#jullesson1



#reactions
v1:
 {1.0}IR = {1.0}IRp
  IRbasal * IR + IR * Ins * k1
v1m:
 {1.0}IRp = {1.0}IR
  IRp * k1m
v2:
 {1.0}IRS1 = {1.0}IRS1p
  IRS1 * IRp * k2
v2m:
 {1.0}IRS1p = {1.0}IRS1
  IRS1p * k2m
v3:
 {1.0}IRS1ser307 = {1.0}IRS1ser307p
  IRS1ser307 * k3 * S6Kp
v3m:
 {1.0}IRS1ser307p = {1.0}IRS1ser307
  IRS1ser307p * k3m
v4:
 {1.0}mTOR = {1.0}mTORp
  k4 * IRS1p * mTOR
v4m:
 {1.0}mTORp = {1.0}mTOR
  mTORp * k4m
v5:
 {1.0}S6K = {1.0}S6Kp
  S6K * mTORp * k5
v5T:
 {1.0}mTORp + {1.0}S6KDN = {1.0}mTORpS6KDN
  S6KDN * mTORp * I
v5m:
 {1.0}S6Kp = {1.0}S6K
  S6Kp * k5m
v6:
 {1.0}S6 = {1.0}S6p
  S6 * k6 * S6Kp
v6m:
 {1.0}S6p = {1.0}S6
  S6p * k6m
v7:
 {1.0}IRi = {1.0}IR
  IRi * k7
v7m:
 {1.0}IRp = {1.0}IRi
  IRp * k7m
vM5T:
 {1.0}mTORpS6KDN = {1.0}mTORp + {1.0}S6KDN
  mTORpS6KDN * k5tm


#parameters
I = 0.0006
IRbasal = 0.0635
Ins = 100.0
k1 = 6.0982
k1m = 366.2795
k2 = 0.4397
k2m = 0.5174
k3 = 20660.1506
k3m = 1.9552
k4 = 0.085
k4m = 0.082
k5 = 0.1965
k5m = 0.1968
k5tm = 1.7709
k6 = 35.9042
k6m = 0.0138
k7 = 0.1499
k7m = 97.5553
default = 1.0


#initial values
IR = 0.9181
IRS1 = 0.9999
IRS1p = 0.0001
IRS1ser307 = 0.4614
IRS1ser307p = 0.5386
IRi = 0.0818
IRp = 0.0001
S6 = 0.7765
S6K = 0.9999
S6KDN = 0.0
S6Kp = 0.0001
S6p = 0.2235
mTOR = 0.9999
mTORp = 0.0001
mTORpS6KDN = 0.0


#assignment rules
!F fig6c_IRS1ser307p = IRS1ser307p * 2.60412436101051
!F fig6g_IRS1ser307p = (IRS1ser307p - 0.538627018751669) / 0.352962547646749 * 100
!F fig6f_S6p = (S6p - 0.000106747023438893) / 0.447502452553838 * 100
!F fig6e_IRS1p = (IRS1p - 0.000106747023438893) / 0.00119368779760948 * 100
!F fig6d_S6p = S6p * 5.0036269004157
!F fig6a_IRS1p = IRS1p * 28765.5323430673
!F fig3b_S6p = S6p * 140.688371115354
!F fig3b_IRS1ser307p = IRS1ser307p * 110.795803138294
!F fig6b_S6Kp = S6Kp * 4455.78636783405