#kim2



#reactions
R1:
 {1.0}X1 = {1.0}X2
  cytoplasm * k1 * X1 * W
R10:
 {1.0}X9 = {1.0}X3 + {1.0}X10
  cytoplasm * k10 * X9
R11:
 {1.0}X10 = $pool
  cytoplasm * k11 * X10
R12:
 $pool = {1.0}X11
  cytoplasm * V12
R13:
 {1.0}X11 = $pool
  nucleus * k13 * X11
R14:
 $pool = {1.0}X12
  nucleus * (k14 + k21 * (X11 + X14))
R15:
 {1.0}X12 = $pool
  cytoplasm * k15 * X12
R16:
 {1.0}X13 + {1.0}X11 = {1.0}X14
  nucleus * (k_plus16 * X11 * X13 - k_minus16 * X14)
R17:
 {1.0}X11 + {1.0}X7 = {1.0}X15
  cytoplasm * (k_plus17 * X7 * X11 - k_minus17 * X15)
R18:
 {1.0}X16 = {1.0}X17
  cytoplasm * (Vmax1 * X16 * W / (Km1 + X16)) * (Ki / (Ki + X23))
R19:
 {1.0}X17 = {1.0}X16
  cytoplasm * (Vmax2 * X17 / (Km2 + X17))
R2:
 {1.0}X2 = {1.0}X1
  cytoplasm * k2 * X2
R20:
 {1.0}X18 = {1.0}X19
  cytoplasm * (kcat1 * X17 * X18 / (Km3 + X18))
R21:
 {1.0}X19 = {1.0}X18
  cytoplasm * Vmax3 * X19 / (Km4 + X19)
R22:
 {1.0}X20 = {1.0}X21
  cytoplasm * kcat2 * X19 * X20 / (Km5 + X20)
R23:
 {1.0}X21 = {1.0}X20
  cytoplasm * Vmax4 * X21 / (Km6 + X21)
R24:
 {1.0}X22 = {1.0}X23
  cytoplasm * kcat3 * X21 * X22 / (Km7 + X22)
R25:
 {1.0}X23 = {1.0}X22
  cytoplasm * Vmax5 * X23 / (Km8 + X23)
R26:
 {1.0}X24 = {1.0}X18 + {1.0}X26
  cytoplasm * kcat4 * X23 * X24 / (Km9 + X24)
R27:
 {1.0}X18 + {1.0}X25 = {1.0}X24
  cytoplasm * (k18 * X18 * X25 - k19 * X24)
R28:
 {1.0}X26 = {1.0}X25
  cytoplasm * Vmax6 * X26 / (Km10 + X26)
R29:
 $pool = {1.0}X27
  cytoplasm * (kcat5 * pow(X14, n1) / (pow(Km11, n1) + pow(X14, n1)))
R3:
 {1.0}X4 = {1.0}X6 + {1.0}X5
  cytoplasm * k3 * X2 * X4
R30:
 {1.0}X27 = $pool
  cytoplasm * k20 * X27
R31:
 {1.0}X18 = {1.0}X19
  cytoplasm * (kcat6 * X27 * X18 / (Km12 + X18))
R32:
 {1.0}X5 = {1.0}X28
  cytoplasm * kcat7 * X23 * X5 / (Km13 + X5)
R33:
 {1.0}X28 = {1.0}X5
  cytoplasm * Vmax7 * X28 / (Km14 + X28)
R4:
 {1.0}X4 = {1.0}X3
  cytoplasm * k4 * X4
R5:
 {1.0}X3 = {1.0}X4
  cytoplasm * k5 * X3
R6:
 {1.0}X6 + {1.0}X5 = {1.0}X4
  cytoplasm * (k_plus6 * X5 * X6 - k_minus6 * X4)
R7:
 {1.0}X12 + {1.0}X7 = {1.0}X6
  cytoplasm * (k_plus7 * X7 * X12 - k_minus7 * X6)
R8:
 {1.0}X11 + {1.0}X3 = {1.0}X8
  cytoplasm * (k_plus8 * X3 * X11 - k_minus8 * X8)
R9:
 {1.0}X8 = {1.0}X9
  cytoplasm * k9 * X8


#parameters
Ki = 9.0
Km1 = 10.0
Km10 = 12.0
Km11 = 15.0
Km12 = 15.0
Km13 = 15.0
Km14 = 15.0
Km2 = 8.0
Km3 = 15.0
Km4 = 15.0
Km5 = 15.0
Km6 = 15.0
Km7 = 15.0
Km8 = 15.0
Km9 = 9.0
V12 = 0.423
Vmax1 = 150.0
Vmax2 = 15.0
Vmax3 = 45.0
Vmax4 = 45.0
Vmax5 = 45.0
Vmax6 = 45.0
Vmax7 = 45.0
W = 0.0
flag_for_wnt_signal = 0.0
k1 = 0.182
k10 = 206.0
k11 = 0.417
k13 = 0.000257
k14 = 8.22e-05
k15 = 0.167
k18 = 0.15
k19 = 39.0
k2 = 0.0182
k20 = 0.015
k21 = 1e-06
k3 = 0.05
k4 = 0.267
k5 = 0.133
k9 = 206.0
k_minus16 = 30.0
k_minus17 = 1200.0
k_minus6 = 0.909
k_minus7 = 50.0
k_minus8 = 120.0
k_plus16 = 1.0
k_plus17 = 1.0
k_plus6 = 0.0909
k_plus7 = 1.0
k_plus8 = 1.0
kcat1 = 1.5
kcat2 = 1.5
kcat3 = 1.5
kcat4 = 1.5
kcat5 = 0.6
kcat6 = 1.5
kcat7 = 1.5
n1 = 2.0
cytoplasm = 1.0
nucleus = 1.0


#initial values
X1 = 100.0
X10 = 0.9881
X11 = 42.7224
X12 = 0.0008
X13 = 6.1879
X14 = 8.8121
X15 = 3.4392
X16 = 200.0
X17 = 0.0
X18 = 112.5585
X19 = 6.486
X2 = 0.0
X20 = 296.1137
X21 = 3.8863
X22 = 297.8897
X23 = 2.1103
X24 = 180.9595
X25 = 418.1788
X26 = 0.8619
X27 = 10.263
X28 = 0.85544
X3 = 0.0153
X4 = 0.0076
X5 = 49.1372
X6 = 0.0015
X7 = 96.6019
X8 = 0.002
X9 = 0.002


#assignment rules
!F X13X14 = X13 + X14