#kallenberger2



#reactions
reaction_1:
 {1.0}FADD = {1.0}DISC
  kon_FADD * CD95act * FADD * cell
reaction_10:
 {1.0}p18 = {1.0}p18inactive
  kdiss_p18 * p18 * cell
reaction_11:
 {1.0}Bid = {1.0}tBid
  kBid * Bid * (p43 + p18) * cell
reaction_12:
 {1.0}PrNES_mCherry = {1.0}PrNES + {1.0}mCherry
  kD374probe * PrNES_mCherry * (p43 + p18) * cell
reaction_13:
 {1.0}PrER_mGFP = {1.0}PrER + {1.0}mGFP
  kD374probe * PrER_mGFP * p18 * cell
reaction_2:
 {1.0}DISC = {1.0}FADD
  koff_FADD * DISC * cell
reaction_3:
 {1.0}p55free + {1.0}DISC = {1.0}DISCp55
  kDISC * p55free * DISC * cell
reaction_4:
 {1.0}DISCp55 = {1.0}p30
  kD216 * DISCp55 * cell
reaction_5:
 {1.0}p43 = {1.0}p18 + {1.0}DISC
  kD216 * p43 * cell
reaction_6:
 {1.0}DISCp55 = {1.0}p43
  kD374trans_p55 * DISCp55 * (DISCp55 + p30) * cell
reaction_7:
 {1.0}DISCp55 = {1.0}p43
  kD374trans_p43 * DISCp55 * p43 * cell
reaction_8:
 {1.0}p30 = {1.0}p18 + {1.0}DISC
  kD374trans_p55 * p30 * (DISCp55 + p30) * cell
reaction_9:
 {1.0}p30 = {1.0}p18 + {1.0}DISC
  kD374trans_p43 * p30 * p43 * cell


#parameters
KDL = 15.421878766215
KDR = 8.98496674617627
kBid = 0.00052867403363568
kD216 = 0.0114186392006403
kD374probe = 0.00152252549827479
kD374trans_p43 = 0.00343995957326369
kD374trans_p55 = 0.000446994772958953
kDISC = 0.000491828591049766
kdiss_p18 = 0.0949914492651531
koff_FADD = 0.00566528253772301
kon_FADD = 0.000811711012144556
cell = 1.0


#initial values
Bid = 224.0
CD95 = 12.0
CD95L = 16.6
DISC = 0.0
DISCp55 = 0.0
FADD = 90.0
PrER = 0.0
PrER_mGFP = 3316.0
PrNES = 0.0
PrNES_mCherry = 1909.0
mCherry = 0.0
mGFP = 0.0
p18 = 0.0
p18inactive = 0.0
p30 = 0.0
p43 = 0.0
p55free = 127.0
tBid = 0.0


#assignment rules
!F CD95act = pow(CD95, 3.0) * pow(KDL, 2.0) * CD95L / ((CD95L + KDL) * (pow(CD95, 2.0) * pow(KDL, 2.0) + KDR * pow(CD95L, 2.0) + 2.0 * KDR * KDL * CD95L + KDR * pow(KDL, 2.0)))