#kallenberger3



#reactions
reaction_1:
 {1.0}FADD = {1.0}DISC
  kon_FADD * CD95act * FADD * cell
reaction_10:
 {1.0}DISCp55 = {1.0}p43
  kD374 * DISCp55 * cell
reaction_11:
 {1.0}DISCp55 = {1.0}p43
  kD374trans_p55 * DISCp55 * (DISCp55 + p30) * cell
reaction_12:
 {1.0}DISCp55 = {1.0}p43
  kD374trans_p43 * DISCp55 * p43 * cell
reaction_13:
 {1.0}p30 = {1.0}p18 + {1.0}DISC
  kD374 * p30 * cell
reaction_14:
 {1.0}p30 = {1.0}p18 + {1.0}DISC
  kD374trans_p55 * p30 * (DISCp55 + p30) * cell
reaction_15:
 {1.0}p30 = {1.0}p18 + {1.0}DISC
  kD374trans_p43 * p30 * p43 * cell
reaction_16:
 {1.0}p18 = {1.0}p18inactive
  kdiss_p18 * p18 * cell
reaction_17:
 {1.0}Bid = {1.0}tBid
  kBid * Bid * (p43 + p18) * cell
reaction_18:
 {1.0}PrNES_mCherry = {1.0}PrNES + {1.0}mCherry
  kD374probe * PrNES_mCherry * (p43 + p18) * cell
reaction_19:
 {1.0}PrER_mGFP = {1.0}PrER + {1.0}mGFP
  kD374probe * PrER_mGFP * p18 * cell
reaction_2:
 {1.0}DISC = {1.0}FADD
  koff_FADD * DISC * cell
reaction_3:
 {1.0}p55free + {1.0}DISC = {1.0}DISCp55
  kDISC * p55free * DISC * cell
reaction_4:
 {1.0}DISCp55 = {1.0}p30
  kD216 * DISCp55 * cell
reaction_5:
 {1.0}DISCp55 = {1.0}p30
  kD216trans_p55 * DISCp55 * (DISCp55 + p30) * cell
reaction_6:
 {1.0}DISCp55 = {1.0}p30
  kD216trans_p43 * DISCp55 * p43 * cell
reaction_7:
 {1.0}p43 = {1.0}p18 + {1.0}DISC
  kD216 * p43 * cell
reaction_8:
 {1.0}p43 = {1.0}p18 + {1.0}DISC
  kD216trans_p55 * p43 * (DISCp55 + p30) * cell
reaction_9:
 {1.0}p43 = {1.0}p18 + {1.0}DISC
  kD216trans_p43 * p43 * p43 * cell


#parameters
KDL = 30.0060394758199
KDR = 57.2050013008496
kBid = 0.00052134055139547
kD216 = 0.00639775937416746
kD216trans_p43 = 5.29906975294056e-05
kD216trans_p55 = 0.000223246421372882
kD374 = 0.000644612643975149
kD374probe = 0.00153710001025539
kD374trans_p43 = 0.00413530054938906
kD374trans_p55 = 0.000543518631342483
kDISC = 0.000364965874405544
kdiss_p18 = 0.064713651554491
koff_FADD = 0.00130854998177646
kon_FADD = 0.00108871858684363
cell = 1.0


#initial values
Bid = 236.0
CD95 = 116.0
CD95L = 16.6
DISC = 0.0
DISCp55 = 0.0
FADD = 93.0
PrER = 0.0
PrER_mGFP = 5178.0
PrNES = 0.0
PrNES_mCherry = 973.0
mCherry = 0.0
mGFP = 0.0
p18 = 0.0
p18inactive = 0.0
p30 = 0.0
p43 = 0.0
p55free = 155.0
tBid = 0.0


#assignment rules
!F CD95act = pow(CD95, 3.0) * pow(KDL, 2.0) * CD95L / ((CD95L + KDL) * (pow(CD95, 2.0) * pow(KDL, 2.0) + KDR * pow(CD95L, 2.0) + 2.0 * KDR * KDL * CD95L + KDR * pow(KDL, 2.0)))