begin name
jullesson2
end name

begin reactions
v1 {1.0}IR = {1.0}IRp
v1m {1.0}IRp = {1.0}IR
v2 {1.0}IRS1 = {1.0}IRS1p
v2m {1.0}IRS1p = {1.0}IRS1
v3 {1.0}IRS1ser307 = {1.0}IRS1ser307p
v3m {1.0}IRS1ser307p = {1.0}IRS1ser307
v4 {1.0}mTOR = {1.0}mTORp
v4m {1.0}mTORp = {1.0}mTOR
v5 {1.0}S6K = {1.0}S6Kp
v5T {1.0}S6KDN + {1.0}mTORp = {1.0}mTORpS6KDN
v5m {1.0}S6Kp = {1.0}S6K
v6 {1.0}S6 = {1.0}S6p
v6m {1.0}S6p = {1.0}S6
v7 {1.0}IRi = {1.0}IR
v7m {1.0}IRp = {1.0}IRi
vM5T {1.0}mTORpS6KDN = {1.0}S6KDN + {1.0}mTORp
end reactions

begin rate equations
v1 = IRbasal*IR[t] + Ins*k1*IR[t]
v1m = k1m*IRp[t]
v2 = k2*IRp[t]*IRS1[t]
v2m = k2m*IRS1p[t]
v3 = k3*IRS1ser307[t]*S6Kp[t]
v3m = k3m*IRS1ser307p[t]
v4 = k4*IRS1p[t]*mTOR[t]
v4m = k4m*mTORp[t]
v5 = k5*mTORp[t]*S6K[t]
v5T = I*mTORp[t]*S6KDN[t]
v5m = k5m*S6Kp[t]
v6 = k6*S6[t]*S6Kp[t]
v6m = k6m*S6p[t]
v7 = k7*IRi[t]
v7m = k7m*IRp[t]
vM5T = k5tm*mTORpS6KDN[t]
end rate equations

begin parameters
I = 0.0006
IRbasal = 0.0635
Ins = 100.0
k1 = 6.0982
k1m = 366.2795
k2 = 0.4397
k2m = 0.5174
k3 = 20660.1506
k3m = 1.9552
k4 = 0.085
k4m = 0.082
k5 = 0.1965
k5m = 0.1968
k5tm = "1.7709e-05"
k6 = 35.9042
k6m = 0.0138
k7 = 0.1499
k7m = 97.5553
default = 1.0
end parameters

begin initial conditions
IR[0] = IRi
IRS1[0] = IRS1i
IRS1p[0] = IRS1pi
IRS1ser307[0] = IRS1ser307i
IRS1ser307p[0] = IRS1ser307pi
IRi[0] = IRii
IRp[0] = IRpi
S6[0] = S6i
S6K[0] = S6Ki
S6KDN[0] = S6KDNi
S6Kp[0] = S6Kpi
S6p[0] = S6pi
mTOR[0] = mTORi
mTORp[0] = mTORpi
mTORpS6KDN[0] = mTORpS6KDNi
end initial conditions

begin initial values
IRi = 0.9181
IRS1i = 0.9999
IRS1pi = 0.0001
IRS1ser307i = 0.5408
IRS1ser307pi = 0.4592
IRii = 0.0818
IRpi = 0.0001
S6i = 0.7765
S6Ki = 0.9999
S6KDNi = 99.7272
S6Kpi = 8.035e-05
S6pi = 0.2235
mTORi = 0.7271
mTORpi = 8.045e-05
mTORpS6KDNi = 0.2728
end initial values

begin assignment rules
fig3bS6p := 140.688371115354*S6p[t]
fig6dS6p := 5.0036269004157*S6p[t]
fig6eIRS1p := 83773.99869569197*(-0.000106747023438893 + IRS1p[t])
fig3bIRS1ser307p := 110.795803138294*IRS1ser307p[t]
fig6bS6Kp := 4455.78636783405*S6Kp[t]
fig6cIRS1ser307p := 2.60412436101051*IRS1ser307p[t]
fig6gIRS1ser307p := 283.31617806680646*(-0.538627018751669 + IRS1ser307p[t])
fig6fS6p := 223.46246244978784*(-0.000106747023438893 + S6p[t])
fig6aIRS1p := 28765.5323430673*IRS1p[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units