begin name kallenberger2 end name begin reactions reaction1 {1.0}FADD = {1.0}DISC reaction10 {1.0}p18 = {1.0}p18inactive reaction11 {1.0}Bid = {1.0}tBid reaction12 {1.0}PrNESmCherry = {1.0}PrNES + {1.0}mCherry reaction13 {1.0}PrERmGFP = {1.0}PrER + {1.0}mGFP reaction2 {1.0}DISC = {1.0}FADD reaction3 {1.0}p55free + {1.0}DISC = {1.0}DISCp55 reaction4 {1.0}DISCp55 = {1.0}p30 reaction5 {1.0}p43 = {1.0}p18 + {1.0}DISC reaction6 {1.0}DISCp55 = {1.0}p43 reaction7 {1.0}DISCp55 = {1.0}p43 reaction8 {1.0}p30 = {1.0}p18 + {1.0}DISC reaction9 {1.0}p30 = {1.0}p18 + {1.0}DISC end reactions begin rate equations reaction1 = CD95act*cell*konFADD*FADD[t] reaction10 = cell*kdissp18*p18[t] reaction11 = cell*kBid*Bid[t]*(p18[t] + p43[t]) reaction12 = cell*kD374probe*(p18[t] + p43[t])*PrNESmCherry[t] reaction13 = cell*kD374probe*p18[t]*PrERmGFP[t] reaction2 = cell*koffFADD*DISC[t] reaction3 = cell*kDISC*DISC[t]*p55free[t] reaction4 = cell*kD216*DISCp55[t] reaction5 = cell*kD216*p43[t] reaction6 = cell*kD374transp55*DISCp55[t]*(DISCp55[t] + p30[t]) reaction7 = cell*kD374transp43*DISCp55[t]*p43[t] reaction8 = cell*kD374transp55*p30[t]*(DISCp55[t] + p30[t]) reaction9 = cell*kD374transp43*p30[t]*p43[t] end rate equations begin parameters KDL = 15.421878766215 KDR = 8.98496674617627 kBid = 0.00052867403363568 kD216 = 0.0114186392006403 kD374probe = 0.00152252549827479 kD374transp43 = 0.00343995957326369 kD374transp55 = 0.000446994772958953 kDISC = 0.000491828591049766 kdissp18 = 0.0949914492651531 koffFADD = 0.00566528253772301 konFADD = 0.000811711012144556 cell = 1.0 end parameters begin initial conditions Bid[0] = Bidi CD95[0] = CD95i CD95L[0] = CD95Li DISC[0] = DISCi DISCp55[0] = DISCp55i FADD[0] = FADDi PrER[0] = PrERi PrERmGFP[0] = PrERmGFPi PrNES[0] = PrNESi PrNESmCherry[0] = PrNESmCherryi mCherry[0] = mCherryi mGFP[0] = mGFPi p18[0] = p18i p18inactive[0] = p18inactivei p30[0] = p30i p43[0] = p43i p55free[0] = p55freei tBid[0] = tBidi end initial conditions begin initial values Bidi = 224.0 CD95i = 12.0 CD95Li = 16.6 DISCi = 0.0 DISCp55i = 0.0 FADDi = 90.0 PrERi = 0.0 PrERmGFPi = 3316.0 PrNESi = 0.0 PrNESmCherryi = 1909.0 mCherryi = 0.0 mGFPi = 0.0 p18i = 0.0 p18inactivei = 0.0 p30i = 0.0 p43i = 0.0 p55freei = 127.0 tBidi = 0.0 end initial values begin assignment rules CD95act := (KDL^2*CD95[t]^3*CD95L[t])/((KDL + CD95L[t])*(KDL^2*KDR + KDL^2*CD95[t]^2 + 2*KDL*KDR*CD95L[t] + KDR*CD95L[t]^2)) end assignment rules begin function definitions end function definitions begin events end events begin process annotations end process annotations begin species annotations end species annotations begin units end units