#kofahl1

FIX: p

#reactions
v_1:
 {1.0}alpha = {1.0}p
  alpha * Bar1aex * k1
v_10:
 {1.0}Gbc + {1.0}complexC = {1.0}complexD
  Gbc*complexC*k10
v_11:
 {1.0}complexD = {1.0}Gbc + {1.0}complexC
  complexD*k11
v_12:
 {1.0}Ste5 + {1.0}Ste11 = {1.0}complexA
  Ste5*Ste11*k12
v_13:
 {1.0}complexA = {1.0}Ste5 + {1.0}Ste11
  complexA*k13
v_14:
 {1.0}Ste7 + {1.0}Fus3 = {1.0}complexB
  Ste7*Fus3*k14
v_15:
 {1.0}complexB = {1.0}Ste7 + {1.0}Fus3
  complexB*k15
v_16:
 {1.0}complexA + {1.0}complexB = {1.0}complexC
  complexA*complexB*k16
v_17:
 {1.0}complexC = {1.0}Ste11 + {1.0}Ste5 + {1.0}Ste7 + {1.0}Fus3
  complexC*k17
v_18:
 {1.0}complexD + {1.0}Ste20 = {1.0}complexE
  complexD*Ste20*k18
v_19:
 {1.0}complexE = {1.0}complexD + {1.0}Ste20
  complexE*k19
v_2:
 {1.0}Ste2 = {1.0}Ste2a
  Ste2 * alpha * k2
v_20:
 {1.0}complexE = {1.0}complexF
  complexE*k20
v_21:
 {1.0}complexE = {1.0}Gbc + {1.0}Ste5 + {1.0}Ste11 + {1.0}Ste7 + {1.0}Fus3 + {1.0}Ste20
  complexE*k21
v_22:
 {1.0}complexF = {1.0}complexG
  complexF*k22
v_23:
 {1.0}complexF = {1.0}Gbc + {1.0}Ste5 + {1.0}Ste11 + {1.0}Ste7 + {1.0}Fus3 + {1.0}Ste20
  complexF*k23
v_24:
 {1.0}complexG = {1.0}complexH
  complexG*k24
v_25:
 {1.0}complexG = {1.0}Gbc + {1.0}Ste5 + {1.0}Ste11 + {1.0}Ste7 + {1.0}Fus3 + {1.0}Ste20
  complexG*k25
v_26:
 {1.0}complexH = {1.0}complexI
  complexH*k26
v_27:
 {1.0}complexH = {1.0}Gbc + {1.0}Ste5 + {1.0}Ste11 + {1.0}Ste7 + {1.0}Fus3 + {1.0}Ste20
  complexH*k27
v_28:
 {1.0}complexI = {1.0}complexL + {1.0}Fus3PP
  complexI*k28
v_29:
 {1.0}complexL + {1.0}Fus3 = {1.0}complexK
  complexL*Fus3*k29
v_3:
 {1.0}Ste2a = {1.0}Ste2
  Ste2a*k3
v_30:
 {1.0}complexK = {1.0}Fus3 + {1.0}complexL
  complexK*k30
v_31:
 {1.0}complexK = {1.0}complexI
  complexK*k31
v_32:
 {1.0}complexL = {1.0}Gbc + {1.0}Ste5 + {1.0}Ste11 + {1.0}Ste7 + {1.0}Ste20
  complexL*k32
v_33:
 {1.0}Fus3PP = {1.0}Fus3
  Fus3PP*k33
v_34:
 {1.0}Ste12 + {1.0}Fus3PP = {1.0}Ste12a
  Ste12*Fus3PP*k34
v_35:
 {1.0}Ste12a = {1.0}Ste12 + {1.0}Fus3PP
  Ste12a*k35
v_36:
 {1.0}Bar1 = {1.0}Bar1a
  Ste12a * Bar1 * k36
v_37:
 {1.0}Bar1a = {1.0}Bar1
  Bar1a*k37
v_38:
 {1.0}Bar1a = {1.0}Bar1aex
  Bar1a*k38
v_39:
 {1.0}Far1 = {1.0}Far1PP
  Far1 * Fus3PP * Fus3PP / (100 * 100 + Fus3PP * Fus3PP) * k39
v_4:
 {1.0}Ste2a = {1.0}p
  Ste2a*k4
v_40:
 {1.0}Far1PP = {1.0}Far1
  Far1PP*k40
v_41:
 {1.0}Far1 = {1.0}Far1U
  Far1 * Cdc28 * k41
v_42:
 {1.0}Far1PP + {1.0}Gbc = {1.0}complexM
  Gbc*Far1PP*k42
v_43:
 {1.0}complexM = {1.0}Gbc + {1.0}Far1PP
  complexM*k43
v_44:
 {1.0}complexN = {1.0}Cdc28 + {1.0}Far1PP
  complexN*k44
v_45:
 {1.0}Cdc28 + {1.0}Far1PP = {1.0}complexN
  Far1PP*Cdc28*k45
v_46:
 {1.0}p = {1.0}Sst2
  Fus3PP**2 / (4**2 + Fus3PP**2) * k46
v_47:
 {1.0}Sst2 = {1.0}p
  Sst2*k47
v_5:
 {1.0}Ste2 = {1.0}p
  Ste2*k5
v_6:
 {1.0}Gabc = {1.0}GaGTP + {1.0}Gbc
  Ste2a * Gabc * k6
v_7:
 {1.0}GaGTP = {1.0}GaGDP
  GaGTP*k7
v_8:
 {1.0}GaGTP = {1.0}GaGDP
  GaGTP * Sst2 * k8
v_9:
 {1.0}GaGDP + {1.0}Gbc = {1.0}Gabc
  GaGDP*Gbc*k9


#parameters
k1 = 0.03
k10 = 0.1
k11 = 5.0
k12 = 1.0
k13 = 3.0
k14 = 1.0
k15 = 3.0
k16 = 3.0
k17 = 100.0
k18 = 5.0
k19 = 1.0
k2 = 0.0012
k20 = 10.0
k21 = 5.0
k22 = 47.0
k23 = 5.0
k24 = 345.0
k25 = 5.0
k26 = 50.0
k27 = 5.0
k28 = 140.0
k29 = 10.0
k3 = 0.6
k30 = 1.0
k31 = 250.0
k32 = 5.0
k33 = 50.0
k34 = 18.0
k35 = 10.0
k36 = 0.1
k37 = 0.1
k38 = 0.01
k39 = 18.0
k4 = 0.24
k40 = 1.0
k41 = 0.02
k42 = 0.1
k43 = 0.01
k44 = 0.01
k45 = 0.1
k46 = 200.0
k47 = 1.0
k5 = 0.024
k6 = 0.0036
k7 = 0.24
k8 = 0.033
k9 = 2000.0
p = 0.0
default_compartment = 1.0


#initial values
Bar1 = 200.0
Bar1a = 0.0
Bar1aex = 0.0
Cdc28 = 300.0
Far1 = 500.0
Far1PP = 0.0
Far1U = 0.0
Fus3 = 686.399701640513
Fus3PP = 0.0
GaGDP = 0.0
GaGTP = 0.0
Gabc = 1666.6666667
Gbc = 0.0
Sst2 = 0.0
Ste11 = 158.33176608789
Ste12 = 200.0
Ste12a = 0.0
Ste2 = 1666.6666667
Ste20 = 1000.0
Ste2a = 0.0
Ste5 = 158.33176608789
Ste7 = 36.3997016405141
alpha = 100.0
complexA = 105.943298120207
complexB = 77.8753625675829
complexC = 235.724935791903
complexD = 0.0
complexE = 0.0
complexF = 0.0
complexG = 0.0
complexH = 0.0
complexI = 0.0
complexK = 0.0
complexL = 0.0
complexM = 0.0
complexN = 0.0


#assignment rules