#kerkhovenCC



#reactions
AKc:
 {0.366643}ADPc = {0.183321}AMPc + {0.183321}ATPc
  AKcAKck1*ADPc**2 - AKcAKck2*AMPc*ATPc
AKg:
 {8.15993}ADPg = {4.07997}AMPg + {4.07997}ATPg
  AKgAKgk1*ADPg**2 - AKgAKgk2*AMPg*ATPg
ALDg:
 {4.07997}Fru16BPg = {4.07997}DHAPg + {4.07997}GA3Pg
  (ALDgALDgVmax*Fru16BPg*(1 - (DHAPg*GA3Pg)/(ALDgALDgKeq*Fru16BPg)))/(ALDgALDgKmFru16BP*(1 + ADPg/ALDgALDgKiADP + AMPg/ALDgALDgKiAMP + ATPg/ALDgALDgKiATP)*(1 + DHAPg/ALDgALDgKmDHAP + Fru16BPg/(ALDgALDgKmFru16BP*(1 + ADPg/ALDgALDgKiADP + AMPg/ALDgALDgKiAMP + ATPg/ALDgALDgKiATP)) + GA3Pg/ALDgALDgKmGA3P + (DHAPg*GA3Pg)/(ALDgALDgKmDHAP*ALDgALDgKmGA3P) + (Fru16BPg*GA3Pg)/(ALDgALDgKiGA3P*ALDgALDgKmFru16BP*(1 + ADPg/ALDgALDgKiADP + AMPg/ALDgALDgKiAMP + ATPg/ALDgALDgKiATP))))
ATPuc:
 {0.183321}ATPc = {0.183321}ADPc
  (ATPucATPuck*ATPc)/ADPc
ENOc:
 {0.183321}P2GAc = {0.183321}PEPc
  (ENOcENOcVmax*(1 - PEPc/(ENOcENOcKeq*P2GAc))*P2GAc)/(ENOcENOcKm2PGA*(1 + PEPc/ENOcENOcKmPEP + P2GAc/ENOcENOcKm2PGA))
G3PDHg:
 {4.07997}DHAPg + {4.07997}NADHg = {4.07997}Gly3Pg + {4.07997}NADg
  (G3PDHgG3PDHgVmax*DHAPg*NADHg*(1 - (Gly3Pg*NADg)/(G3PDHgG3PDHgKeq*DHAPg*NADHg)))/(G3PDHgG3PDHgKmDHAP*G3PDHgG3PDHgKmNADH*(1 + DHAPg/G3PDHgG3PDHgKmDHAP + Gly3Pg/G3PDHgG3PDHgKmGly3P)*(1 + NADHg/G3PDHgG3PDHgKmNADH + NADg/G3PDHgG3PDHgKmNAD))
G6PDHc:
 {0.183321}Glc6Pc + {0.183321}NADPc = {0.183321}NADPHc + {0.183321}P6GLc
  (G6PDHcG6PDHcVmax*Glc6Pc*NADPc*(1 - (NADPHc*P6GLc)/(G6PDHcG6PDHcKeq*Glc6Pc*NADPc)))/(G6PDHcG6PDHcKmGlc6P*G6PDHcG6PDHcKmNADP*(1 + NADPHc/G6PDHcG6PDHcKmNADPH + NADPc/G6PDHcG6PDHcKmNADP)*(1 + Glc6Pc/G6PDHcG6PDHcKmGlc6P + P6GLc/G6PDHcG6PDHcKm6PGL))
G6PDHg:
 {4.07997}Glc6Pg + {4.07997}NADPg = {4.07997}NADPHg + {4.07997}P6GLg
  (G6PDHgG6PDHgVmax*Glc6Pg*NADPg*(1 - (NADPHg*P6GLg)/(G6PDHgG6PDHgKeq*Glc6Pg*NADPg)))/(G6PDHgG6PDHgKmGlc6P*G6PDHgG6PDHgKmNADP*(1 + NADPHg/G6PDHgG6PDHgKmNADPH + NADPg/G6PDHgG6PDHgKmNADP)*(1 + Glc6Pg/G6PDHgG6PDHgKmGlc6P + P6GLg/G6PDHgG6PDHgKm6PGL))
G6PPc:
 {0.183321}Glc6Pc = {0.183321}Glcc
  (G6PPcG6PPcVmax*Glc6Pc*(1 - Glcc/(G6PPcG6PPcKeq*Glc6Pc)))/(G6PPcG6PPcKmGlc6P*(1 + Glc6Pc/G6PPcG6PPcKmGlc6P + Glcc/G6PPcG6PPcKmGlc))
GAPDHg:
 {4.07997}GA3Pg + {4.07997}NADg = {4.07997}NADHg + {4.07997}B13PGAg
  (GAPDHgGAPDHgVmax*GA3Pg*NADg*(1 - (NADHg*B13PGAg)/(GAPDHgGAPDHgKeq*GA3Pg*NADg)))/(GAPDHgGAPDHgKmGA3P*GAPDHgGAPDHgKmNAD*(1 + NADHg/GAPDHgGAPDHgKmNADH + NADg/GAPDHgGAPDHgKmNAD)*(1 + GA3Pg/GAPDHgGAPDHgKmGA3P + B13PGAg/GAPDHgGAPDHgKm13BPGA))
GDAg:
 {0.183321}DHAPc + {4.07997}Gly3Pg = {4.07997}DHAPg + {0.183321}Gly3Pc
  -(GDAgGDAgk*DHAPg*Gly3Pc) + GDAgGDAgk*DHAPc*Gly3Pg
GKg:
 {4.07997}ADPg + {4.07997}Gly3Pg = {4.07997}ATPg
  (GKgGKgVmax*ADPg*(1 - (Glye*ATPg)/(GKgGKgKeq*ADPg*Gly3Pg))*Gly3Pg)/(GKgGKgKmADP*GKgGKgKmGly3P*(1 + ADPg/GKgGKgKmADP + ATPg/GKgGKgKmATP)*(1 + Glye/GKgGKgKmGly + Gly3Pg/GKgGKgKmGly3P))
GPOc:
 {0.183321}Gly3Pc = {0.183321}DHAPc
  (GPOcGPOcVmax*Gly3Pc)/(GPOcGPOcKmGly3P*(1 + Gly3Pc/GPOcGPOcKmGly3P))
GlcTc:
 $pool = {0.183321}Glcc
  (GlcTcGlcTcVmax*(Glce - Glcc))/(GlcTcGlcTcKmGlc + Glce + Glcc + (GlcTcGlcTcalpha*Glce*Glcc)/GlcTcGlcTcKmGlc)
GlcTg:
 {0.183321}Glcc = {4.07997}Glcg
  GlcTgGlcTgk1*Glcc - GlcTgGlcTgk2*Glcg
HXKc:
 {0.183321}ATPc + {0.183321}Glcc = {0.183321}ADPc + {0.183321}Glc6Pc
  (HXKcHXKcVmax*ATPc*(1 - (ADPc*Glc6Pc)/(HXKcHXKcKeq*ATPc*Glcc))*Glcc)/(HXKcHXKcKmATP*HXKcHXKcKmGlc*(1 + ADPc/HXKcHXKcKmADP + ATPc/HXKcHXKcKmATP)*(1 + Glc6Pc/HXKcHXKcKmGlc6P + Glcc/HXKcHXKcKmGlc))
HXKg:
 {4.07997}ATPg + {4.07997}Glcg = {4.07997}ADPg + {4.07997}Glc6Pg
  (HXKgHXKgVmax*ATPg*(1 - (ADPg*Glc6Pg)/(HXKgHXKgKeq*ATPg*Glcg))*Glcg)/(HXKgHXKgKmATP*HXKgHXKgKmGlc*(1 + ADPg/HXKgHXKgKmADP + ATPg/HXKgHXKgKmATP)*(1 + Glc6Pg/HXKgHXKgKmGlc6P + Glcg/HXKgHXKgKmGlc))
NADPHuc:
 {0.183321}NADPHc = {0.183321}NADPc
  NADPHucNADPHuck*NADPHc
NADPHug:
 {4.07997}NADPHg = {4.07997}NADPg
  NADPHugNADPHugk*NADPHg
P3GATg:
 {4.07997}P3GAg = {0.183321}P3GAc
  -(P3GATgP3GATgk*P3GAc) + P3GATgP3GATgk*P3GAg
P6GDHc:
 {0.183321}NADPc + {0.183321}P6Gc = {0.183321}NADPHc + {0.183321}Rul5Pc
  (P6GDHcP6GDHcVmax*NADPc*(1 - (NADPHc*Rul5Pc)/(P6GDHcP6GDHcKeq*NADPc*P6Gc))*P6Gc)/(P6GDHcP6GDHcKm6PG*P6GDHcP6GDHcKmNADP*(1 + NADPHc/P6GDHcP6GDHcKmNADPH + NADPc/P6GDHcP6GDHcKmNADP)*(1 + Rul5Pc/P6GDHcP6GDHcKmRul5P + P6Gc/P6GDHcP6GDHcKm6PG))
P6GDHg:
 {4.07997}NADPg + {4.07997}P6Gg = {4.07997}NADPHg + {4.07997}Rul5Pg
  (P6GDHgP6GDHgVmax*NADPg*(1 - (NADPHg*Rul5Pg)/(P6GDHgP6GDHgKeq*NADPg*P6Gg))*P6Gg)/(P6GDHgP6GDHgKm6PG*P6GDHgP6GDHgKmNADP*(1 + NADPHg/P6GDHgP6GDHgKmNADPH + NADPg/P6GDHgP6GDHgKmNADP)*(1 + Rul5Pg/P6GDHgP6GDHgKmRul5P + P6Gg/P6GDHgP6GDHgKm6PG))
PFKg:
 {4.07997}ATPg + {4.07997}Fru6Pg = {4.07997}ADPg + {4.07997}Fru16BPg
  (PFKgPFKgKi1*PFKgPFKgVmax*ATPg*(1 - (ADPg*Fru16BPg)/(PFKgPFKgKeq*ATPg*Fru6Pg))*Fru6Pg)/(PFKgPFKgKmATP*PFKgPFKgKmFru6P*(PFKgPFKgKi1 + Fru16BPg)*(PFKgPFKgKsATP/PFKgPFKgKmATP + ADPg/PFKgPFKgKmADP + ATPg/PFKgPFKgKmATP + (ADPg*Fru16BPg)/(PFKgPFKgKi2*PFKgPFKgKmADP) + Fru6Pg/PFKgPFKgKmFru6P + (ATPg*Fru6Pg)/(PFKgPFKgKmATP*PFKgPFKgKmFru6P)))
PGAMc:
 {0.183321}P3GAc = {0.183321}P2GAc
  (PGAMcPGAMcVmax*(1 - P2GAc/(PGAMcPGAMcKeq*P3GAc))*P3GAc)/(PGAMcPGAMcKm3PGA*(1 + P2GAc/PGAMcPGAMcKm2PGA + P3GAc/PGAMcPGAMcKm3PGA))
PGIg:
 {4.07997}Glc6Pg = {4.07997}Fru6Pg
  (PGIgPGIgVmax*(1 - Fru6Pg/(PGIgPGIgKeq*Glc6Pg))*Glc6Pg)/(PGIgPGIgKmGlc6P*(1 + Fru6Pg/PGIgPGIgKmFru6P + Glc6Pg/PGIgPGIgKmGlc6P + P6Gg/PGIgPGIgKi6PG))
PGKg:
 {4.07997}ADPg + {4.07997}B13PGAg = {4.07997}ATPg + {4.07997}P3GAg
  (PGKgPGKgVmax*ADPg*B13PGAg*(1 - (ATPg*P3GAg)/(PGKgPGKgKeq*ADPg*B13PGAg)))/(PGKgPGKgKm13BPGA*PGKgPGKgKmADP*(1 + ADPg/PGKgPGKgKmADP + ATPg/PGKgPGKgKmATP)*(1 + B13PGAg/PGKgPGKgKm13BPGA + P3GAg/PGKgPGKgKm3PGA))
PGLc:
 {0.183321}P6GLc = {0.183321}P6Gc
  cytosol*PGLcPGLck*(P6GLc - P6Gc/PGLcPGLcKeq) + (PGLcPGLcVmax*P6GLc*(1 - P6Gc/(PGLcPGLcKeq*P6GLc)))/(PGLcPGLcKm6PGL*(1 + P6GLc/PGLcPGLcKm6PGL + P6Gc/PGLcPGLcKm6PG))
PGLg:
 {4.07997}P6GLg = {4.07997}P6Gg
  glycosome*PGLgPGLgk*(P6GLg - P6Gg/PGLgPGLgKeq) + (PGLgPGLgVmax*P6GLg*(1 - P6Gg/(PGLgPGLgKeq*P6GLg)))/(PGLgPGLgKm6PGL*(1 + P6GLg/PGLgPGLgKm6PGL + P6Gg/PGLgPGLgKm6PG))
PPIc:
 {0.183321}Rul5Pc = $pool
  (PPIcPPIcVmax*(1 - Rib5Pc/(PPIcPPIcKeq*Rul5Pc))*Rul5Pc)/(PPIcPPIcKmRul5P*(1 + Rib5Pc/PPIcPPIcKmRib5P + Rul5Pc/PPIcPPIcKmRul5P))
PPIg:
 {4.07997}Rul5Pg = {4.07997}Rib5Pg
  (PPIgPPIgVmax*(1 - Rib5Pg/(PPIgPPIgKeq*Rul5Pg))*Rul5Pg)/(PPIgPPIgKmRul5P*(1 + Rib5Pg/PPIgPPIgKmRib5P + Rul5Pg/PPIgPPIgKmRul5P))
PYKc:
 {0.183321}ADPc + {0.183321}PEPc = {0.183321}ATPc + {0.183321}Pyrc
  (PYKcPYKcVmax*ADPc*(PEPc/(PYKcPYKcKmPEP*(1 + ADPc/PYKcPYKcKiADP + ATPc/PYKcPYKcKiATP)))**PYKcPYKcn*(1 - (ATPc*Pyrc)/(PYKcPYKcKeq*ADPc*PEPc)))/(PYKcPYKcKmADP*(1 + ADPc/PYKcPYKcKmADP + ATPc/PYKcPYKcKmATP)*(1 + (PEPc/(PYKcPYKcKmPEP*(1 + ADPc/PYKcPYKcKiADP + ATPc/PYKcPYKcKiATP)))**PYKcPYKcn + Pyrc/PYKcPYKcKmPyr))
PyrTc:
 {0.183321}Pyrc = $pool
  (PyrTcPyrTcVmax*Pyrc)/(PyrTcPyrTcKmPyr*(1 + Pyrc/PyrTcPyrTcKmPyr))
RKg:
 {4.07997}ADPg + {4.07997}Rib5Pg = {4.07997}ATPg
  (RKgRKgVmax*ADPg*(1 - (Ribg*ATPg)/(RKgRKgKeq*ADPg*Rib5Pg))*Rib5Pg)/(RKgRKgKmADP*RKgRKgKmRib5P*(1 + ADPg/RKgRKgKmADP + ATPg/RKgRKgKmATP)*(1 + Ribg/RKgRKgKmRib + Rib5Pg/RKgRKgKmRib5P))
TOXc:
 {0.183321}TSH2c = {0.183321}TS2c
  TOXcTOXck*TSH2c
TPIg:
 {4.07997}DHAPg = {4.07997}GA3Pg
  (TPIgTPIgVmax*DHAPg*(1 - GA3Pg/(TPIgTPIgKeq*DHAPg)))/(TPIgTPIgKmDHAP*(1 + DHAPg/TPIgTPIgKmDHAP + GA3Pg/TPIgTPIgKmGA3P))
TRc:
 {0.183321}NADPHc + {0.183321}TS2c = {0.183321}NADPc + {0.183321}TSH2c
  (TRcTRcVmax*NADPHc*TS2c*(1 - (NADPc*TSH2c)/(TRcTRcKeq*NADPHc*TS2c)))/(TRcTRcKmNADPH*TRcTRcKmTS2*(1 + NADPHc/TRcTRcKmNADPH + NADPc/TRcTRcKmNADP)*(1 + TS2c/TRcTRcKmTS2 + TSH2c/TRcTRcKmTSH2))


#parameters
AKcAKck1 = 480.0
AKcAKck2 = 1000.0
AKgAKgk1 = 480.0
AKgAKgk2 = 1000.0
ALDgALDgKeq = 0.084
ALDgALDgKiADP = 1.51
ALDgALDgKiAMP = 3.65
ALDgALDgKiATP = 0.68
ALDgALDgKiGA3P = 0.098
ALDgALDgKmDHAP = 0.015
ALDgALDgKmFru16BP = 0.009
ALDgALDgKmGA3P = 0.067
ALDgALDgVmax = 560.0
ATPucATPuck = 50.0
CO2c = 0.0
CO2g = 0.0
ENOcENOcKeq = 4.17
ENOcENOcKm2PGA = 0.054
ENOcENOcKmPEP = 0.24
ENOcENOcVmax = 598.0
G3PDHgG3PDHgKeq = 17085.0
G3PDHgG3PDHgKmDHAP = 0.1
G3PDHgG3PDHgKmGly3P = 2.0
G3PDHgG3PDHgKmNAD = 0.4
G3PDHgG3PDHgKmNADH = 0.01
G3PDHgG3PDHgVmax = 465.0
G6PDHcG6PDHcKeq = 5.02
G6PDHcG6PDHcKm6PGL = 0.04
G6PDHcG6PDHcKmGlc6P = 0.058
G6PDHcG6PDHcKmNADP = 0.0094
G6PDHcG6PDHcKmNADPH = 0.0001
G6PDHcG6PDHcVmax = 8.4
G6PDHgG6PDHgKeq = 5.02
G6PDHgG6PDHgKm6PGL = 0.04
G6PDHgG6PDHgKmGlc6P = 0.058
G6PDHgG6PDHgKmNADP = 0.0094
G6PDHgG6PDHgKmNADPH = 0.0001
G6PDHgG6PDHgVmax = 8.4
G6PPcG6PPcKeq = 263.0
G6PPcG6PPcKmGlc = 5.6
G6PPcG6PPcKmGlc6P = 5.6
G6PPcG6PPcVmax = 28.0
GAPDHgGAPDHgKeq = 0.066
GAPDHgGAPDHgKm13BPGA = 0.1
GAPDHgGAPDHgKmGA3P = 0.15
GAPDHgGAPDHgKmNAD = 0.45
GAPDHgGAPDHgKmNADH = 0.02
GAPDHgGAPDHgVmax = 720.9
GDAgGDAgk = 600.0
GKgGKgKeq = 0.000837
GKgGKgKmADP = 0.56
GKgGKgKmATP = 0.24
GKgGKgKmGly = 0.44
GKgGKgKmGly3P = 3.83
GKgGKgVmax = 200.0
GPOcGPOcKmGly3P = 1.7
GPOcGPOcVmax = 368.0
GlcTcGlcTcKmGlc = 1.0
GlcTcGlcTcVmax = 111.7
GlcTcGlcTcalpha = 0.75
GlcTgGlcTgk1 = 250000.0
GlcTgGlcTgk2 = 250000.0
Glce = 5.0
Glye = 0.0
HXKcHXKcKeq = 759.0
HXKcHXKcKmADP = 0.126
HXKcHXKcKmATP = 0.116
HXKcHXKcKmGlc = 0.1
HXKcHXKcKmGlc6P = 2.7
HXKcHXKcVmax = 154.32
HXKgHXKgKeq = 759.0
HXKgHXKgKmADP = 0.126
HXKgHXKgKmATP = 0.116
HXKgHXKgKmGlc = 0.1
HXKgHXKgKmGlc6P = 2.7
HXKgHXKgVmax = 1774.68
NADPHucNADPHuck = 2.0
NADPHugNADPHugk = 2.0
P3GATgP3GATgk = 250.0
P6GDHcP6GDHcKeq = 47.0
P6GDHcP6GDHcKm6PG = 0.0035
P6GDHcP6GDHcKmNADP = 0.001
P6GDHcP6GDHcKmNADPH = 0.0006
P6GDHcP6GDHcKmRul5P = 0.03
P6GDHcP6GDHcVmax = 10.6
P6GDHgP6GDHgKeq = 47.0
P6GDHgP6GDHgKm6PG = 0.0035
P6GDHgP6GDHgKmNADP = 0.001
P6GDHgP6GDHgKmNADPH = 0.0006
P6GDHgP6GDHgKmRul5P = 0.03
P6GDHgP6GDHgVmax = 10.6
PFKgPFKgKeq = 1035.0
PFKgPFKgKi1 = 15.8
PFKgPFKgKi2 = 10.7
PFKgPFKgKmADP = 1.0
PFKgPFKgKmATP = 0.0648
PFKgPFKgKmFru6P = 0.999
PFKgPFKgKsATP = 0.0393
PFKgPFKgVmax = 1708.0
PGAMcPGAMcKeq = 0.17
PGAMcPGAMcKm2PGA = 0.16
PGAMcPGAMcKm3PGA = 0.15
PGAMcPGAMcVmax = 225.0
PGIgPGIgKeq = 0.457
PGIgPGIgKi6PG = 0.14
PGIgPGIgKmFru6P = 0.12
PGIgPGIgKmGlc6P = 0.4
PGIgPGIgVmax = 1305.0
PGKgPGKgKeq = 3377.0
PGKgPGKgKm13BPGA = 0.003
PGKgPGKgKm3PGA = 1.62
PGKgPGKgKmADP = 0.1
PGKgPGKgKmATP = 0.29
PGKgPGKgVmax = 2862.0
PGLcPGLcKeq = 20000.0
PGLcPGLcKm6PG = 0.05
PGLcPGLcKm6PGL = 0.05
PGLcPGLcVmax = 28.0
PGLcPGLck = 0.055
PGLgPGLgKeq = 20000.0
PGLgPGLgKm6PG = 0.05
PGLgPGLgKm6PGL = 0.05
PGLgPGLgVmax = 5.0
PGLgPGLgk = 0.055
PPIcPPIcKeq = 5.6
PPIcPPIcKmRib5P = 4.0
PPIcPPIcKmRul5P = 1.4
PPIcPPIcVmax = 72.0
PPIgPPIgKeq = 5.6
PPIgPPIgKmRib5P = 4.0
PPIgPPIgKmRul5P = 1.4
PPIgPPIgVmax = 72.0
PYKcPYKcKeq = 10800.0
PYKcPYKcKiADP = 0.64
PYKcPYKcKiATP = 0.57
PYKcPYKcKmADP = 0.114
PYKcPYKcKmATP = 15.0
PYKcPYKcKmPEP = 0.34
PYKcPYKcKmPyr = 50.0
PYKcPYKcVmax = 1020.0
PYKcPYKcn = 2.5
Pig = 0.0
PyrTcPyrTcKmPyr = 1.96
PyrTcPyrTcVmax = 230.0
Pyre = 0.0
RKgRKgKeq = 0.0036
RKgRKgKmADP = 0.25
RKgRKgKmATP = 0.24
RKgRKgKmRib = 0.51
RKgRKgKmRib5P = 0.39
RKgRKgVmax = 10.0
Rib5Pc = 0.01
Ribg = 0.01
TOXcTOXck = 2.0
TPIgTPIgKeq = 0.046
TPIgTPIgKmDHAP = 1.2
TPIgTPIgKmGA3P = 0.25
TPIgTPIgVmax = 999.3
TRcTRcKeq = 434.0
TRcTRcKmNADP = 0.081
TRcTRcKmNADPH = 0.00077
TRcTRcKmTS2 = 0.0069
TRcTRcKmTSH2 = 0.0018
TRcTRcVmax = 252.0
cytosol = 5.4549
glycosome = 0.2451
default = 1.0


#initial values
ADPc = 1.3165
ADPg = 1.519
AMPc = 2.2418
AMPg = 4.2405
ATPc = 0.3417
ATPg = 0.2405
B13PGAg = 0.5
DHAPc = 2.23132912
DHAPg = 8.483130623
Fru16BPg = 10.0
Fru6Pg = 0.5
GA3Pg = 2.5
Glc6Pc = 0.5
Glc6Pg = 0.5
Glcc = 0.1
Glcg = 0.1
Gly3Pc = 2.76867088
Gly3Pg = 10.51686938
NADHg = 2.0
NADPHc = 3.9
NADPHg = 3.9
NADPc = 0.1
NADPg = 0.1
NADg = 2.0
P2GAc = 0.1
P3GAc = 0.1
P3GAg = 0.1
P6GLc = 0.0795278
P6GLg = 0.0795278
P6Gc = 0.0841958
P6Gg = 0.0841958
PEPc = 1.0
Pyrc = 10.0
Rib5Pg = 0.01
Rul5Pc = 0.41282
Rul5Pg = 0.41282
TS2c = 0.37
TSH2c = 0.01


#assignment rules