#jiang1



#reactions
GAPflow:
 {1.0}GAP = $pool
  CYTOPLASM * GAP * flow
GLCflow:
 $pool = {1.0}GLC
  CYTOPLASM * (Glc_F * pow(10, -3) - GLC) * flow
LACflow:
 {1.0}LAC = $pool
  CYTOPLASM * LAC * flow
hidden_1:
 {1.0}AMP + {1.0}ATP_cyt = {2.0}ADP_cyt
  CYTOPLASM * (k9f * AMP * ATP_cyt - k9b * pow(ADP_cyt, 2))
v1:
 {1.0}GLC + {1.0}ATP_cyt = {1.0}F6P + {1.0}ADP_cyt
  CYTOPLASM * (V1 * ATP_cyt * GLC / ((K1GLC + GLC) * (K1ATP + ATP_cyt)))
v10:
 {1.0}OXA + {1.0}Acetyl_CoA = {1.0}Cit + {1.0}CoA
  MATRIX * (V * Acetyl_CoA * OXA * v10_CS / (Acetyl_CoA * OXA + Ka * OXA + Kb * Acetyl_CoA + Kia * Kib))
v11:
 {1.0}Cit = {1.0}IsoCit
  MATRIX * ((KcF * Kp * Cit - KcR * Ks * IsoCit) * v11_ACO / (Ks * IsoCit + Kp * Cit + Ks * Kp))
v12:
 {1.0}IsoCit + {1.0}NAD_p = {1.0}OG + {1.0}NADH
  MATRIX * (KcF * v12_IDHa * (IsoCit * IsoCit + b * ADP * IsoCit) / (IsoCit * IsoCit + c * IsoCit + d * ADP + e * ADP * IsoCit + f))
v14:
 {1.0}OG + {1.0}CoA + {1.0}NAD_p = {1.0}CO2 + {1.0}SCoA + {1.0}NADH
  MATRIX * (KcF * v14_OGDC * OG * CoA * NAD_p / (KmC * OG * CoA + KmB * OG * NAD_p + KmA * CoA * NAD_p + OG * CoA * NAD_p + KmA * KmP * Kib * Kic / KmR / Kip / Kiq * SCoA * NADH + KmC / Kir * OG * CoA * NADH + KmB / Kiq * OG * NAD_p * SCoA + KmA * KmP * Kib * Kic / KmR / Kip / Kia / Kiq * OG * SCoA * NADH))
v15:
 {1.0}GDP + {1.0}SCoA + {1.0}Pi = {1.0}Suc + {1.0}GTP + {1.0}CoA
  MATRIX * ((GDP * SCoA * pi - Suc * GTP * CoA / Keq) * (Kc1 * v15_SCS + Kc2 * v15_SCS * (KmC * Suc / KmC2 * Kip + pi / KmC2)) / (Kia * KmB * pi + KmB * GDP * pi + KmA * SCoA * pi + KmC * GDP * SCoA + GDP * SCoA * pi + GDP * SCoA * pi * pi / KmC2 + Kia * KmB * KmC * Suc / Kip + Kia * KmB * KmC * Suc * GTP / Kip / Kiq + Kia * KmB * KmC * Suc * CoA / Kip / Kir + Kia * KmB * Kic * GTP * CoA / KmQ / Kir + Kia * KmB * KmC * Suc * GTP * CoA / Kip / KmQ / Kir + Kia * KmB * KmC * Suc * Suc * GTP * CoA / Kip / KmP2 / KmQ / Kir + Kia * KmB * pi * GTP / Kiq + Kia * KmB * pi * CoA / Kir + Kia * KmB * pi * GTP * CoA / KmQ / Kir + Kia * KmB * pi * Suc * GTP * CoA / KmP2 / KmQ / Kir + KmB * KmC * GDP * Suc / Kip + KmA * KmC * SCoA * Suc / Kip + KmC * GDP * SCoA * Suc / Kip + KmC * GDP * SCoA * pi * Suc / KmC2 / Kip + KmA * SCoA * pi * GTP / Kiq + KmB * GDP * pi * CoA / Kir + KmA * KmC * SCoA * Suc * GTP / Kip / Kiq + KmB * KmC * GDP * Suc * CoA / Kip / Kir))
v16:
 {1.0}Suc + {1.0}Q = {1.0}Fum + {1.0}QH2
  MATRIX * (KcF * KcR * v16_SDH * (Suc * Q - Fum * QH2 / Keq) / (KcR * KmS2 * Suc + KcR * KmS1 * Q + KcF * KmP2 * Fum / Keq + KcF * KmP1 * QH2 / Keq + KcR * Suc * Q + KcF * KmP2 * Suc * Fum / (Keq * KiS1) + KcF * Fum * QH2 / Keq + KcR * KmS1 * Q * QH2 / KiP2))
v17:
 {1.0}Fum = {1.0}Mal
  MATRIX * ((KcF * Kp * Fum - KcR * Ks * Mal) * v17_FM / (Ks * Mal + Kp * Fum + Ks * Kp))
v18:
 {1.0}Mal + {1.0}NAD_p = {1.0}NADH + {1.0}OXA
  MATRIX * ((KcF * Mal * NAD_p / KiS1 / KmS2 - KcR * OXA * NADH / KmP1 / KiP2) * v18_MDH / (1 + Mal / KiS1 + KmS1 * NAD_p / KiS1 / KmS2 + KmP2 * OXA / KmP1 / KiP2 + NADH / KiP2 + Mal * NAD_p / KiS1 / KmS2 + KmP2 * Mal * OXA / KiS1 / KmP1 / KiP2 + KmS1 * NAD_p * NADH / KiS1 / KmS2 / KiP2 + OXA * NADH / KmP1 * KiP2 + Mal * NAD_p * OXA / KiS1 / KmS2 / KiP1 + NAD_p * OXA * NADH / KiS2 / KmP1 / KiP2))
v2:
 {1.0}F6P + {1.0}ATP_cyt = {1.0}FBP + {1.0}ADP_cyt
  CYTOPLASM * (V2 * ATP_cyt * pow(F6P, 2) / ((K2 * (1 + k2 * pow(ATP_cyt / AMP, 2)) + pow(F6P, 2)) * (K2ATP + ATP_cyt)))
v20:
 {1.0}Ala + {1.0}OG = {1.0}Glu + {1.0}Pyr
  MATRIX * (KcF * KcR * v20_AlaTA * (Ala * OG - Glu * Pyr / Keq) / (KcR * KmS2 * Ala + KcR * KmS1 * OG + KcF * KmP2 * Glu / Keq + KcF * KmP1 * Pyr / Keq + KcR * Ala * OG + KcF * KmP2 * Ala * Glu / (Keq * KiS1) + KcF * Glu * Pyr / Keq + KcR * KmS1 * OG * Pyr / KiP2))
v21:
 {1.0}OXA + {1.0}Glu = {1.0}Asp + {1.0}OG
  MATRIX * (KcF * KcR * v21_AspTA * (OXA * Glu - Asp * OG / Keq) / (KcR * KmS2 * OXA + KcR * KmS1 * Glu + KcF * KmP2 * Asp / Keq + KcF * KmP1 * OG / Keq + KcR * OXA * Glu + KcF * KmP2 * OXA * Asp / (Keq * KiS1) + KcF * Asp * OG / Keq + KcR * KmS1 * Glu * OG / KiP2))
v22:
 {1.0}Glu_cyt + {1.0}Asp = {1.0}Asp_cyt + {1.0}Glu
  MATRIX * ((Asp * Glu_cyt / alpha / KiS1 / KiS2 * KcF - Glu * Asp_cyt / beta / KiP1 / KiP2 * KcR) * v22_AGC / (1 + Asp / KiS1 + Glu_cyt / KiS2 + Glu / KiP1 + Asp_cyt / KiP2 + Asp * Glu_cyt / alpha / KiS1 / KiS2 + Glu * Asp_cyt / beta / KiP1 / KiP2 + Glu_cyt * Asp_cyt / gamma / KiS2 / KiP2 + Asp * Glu / delta / KiS1 / KiP1))
v24:
 {1.0}NADH + {1.0}Q = {1.0}NAD_p + {1.0}QH2
  MATRIX * (KcF * KcR * v24_Complex_I * (NADH * Q - NAD_p * QH2 / Keq) / (KcR * KmS2 * NADH + KcR * KmS1 * Q + KcF * KmP2 * NAD_p / Keq + KcF * KmP1 * QH2 / Keq + KcR * NADH * Q + KcF * KmP2 * NADH * NAD_p / (Keq * KiS1) + KcF * NAD_p * QH2 / Keq + KcR * KmS1 * Q * QH2 / KiP2))
v25:
 {1.0}QH2 + {2.0}Cytc3p = {1.0}Q + {2.0}Cytc2p
  MT_IMS * (KcF * v25_Complex_III * QH2 * Cytc3p / ((KmA * Kq2 * Kb2 + KmA * Kq2 * Cytc3p + KcF / k8 * Kq1 * QH2 * Kb1 + KcF / k8 * Kq1 * QH2 * Cytc3p) * Cytc2p + KmA * Cytc3p + KmB * QH2 + QH2 * Cytc3p))
v26:
 {1.0}Cytc2p = {1.0}Cytc3p
  MT_IMS * (KcF * v26_Complex_IV * Cytc2p / (Ks + Cytc2p))
v27:
 {1.0}Cit_cyt + {1.0}CoA_cyt = {1.0}OXA_cyt + {1.0}Acetyl_CoA_cyt
  CYTOPLASM * Kid * Kc * (V * Acetyl_CoA_cyt * OXA_cyt * v10_CS / (Acetyl_CoA_cyt * OXA_cyt + Ka * OXA_cyt + Kb * Acetyl_CoA_cyt + Kia * Kib)) / (Keq * Kia * Kb)
v28:
 {1.0}ADP + {1.0}Pi = {1.0}ATP + {1.0}H2O
  MATRIX * v28_Complex_V * V * ADP / (Km + ADP + ADP * ADP / Ki)
v29:
 {1.0}Cit_cyt = {1.0}IsoCitcyt
  CYTOPLASM * ((KcF * Kp * Cit_cyt - KcR * Ks * IsoCitcyt) * v29_ACO / (Ks * IsoCitcyt + Kp * Cit_cyt + Ks * Kp))
v3:
 {1.0}FBP = {2.0}GAP
  CYTOPLASM * (k3f * FBP - k3b * pow(GAP, 2))
v30:
 {1.0}Mal_cyt + {1.0}OG = {1.0}OG_cyt + {1.0}Mal
  MATRIX * ((OG * Mal_cyt / alpha / KiS1 / KiS2 * KcF - Mal * OG_cyt / beta / KiP1 / KiP2 * KcR) * v30_OGC / (1 + OG / KiS1 + Mal_cyt / KiS2 + Mal / KiP1 + OG_cyt / KiP2 + OG * Mal_cyt / alpha / KiS1 / KiS2 + Mal * OG_cyt / beta / KiP1 / KiP2 + Mal_cyt * OG_cyt / gamma / KiS2 / KiP2 + OG * Mal / delta / KiS1 / KiP1))
v31:
 {1.0}NADH_cyt + {1.0}OXA_cyt = {1.0}Mal_cyt + {1.0}NAD
  CYTOPLASM * (v31_MDH * (k1 * k2 * k3 * k4 * NADH_cyt * OXA_cyt - kminus1 * kminus2 * kminus3 * kminus4 * Mal_cyt * NAD) / (kminus1 * (kminus2 + k3) * k4 + k1 * (kminus2 + k3) * k4 * NADH_cyt + kminus1 * (kminus2 + k3) * kminus4 * NAD + k2 * k3 * k4 * OXA_cyt + kminus1 * kminus2 * kminus3 * Mal_cyt + k1 * k2 * (k3 + k4) * NADH_cyt * OXA_cyt + (kminus1 + kminus2) * kminus3 * kminus4 * Mal_cyt * NAD + k1 + kminus2 + kminus3 * NADH_cyt * Mal_cyt + k1 * k2 * kminus3 * NADH_cyt * OXA_cyt * Mal_cyt + k2 * k3 * kminus4 * OXA_cyt * NAD + k2 * kminus3 * kminus4 * OXA_cyt * Mal_cyt * NAD))
v32:
 {1.0}Asp_cyt + {1.0}OG_cyt = {1.0}OXA_cyt + {1.0}Glu_cyt
  CYTOPLASM * (KcF * KcR * v32_AspTA * (Asp_cyt * OG_cyt - OXA_cyt * Glu_cyt / Keq) / (KcR * KmS2 * Asp_cyt + KcR * KmS1 * OG_cyt + KcF * KmP2 * OXA_cyt / Keq + KcF * KmP1 * Glu_cyt / Keq + KcR * Asp_cyt * OG_cyt + KcF * KmP2 * Asp_cyt * OXA_cyt / (Keq * KiS1) + KcF * OXA_cyt * Glu_cyt / Keq + KcR * KmS1 * OG_cyt * Glu_cyt / KiP2))
v33:
 {1.0}Cit_cyt + {1.0}Mal = {1.0}Mal_cyt + {1.0}Cit
  MATRIX * ((Cit_cyt * Mal / alpha / KiS1 / KiS2 * KcF - Mal_cyt * Cit / beta / KiP1 / KiP2 * KcR) * v33_CIC / (1 + Cit_cyt / KiS1 + Mal / KiS2 + Mal_cyt / KiP1 + Cit / KiP2 + Cit_cyt * Mal / alpha / KiS1 / KiS2 + Mal_cyt * Cit / beta / KiP1 / KiP2 + Mal * Cit / gamma / KiS2 / KiP2 + Cit_cyt * Mal_cyt / delta / KiS1 / KiP1))
v34:
 {1.0}ETFred + {1.0}Q = {1.0}ETFox + {1.0}QH2
  MATRIX * (KcF * KcR * v34_ETF_QO * (ETFred * Q - ETFox * QH2 / Keq) / (KcR * KmS2 * ETFred + KcR * KmS1 * Q + KcF * KmP2 * ETFox / Keq + KcF * KmP1 * QH2 / Keq + KcR * ETFred * Q + KcF * KmP2 * ETFred * ETFox / (Keq * KiS1) + KcF * ETFox * QH2 / Keq + KcR * KmS1 * Q * QH2 / KiP2))
v35:
 {1.0}FADH2 + {1.0}ETFox = {1.0}ETFred + {1.0}FAD
  MATRIX * (KcF * KcR * v35_ACD * (FADH2 * ETFox - ETFred * FAD / Keq) / (KcR * KiS1 * KmS2 + KcR * KmS2 * FADH2 + KcR * KmS1 * ETFox + KcF * KmP2 * ETFred / Keq + KcF * KmP1 * FAD / Keq + KcR * FADH2 * ETFox + KcF * KmP2 * FADH2 * ETFred / (Keq * KiS1) + KcF * ETFred * FAD / Keq + KcR * KmS1 * ETFox * FAD / KiP2 + KcR * FADH2 * ETFox * ETFred / KiP1 + KcF * ETFox * ETFred * FAD / (KiS2 * Keq)))
v36:
 {1.0}ATP + {1.0}CO2 + {1.0}Pyr = {1.0}Pi + {1.0}ADP + {1.0}OXA
  MATRIX * (KcF * KcR * v36_PC * (ATP * CO2 * Pyr - pi * ADP * OXA / Keq) / (Kia * KmB * KcR * Pyr + KmC * KcR * ATP * CO2 + KmA * KcR * CO2 * Pyr + KmB * KcR * ATP * Pyr + KcR * ATP * CO2 * Pyr + Kip * KmQ * KcF * OXA / Keq + KmQ * KcF * pi * OXA / Keq + KmP * KcF * ADP * OXA / Keq + KmR * KcF * pi * ADP / Keq + KcF * pi * ADP * OXA / Keq + Kia * KmB * KcR * Pyr * pi / Kip + Kia * KmB * KcR * Pyr * ADP / Kia + Kiq * KmP * KcF * CO2 * OXA / Kib / Keq + Kia * KmP * KcF * ATP * OXA / Kia / Keq + KmA * KcR * ATP * CO2 * OXA / Kir + KmR * KcF * Pyr * pi * ADP / Kic / Keq + KmA * KcR * CO2 * Pyr * ADP / Kiq + KmA * KcR * CO2 * Pyr * pi / Kip + KmP * KcF * CO2 * ADP * OXA / Kib / Keq + KmQ * KcF * CO2 * pi * OXA / Kib / Keq))
v37:
 {1.0}G3P + {1.0}FAD = {1.0}FADH2 + {1.0}DHAP
  CYTOPLASM * (V * v37_GUT2P * G3P / (K + G3P))
v38:
 {1.0}NADH_cyt + {1.0}DHAP = {1.0}G3P + {1.0}NAD
  CYTOPLASM * (V * v38_GUT2P * NADH_cyt / (K + NADH_cyt))
v39:
 {1.0}Mal_cyt + {1.0}NADP_cyt = {1.0}NADPH_cyt + {1.0}PYR_cyt
  CYTOPLASM * (v39_MDH * Kcat * Mal_cyt * NADP_cyt / ((Kmal + Mal_cyt) * (Knadp + NADP_cyt)))
v4:
 {1.0}GAP + {1.0}NAD = {1.0}DPG + {1.0}NADH_cyt
  CYTOPLASM * (V4 * NAD * GAP / ((K4GAP + GAP) * (K4NAD + NAD)))
v40:
 {1.0}ADP_cyt = {1.0}ADP
  MATRIX * (V * v40_AAC * ADP_cyt / (K + ADP_cyt))
v41:
 {1.0}IsoCitcyt + {1.0}NADP_cyt = {1.0}OG_cyt + {1.0}NADPH_cyt
  CYTOPLASM * v41_IDHc * (IsoCitcyt * NADP_cyt / (phi0 * IsoCitcyt * NADP_cyt + phi1 * NADP_cyt + phi2 * IsoCitcyt + phi12) - OG_cyt * NADPH_cyt * CO2 / (phir0 * OG_cyt * NADPH_cyt * CO2 + phir1 * NADPH_cyt * CO2 + phir2 * OG_cyt * CO2 + phir3 * OG_cyt * NADPH_cyt + phir12 * CO2 + phir13 * NADPH_cyt + phir23 * OG_cyt + phir123))
v42:
 {1.0}IsoCitcyt + {1.0}Mal = {1.0}Mal_cyt + {1.0}IsoCit
  MATRIX * ((IsoCitcyt * Mal / alpha / KiS1 / KiS2 * KcF - Mal_cyt * IsoCit / beta / KiP1 / KiP2 * KcR) * v42_CIC / (1 + IsoCitcyt / KiS1 + Mal / KiS2 + Mal_cyt / KiP1 + IsoCit / KiP2 + IsoCitcyt * Mal / alpha / KiS1 / KiS2 + Mal_cyt * IsoCit / beta / KiP1 / KiP2 + Mal * IsoCit / gamma / KiS2 / KiP2 + IsoCitcyt * Mal_cyt / delta / KiS1 / KiP1))
v43:
 {1.0}ATP = {1.0}ATP_cyt
  MATRIX * (V * v43_AAC * ATP / (K + ATP))
v44:
 {1.0}Mal + {1.0}NADP_p = {1.0}NADPH + {1.0}Pyr
  MATRIX * (v44_MDH * Kcat * Mal / (Km + Mal))
v5:
 {1.0}DPG + {1.0}ADP_cyt = {1.0}PEP + {1.0}ATP_cyt
  CYTOPLASM * (k5f * DPG * ADP_cyt - k5b * PEP * ATP_cyt)
v6:
 {1.0}PEP + {1.0}ADP_cyt = {1.0}PYR_cyt + {1.0}ATP_cyt
  CYTOPLASM * (V6 * ADP_cyt * PEP / ((K6PEP + PEP) * (K6ADP + ADP_cyt)))
v7:
 {1.0}PYR_cyt + {1.0}NADH_cyt = {1.0}LAC + {1.0}NAD
  CYTOPLASM * (k8f * NADH_cyt * PYR_cyt - k8b * NAD * LAC)
v8:
 {1.0}PYR_cyt = {1.0}Pyr
  MATRIX * (V * PYR_cyt * v8_PYC / (K + PYR_cyt))
v9:
 {1.0}Pyr + {1.0}CoA + {1.0}NAD_p = {1.0}CO2 + {1.0}Acetyl_CoA + {1.0}NADH
  MATRIX * (KcF * v9_PDC * Pyr * CoA * NAD_p / (KmC * Pyr * CoA + KmB * Pyr * NAD_p + KmA * CoA * NAD_p + Pyr * CoA * NAD_p + KmA * KmP * Kib * Kic / KmR / Kip / Kiq * Acetyl_CoA * NADH + KmC / Kir * Pyr * CoA * NADH + KmB / Kiq * Pyr * NAD_p * Acetyl_CoA + KmA * KmP * Kib * Kic / KmR / Kip / Kia / Kiq * Pyr * Acetyl_CoA * NADH))


#parameters
flow = 0.011
v24_KmS1 = 9.2e-06
GLCflow_Glc_F = 64.941
v1_V1 = 0.0005
v1_K1GLC = 0.0001
v1_K1ATP = 6.3e-05
v2_V2 = 0.0015
v2_K2 = 1.6e-09
v2_k2 = 0.017
v2_K2ATP = 1e-05
v3_k3f = 1.0
v3_k3b = 0.05
v4_V4 = 0.01
v4_K4GAP = 0.001
v4_K4NAD = 0.001
v5_k5f = 1000.0
v5_k5b = 500.0
v6_V6 = 0.01
v6_K6PEP = 0.0002
v6_K6ADP = 0.0003
v7_k8f = 1000.0
v7_k8b = 0.143
hidden_1_k9f = 10000.0
hidden_1_k9b = 10000.0
v8_V = 1e-08
v8_K = 1.5e-07
v8_v8_PYC = 0.00033211
v9_KmA = 2.5e-05
v9_KmB = 1.3e-05
v9_KmC = 5e-05
v9_KmP = 5.9e-07
v9_KmR = 6.9e-07
v9_Kia = 0.00055
v9_Kib = 0.0003
v9_Kic = 0.00018
v9_Kip = 6e-05
v9_Kiq = 3.5e-05
v9_Kir = 3.6e-05
v9_KcF = 856.0
v9_v9_PDC = 3.8617e-07
v10_V = 0.005267
v10_Ka = 1.18e-05
v10_Kb = 4.8e-06
v10_Kia = 1e-05
v10_Kib = 4e-06
v10_v10_CS = 3.8617e-07
v11_Ks = 0.0005
v11_Kp = 0.00011
v11_KcF = 20.47
v11_KcR = 31.44
v11_v11_ACO = 3.8617e-07
v12_KcF = 105.0
v12_b = 29.6
v12_c = 0.00023
v12_d = 7.8e-05
v12_e = 0.00064
v12_f = 0.00036
v12_v12_IDHa = 3.8617e-07
v14_KmA = 0.00022
v14_KmB = 2.5e-05
v14_KmC = 5e-05
v14_KmP = 0.0003
v14_KmR = 0.0006
v14_Kia = 0.00072
v14_Kib = 0.00074
v14_Kic = 0.0001
v14_Kip = 1.1e-06
v14_Kiq = 8.1e-05
v14_Kir = 2.5e-05
v14_KcF = 177.0
v14_v14_OGDC = 3.8617e-07
v15_KmA = 5e-06
v15_KmB = 3.5e-05
v15_KmC = 0.00045
v15_KmP = 0.0006
v15_KmQ = 7.5e-06
v15_KmC2 = 0.00045
v15_KmP2 = 0.0006
v15_Keq = 8.375
v15_Kia = 0.0004
v15_Kib = 2e-05
v15_Kic = 3e-05
v15_Kip = 0.07
v15_Kiq = 5e-06
v15_Kir = 6.7e-06
v15_Kc1 = 100.0
v15_Kc2 = 100.0
v15_v15_SCS = 3.8617e-07
v16_KmS1 = 3e-05
v16_KmS2 = 6.9e-05
v16_KmP1 = 3e-07
v16_KmP2 = 1.5e-06
v16_KiS1 = 4.1e-06
v16_KiP2 = 5.6e-06
v16_Keq = 0.037
v16_KcF = 69.3
v16_KcR = 1.73
v16_v16_SDH = 9.9211e-05
v17_Kp = 2.5e-05
v17_Ks = 5e-06
v17_KcF = 800.0
v17_KcR = 900.0
v17_v17_FM = 3.8617e-07
v18_KmS1 = 7.2e-05
v18_KmS2 = 0.00011
v18_KmP1 = 0.0016
v18_KmP2 = 0.00017
v18_KiS1 = 1.1e-05
v18_KiS2 = 0.0001
v18_KiP1 = 0.0071
v18_KiP2 = 0.0019
v18_KcF = 0.39
v18_KcR = 0.04
v18_v18_MDH = 3.8617e-07
v20_KmS1 = 0.002
v20_KmS2 = 0.0004
v20_KmP1 = 0.032
v20_KmP2 = 0.0004
v20_KiS1 = 0.0087
v20_KiP2 = 0.012
v20_Keq = 0.69
v20_KcF = 337.0
v20_KcR = 0.15
v20_v20_AlaTA = 3.8617e-07
v21_KmS1 = 0.0009
v21_KmS2 = 0.0001
v21_KmP1 = 4e-05
v21_KmP2 = 0.004
v21_KiS1 = 0.002
v21_KiP2 = 0.0083
v21_Keq = 6.2
v21_KcF = 300.0
v21_KcR = 1000.0
v21_v21_AspTA = 3.8617e-07
v22_KiS1 = 8e-05
v22_KiS2 = 0.0032
v22_KiP1 = 0.00018
v22_KiP2 = 0.0028
v22_KcF = 10.0
v22_KcR = 10.0
v22_alpha = 1.0
v22_beta = 1.0
v22_gamma = 1.0
v22_delta = 1.0
v22_v22_AGC = 0.00033211
v24_KmS2 = 0.00026
v24_KmP1 = 9.9e-06
v24_KmP2 = 5.9e-05
v24_KiS1 = 2.1e-08
v24_KiP2 = 9.8e-08
v24_Keq = 407.9
v24_KcF = 498.0
v24_KcR = 229.0
v24_v24_Complex_I = 0.00033211
v25_KmA = 2.8e-05
v25_KmB = 3e-06
v25_Kb1 = 5.4e-06
v25_Kb2 = 5.7e-06
v25_Kq1 = 2.8e-06
v25_Kq2 = 1.9e-06
v25_k8 = 622.1
v25_KcF = 426.8
v25_v25_Complex_III = 9.963e-09
v26_Ks = 0.00011
v26_KcF = 0.000935
v26_v26_Complex_IV = 0.002325
v27_V = 0.004833
v27_Ka = 5e-06
v27_Kb = 4.5e-06
v27_Kc = 3.9e-05
v27_Kia = 5e-06
v27_Kib = 4.5e-06
v27_Kid = 0.0043
v27_Keq = 18000000.0
v27_v10_CS = 3.8617e-07
v28_V = 0.075
v28_Km = 0.0045
v28_Ki = 0.047
v28_v28_Complex_V = 0.0033211
v29_Ks = 0.0005
v29_Kp = 0.00011
v29_KcF = 20.47
v29_KcR = 31.44
v29_v29_ACO = 3.8617e-07
v30_KiS1 = 0.0003
v30_KiS2 = 0.0007
v30_KiP1 = 0.0014
v30_KiP2 = 0.00017
v30_KcF = 3.675
v30_KcR = 4.83
v30_alpha = 1.0
v30_beta = 1.0
v30_gamma = 1.0
v30_delta = 1.0
v30_v30_OGC = 0.00033211
v31_k1 = 34000000.0
v31_k2 = 35000000.0
v31_k3 = 4650.0
v31_k4 = 214.0
v31_kminus1 = 26.0
v31_kminus2 = 1400.0
v31_kminus3 = 570000.0
v31_kminus4 = 260000.0
v31_v31_MDH = 3.8617e-07
v32_KmS1 = 0.0009
v32_KmS2 = 0.0001
v32_KmP1 = 4e-05
v32_KmP2 = 0.004
v32_KiS1 = 0.002
v32_KiP2 = 0.0083
v32_Keq = 6.2
v32_KcF = 300.0
v32_KcR = 1000.0
v32_v32_AspTA = 3.8617e-07
v33_KiS1 = 0.00013
v33_KiS2 = 0.00044
v33_KiP1 = 0.00033
v33_KiP2 = 4.18e-05
v33_KcF = 5.6
v33_KcR = 3.5
v33_alpha = 1.0
v33_beta = 1.0
v33_gamma = 1.0
v33_delta = 1.0
v33_v33_CIC = 0.00033211
v34_KmS1 = 3.1e-07
v34_KmS2 = 3.9e-07
v34_KmP1 = 3.2e-07
v34_KmP2 = 4.2e-09
v34_KiS1 = 3.1e-07
v34_KiP2 = 3e-07
v34_Keq = 0.66
v34_KcF = 78.0
v34_KcR = 101.0
v34_v34_ETF_QO = 3.3211e-05
v35_KmS1 = 3.9e-05
v35_KmS2 = 1.2e-07
v35_KmP1 = 1.08e-06
v35_KmP2 = 2.42e-05
v35_KiS1 = 7.6e-05
v35_KiS2 = 2.4e-07
v35_KiP1 = 7.53e-05
v35_KiP2 = 1.19e-05
v35_Keq = 8.99
v35_KcF = 2.18
v35_KcR = 0.3
v35_v35_ACD = 3.3211e-05
v36_KmA = 0.00011
v36_KmB = 0.00163
v36_KmC = 0.00037
v36_KmP = 0.016
v36_KmQ = 0.00024
v36_KmR = 5.1e-05
v36_Keq = 9.0
v36_Kia = 0.00015
v36_Kib = 0.0016
v36_Kic = 0.00013
v36_Kip = 0.0079
v36_Kiq = 0.00019
v36_Kir = 0.00024
v36_KcF = 200.0
v36_KcR = 20.0
v36_v36_PC = 3.8617e-07
v37_K = 3.4e-05
v37_V = 3.99e-08
v37_v37_GUT2P = 0.001
v38_K = 34.0
v38_V = 0.0399
v38_v38_GUT2P = 0.001
v40_V = 0.1667
v40_K = 0.012
v40_v40_AAC = 0.00033211
v41_phi0 = 0.051
v41_phi1 = 9.5e-08
v41_phi2 = 9.6e-07
v41_phi12 = 9e-08
v41_phir0 = 0.066
v41_phir1 = 3.7e-07
v41_phir2 = 2.9e-05
v41_phir3 = 0.00025
v41_phir12 = 6e-12
v41_phir13 = 1.3e-10
v41_phir23 = 9.4e-08
v41_phir123 = 4.6e-14
v41_v41_IDHc = 3.8617e-07
v42_KiS1 = 0.00013
v42_KiS2 = 0.00044
v42_KiP1 = 0.00033
v42_KiP2 = 4.18e-05
v42_KcF = 5.6
v42_KcR = 3.5
v42_alpha = 1.0
v42_beta = 1.0
v42_gamma = 1.0
v42_delta = 1.0
v42_v42_CIC = 0.00033211
v43_V = 1.11667
v43_K = 0.005
v43_v43_AAC = 0.00033211
v39_Kcat = 0.333
v39_Kmal = 0.000125
v39_Knadp = 0.011
v39_v39_MDH = 3.8617e-07
v44_Kcat = 130.5
v44_Km = 0.01295
v44_v44_MDH = 3.8617e-07
CYTOPLASM = 1.0
MATRIX = 1.0
MT_IM = 1.0
MT_IMS = 1.0


#initial values
ADP = 0.00045
ADP_cyt = 0.000108367
AMP = 2.61149e-06
ATP = 0.0045
ATP_cyt = 0.00449064
Acetyl_CoA = 3e-05
Acetyl_CoA_cyt = 3e-05
Ala = 0.00344
Asp = 0.00114
Asp_cyt = 0.00114
CO2 = 0.00163
Cit = 0.00042
Cit_cyt = 0.00042
CoA = 0.000272
CoA_cyt = 0.000272
Cytc2p = 0.00011
Cytc3p = 0.003
DHAP = 0.0076925
DPG = 0.000299109
ETFox = 0.00032
ETFred = 0.00031
F6P = 0.00065939
FAD = 0.00101
FADH2 = 7.2e-05
FBP = 7.70135e-06
Fum = 6.5e-05
G3P = 0.0076925
GAP = 1.90919e-06
GDP = 0.00045
GLC = 1.12817e-05
GTP = 0.0045
Glu = 0.00303
Glu_cyt = 0.00303
H2O = 0.001
IsoCit = 0.00042
IsoCitcyt = 0.00042
LAC = 0.00033981
Mal = 0.0005
Mal_cyt = 0.0005
NAD = 0.00362057
NADH = 0.00072
NADH_cyt = 0.000616118
NADPH = 7.2e-05
NADPH_cyt = 0.000616118
NADP_cyt = 0.00362057
NADP_p = 0.0101
NAD_p = 0.0101
OG = 2.1e-05
OG_cyt = 2.1e-05
OXA = 4e-06
OXA_cyt = 4e-06
PEP = 2.1125e-06
PYR_cyt = 4.22702e-06
Pi = 0.004
Pyr = 0.001025
Q = 0.026
QH2 = 0.028
SCoA = 0.0002941
Suc = 0.00295


#assignment rules