(* Generated by JWS Online *) (* This is an experimental feature of JWS Online. Please report any mistakes.*) (* Note that the following notable SBML entities or features are not supported in notebook outputyet: *) (* Events *) (* Constraints *) (* Units and UnitDefinitions *) (* AlgebraicRules *) (* conversionFactors *) variables = { ADP\[LetterSpace]c[t], ADP\[LetterSpace]g[t], AMP\[LetterSpace]c[t], AMP\[LetterSpace]g[t], ATP\[LetterSpace]c[t], ATP\[LetterSpace]g[t], DHAP\[LetterSpace]c[t], DHAP\[LetterSpace]g[t], Fru16BP\[LetterSpace]g[t], Fru6P\[LetterSpace]g[t], GA3P\[LetterSpace]g[t], Glc6P\[LetterSpace]c[t], Glc6P\[LetterSpace]g[t], Glc\[LetterSpace]c[t], Glc\[LetterSpace]g[t], Gly3P\[LetterSpace]c[t], Gly3P\[LetterSpace]g[t], NADH\[LetterSpace]g[t], NADPH\[LetterSpace]c[t], NADPH\[LetterSpace]g[t], NADP\[LetterSpace]c[t], NADP\[LetterSpace]g[t], NAD\[LetterSpace]g[t], PEP\[LetterSpace]c[t], Pyr\[LetterSpace]c[t], Rib5P\[LetterSpace]g[t], Rul5P\[LetterSpace]c[t], Rul5P\[LetterSpace]g[t], TS2\[LetterSpace]c[t], TSH2\[LetterSpace]c[t], \[LetterSpace]13BPGA\[LetterSpace]g[t], \[LetterSpace]2PGA\[LetterSpace]c[t], \[LetterSpace]3PGA\[LetterSpace]c[t], \[LetterSpace]3PGA\[LetterSpace]g[t], \[LetterSpace]6PGL\[LetterSpace]c[t], \[LetterSpace]6PGL\[LetterSpace]g[t], \[LetterSpace]6PG\[LetterSpace]c[t], \[LetterSpace]6PG\[LetterSpace]g[t] }; initialValues = { ADP\[LetterSpace]c[0] == 1.3165, ADP\[LetterSpace]g[0] == 1.519, AMP\[LetterSpace]c[0] == 2.2418, AMP\[LetterSpace]g[0] == 4.2405, ATP\[LetterSpace]c[0] == 0.3417, ATP\[LetterSpace]g[0] == 0.2405, DHAP\[LetterSpace]c[0] == 2.23132912, DHAP\[LetterSpace]g[0] == 8.483130623, Fru16BP\[LetterSpace]g[0] == 10.0, Fru6P\[LetterSpace]g[0] == 0.5, GA3P\[LetterSpace]g[0] == 2.5, Glc6P\[LetterSpace]c[0] == 0.5, Glc6P\[LetterSpace]g[0] == 0.5, Glc\[LetterSpace]c[0] == 0.1, Glc\[LetterSpace]g[0] == 0.1, Gly3P\[LetterSpace]c[0] == 2.76867088, Gly3P\[LetterSpace]g[0] == 10.51686938, NADH\[LetterSpace]g[0] == 2.0, NADPH\[LetterSpace]c[0] == 3.9, NADPH\[LetterSpace]g[0] == 3.9, NADP\[LetterSpace]c[0] == 0.1, NADP\[LetterSpace]g[0] == 0.1, NAD\[LetterSpace]g[0] == 2.0, PEP\[LetterSpace]c[0] == 1.0, Pyr\[LetterSpace]c[0] == 10.0, Rib5P\[LetterSpace]g[0] == 0.01, Rul5P\[LetterSpace]c[0] == 0.41282, Rul5P\[LetterSpace]g[0] == 0.41282, TS2\[LetterSpace]c[0] == 0.37, TSH2\[LetterSpace]c[0] == 0.01, \[LetterSpace]13BPGA\[LetterSpace]g[0] == 0.5, \[LetterSpace]2PGA\[LetterSpace]c[0] == 0.1, \[LetterSpace]3PGA\[LetterSpace]c[0] == 0.1, \[LetterSpace]3PGA\[LetterSpace]g[0] == 0.1, \[LetterSpace]6PGL\[LetterSpace]c[0] == 0.0795278, \[LetterSpace]6PGL\[LetterSpace]g[0] == 0.0795278, \[LetterSpace]6PG\[LetterSpace]c[0] == 0.0841958, \[LetterSpace]6PG\[LetterSpace]g[0] == 0.0841958 }; rates = { AK\[LetterSpace]c, AK\[LetterSpace]g, ALD\[LetterSpace]g, ATPu\[LetterSpace]c, ENO\[LetterSpace]c, G3PDH\[LetterSpace]g, G6PDH\[LetterSpace]c, G6PDH\[LetterSpace]g, G6PP\[LetterSpace]c, GAPDH\[LetterSpace]g, GDA\[LetterSpace]g, GK\[LetterSpace]g, GPO\[LetterSpace]c, GlcT\[LetterSpace]c, GlcT\[LetterSpace]g, HXK\[LetterSpace]c, HXK\[LetterSpace]g, NADPHu\[LetterSpace]c, NADPHu\[LetterSpace]g, PFK\[LetterSpace]g, PGAM\[LetterSpace]c, PGI\[LetterSpace]g, PGK\[LetterSpace]g, PGL\[LetterSpace]c, PGL\[LetterSpace]g, PPI\[LetterSpace]c, PPI\[LetterSpace]g, PYK\[LetterSpace]c, PyrT\[LetterSpace]c, RK\[LetterSpace]g, TOX\[LetterSpace]c, TPI\[LetterSpace]g, TR\[LetterSpace]c, \[LetterSpace]3PGAT\[LetterSpace]g, \[LetterSpace]6PGDH\[LetterSpace]c, \[LetterSpace]6PGDH\[LetterSpace]g }; rateEquations = { AK\[LetterSpace]c -> vAK[ADP\[LetterSpace]c[t], AMP\[LetterSpace]c[t], ATP\[LetterSpace]c[t], AK\[LetterSpace]c\[LetterSpace]AK\[LetterSpace]c\[LetterSpace]k1, AK\[LetterSpace]c\[LetterSpace]AK\[LetterSpace]c\[LetterSpace]k2], AK\[LetterSpace]g -> vAK[ADP\[LetterSpace]g[t], AMP\[LetterSpace]g[t], ATP\[LetterSpace]g[t], AK\[LetterSpace]g\[LetterSpace]AK\[LetterSpace]g\[LetterSpace]k1, AK\[LetterSpace]g\[LetterSpace]AK\[LetterSpace]g\[LetterSpace]k2], ALD\[LetterSpace]g -> (ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]Vmax*Fru16BP\[LetterSpace]g[t]*(1 - (DHAP\[LetterSpace]g[t]*GA3P\[LetterSpace]g[t])/(ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]Keq*Fru16BP\[LetterSpace]g[t])))/(ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KmFru16BP*(1 + ADP\[LetterSpace]g[t]/ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiADP + AMP\[LetterSpace]g[t]/ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiAMP + ATP\[LetterSpace]g[t]/ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiATP)*(1 + DHAP\[LetterSpace]g[t]/ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KmDHAP + Fru16BP\[LetterSpace]g[t]/(ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KmFru16BP*(1 + ADP\[LetterSpace]g[t]/ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiADP + AMP\[LetterSpace]g[t]/ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiAMP + ATP\[LetterSpace]g[t]/ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiATP)) + GA3P\[LetterSpace]g[t]/ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KmGA3P + (DHAP\[LetterSpace]g[t]*GA3P\[LetterSpace]g[t])/(ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KmDHAP*ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KmGA3P) + (Fru16BP\[LetterSpace]g[t]*GA3P\[LetterSpace]g[t])/(ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiGA3P*ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KmFru16BP*(1 + ADP\[LetterSpace]g[t]/ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiADP + AMP\[LetterSpace]g[t]/ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiAMP + ATP\[LetterSpace]g[t]/ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiATP)))), ATPu\[LetterSpace]c -> (ATPu\[LetterSpace]c\[LetterSpace]ATPu\[LetterSpace]c\[LetterSpace]k*ATP\[LetterSpace]c[t])/ADP\[LetterSpace]c[t], ENO\[LetterSpace]c -> v1sub1prod[ENO\[LetterSpace]c\[LetterSpace]ENO\[LetterSpace]c\[LetterSpace]Vmax, ENO\[LetterSpace]c\[LetterSpace]ENO\[LetterSpace]c\[LetterSpace]Keq, \[LetterSpace]2PGA\[LetterSpace]c[t], ENO\[LetterSpace]c\[LetterSpace]ENO\[LetterSpace]c\[LetterSpace]Km2PGA, PEP\[LetterSpace]c[t], ENO\[LetterSpace]c\[LetterSpace]ENO\[LetterSpace]c\[LetterSpace]KmPEP], G3PDH\[LetterSpace]g -> v2sub2prod[G3PDH\[LetterSpace]g\[LetterSpace]G3PDH\[LetterSpace]g\[LetterSpace]Vmax, G3PDH\[LetterSpace]g\[LetterSpace]G3PDH\[LetterSpace]g\[LetterSpace]Keq, DHAP\[LetterSpace]g[t], G3PDH\[LetterSpace]g\[LetterSpace]G3PDH\[LetterSpace]g\[LetterSpace]KmDHAP, NADH\[LetterSpace]g[t], G3PDH\[LetterSpace]g\[LetterSpace]G3PDH\[LetterSpace]g\[LetterSpace]KmNADH, Gly3P\[LetterSpace]g[t], G3PDH\[LetterSpace]g\[LetterSpace]G3PDH\[LetterSpace]g\[LetterSpace]KmGly3P, NAD\[LetterSpace]g[t], G3PDH\[LetterSpace]g\[LetterSpace]G3PDH\[LetterSpace]g\[LetterSpace]KmNAD], G6PDH\[LetterSpace]c -> v2sub2prod[G6PDH\[LetterSpace]c\[LetterSpace]G6PDH\[LetterSpace]c\[LetterSpace]Vmax, G6PDH\[LetterSpace]c\[LetterSpace]G6PDH\[LetterSpace]c\[LetterSpace]Keq, Glc6P\[LetterSpace]c[t], G6PDH\[LetterSpace]c\[LetterSpace]G6PDH\[LetterSpace]c\[LetterSpace]KmGlc6P, NADP\[LetterSpace]c[t], G6PDH\[LetterSpace]c\[LetterSpace]G6PDH\[LetterSpace]c\[LetterSpace]KmNADP, \[LetterSpace]6PGL\[LetterSpace]c[t], G6PDH\[LetterSpace]c\[LetterSpace]G6PDH\[LetterSpace]c\[LetterSpace]Km6PGL, NADPH\[LetterSpace]c[t], G6PDH\[LetterSpace]c\[LetterSpace]G6PDH\[LetterSpace]c\[LetterSpace]KmNADPH], G6PDH\[LetterSpace]g -> v2sub2prod[G6PDH\[LetterSpace]g\[LetterSpace]G6PDH\[LetterSpace]g\[LetterSpace]Vmax, G6PDH\[LetterSpace]g\[LetterSpace]G6PDH\[LetterSpace]g\[LetterSpace]Keq, Glc6P\[LetterSpace]g[t], G6PDH\[LetterSpace]g\[LetterSpace]G6PDH\[LetterSpace]g\[LetterSpace]KmGlc6P, NADP\[LetterSpace]g[t], G6PDH\[LetterSpace]g\[LetterSpace]G6PDH\[LetterSpace]g\[LetterSpace]KmNADP, \[LetterSpace]6PGL\[LetterSpace]g[t], G6PDH\[LetterSpace]g\[LetterSpace]G6PDH\[LetterSpace]g\[LetterSpace]Km6PGL, NADPH\[LetterSpace]g[t], G6PDH\[LetterSpace]g\[LetterSpace]G6PDH\[LetterSpace]g\[LetterSpace]KmNADPH], G6PP\[LetterSpace]c -> v1sub1prod[G6PP\[LetterSpace]c\[LetterSpace]G6PP\[LetterSpace]c\[LetterSpace]Vmax, G6PP\[LetterSpace]c\[LetterSpace]G6PP\[LetterSpace]c\[LetterSpace]Keq, Glc6P\[LetterSpace]c[t], G6PP\[LetterSpace]c\[LetterSpace]G6PP\[LetterSpace]c\[LetterSpace]KmGlc6P, Glc\[LetterSpace]c[t], G6PP\[LetterSpace]c\[LetterSpace]G6PP\[LetterSpace]c\[LetterSpace]KmGlc], GAPDH\[LetterSpace]g -> v2sub2prod[GAPDH\[LetterSpace]g\[LetterSpace]GAPDH\[LetterSpace]g\[LetterSpace]Vmax, GAPDH\[LetterSpace]g\[LetterSpace]GAPDH\[LetterSpace]g\[LetterSpace]Keq, GA3P\[LetterSpace]g[t], GAPDH\[LetterSpace]g\[LetterSpace]GAPDH\[LetterSpace]g\[LetterSpace]KmGA3P, NAD\[LetterSpace]g[t], GAPDH\[LetterSpace]g\[LetterSpace]GAPDH\[LetterSpace]g\[LetterSpace]KmNAD, \[LetterSpace]13BPGA\[LetterSpace]g[t], GAPDH\[LetterSpace]g\[LetterSpace]GAPDH\[LetterSpace]g\[LetterSpace]Km13BPGA, NADH\[LetterSpace]g[t], GAPDH\[LetterSpace]g\[LetterSpace]GAPDH\[LetterSpace]g\[LetterSpace]KmNADH], GDA\[LetterSpace]g -> -(GDA\[LetterSpace]g\[LetterSpace]GDA\[LetterSpace]g\[LetterSpace]k*DHAP\[LetterSpace]g[t]*Gly3P\[LetterSpace]c[t]) + GDA\[LetterSpace]g\[LetterSpace]GDA\[LetterSpace]g\[LetterSpace]k*DHAP\[LetterSpace]c[t]*Gly3P\[LetterSpace]g[t], GK\[LetterSpace]g -> v2sub2prod[GK\[LetterSpace]g\[LetterSpace]GK\[LetterSpace]g\[LetterSpace]Vmax, GK\[LetterSpace]g\[LetterSpace]GK\[LetterSpace]g\[LetterSpace]Keq, Gly3P\[LetterSpace]g[t], GK\[LetterSpace]g\[LetterSpace]GK\[LetterSpace]g\[LetterSpace]KmGly3P, ADP\[LetterSpace]g[t], GK\[LetterSpace]g\[LetterSpace]GK\[LetterSpace]g\[LetterSpace]KmADP, Gly\[LetterSpace]e, GK\[LetterSpace]g\[LetterSpace]GK\[LetterSpace]g\[LetterSpace]KmGly, ATP\[LetterSpace]g[t], GK\[LetterSpace]g\[LetterSpace]GK\[LetterSpace]g\[LetterSpace]KmATP], GPO\[LetterSpace]c -> v1sub[GPO\[LetterSpace]c\[LetterSpace]GPO\[LetterSpace]c\[LetterSpace]Vmax, Gly3P\[LetterSpace]c[t], GPO\[LetterSpace]c\[LetterSpace]GPO\[LetterSpace]c\[LetterSpace]KmGly3P], GlcT\[LetterSpace]c -> (GlcT\[LetterSpace]c\[LetterSpace]GlcT\[LetterSpace]c\[LetterSpace]Vmax*(Glc\[LetterSpace]e - Glc\[LetterSpace]c[t]))/(GlcT\[LetterSpace]c\[LetterSpace]GlcT\[LetterSpace]c\[LetterSpace]KmGlc + Glc\[LetterSpace]e + Glc\[LetterSpace]c[t] + (GlcT\[LetterSpace]c\[LetterSpace]GlcT\[LetterSpace]c\[LetterSpace]alpha*Glc\[LetterSpace]e*Glc\[LetterSpace]c[t])/GlcT\[LetterSpace]c\[LetterSpace]GlcT\[LetterSpace]c\[LetterSpace]KmGlc), GlcT\[LetterSpace]g -> mass\[LetterSpace]action\[LetterSpace]rev[GlcT\[LetterSpace]g\[LetterSpace]GlcT\[LetterSpace]g\[LetterSpace]k1, Glc\[LetterSpace]c[t], GlcT\[LetterSpace]g\[LetterSpace]GlcT\[LetterSpace]g\[LetterSpace]k2, Glc\[LetterSpace]g[t]], HXK\[LetterSpace]c -> v2sub2prod[HXK\[LetterSpace]c\[LetterSpace]HXK\[LetterSpace]c\[LetterSpace]Vmax, HXK\[LetterSpace]c\[LetterSpace]HXK\[LetterSpace]c\[LetterSpace]Keq, Glc\[LetterSpace]c[t], HXK\[LetterSpace]c\[LetterSpace]HXK\[LetterSpace]c\[LetterSpace]KmGlc, ATP\[LetterSpace]c[t], HXK\[LetterSpace]c\[LetterSpace]HXK\[LetterSpace]c\[LetterSpace]KmATP, Glc6P\[LetterSpace]c[t], HXK\[LetterSpace]c\[LetterSpace]HXK\[LetterSpace]c\[LetterSpace]KmGlc6P, ADP\[LetterSpace]c[t], HXK\[LetterSpace]c\[LetterSpace]HXK\[LetterSpace]c\[LetterSpace]KmADP], HXK\[LetterSpace]g -> v2sub2prod[HXK\[LetterSpace]g\[LetterSpace]HXK\[LetterSpace]g\[LetterSpace]Vmax, HXK\[LetterSpace]g\[LetterSpace]HXK\[LetterSpace]g\[LetterSpace]Keq, Glc\[LetterSpace]g[t], HXK\[LetterSpace]g\[LetterSpace]HXK\[LetterSpace]g\[LetterSpace]KmGlc, ATP\[LetterSpace]g[t], HXK\[LetterSpace]g\[LetterSpace]HXK\[LetterSpace]g\[LetterSpace]KmATP, Glc6P\[LetterSpace]g[t], HXK\[LetterSpace]g\[LetterSpace]HXK\[LetterSpace]g\[LetterSpace]KmGlc6P, ADP\[LetterSpace]g[t], HXK\[LetterSpace]g\[LetterSpace]HXK\[LetterSpace]g\[LetterSpace]KmADP], NADPHu\[LetterSpace]c -> mass\[LetterSpace]action\[LetterSpace]irrev[NADPHu\[LetterSpace]c\[LetterSpace]NADPHu\[LetterSpace]c\[LetterSpace]k, NADPH\[LetterSpace]c[t]], NADPHu\[LetterSpace]g -> mass\[LetterSpace]action\[LetterSpace]irrev[NADPHu\[LetterSpace]g\[LetterSpace]NADPHu\[LetterSpace]g\[LetterSpace]k, NADPH\[LetterSpace]g[t]], PFK\[LetterSpace]g -> (PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]Ki1*PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]Vmax*ATP\[LetterSpace]g[t]*(1 - (ADP\[LetterSpace]g[t]*Fru16BP\[LetterSpace]g[t])/(PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]Keq*ATP\[LetterSpace]g[t]*Fru6P\[LetterSpace]g[t]))*Fru6P\[LetterSpace]g[t])/(PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KmATP*PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KmFru6P*(PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]Ki1 + Fru16BP\[LetterSpace]g[t])*(PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KsATP/PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KmATP + ADP\[LetterSpace]g[t]/PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KmADP + ATP\[LetterSpace]g[t]/PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KmATP + (ADP\[LetterSpace]g[t]*Fru16BP\[LetterSpace]g[t])/(PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]Ki2*PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KmADP) + Fru6P\[LetterSpace]g[t]/PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KmFru6P + (ATP\[LetterSpace]g[t]*Fru6P\[LetterSpace]g[t])/(PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KmATP*PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KmFru6P))), PGAM\[LetterSpace]c -> v1sub1prod[PGAM\[LetterSpace]c\[LetterSpace]PGAM\[LetterSpace]c\[LetterSpace]Vmax, PGAM\[LetterSpace]c\[LetterSpace]PGAM\[LetterSpace]c\[LetterSpace]Keq, \[LetterSpace]3PGA\[LetterSpace]c[t], PGAM\[LetterSpace]c\[LetterSpace]PGAM\[LetterSpace]c\[LetterSpace]Km3PGA, \[LetterSpace]2PGA\[LetterSpace]c[t], PGAM\[LetterSpace]c\[LetterSpace]PGAM\[LetterSpace]c\[LetterSpace]Km2PGA], PGI\[LetterSpace]g -> (PGI\[LetterSpace]g\[LetterSpace]PGI\[LetterSpace]g\[LetterSpace]Vmax*(1 - Fru6P\[LetterSpace]g[t]/(PGI\[LetterSpace]g\[LetterSpace]PGI\[LetterSpace]g\[LetterSpace]Keq*Glc6P\[LetterSpace]g[t]))*Glc6P\[LetterSpace]g[t])/(PGI\[LetterSpace]g\[LetterSpace]PGI\[LetterSpace]g\[LetterSpace]KmGlc6P*(1 + Fru6P\[LetterSpace]g[t]/PGI\[LetterSpace]g\[LetterSpace]PGI\[LetterSpace]g\[LetterSpace]KmFru6P + Glc6P\[LetterSpace]g[t]/PGI\[LetterSpace]g\[LetterSpace]PGI\[LetterSpace]g\[LetterSpace]KmGlc6P + \[LetterSpace]6PG\[LetterSpace]g[t]/PGI\[LetterSpace]g\[LetterSpace]PGI\[LetterSpace]g\[LetterSpace]Ki6PG)), PGK\[LetterSpace]g -> v2sub2prod[PGK\[LetterSpace]g\[LetterSpace]PGK\[LetterSpace]g\[LetterSpace]Vmax, PGK\[LetterSpace]g\[LetterSpace]PGK\[LetterSpace]g\[LetterSpace]Keq, \[LetterSpace]13BPGA\[LetterSpace]g[t], PGK\[LetterSpace]g\[LetterSpace]PGK\[LetterSpace]g\[LetterSpace]Km13BPGA, ADP\[LetterSpace]g[t], PGK\[LetterSpace]g\[LetterSpace]PGK\[LetterSpace]g\[LetterSpace]KmADP, \[LetterSpace]3PGA\[LetterSpace]g[t], PGK\[LetterSpace]g\[LetterSpace]PGK\[LetterSpace]g\[LetterSpace]Km3PGA, ATP\[LetterSpace]g[t], PGK\[LetterSpace]g\[LetterSpace]PGK\[LetterSpace]g\[LetterSpace]KmATP], PGL\[LetterSpace]c -> v1sub1prod[PGL\[LetterSpace]c\[LetterSpace]PGL\[LetterSpace]c\[LetterSpace]Vmax, PGL\[LetterSpace]c\[LetterSpace]PGL\[LetterSpace]c\[LetterSpace]Keq, \[LetterSpace]6PGL\[LetterSpace]c[t], PGL\[LetterSpace]c\[LetterSpace]PGL\[LetterSpace]c\[LetterSpace]Km6PGL, \[LetterSpace]6PG\[LetterSpace]c[t], PGL\[LetterSpace]c\[LetterSpace]PGL\[LetterSpace]c\[LetterSpace]Km6PG] + cytosol*PGL\[LetterSpace]c\[LetterSpace]PGL\[LetterSpace]c\[LetterSpace]k*(\[LetterSpace]6PGL\[LetterSpace]c[t] - \[LetterSpace]6PG\[LetterSpace]c[t]/PGL\[LetterSpace]c\[LetterSpace]PGL\[LetterSpace]c\[LetterSpace]Keq), PGL\[LetterSpace]g -> v1sub1prod[PGL\[LetterSpace]g\[LetterSpace]PGL\[LetterSpace]g\[LetterSpace]Vmax, PGL\[LetterSpace]g\[LetterSpace]PGL\[LetterSpace]g\[LetterSpace]Keq, \[LetterSpace]6PGL\[LetterSpace]g[t], PGL\[LetterSpace]g\[LetterSpace]PGL\[LetterSpace]g\[LetterSpace]Km6PGL, \[LetterSpace]6PG\[LetterSpace]g[t], PGL\[LetterSpace]g\[LetterSpace]PGL\[LetterSpace]g\[LetterSpace]Km6PG] + glycosome*PGL\[LetterSpace]g\[LetterSpace]PGL\[LetterSpace]g\[LetterSpace]k*(\[LetterSpace]6PGL\[LetterSpace]g[t] - \[LetterSpace]6PG\[LetterSpace]g[t]/PGL\[LetterSpace]g\[LetterSpace]PGL\[LetterSpace]g\[LetterSpace]Keq), PPI\[LetterSpace]c -> v1sub1prod[PPI\[LetterSpace]c\[LetterSpace]PPI\[LetterSpace]c\[LetterSpace]Vmax, PPI\[LetterSpace]c\[LetterSpace]PPI\[LetterSpace]c\[LetterSpace]Keq, Rul5P\[LetterSpace]c[t], PPI\[LetterSpace]c\[LetterSpace]PPI\[LetterSpace]c\[LetterSpace]KmRul5P, Rib5P\[LetterSpace]c, PPI\[LetterSpace]c\[LetterSpace]PPI\[LetterSpace]c\[LetterSpace]KmRib5P], PPI\[LetterSpace]g -> v1sub1prod[PPI\[LetterSpace]g\[LetterSpace]PPI\[LetterSpace]g\[LetterSpace]Vmax, PPI\[LetterSpace]g\[LetterSpace]PPI\[LetterSpace]g\[LetterSpace]Keq, Rul5P\[LetterSpace]g[t], PPI\[LetterSpace]g\[LetterSpace]PPI\[LetterSpace]g\[LetterSpace]KmRul5P, Rib5P\[LetterSpace]g[t], PPI\[LetterSpace]g\[LetterSpace]PPI\[LetterSpace]g\[LetterSpace]KmRib5P], PYK\[LetterSpace]c -> (PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]Vmax*ADP\[LetterSpace]c[t]*(PEP\[LetterSpace]c[t]/(PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KmPEP*(1 + ADP\[LetterSpace]c[t]/PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KiADP + ATP\[LetterSpace]c[t]/PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KiATP)))^PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]n*(1 - (ATP\[LetterSpace]c[t]*Pyr\[LetterSpace]c[t])/(PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]Keq*ADP\[LetterSpace]c[t]*PEP\[LetterSpace]c[t])))/(PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KmADP*(1 + ADP\[LetterSpace]c[t]/PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KmADP + ATP\[LetterSpace]c[t]/PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KmATP)*(1 + (PEP\[LetterSpace]c[t]/(PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KmPEP*(1 + ADP\[LetterSpace]c[t]/PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KiADP + ATP\[LetterSpace]c[t]/PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KiATP)))^PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]n + Pyr\[LetterSpace]c[t]/PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KmPyr)), PyrT\[LetterSpace]c -> v1sub[PyrT\[LetterSpace]c\[LetterSpace]PyrT\[LetterSpace]c\[LetterSpace]Vmax, Pyr\[LetterSpace]c[t], PyrT\[LetterSpace]c\[LetterSpace]PyrT\[LetterSpace]c\[LetterSpace]KmPyr], RK\[LetterSpace]g -> v2sub2prod[RK\[LetterSpace]g\[LetterSpace]RK\[LetterSpace]g\[LetterSpace]Vmax, RK\[LetterSpace]g\[LetterSpace]RK\[LetterSpace]g\[LetterSpace]Keq, Rib5P\[LetterSpace]g[t], RK\[LetterSpace]g\[LetterSpace]RK\[LetterSpace]g\[LetterSpace]KmRib5P, ADP\[LetterSpace]g[t], RK\[LetterSpace]g\[LetterSpace]RK\[LetterSpace]g\[LetterSpace]KmADP, Rib\[LetterSpace]g, RK\[LetterSpace]g\[LetterSpace]RK\[LetterSpace]g\[LetterSpace]KmRib, ATP\[LetterSpace]g[t], RK\[LetterSpace]g\[LetterSpace]RK\[LetterSpace]g\[LetterSpace]KmATP], TOX\[LetterSpace]c -> mass\[LetterSpace]action\[LetterSpace]irrev[TOX\[LetterSpace]c\[LetterSpace]TOX\[LetterSpace]c\[LetterSpace]k, TSH2\[LetterSpace]c[t]], TPI\[LetterSpace]g -> v1sub1prod[TPI\[LetterSpace]g\[LetterSpace]TPI\[LetterSpace]g\[LetterSpace]Vmax, TPI\[LetterSpace]g\[LetterSpace]TPI\[LetterSpace]g\[LetterSpace]Keq, DHAP\[LetterSpace]g[t], TPI\[LetterSpace]g\[LetterSpace]TPI\[LetterSpace]g\[LetterSpace]KmDHAP, GA3P\[LetterSpace]g[t], TPI\[LetterSpace]g\[LetterSpace]TPI\[LetterSpace]g\[LetterSpace]KmGA3P], TR\[LetterSpace]c -> v2sub2prod[TR\[LetterSpace]c\[LetterSpace]TR\[LetterSpace]c\[LetterSpace]Vmax, TR\[LetterSpace]c\[LetterSpace]TR\[LetterSpace]c\[LetterSpace]Keq, TS2\[LetterSpace]c[t], TR\[LetterSpace]c\[LetterSpace]TR\[LetterSpace]c\[LetterSpace]KmTS2, NADPH\[LetterSpace]c[t], TR\[LetterSpace]c\[LetterSpace]TR\[LetterSpace]c\[LetterSpace]KmNADPH, TSH2\[LetterSpace]c[t], TR\[LetterSpace]c\[LetterSpace]TR\[LetterSpace]c\[LetterSpace]KmTSH2, NADP\[LetterSpace]c[t], TR\[LetterSpace]c\[LetterSpace]TR\[LetterSpace]c\[LetterSpace]KmNADP], \[LetterSpace]3PGAT\[LetterSpace]g -> mass\[LetterSpace]action\[LetterSpace]rev[\[LetterSpace]3PGAT\[LetterSpace]g\[LetterSpace]\[LetterSpace]3PGAT\[LetterSpace]g\[LetterSpace]k, \[LetterSpace]3PGA\[LetterSpace]g[t], \[LetterSpace]3PGAT\[LetterSpace]g\[LetterSpace]\[LetterSpace]3PGAT\[LetterSpace]g\[LetterSpace]k, \[LetterSpace]3PGA\[LetterSpace]c[t]], \[LetterSpace]6PGDH\[LetterSpace]c -> v2sub2prod[\[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]Vmax, \[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]Keq, \[LetterSpace]6PG\[LetterSpace]c[t], \[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]Km6PG, NADP\[LetterSpace]c[t], \[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]KmNADP, Rul5P\[LetterSpace]c[t], \[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]KmRul5P, NADPH\[LetterSpace]c[t], \[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]KmNADPH], \[LetterSpace]6PGDH\[LetterSpace]g -> v2sub2prod[\[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]Vmax, \[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]Keq, \[LetterSpace]6PG\[LetterSpace]g[t], \[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]Km6PG, NADP\[LetterSpace]g[t], \[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]KmNADP, Rul5P\[LetterSpace]g[t], \[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]KmRul5P, NADPH\[LetterSpace]g[t], \[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]KmNADPH] }; parameters = { CO2\[LetterSpace]c -> 0.0, CO2\[LetterSpace]g -> 0.0, Glc\[LetterSpace]e -> 5.0, Gly\[LetterSpace]e -> 0.0, Pi\[LetterSpace]g -> 0.0, Pyr\[LetterSpace]e -> 0.0, Rib5P\[LetterSpace]c -> 0.01, Rib\[LetterSpace]g -> 0.01, TPI\[LetterSpace]g\[LetterSpace]TPI\[LetterSpace]g\[LetterSpace]Vmax -> 999.3, TPI\[LetterSpace]g\[LetterSpace]TPI\[LetterSpace]g\[LetterSpace]Keq -> 0.046, TPI\[LetterSpace]g\[LetterSpace]TPI\[LetterSpace]g\[LetterSpace]KmDHAP -> 1.2, TPI\[LetterSpace]g\[LetterSpace]TPI\[LetterSpace]g\[LetterSpace]KmGA3P -> 0.25, PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]Vmax -> 1020.0, PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KmPEP -> 0.34, PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KiATP -> 0.57, PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KiADP -> 0.64, PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]n -> 2.5, PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KmADP -> 0.114, PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]Keq -> 10800.0, PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KmPyr -> 50.0, PYK\[LetterSpace]c\[LetterSpace]PYK\[LetterSpace]c\[LetterSpace]KmATP -> 15.0, PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]Vmax -> 1708.0, PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]Ki1 -> 15.8, PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KmFru6P -> 0.999, PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KmATP -> 0.0648, PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]Keq -> 1035.0, PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KsATP -> 0.0393, PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]KmADP -> 1.0, PFK\[LetterSpace]g\[LetterSpace]PFK\[LetterSpace]g\[LetterSpace]Ki2 -> 10.7, G6PDH\[LetterSpace]g\[LetterSpace]G6PDH\[LetterSpace]g\[LetterSpace]Vmax -> 8.4, G6PDH\[LetterSpace]g\[LetterSpace]G6PDH\[LetterSpace]g\[LetterSpace]Keq -> 5.02, G6PDH\[LetterSpace]g\[LetterSpace]G6PDH\[LetterSpace]g\[LetterSpace]KmGlc6P -> 0.058, G6PDH\[LetterSpace]g\[LetterSpace]G6PDH\[LetterSpace]g\[LetterSpace]KmNADP -> 0.0094, G6PDH\[LetterSpace]g\[LetterSpace]G6PDH\[LetterSpace]g\[LetterSpace]Km6PGL -> 0.04, G6PDH\[LetterSpace]g\[LetterSpace]G6PDH\[LetterSpace]g\[LetterSpace]KmNADPH -> 0.0001, PGAM\[LetterSpace]c\[LetterSpace]PGAM\[LetterSpace]c\[LetterSpace]Vmax -> 225.0, PGAM\[LetterSpace]c\[LetterSpace]PGAM\[LetterSpace]c\[LetterSpace]Keq -> 0.17, PGAM\[LetterSpace]c\[LetterSpace]PGAM\[LetterSpace]c\[LetterSpace]Km3PGA -> 0.15, PGAM\[LetterSpace]c\[LetterSpace]PGAM\[LetterSpace]c\[LetterSpace]Km2PGA -> 0.16, PyrT\[LetterSpace]c\[LetterSpace]PyrT\[LetterSpace]c\[LetterSpace]Vmax -> 230.0, PyrT\[LetterSpace]c\[LetterSpace]PyrT\[LetterSpace]c\[LetterSpace]KmPyr -> 1.96, G6PDH\[LetterSpace]c\[LetterSpace]G6PDH\[LetterSpace]c\[LetterSpace]Vmax -> 8.4, G6PDH\[LetterSpace]c\[LetterSpace]G6PDH\[LetterSpace]c\[LetterSpace]Keq -> 5.02, G6PDH\[LetterSpace]c\[LetterSpace]G6PDH\[LetterSpace]c\[LetterSpace]KmGlc6P -> 0.058, G6PDH\[LetterSpace]c\[LetterSpace]G6PDH\[LetterSpace]c\[LetterSpace]KmNADP -> 0.0094, G6PDH\[LetterSpace]c\[LetterSpace]G6PDH\[LetterSpace]c\[LetterSpace]Km6PGL -> 0.04, G6PDH\[LetterSpace]c\[LetterSpace]G6PDH\[LetterSpace]c\[LetterSpace]KmNADPH -> 0.0001, ENO\[LetterSpace]c\[LetterSpace]ENO\[LetterSpace]c\[LetterSpace]Vmax -> 598.0, ENO\[LetterSpace]c\[LetterSpace]ENO\[LetterSpace]c\[LetterSpace]Keq -> 4.17, ENO\[LetterSpace]c\[LetterSpace]ENO\[LetterSpace]c\[LetterSpace]Km2PGA -> 0.054, ENO\[LetterSpace]c\[LetterSpace]ENO\[LetterSpace]c\[LetterSpace]KmPEP -> 0.24, HXK\[LetterSpace]g\[LetterSpace]HXK\[LetterSpace]g\[LetterSpace]Vmax -> 1774.68, HXK\[LetterSpace]g\[LetterSpace]HXK\[LetterSpace]g\[LetterSpace]Keq -> 759.0, HXK\[LetterSpace]g\[LetterSpace]HXK\[LetterSpace]g\[LetterSpace]KmGlc -> 0.1, HXK\[LetterSpace]g\[LetterSpace]HXK\[LetterSpace]g\[LetterSpace]KmATP -> 0.116, HXK\[LetterSpace]g\[LetterSpace]HXK\[LetterSpace]g\[LetterSpace]KmGlc6P -> 2.7, HXK\[LetterSpace]g\[LetterSpace]HXK\[LetterSpace]g\[LetterSpace]KmADP -> 0.126, RK\[LetterSpace]g\[LetterSpace]RK\[LetterSpace]g\[LetterSpace]Vmax -> 10.0, RK\[LetterSpace]g\[LetterSpace]RK\[LetterSpace]g\[LetterSpace]Keq -> 0.0036, RK\[LetterSpace]g\[LetterSpace]RK\[LetterSpace]g\[LetterSpace]KmRib5P -> 0.39, RK\[LetterSpace]g\[LetterSpace]RK\[LetterSpace]g\[LetterSpace]KmADP -> 0.25, RK\[LetterSpace]g\[LetterSpace]RK\[LetterSpace]g\[LetterSpace]KmRib -> 0.51, RK\[LetterSpace]g\[LetterSpace]RK\[LetterSpace]g\[LetterSpace]KmATP -> 0.24, \[LetterSpace]3PGAT\[LetterSpace]g\[LetterSpace]\[LetterSpace]3PGAT\[LetterSpace]g\[LetterSpace]k -> 250.0, NADPHu\[LetterSpace]c\[LetterSpace]NADPHu\[LetterSpace]c\[LetterSpace]k -> 2.0, HXK\[LetterSpace]c\[LetterSpace]HXK\[LetterSpace]c\[LetterSpace]Vmax -> 154.32, HXK\[LetterSpace]c\[LetterSpace]HXK\[LetterSpace]c\[LetterSpace]Keq -> 759.0, HXK\[LetterSpace]c\[LetterSpace]HXK\[LetterSpace]c\[LetterSpace]KmGlc -> 0.1, HXK\[LetterSpace]c\[LetterSpace]HXK\[LetterSpace]c\[LetterSpace]KmATP -> 0.116, HXK\[LetterSpace]c\[LetterSpace]HXK\[LetterSpace]c\[LetterSpace]KmGlc6P -> 2.7, HXK\[LetterSpace]c\[LetterSpace]HXK\[LetterSpace]c\[LetterSpace]KmADP -> 0.126, NADPHu\[LetterSpace]g\[LetterSpace]NADPHu\[LetterSpace]g\[LetterSpace]k -> 2.0, AK\[LetterSpace]c\[LetterSpace]AK\[LetterSpace]c\[LetterSpace]k1 -> 480.0, AK\[LetterSpace]c\[LetterSpace]AK\[LetterSpace]c\[LetterSpace]k2 -> 1000.0, G6PP\[LetterSpace]c\[LetterSpace]G6PP\[LetterSpace]c\[LetterSpace]Vmax -> 28.0, G6PP\[LetterSpace]c\[LetterSpace]G6PP\[LetterSpace]c\[LetterSpace]Keq -> 263.0, G6PP\[LetterSpace]c\[LetterSpace]G6PP\[LetterSpace]c\[LetterSpace]KmGlc6P -> 5.6, G6PP\[LetterSpace]c\[LetterSpace]G6PP\[LetterSpace]c\[LetterSpace]KmGlc -> 5.6, \[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]Vmax -> 10.6, \[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]Keq -> 47.0, \[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]Km6PG -> 0.0035, \[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]KmNADP -> 0.001, \[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]KmRul5P -> 0.03, \[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]g\[LetterSpace]KmNADPH -> 0.0006, PGI\[LetterSpace]g\[LetterSpace]PGI\[LetterSpace]g\[LetterSpace]Vmax -> 1305.0, PGI\[LetterSpace]g\[LetterSpace]PGI\[LetterSpace]g\[LetterSpace]KmGlc6P -> 0.4, PGI\[LetterSpace]g\[LetterSpace]PGI\[LetterSpace]g\[LetterSpace]Keq -> 0.457, PGI\[LetterSpace]g\[LetterSpace]PGI\[LetterSpace]g\[LetterSpace]KmFru6P -> 0.12, PGI\[LetterSpace]g\[LetterSpace]PGI\[LetterSpace]g\[LetterSpace]Ki6PG -> 0.14, AK\[LetterSpace]g\[LetterSpace]AK\[LetterSpace]g\[LetterSpace]k1 -> 480.0, AK\[LetterSpace]g\[LetterSpace]AK\[LetterSpace]g\[LetterSpace]k2 -> 1000.0, TOX\[LetterSpace]c\[LetterSpace]TOX\[LetterSpace]c\[LetterSpace]k -> 2.0, GDA\[LetterSpace]g\[LetterSpace]GDA\[LetterSpace]g\[LetterSpace]k -> 600.0, PGL\[LetterSpace]c\[LetterSpace]PGL\[LetterSpace]c\[LetterSpace]Vmax -> 28.0, PGL\[LetterSpace]c\[LetterSpace]PGL\[LetterSpace]c\[LetterSpace]Keq -> 20000.0, PGL\[LetterSpace]c\[LetterSpace]PGL\[LetterSpace]c\[LetterSpace]Km6PGL -> 0.05, PGL\[LetterSpace]c\[LetterSpace]PGL\[LetterSpace]c\[LetterSpace]Km6PG -> 0.05, PGL\[LetterSpace]c\[LetterSpace]PGL\[LetterSpace]c\[LetterSpace]k -> 0.055, \[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]Vmax -> 10.6, \[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]Keq -> 47.0, \[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]Km6PG -> 0.0035, \[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]KmNADP -> 0.001, \[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]KmRul5P -> 0.03, \[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]\[LetterSpace]6PGDH\[LetterSpace]c\[LetterSpace]KmNADPH -> 0.0006, PPI\[LetterSpace]c\[LetterSpace]PPI\[LetterSpace]c\[LetterSpace]Vmax -> 72.0, PPI\[LetterSpace]c\[LetterSpace]PPI\[LetterSpace]c\[LetterSpace]Keq -> 5.6, PPI\[LetterSpace]c\[LetterSpace]PPI\[LetterSpace]c\[LetterSpace]KmRul5P -> 1.4, PPI\[LetterSpace]c\[LetterSpace]PPI\[LetterSpace]c\[LetterSpace]KmRib5P -> 4.0, PPI\[LetterSpace]g\[LetterSpace]PPI\[LetterSpace]g\[LetterSpace]Vmax -> 72.0, PPI\[LetterSpace]g\[LetterSpace]PPI\[LetterSpace]g\[LetterSpace]Keq -> 5.6, PPI\[LetterSpace]g\[LetterSpace]PPI\[LetterSpace]g\[LetterSpace]KmRul5P -> 1.4, PPI\[LetterSpace]g\[LetterSpace]PPI\[LetterSpace]g\[LetterSpace]KmRib5P -> 4.0, GlcT\[LetterSpace]g\[LetterSpace]GlcT\[LetterSpace]g\[LetterSpace]k1 -> 250000.0, GlcT\[LetterSpace]g\[LetterSpace]GlcT\[LetterSpace]g\[LetterSpace]k2 -> 250000.0, GlcT\[LetterSpace]c\[LetterSpace]GlcT\[LetterSpace]c\[LetterSpace]Vmax -> 111.7, GlcT\[LetterSpace]c\[LetterSpace]GlcT\[LetterSpace]c\[LetterSpace]KmGlc -> 1.0, GlcT\[LetterSpace]c\[LetterSpace]GlcT\[LetterSpace]c\[LetterSpace]alpha -> 0.75, PGL\[LetterSpace]g\[LetterSpace]PGL\[LetterSpace]g\[LetterSpace]Vmax -> 5.0, PGL\[LetterSpace]g\[LetterSpace]PGL\[LetterSpace]g\[LetterSpace]Keq -> 20000.0, PGL\[LetterSpace]g\[LetterSpace]PGL\[LetterSpace]g\[LetterSpace]Km6PGL -> 0.05, PGL\[LetterSpace]g\[LetterSpace]PGL\[LetterSpace]g\[LetterSpace]Km6PG -> 0.05, PGL\[LetterSpace]g\[LetterSpace]PGL\[LetterSpace]g\[LetterSpace]k -> 0.055, TR\[LetterSpace]c\[LetterSpace]TR\[LetterSpace]c\[LetterSpace]Vmax -> 252.0, TR\[LetterSpace]c\[LetterSpace]TR\[LetterSpace]c\[LetterSpace]Keq -> 434.0, TR\[LetterSpace]c\[LetterSpace]TR\[LetterSpace]c\[LetterSpace]KmTS2 -> 0.0069, TR\[LetterSpace]c\[LetterSpace]TR\[LetterSpace]c\[LetterSpace]KmNADPH -> 0.00077, TR\[LetterSpace]c\[LetterSpace]TR\[LetterSpace]c\[LetterSpace]KmTSH2 -> 0.0018, TR\[LetterSpace]c\[LetterSpace]TR\[LetterSpace]c\[LetterSpace]KmNADP -> 0.081, PGK\[LetterSpace]g\[LetterSpace]PGK\[LetterSpace]g\[LetterSpace]Vmax -> 2862.0, PGK\[LetterSpace]g\[LetterSpace]PGK\[LetterSpace]g\[LetterSpace]Keq -> 3377.0, PGK\[LetterSpace]g\[LetterSpace]PGK\[LetterSpace]g\[LetterSpace]Km13BPGA -> 0.003, PGK\[LetterSpace]g\[LetterSpace]PGK\[LetterSpace]g\[LetterSpace]KmADP -> 0.1, PGK\[LetterSpace]g\[LetterSpace]PGK\[LetterSpace]g\[LetterSpace]Km3PGA -> 1.62, PGK\[LetterSpace]g\[LetterSpace]PGK\[LetterSpace]g\[LetterSpace]KmATP -> 0.29, G3PDH\[LetterSpace]g\[LetterSpace]G3PDH\[LetterSpace]g\[LetterSpace]Vmax -> 465.0, G3PDH\[LetterSpace]g\[LetterSpace]G3PDH\[LetterSpace]g\[LetterSpace]Keq -> 17085.0, G3PDH\[LetterSpace]g\[LetterSpace]G3PDH\[LetterSpace]g\[LetterSpace]KmDHAP -> 0.1, G3PDH\[LetterSpace]g\[LetterSpace]G3PDH\[LetterSpace]g\[LetterSpace]KmNADH -> 0.01, G3PDH\[LetterSpace]g\[LetterSpace]G3PDH\[LetterSpace]g\[LetterSpace]KmGly3P -> 2.0, G3PDH\[LetterSpace]g\[LetterSpace]G3PDH\[LetterSpace]g\[LetterSpace]KmNAD -> 0.4, ATPu\[LetterSpace]c\[LetterSpace]ATPu\[LetterSpace]c\[LetterSpace]k -> 50.0, GK\[LetterSpace]g\[LetterSpace]GK\[LetterSpace]g\[LetterSpace]Vmax -> 200.0, GK\[LetterSpace]g\[LetterSpace]GK\[LetterSpace]g\[LetterSpace]Keq -> 0.000837, GK\[LetterSpace]g\[LetterSpace]GK\[LetterSpace]g\[LetterSpace]KmGly3P -> 3.83, GK\[LetterSpace]g\[LetterSpace]GK\[LetterSpace]g\[LetterSpace]KmADP -> 0.56, GK\[LetterSpace]g\[LetterSpace]GK\[LetterSpace]g\[LetterSpace]KmGly -> 0.44, GK\[LetterSpace]g\[LetterSpace]GK\[LetterSpace]g\[LetterSpace]KmATP -> 0.24, ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]Vmax -> 560.0, ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KmFru16BP -> 0.009, ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiATP -> 0.68, ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiADP -> 1.51, ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiAMP -> 3.65, ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]Keq -> 0.084, ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KmGA3P -> 0.067, ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KmDHAP -> 0.015, ALD\[LetterSpace]g\[LetterSpace]ALD\[LetterSpace]g\[LetterSpace]KiGA3P -> 0.098, GAPDH\[LetterSpace]g\[LetterSpace]GAPDH\[LetterSpace]g\[LetterSpace]Vmax -> 720.9, GAPDH\[LetterSpace]g\[LetterSpace]GAPDH\[LetterSpace]g\[LetterSpace]Keq -> 0.066, GAPDH\[LetterSpace]g\[LetterSpace]GAPDH\[LetterSpace]g\[LetterSpace]KmGA3P -> 0.15, GAPDH\[LetterSpace]g\[LetterSpace]GAPDH\[LetterSpace]g\[LetterSpace]KmNAD -> 0.45, GAPDH\[LetterSpace]g\[LetterSpace]GAPDH\[LetterSpace]g\[LetterSpace]Km13BPGA -> 0.1, GAPDH\[LetterSpace]g\[LetterSpace]GAPDH\[LetterSpace]g\[LetterSpace]KmNADH -> 0.02, GPO\[LetterSpace]c\[LetterSpace]GPO\[LetterSpace]c\[LetterSpace]Vmax -> 368.0, GPO\[LetterSpace]c\[LetterSpace]GPO\[LetterSpace]c\[LetterSpace]KmGly3P -> 1.7, cytosol -> 5.4549, default -> 1.0, glycosome -> 0.2451 }; assignments = { vAK[ADP_,AMP_,ATP_,k1_,k2_] -> ADP^2*k1 - AMP*ATP*k2, v2sub2prod\[LetterSpace]compinhib[Vfmax_,Keq_,S1_,Ks1_,S2_,Ks2_,P1_,Kp1_,P2_,Kp2_,I1_,Ki1_,I2_,Ki2_] -> (S1*(1 - (P1*P2)/(Keq*S1*S2))*S2*Vfmax)/(Ks1*Ks2*(1 + P1/Kp1 + S1/Ks1)*(1 + I1/Ki1 + I2/Ki2 + P2/Kp2 + S2/Ks2)), v1sub1prod[Vfmax_,Keq_,S_,Ks_,P_,Kp_] -> ((1 - P/(Keq*S))*S*Vfmax)/(Ks*(1 + P/Kp + S/Ks)), mass\[LetterSpace]action\[LetterSpace]irrev[k_,S_] -> k*S, v2sub2prod[Vfmax_,Keq_,S1_,Ks1_,S2_,Ks2_,P1_,Kp1_,P2_,Kp2_] -> (S1*(1 - (P1*P2)/(Keq*S1*S2))*S2*Vfmax)/(Ks1*Ks2*(1 + P1/Kp1 + S1/Ks1)*(1 + P2/Kp2 + S2/Ks2)), v1sub[Vfmax_,S_,Ks_] -> (S*Vfmax)/(Ks*(1 + S/Ks)), mass\[LetterSpace]action\[LetterSpace]rev[k1_,S_,k2_,P_] -> -(k2*P) + k1*S }; events = { }; speciesAnnotations = { }; reactionAnnotations = { }; units = { {"time" -> "", "metabolite" -> "", "extent" -> ""} }; (* Time evolution *) odes = { ADP\[LetterSpace]c'[t] == 1.0*HXK\[LetterSpace]c +1.0*ATPu\[LetterSpace]c -1.0*PYK\[LetterSpace]c -2.0*AK\[LetterSpace]c, ADP\[LetterSpace]g'[t] == 1.0*PFK\[LetterSpace]g +1.0*HXK\[LetterSpace]g -1.0*RK\[LetterSpace]g -2.0*AK\[LetterSpace]g -1.0*PGK\[LetterSpace]g -1.0*GK\[LetterSpace]g, AMP\[LetterSpace]c'[t] == 1.0*AK\[LetterSpace]c , AMP\[LetterSpace]g'[t] == 1.0*AK\[LetterSpace]g , ATP\[LetterSpace]c'[t] == 1.0*PYK\[LetterSpace]c +1.0*AK\[LetterSpace]c -1.0*HXK\[LetterSpace]c -1.0*ATPu\[LetterSpace]c, ATP\[LetterSpace]g'[t] == 1.0*RK\[LetterSpace]g +1.0*AK\[LetterSpace]g +1.0*PGK\[LetterSpace]g +1.0*GK\[LetterSpace]g -1.0*PFK\[LetterSpace]g -1.0*HXK\[LetterSpace]g, DHAP\[LetterSpace]c'[t] == 1.0*GPO\[LetterSpace]c -1.0*GDA\[LetterSpace]g, DHAP\[LetterSpace]g'[t] == 1.0*GDA\[LetterSpace]g +1.0*ALD\[LetterSpace]g -1.0*TPI\[LetterSpace]g -1.0*G3PDH\[LetterSpace]g, Fru16BP\[LetterSpace]g'[t] == 1.0*PFK\[LetterSpace]g -1.0*ALD\[LetterSpace]g, Fru6P\[LetterSpace]g'[t] == 1.0*PGI\[LetterSpace]g -1.0*PFK\[LetterSpace]g, GA3P\[LetterSpace]g'[t] == 1.0*TPI\[LetterSpace]g +1.0*ALD\[LetterSpace]g -1.0*GAPDH\[LetterSpace]g, Glc6P\[LetterSpace]c'[t] == 1.0*HXK\[LetterSpace]c -1.0*G6PDH\[LetterSpace]c -1.0*G6PP\[LetterSpace]c, Glc6P\[LetterSpace]g'[t] == 1.0*HXK\[LetterSpace]g -1.0*G6PDH\[LetterSpace]g -1.0*PGI\[LetterSpace]g, Glc\[LetterSpace]c'[t] == 1.0*G6PP\[LetterSpace]c +1.0*GlcT\[LetterSpace]c -1.0*HXK\[LetterSpace]c -1.0*GlcT\[LetterSpace]g, Glc\[LetterSpace]g'[t] == 1.0*GlcT\[LetterSpace]g -1.0*HXK\[LetterSpace]g, Gly3P\[LetterSpace]c'[t] == 1.0*GDA\[LetterSpace]g -1.0*GPO\[LetterSpace]c, Gly3P\[LetterSpace]g'[t] == 1.0*G3PDH\[LetterSpace]g -1.0*GDA\[LetterSpace]g -1.0*GK\[LetterSpace]g, NADH\[LetterSpace]g'[t] == 1.0*GAPDH\[LetterSpace]g -1.0*G3PDH\[LetterSpace]g, NADPH\[LetterSpace]c'[t] == 1.0*G6PDH\[LetterSpace]c +1.0*\[LetterSpace]6PGDH\[LetterSpace]c -1.0*NADPHu\[LetterSpace]c -1.0*TR\[LetterSpace]c, NADPH\[LetterSpace]g'[t] == 1.0*G6PDH\[LetterSpace]g +1.0*\[LetterSpace]6PGDH\[LetterSpace]g -1.0*NADPHu\[LetterSpace]g, NADP\[LetterSpace]c'[t] == 1.0*NADPHu\[LetterSpace]c +1.0*TR\[LetterSpace]c -1.0*G6PDH\[LetterSpace]c -1.0*\[LetterSpace]6PGDH\[LetterSpace]c, NADP\[LetterSpace]g'[t] == 1.0*NADPHu\[LetterSpace]g -1.0*G6PDH\[LetterSpace]g -1.0*\[LetterSpace]6PGDH\[LetterSpace]g, NAD\[LetterSpace]g'[t] == 1.0*G3PDH\[LetterSpace]g -1.0*GAPDH\[LetterSpace]g, PEP\[LetterSpace]c'[t] == 1.0*ENO\[LetterSpace]c -1.0*PYK\[LetterSpace]c, Pyr\[LetterSpace]c'[t] == 1.0*PYK\[LetterSpace]c -1.0*PyrT\[LetterSpace]c, Rib5P\[LetterSpace]g'[t] == 1.0*PPI\[LetterSpace]g -1.0*RK\[LetterSpace]g, Rul5P\[LetterSpace]c'[t] == 1.0*\[LetterSpace]6PGDH\[LetterSpace]c -1.0*PPI\[LetterSpace]c, Rul5P\[LetterSpace]g'[t] == 1.0*\[LetterSpace]6PGDH\[LetterSpace]g -1.0*PPI\[LetterSpace]g, TS2\[LetterSpace]c'[t] == 1.0*TOX\[LetterSpace]c -1.0*TR\[LetterSpace]c, TSH2\[LetterSpace]c'[t] == 1.0*TR\[LetterSpace]c -1.0*TOX\[LetterSpace]c, \[LetterSpace]13BPGA\[LetterSpace]g'[t] == 1.0*GAPDH\[LetterSpace]g -1.0*PGK\[LetterSpace]g, \[LetterSpace]2PGA\[LetterSpace]c'[t] == 1.0*PGAM\[LetterSpace]c -1.0*ENO\[LetterSpace]c, \[LetterSpace]3PGA\[LetterSpace]c'[t] == 1.0*\[LetterSpace]3PGAT\[LetterSpace]g -1.0*PGAM\[LetterSpace]c, \[LetterSpace]3PGA\[LetterSpace]g'[t] == 1.0*PGK\[LetterSpace]g -1.0*\[LetterSpace]3PGAT\[LetterSpace]g, \[LetterSpace]6PGL\[LetterSpace]c'[t] == 1.0*G6PDH\[LetterSpace]c -1.0*PGL\[LetterSpace]c, \[LetterSpace]6PGL\[LetterSpace]g'[t] == 1.0*G6PDH\[LetterSpace]g -1.0*PGL\[LetterSpace]g, \[LetterSpace]6PG\[LetterSpace]c'[t] == 1.0*PGL\[LetterSpace]c -1.0*\[LetterSpace]6PGDH\[LetterSpace]c, \[LetterSpace]6PG\[LetterSpace]g'[t] == 1.0*PGL\[LetterSpace]g -1.0*\[LetterSpace]6PGDH\[LetterSpace]g }; timeCourse = NDSolve[Join[odes, initialValues]//.rateEquations//.assignments//.parameters, variables, {t, 0, 100}]; (* Steady-state solution initialized with result of time evolution *) findRootEquations = odes /.D[_[t],t]->0; findRootVariables = Partition[Flatten[{#, #/.timeCourse/.t->100} &/@variables],2]; steadyStateVariables = FindRoot[findRootEquations//.rateEquations//.assignments//.parameters, findRootVariables, MaxIterations->100] fluxes = #//.assignments//.parameters/.steadyStateVariables&/@rateEquations (* Plot the time evolution of the variables *) plotTable=Table[Plot[variables[[i]]/.parameters/.timeCourse,{t,0,100},PlotLegends->variables[[i]],PlotRange->Full],{i,Length[variables]}]