re128V44*s107[t])/(re128K44 + s107[t])
re129 = (29.256*E^(re129tau*(re129delay - s39[t]/re129tc)))/((1 + 2*E^(re129tau*(re129delay - s39[t]/re129tc)) + E^(2*re129tau*(re129delay - s39[t]/re129tc)))*re129uc)
re131 = kDD*s51[t]
re132 = kDD*s45[t]
re133 = kDD*s50[t]
re134 = kDD*s66[t]
re135 = kDD*s65[t]
re136 = kDD*s61[t]
re137 = kDD*s62[t]
re138 = kDD*s58[t]
re139 = kDD*s60[t]
re3 = -(k6*s3[t]*(BT - s4[t])) + k7*s4[t]
re37 = k15*s47[t]*s51[t]
re38 = -(k18*s50[t]) + k17*s48[t]*s51[t]
re4 = kCCE*((Cao*fracK)/(Cao + K3) - s2[t])*(s1[t] - s2[t])
re41 = -(k12*s48[t]) + k11*s3[t]*s52[t]
re42 = -(k14*s47[t]) + k13*s3[t]*s48[t]
re5 = (0.5*k1*(RT - half*RT*(E^(-(s12[t]/tauI)) + E^(-(s12[t]/tauII)) + ((E^(-(s12[t]/tauI)) - E^(-(s12[t]/tauII)))*(tauI + tauII))/(tauI - tauII)))*s3[t])/(K1 + s3[t])
re50 = gam*k14*s45[t] - k13*s3[t]*s50[t]
re51 = k90*s45[t]*s57[t]
re52 = gam*k14*s58[t] - k13*s3[t]*s61[t]
re53 = kr90*s61[t]
re54 = gam*k14*s60[t] - k13*s3[t]*s62[t]
re55 = (kp*s27[t]*s58[t])/(Kmp + s58[t]) - (Vdp*s60[t])/(Kmdp + s60[t])
re56 = (kp*s27[t]*s61[t])/(Kmp + s61[t]) - (Vdp*s62[t])/(Kmdp + s62[t])
re57 = E^(re57unity - (s23[t]/re57tf)^1.8)*re57normal*(s23[t]/re57unimol)^0.8*(re57unity - (s23[t]/re57tf)^1.8)
re58 = (re58k58*s19[t]*s20[t])/(re58Km58 + s19[t])
re59 = (re59k59*s17[t]*s18[t])/(re59Km59 + s17[t])
re6 = 0.5*k2*s6[t]
re60 = re60k60*s16[t]*s17[t] - re60kr60*s28[t]
re61 = (re61k61*s14[t]*s28[t])/(re61Km61 + s28[t])
re62 = (re62k62*s24[t]*s26[t])/(re62Km62 + s26[t])
re63 = (re63k63*s15[t]*s26[t])/(re63Km63 + s26[t])
re64 = (re64k64*s15[t]*s27[t])/(re64Km64 + s27[t])
re65 = (re65k65*s15[t]*s27[t])/(re65Km65 + s27[t])
re66 = re66k66*s17[t]*s25[t]
re67 = re67k67*s14[t]
re68 = re68unitime
re69 = re69Kcamno*(s45[t] + s58[t]) + re69Kpcamno*s60[t] + re69Kpno*(s62[t] + s65[t])
re7 = 0.5*k5*s2[t]^2 - (0.5*k4*s3[t]^2)/(K3 + s3[t])^2 + (0.5*k3*kCICR*s2[t]*s3[t]*s6[t]^3)/((KCICR + s3[t])*(K2 + s6[t])^3)
re70 = (Vdp*s65[t])/(Kmdp + s65[t])
re71 = kr90*s66[t]
re72 = k18*s62[t] - k17*s48[t]*s65[t]
re8 = (0.5*dotVhi*s3[t]^4)/(Khi^4 + s3[t]^4)
re9 = (0.5*dotVex*s3[t])/(K5 + s3[t])
end rate equations

begin parameters
BT = 120000.0
Cao = 100.0
K1 = 0.0
K2 = 200.0
K3 = 150.0
K4 = 80.0
K5 = 321.0
KCICR = 0.0
Khi = 380.0
Kmdp = 20.0
Kmp = 5.0
RT = 44000.0
VcVs = 3.5
Vdp = 4.0
alp = 10.0
dotVex = 18330.0
dotVhi = 4760.0
dotVp = 1630.0
dotqinpass = 6000.0
dotqinstim = 2500.0
fracK = 7071067.81
gam = 0.1
half = 0.5
k1 = 0.0012
k11 = 0.004
k12 = 10.3
k13 = 0.08
k14 = 1152.0
k15 = 0.015
k16 = 0.0
k17 = 0.00015
k18 = 1.5
k2 = 2.0
k3 = 6.64
k4 = 5000.0
k5 = "1e-10"
k6 = 0.1
k7 = 300.0
k8 = "7.5e-05"
k90 = 0.002
kDD = "9.45e-05"
kCCE = 0.0
kCICR = 1.0
kp = 0.1
kr90 = 1.5
tauI = 33.0
tauII = 0.005
re11unisec = 1.0
re57normal = 0.907
re57unity = 1.0
re57unimol = 1.0
re57tf = 15.0
re58k58 = 0.2
re58Km58 = 6170.0
re59k59 = 7.5
re59Km59 = 80.9
re60k60 = 0.045
re60kr60 = 0.089
re61k61 = 20.0
re61Km61 = 80000.0
re62k62 = 20.0
re62Km62 = 80000.0
re63k63 = 0.037
re63Km63 = 8800.0
re64k64 = 0.04
re64Km64 = 48000.0
re65k65 = 0.163
re65Km65 = 48000.0
re66k66 = 0.0007
re67k67 = 0.98
re68unitime = 1.0
re69Kcamno = 17.0
re69Kpno = 5.0
re69Kpcamno = 17.0
re102normal = 4.0
re102tf = 60.0
re102unity = 1.0
re102unimol = 1.0
re102tinynum = "1e-06"
re103normal = 0.026
re103tf = 540.0
re103unity = 1.0
re103unimol = 1.0
re104k105 = 0.1
re104k105 = 1.0
re105kcatsrc = 8.33
re105k6 = 5.0
re106k107 = 60.0
re106k107 = 546.0
re107k108 = 2040.0
re107k108 = 15700.0
re108V10 = 154.0
re108K10 = 340.0
re109k9 = 40.8
re110kT = 0.001
re111ktr1 = 0.00012
re111ktr1k2 = "9e-06"
re111tr2 = "3e-06"
re112k111 = 0.222
re112K111 = 0.181
re113V12 = 0.289
re113K12 = 0.0571
re114k113 = 0.035
re114K113 = 10.0
re115K18 = 8.0
re115V18 = 0.125
re116k19 = 0.005
re116K19 = 15.0
re117K20 = 15.0
re117V20 = 0.375
re118k21 = 0.002
re118K21 = 30.0
re119K22 = 15.0
re119V22 = 0.05
re120kD = "2.8e-05"
re121kP = 0.02824
re121K30 = 16.0
re122unitime = 1.0
re123V37 = 0.375
re123K37 = 15.0
re124k38 = 0.005
re124K38 = 15.0
re125V39 = 0.05
re125K39 = 15.0
re126k40 = 0.002
re126K40 = 30.0
re127K43 = 25.0
re127k43 = "4e-05"
re128K44 = 5.0
re128V44 = 0.002
re129tau = 0.55
re129tc = 3600.0
re129uc = 3600.0
re129delay = 5.0
re129unity = 20.0
c1 = 1.0
c2 = 1.0
c3 = 1.0
default = 1.0
end parameters

begin initial conditions
s1[0] = s1i
s10[0] = s10i
s100[0] = s100i
s101[0] = s101i
s102[0] = s102i
s103[0] = s103i
s104[0] = s104i
s105[0] = s105i
s106[0] = s106i
s107[0] = s107i
s108[0] = s108i
s11[0] = s11i
s110[0] = s110i
s111[0] = s111i
s112[0] = s112i
s113[0] = s113i
s114[0] = s114i
s115[0] = s115i
s116[0] = s116i
s117[0] = s117i
s118[0] = s118i
s119[0] = s119i
s12[0] = s12i
s13[0] = s13i
s14[0] = s14i
s15[0] = s15i
s16[0] = s16i
s17[0] = s17i
s18[0] = s18i
s19[0] = s19i
s2[0] = s2i
s20[0] = s20i
s21[0] = s21i
s22[0] = s22i
s23[0] = s23i
s24[0] = s24i
s25[0] = s25i
s26[0] = s26i
s27[0] = s27i
s28[0] = s28i
s3[0] = s3i
s35[0] = s35i
s37[0] = s37i
s38[0] = s38i
s39[0] = s39i
s4[0] = s4i
s42[0] = s42i
s43[0] = s43i
s44[0] = s44i
s45[0] = s45i
s47[0] = s47i
s48[0] = s48i
s49[0] = s49i
s5[0] = s5i
s50[0] = s50i
s51[0] = s51i
s52[0] = s52i
s57[0] = s57i
s58[0] = s58i
s6[0] = s6i
s60[0] = s60i
s61[0] = s61i
s62[0] = s62i
s63[0] = s63i
s64[0] = s64i
s65[0] = s65i
s66[0] = s66i
s7[0] = s7i
s8[0] = s8i
s9[0] = s9i
s91[0] = s91i
s92[0] = s92i
s93[0] = s93i
s94[0] = s94i
s95[0] = s95i
s96[0] = s96i
s97[0] = s97i
s98[0] = s98i
s99[0] = s99i
end initial conditions

begin initial values
s1i = 1500000.0
s10i = 0.0
s100i = 0.288
s101i = 1.486
s102i = 0.616
s103i = 119.384
s104i = 0.003
s105i = 0.0
s106i = 3.214
s107i = 0.0
s108i = 0.0
s11i = 0.0
s110i = 0.857
s111i = 3.23
s112i = 15.962
s113i = 5.577
s114i = 1.193
s115i = 0.09
s116i = 0.0
s117i = 0.0
s118i = 0.0
s119i = 0.0
s12i = 0.0
s13i = 0.0
s14i = 0.246
s15i = 150.0
s16i = 167.616
s17i = 0.345
s18i = 0.1
s19i = 6967.271
s2i = 2830000.0
s20i = 0.03
s21i = 0.0
s22i = 99.97
s23i = 0.0
s24i = 3.0
s25i = 999.754
s26i = 1.457
s27i = 1.723
s28i = 29.203
s3i = 117.2
s35i = 0.0
s37i = 10000.0
s38i = 0.0
s39i = 0.0
s4i = 3870.0
s42i = 50.0
s43i = 0.006
s44i = 0.0
s45i = 0.0415
s47i = 2.827
s48i = 347.52
s49i = 10.0
s5i = 0.0
s50i = 2.12
s51i = 34.98
s52i = 7635.36
s57i = 199987.0
s58i = 1.037
s6i = 0.0
s60i = 0.0089
s61i = 10.98
s62i = 0.106
s63i = 500000.0
s64i = 0.0
s65i = 0.643
s66i = 0.083
s7i = 0.0
s8i = 0.0
s9i = 0.0
s91i = 819.25
s92i = 18.0
s93i = 0.605
s94i = 72.0
s95i = 57.0
s96i = 299.706
s97i = 98.514
s98i = 157.162
s99i = 299.997
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units